WO2009041447A1 - 5員複素環化合物 - Google Patents
5員複素環化合物 Download PDFInfo
- Publication number
- WO2009041447A1 WO2009041447A1 PCT/JP2008/067208 JP2008067208W WO2009041447A1 WO 2009041447 A1 WO2009041447 A1 WO 2009041447A1 JP 2008067208 W JP2008067208 W JP 2008067208W WO 2009041447 A1 WO2009041447 A1 WO 2009041447A1
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- ring
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/42—Benzene-sulfonamido pyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/24—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/30—Oxygen or sulfur atoms
- C07D233/42—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/32—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16195491.2A EP3162798B1 (en) | 2007-09-28 | 2008-09-24 | 5-membered heterocyclic compound |
EP08833168.1A EP2196459B1 (en) | 2007-09-28 | 2008-09-24 | 5-membered heterocyclic compound |
JP2009534334A JP5379690B2 (ja) | 2007-09-28 | 2008-09-24 | 5員複素環化合物 |
US12/680,184 US8334301B2 (en) | 2007-09-28 | 2008-09-24 | 5-Membered heterocyclic compound |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007256275 | 2007-09-28 | ||
JP2007-256275 | 2007-09-28 | ||
JP2008-218852 | 2008-08-27 | ||
JP2008218852 | 2008-08-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009041447A1 true WO2009041447A1 (ja) | 2009-04-02 |
Family
ID=40511330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/067208 WO2009041447A1 (ja) | 2007-09-28 | 2008-09-24 | 5員複素環化合物 |
Country Status (5)
Country | Link |
---|---|
US (1) | US8334301B2 (ja) |
EP (2) | EP2196459B1 (ja) |
JP (1) | JP5379690B2 (ja) |
KR (1) | KR101559597B1 (ja) |
WO (1) | WO2009041447A1 (ja) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011004882A1 (ja) | 2009-07-09 | 2011-01-13 | ラクオリア創薬株式会社 | 消化管運動異常が関与する疾患を治療するためのアシッドポンプ拮抗剤 |
US8569353B2 (en) | 2010-07-15 | 2013-10-29 | Dainippon Sumitomo Pharma Co., Ltd. | Pyrazole compound |
WO2014003199A1 (en) | 2012-06-27 | 2014-01-03 | Takeda Pharmaceutical Company Limited | Liquid preparations of amines and organic acids stabilized by salts |
WO2014075575A1 (zh) | 2012-11-19 | 2014-05-22 | 江苏豪森药业股份有限公司 | 吡咯磺酰类衍生物、其制备方法及其在医药上的应用 |
US8895588B2 (en) | 2009-03-26 | 2014-11-25 | Takeda Pharmaceutical Company Limited | Pyrazole compound |
US9186411B2 (en) | 2008-07-28 | 2015-11-17 | Takeda Pharmaceutical Company Limited | Pharmaceutical composition |
AU2011238616B2 (en) * | 2010-03-30 | 2016-08-04 | Verseon Corporation | Multisubstituted aromatic compounds as inhibitors of thrombin |
US9533970B2 (en) | 2013-03-15 | 2017-01-03 | Verseon Corporation | Multisubstituted aromatic compounds as serine protease inhibitors |
US9951025B2 (en) | 2013-03-15 | 2018-04-24 | Verseon Corporation | Halogenopyrazoles as inhibitors of thrombin |
US10189810B2 (en) | 2014-09-17 | 2019-01-29 | Verseon Corporation | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
