WO2006040569A8 - Thiophene amide compounds for use in the treatment or prophylaxis of cancers - Google Patents
Thiophene amide compounds for use in the treatment or prophylaxis of cancersInfo
- Publication number
- WO2006040569A8 WO2006040569A8 PCT/GB2005/003957 GB2005003957W WO2006040569A8 WO 2006040569 A8 WO2006040569 A8 WO 2006040569A8 GB 2005003957 W GB2005003957 W GB 2005003957W WO 2006040569 A8 WO2006040569 A8 WO 2006040569A8
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- optionally substituted
- group
- prophylaxis
- treatment
- compound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61878004P | 2004-10-14 | 2004-10-14 | |
US60/618,780 | 2004-10-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006040569A1 WO2006040569A1 (en) | 2006-04-20 |
WO2006040569A8 true WO2006040569A8 (en) | 2007-04-26 |
Family
ID=35502547
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2005/003957 WO2006040569A1 (en) | 2004-10-14 | 2005-10-14 | Thiophene amide compounds for use in the treatment or prophylaxis of cancers |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2006040569A1 (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20080103996A (en) | 2006-02-16 | 2008-11-28 | 쉐링 코포레이션 | Pyrrolidine derivatives as erk inhibitors |
JP4884072B2 (en) * | 2006-05-12 | 2012-02-22 | 三井化学アグロ株式会社 | Heterocyclic derivatives and their use as insecticides |
RU2525389C2 (en) | 2008-02-21 | 2014-08-10 | Мерк Шарп И Доум Корп. | Compounds which are erk inhibitors |
EP2297097A2 (en) * | 2008-06-11 | 2011-03-23 | Irm Llc | Compounds and compositions useful for the treatment of malaria |
FR2945289A1 (en) | 2009-05-11 | 2010-11-12 | Sanofi Aventis | 2-CYCLOAMINO-5- (PYRIDIN-4-YL) IMIDAZO-2,1-B1 DERIVATIVES 1,3,4! THIADIAZOLE, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
US9408885B2 (en) | 2011-12-01 | 2016-08-09 | Vib Vzw | Combinations of therapeutic agents for treating melanoma |
WO2014043633A1 (en) | 2012-09-17 | 2014-03-20 | Agios Pharmaceuticals, Inc. | Use of e-cadherin and vimentin for selection of treatment responsive patients |
US10011574B2 (en) | 2012-11-21 | 2018-07-03 | Agios Pharmaceuticals, Inc. | Glutaminase inhibitors and method of use |
WO2014079011A1 (en) | 2012-11-22 | 2014-05-30 | Agios Pharmaceuticals, Inc. | Heterocyclic compounds for inhibiting glutaminase and their methods of use |
KR20160127149A (en) * | 2014-03-21 | 2016-11-02 | 아지오스 파마슈티컬스 아이엔씨. | Compounds and Their Methods of Use |
WO2017117532A1 (en) * | 2015-12-31 | 2017-07-06 | Cantley Lewis C | Small molecule inhibitor of 3-phosphoglycerate dehydrogenase and uses thereof |
EP3579872A1 (en) | 2017-02-10 | 2019-12-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway |
CA3086765A1 (en) | 2017-12-28 | 2019-07-04 | Tract Pharmaceuticals, Inc. | Stem cell culture systems for columnar epithelial stem cells, and uses related thereto |
EP3801504A4 (en) * | 2018-06-11 | 2022-07-27 | Northeastern University | Selective ligands for modulation of girk channels |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1196390B (en) * | 1984-12-28 | 1988-11-16 | Consiglio Nazionale Ricerche | New pharmaceutical compsns. useful in tumour therapy |
US6187799B1 (en) * | 1997-05-23 | 2001-02-13 | Onyx Pharmaceuticals | Inhibition of raf kinase activity using aryl ureas |
US6037340A (en) * | 1997-05-28 | 2000-03-14 | Cadus Pharmaceutical Corporation | Synthesis and use of thiophene- and pyrrole-based heteroaromatic compounds |
WO2001025190A1 (en) * | 1999-10-01 | 2001-04-12 | Japan Energy Corporation | Novel diarylamide derivatives and use thereof as medicines |
US6414013B1 (en) * | 2000-06-19 | 2002-07-02 | Pharmacia & Upjohn S.P.A. | Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention |
JP2003267869A (en) * | 2002-03-13 | 2003-09-25 | Toray Ind Inc | Thiophene derivative- or indole derivative-containing medicine |
JP2005531608A (en) * | 2002-06-06 | 2005-10-20 | スミスクライン・ビーチャム・コーポレイション | NF-κB inhibitor |
US7196106B2 (en) * | 2002-11-05 | 2007-03-27 | Merck & Co., Inc | Cyanothiophene derivatives, compositions containing such compounds and methods of use |
GB0308511D0 (en) * | 2003-04-14 | 2003-05-21 | Astex Technology Ltd | Pharmaceutical compounds |
US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
JP2007508318A (en) * | 2003-10-09 | 2007-04-05 | エートン ファーマ インコーポレーティッド | Thiophene and benzothiophene hydroxamic acid derivatives |
WO2005100338A1 (en) * | 2004-04-13 | 2005-10-27 | Astex Therapeutics Limited | 5-morpholinylmethylthiophenyl pharmaceutial compounds as p38 map kinase modulators |
-
2005
- 2005-10-14 WO PCT/GB2005/003957 patent/WO2006040569A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2006040569A1 (en) | 2006-04-20 |
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