WO2009048123A1 - ビス（トリメチルシリル）フェニル化合物又はその塩、及びその用途 - Google Patents

ビス（トリメチルシリル）フェニル化合物又はその塩、及びその用途 Download PDF

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Publication number
WO2009048123A1
WO2009048123A1 PCT/JP2008/068421 JP2008068421W WO2009048123A1 WO 2009048123 A1 WO2009048123 A1 WO 2009048123A1 JP 2008068421 W JP2008068421 W JP 2008068421W WO 2009048123 A1 WO2009048123 A1 WO 2009048123A1
Authority
WO
WIPO (PCT)
Prior art keywords
trimethylsilyl
bis
salt
bound
alkyl group
Prior art date
Application number
PCT/JP2008/068421
Other languages
English (en)
French (fr)
Inventor
Yoshimitsu Suda
Hiromi Oshiumi
Koji Murakami
Original Assignee
Taiho Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co., Ltd. filed Critical Taiho Pharmaceutical Co., Ltd.
Priority to CN200880110915A priority Critical patent/CN101821274A/zh
Priority to EP08837758A priority patent/EP2202235A4/en
Priority to US12/682,097 priority patent/US7855300B2/en
Priority to JP2009537034A priority patent/JPWO2009048123A1/ja
Publication of WO2009048123A1 publication Critical patent/WO2009048123A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

　本発明は、優れた抗腫瘍活性を示し、核内受容体ＲＡＲαに選択的に作用することによって皮膚障害など既存のレチノイドに見られるような副作用が軽減され、臨床利益の大幅な改善が期待できる化合物を提供する。具体的には、本発明は、一般式（Ｉ） [式中、ＸはＮ又はＣＨを示し、ＹはＯ又はＳを示し、Ｒ１、Ｒ２及びＲ３は同一又は異なって水素原子又は低級アルキル基を示し、Ｒ４及びＲ５は同一又は異なって、水素原子、低級アルキル基又はハロゲン原子を示し、Ｒ１が結合している炭素原子とＲ２が結合している炭素原子との間の結合は、一重結合又は二重結合を示す。] で表されるビス（トリメチルシリル）フェニル化合物又はその塩を提供する。
PCT/JP2008/068421 2007-10-11 2008-10-10 ビス（トリメチルシリル）フェニル化合物又はその塩、及びその用途 WO2009048123A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN200880110915A CN101821274A (zh) 2007-10-11 2008-10-10 双(三甲基硅烷基)苯基化合物或其盐及其用途
EP08837758A EP2202235A4 (en) 2007-10-11 2008-10-10 COMPOUND BIS (TRIMETHYLSILYL) PHENYL OR A SALT THEREOF, AND USE THEREOF
US12/682,097 US7855300B2 (en) 2007-10-11 2008-10-10 Bis(trimethylsilyl)phenyl compound or salt thereof, and use thereof
JP2009537034A JPWO2009048123A1 (ja) 2007-10-11 2008-10-10 ビス（トリメチルシリル）フェニル化合物又はその塩、及びその用途

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-265464 2007-10-11
JP2007265464 2007-10-11

Publications (1)

Publication Number Publication Date
WO2009048123A1 true WO2009048123A1 (ja) 2009-04-16

Family

ID=40549266

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/068421 WO2009048123A1 (ja) 2007-10-11 2008-10-10 ビス（トリメチルシリル）フェニル化合物又はその塩、及びその用途

Country Status (6)

Country Link
US (1) US7855300B2 (ja)
EP (1) EP2202235A4 (ja)
JP (1) JPWO2009048123A1 (ja)
CN (1) CN101821274A (ja)
TW (1) TW200922554A (ja)
WO (1) WO2009048123A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2019044852A1 (ja) * 2017-08-31 2020-10-29 株式会社 資生堂 レチノイドの副作用に対する感受性の決定方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02247185A (ja) 1989-03-20 1990-10-02 Koichi Shudo 新規安息香酸誘導体及びその製造方法
WO1996032101A1 (fr) 1995-04-10 1996-10-17 Taiho Pharmaceutical Co., Ltd. Inhibiteur de la metastase cancereuse

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2752630B2 (ja) * 1988-03-29 1998-05-18 大鵬薬品工業株式会社 新規安息香酸誘導体及びその製造方法
JP4398585B2 (ja) * 1997-11-12 2010-01-13 有限会社ケムフィズ レチノイドレセプター作用剤
JP5284574B2 (ja) 2006-10-06 2013-09-11 財団法人乙卯研究所 レチノイドプロドラッグ化合物
JPWO2009057199A1 (ja) 2007-10-31 2011-03-10 財団法人乙卯研究所 レチノイドプロドラッグ化合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02247185A (ja) 1989-03-20 1990-10-02 Koichi Shudo 新規安息香酸誘導体及びその製造方法
WO1996032101A1 (fr) 1995-04-10 1996-10-17 Taiho Pharmaceutical Co., Ltd. Inhibiteur de la metastase cancereuse

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
AM. J. PHYSIOL., vol. 269, July 1995 (1995-07-01), pages E91 - E98
B. E. MARYANOFF ET AL., CHEM. REV., vol. 89, 1989, pages 863 - 927
BLOOD., vol. 87, no. 5, 1 March 1996 (1996-03-01), pages 1939 - 1950
DEVELOPMENT OF PHARMACEUTICAL PRODUCTS, vol. 7, 1990, pages 163 - 198
DEVELOPMENT, vol. 113, no. 3, November 1991 (1991-11-01), pages 723 - 734
HECK, R. F., ORG. REACT., vol. 27, 1982, pages 345 - 390
JOURNAL OF CLINICAL ONCOLOGY, vol. 10, no. 5, May 1992 (1992-05-01), pages 839 - 864
JOURNAL OF CLINICAL ONCOLOGY, vol. 20, no. 16, 2002, pages 3522 - 3532
M. JESBERGER, SYNTHESIS, vol. 12, 2003, pages 1920 - 1927
TAKERU YAMAKAWA. ET AL., J. MED. CHEM., vol. 33, no. 5, 1990

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2019044852A1 (ja) * 2017-08-31 2020-10-29 株式会社 資生堂 レチノイドの副作用に対する感受性の決定方法
JP7267198B2 (ja) 2017-08-31 2023-05-01 株式会社 資生堂 レチノイドの副作用に対する感受性の決定方法

Also Published As

Publication number Publication date
US20100210591A1 (en) 2010-08-19
JPWO2009048123A1 (ja) 2011-02-24
US7855300B2 (en) 2010-12-21
TW200922554A (en) 2009-06-01
CN101821274A (zh) 2010-09-01
EP2202235A4 (en) 2011-08-17
EP2202235A1 (en) 2010-06-30

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