US10532995B2 (en) | 2015-02-27 | 2020-01-14 | Verseon Corporation | Substituted pyrazole compounds as serine protease inhibitors |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CL2008002834A1 (es) * | 2007-09-28 | 2009-09-11 | Takeda Pharmaceuticals Co | Compuestos heterociclicos de 5 miembros, composicion farmaceutica, util para el tratamiento de la ulcera peptidica, sindrome de zollinger-ellison, gastritis, esofagitis por reflujo, enfermedad sintomatica por reflujo gastroesofagico, esofago de barrett, cancer gastrico, hiperacidez gastrica o ulcera debido a estres posquirurgico. |
CN104039776B (zh) * | 2012-08-03 | 2016-06-08 | 上海恒瑞医药有限公司 | 苯并呋喃类衍生物、其制备方法及其在医药上的应用 |
CN105985278A (zh) * | 2015-01-27 | 2016-10-05 | 江苏柯菲平医药股份有限公司 | 吡咯磺酰类衍生物、其制备方法及其在医药上的应用 |
CN106432191A (zh) * | 2015-08-10 | 2017-02-22 | 陕西合成药业股份有限公司 | 一种新的吡咯类衍生物、其制备方法及其在医药上的应用 |
GB201602934D0 (en) | 2016-02-19 | 2016-04-06 | Cancer Res Inst Royal | Compounds |
US20200288710A1 (en) | 2016-03-15 | 2020-09-17 | Bayer Cropscience Aktiengesellschaft | Substituted sulphonamides for controlling animal pests |
Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004007504A1 (en) | 2002-07-17 | 2004-01-22 | Pharmacia Italia S.P.A. | Heterobicyclic pyrazole derivatives as kinase inhibitors |
US20040214855A1 (en) | 2003-04-23 | 2004-10-28 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
WO2004098589A1 (en) | 2003-05-02 | 2004-11-18 | Elan Pharmaceuticals, Inc. | 4- bromo - 5 - (2- chloro - benzoylamino) - 1h - pyrazole - 3 - carboxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases |
WO2004103968A1 (en) | 2003-05-26 | 2004-12-02 | Aponetics Ag | Sulfopyrroles |
WO2005063736A1 (ja) * | 2003-12-26 | 2005-07-14 | Daiichi Pharmaceutical Co., Ltd. | アミノアルキルピラゾール誘導体 |
WO2006036024A1 (ja) | 2004-09-30 | 2006-04-06 | Takeda Pharmaceutical Company Limited | プロトンポンプ阻害薬 |
FR2881744A1 (fr) * | 2005-02-09 | 2006-08-11 | Sanofi Aventis Sa | Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique |
WO2007026916A1 (en) | 2005-08-30 | 2007-03-08 | Takeda Pharmaceutical Company Limited | 1-heterocyclylsulfonyl, 2-aminomethyl, 5- (hetero-) aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors |
WO2007068815A2 (fr) * | 2005-12-12 | 2007-06-21 | Sanofi-Aventis | Derives heterocycliques, leur preparation et leur application en therapeutique. |
JP2007256275A (ja) | 2006-02-24 | 2007-10-04 | Cem Corp | マイクロ波支援化学作用のための濾過装置とそれに関わる方法 |
WO2007114338A1 (ja) | 2006-03-31 | 2007-10-11 | Takeda Pharmaceutical Company Limited | 酸分泌抑制薬 |
WO2008017932A2 (en) | 2006-08-09 | 2008-02-14 | Pfizer Products Inc. | Heterocycles useful as inhibitors of carbonic anhydrase |
JP2008218852A (ja) | 2007-03-07 | 2008-09-18 | Renesas Technology Corp | 半導体装置の製造方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4020082A (en) * | 1970-02-21 | 1977-04-26 | Enzo Marchetti | 2-Aminomethyl- and 2-(2-aminoethyl)-substituted 4,5-diphenyloxazoles |
IT1033040B (it) | 1970-02-21 | 1979-07-10 | Serono Ist Farm | 4 5 difenilossazoli 2 amminometil e 2,2 amminoetil sostituiti |
CH587836A5 (ja) | 1974-01-31 | 1977-05-13 | Serono Lab | |
US20040132788A1 (en) * | 1999-10-11 | 2004-07-08 | Chabrier De Lassauniere Pierre-Etienne | Derivatives of heterocycles with 5 members, their preparation and their use as medicaments |
TWI320039B (en) * | 2001-09-21 | 2010-02-01 | Lactam-containing compounds and derivatives thereof as factor xa inhibitors | |
US7214800B2 (en) * | 2002-05-09 | 2007-05-08 | Cytokinetics, Inc. | Compounds, compositions, and methods |
JP2007527920A (ja) | 2004-03-08 | 2007-10-04 | ワイス | イオンチャンネルモジュレーター |
KR20060017929A (ko) * | 2004-08-04 | 2006-02-28 | 동화약품공업주식회사 | 티아졸 유도체가 치환된 신규한 벤즈아미딘 유도체, 그의제조방법 및 이를 유효성분으로 하는 약학 조성물 |
US20090221488A1 (en) * | 2005-12-08 | 2009-09-03 | Wood Kenneth W | Certain Compositions and Methods of Treatment |
KR101101675B1 (ko) * | 2006-10-02 | 2011-12-30 | 노파르티스 아게 | 단백질 키나제 억제제로서의 화합물 및 조성물 |
CL2008002834A1 (es) * | 2007-09-28 | 2009-09-11 | Takeda Pharmaceuticals Co | Compuestos heterociclicos de 5 miembros, composicion farmaceutica, util para el tratamiento de la ulcera peptidica, sindrome de zollinger-ellison, gastritis, esofagitis por reflujo, enfermedad sintomatica por reflujo gastroesofagico, esofago de barrett, cancer gastrico, hiperacidez gastrica o ulcera debido a estres posquirurgico. |
-
2008
- 2008-09-24 JP JP2009534334A patent/JP5379690B2/ja active Active
- 2008-09-24 EP EP08833168.1A patent/EP2196459B1/en active Active
- 2008-09-24 EP EP16195491.2A patent/EP3162798B1/en active Active
- 2008-09-24 US US12/680,184 patent/US8334301B2/en active Active
- 2008-09-24 KR KR1020107009271A patent/KR101559597B1/ko active IP Right Grant
- 2008-09-24 WO PCT/JP2008/067208 patent/WO2009041447A1/ja active Application Filing
Patent Citations (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004007504A1 (en) | 2002-07-17 | 2004-01-22 | Pharmacia Italia S.P.A. | Heterobicyclic pyrazole derivatives as kinase inhibitors |
US20040214855A1 (en) | 2003-04-23 | 2004-10-28 | Pfizer Inc | Cannabinoid receptor ligands and uses thereof |
WO2004098589A1 (en) | 2003-05-02 | 2004-11-18 | Elan Pharmaceuticals, Inc. | 4- bromo - 5 - (2- chloro - benzoylamino) - 1h - pyrazole - 3 - carboxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases |
WO2004103968A1 (en) | 2003-05-26 | 2004-12-02 | Aponetics Ag | Sulfopyrroles |
WO2005063736A1 (ja) * | 2003-12-26 | 2005-07-14 | Daiichi Pharmaceutical Co., Ltd. | アミノアルキルピラゾール誘導体 |
WO2006036024A1 (ja) | 2004-09-30 | 2006-04-06 | Takeda Pharmaceutical Company Limited | プロトンポンプ阻害薬 |
FR2881744A1 (fr) * | 2005-02-09 | 2006-08-11 | Sanofi Aventis Sa | Derives de n-[(4,5-diphenyl-2-thienyl)methyl]amine, leur preparation et leur application en therapeutique |
WO2007026916A1 (en) | 2005-08-30 | 2007-03-08 | Takeda Pharmaceutical Company Limited | 1-heterocyclylsulfonyl, 2-aminomethyl, 5- (hetero-) aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors |
WO2007068815A2 (fr) * | 2005-12-12 | 2007-06-21 | Sanofi-Aventis | Derives heterocycliques, leur preparation et leur application en therapeutique. |
JP2007256275A (ja) | 2006-02-24 | 2007-10-04 | Cem Corp | マイクロ波支援化学作用のための濾過装置とそれに関わる方法 |
WO2007114338A1 (ja) | 2006-03-31 | 2007-10-11 | Takeda Pharmaceutical Company Limited | 酸分泌抑制薬 |
WO2008017932A2 (en) | 2006-08-09 | 2008-02-14 | Pfizer Products Inc. | Heterocycles useful as inhibitors of carbonic anhydrase |
JP2008218852A (ja) | 2007-03-07 | 2008-09-18 | Renesas Technology Corp | 半導体装置の製造方法 |
Non-Patent Citations (24)
Title |
---|
"Pharmaceutical Research and Development", vol. 7, 1990, HIROKAWA PUBLISHING CO., pages: 163 - 198 |
"Shinjikken Kagaku Koza", vol. 14-11, MARUZEN PRESS, pages: 652 - 656 |
"Shinjikken Kagaku Koza", vol. 14-III, MARUZEN PRESS, pages: 1380 - 1385 |
"Shinjikken Kagaku Koza", vol. 20, MARUZEN PRESS, pages: 431 - 436 |
ASPRONI,B. ET AL.: "Synthesis and Pharmacological Evaluation of 1-[(1,2-Diphenyl-1H-4-imidazolyl) methyl]-4-phenylpiperazines with Clozapine-Like Mixed Activities at Dopamine D2, Serotonin, and GABAA Receptors", JOURNAL OF MEDICINAL CHEMISTRY, vol. 45, no. 21, 2002, pages 4655 - 4668, XP001197286 * |
BIOORG. MED. CHEM., vol. 12, 2004, pages 1221 |
BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 16, 2006, pages 731 |
CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 31, 1981, pages 1228 |
HETEROCYCLES, vol. 38, 1994, pages 959 |
HETEROCYCLES, vol. 40, 1995, pages 925 |
JOURNAL OF ORGANIC CHEMISTRY, vol. 46, 1981, pages 2596 |
JOURNAL OF ORGANIC CHEMISTRY, vol. 68, 2003, pages 2861 |
ORGANIC LETTERS, vol. 3, 2001, pages 1261 |
See also references of EP2196459A4 * |
SMALLHEER,J.M. ET AL.: "SAR and factor IXa crystal structure of a dual inhibitor of factors IXa and Xa", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 14, no. 21, 2004, pages 5263 - 5267, XP004580511 * |
SYNLETT, vol. 15, 2007, pages 2331 |
SYNTHESIS, 1994, pages 639 |
SYNTHESIS, vol. 7, 1986, pages 564 - 565 |
SYNTHETIC COMMUNICATIONS, vol. 11, 1981, pages 513 |
TANAKA,A. ET AL.: "Antiplatelet Agents Based on Cyclooxygenase Inhibition without Ulcerogenesis. Evaluation and Synthesis of 4,5-Bis(4- methoxyphenyl)-2-substituted-thiazoles", JOURNAL OF MEDICINAL CHEMISTRY, vol. 37, no. 8, 1994, pages 1189 - 99, XP002268971 * |
TANITAME,A. ET AL.: "Synthesis and antibacterial activity of novel and potent DNA gyrase inhibitors with azole ring", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 12, no. 21, 2004, pages 5515 - 5524, XP004588154 * |
THEODORA W. GREENE; PETER G. M. WUTS: "Protective Groups in Organic Synthesis", 1999, WILEY-INTERSCIENCE |
TSUJI,K. ET AL.: "Studies on anti-inflammatory agents. VI. Synthesis and pharmacological properties of 2,3-diarylthiophenes", CHEMICAL & PHARMACEUTICAL BULLETIN, vol. 46, no. 2, 1998, pages 279 - 286, XP008132349 * |
WALLMARK ET AL., BIOCHIM. BIOPHYS. ACTA, vol. 728, 1983, pages 31 |
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EP3162798A1 (en) | 2017-05-03 |
US20100210696A1 (en) | 2010-08-19 |
US8334301B2 (en) | 2012-12-18 |
EP2196459B1 (en) | 2016-11-02 |
EP2196459A4 (en) | 2011-06-15 |
EP2196459A1 (en) | 2010-06-16 |
JPWO2009041447A1 (ja) | 2011-01-27 |
JP5379690B2 (ja) | 2013-12-25 |
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KR20100061849A (ko) | 2010-06-09 |
EP3162798B1 (en) | 2021-04-14 |
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