WO2009032123A3 - Dérivés d'indole tétracycliques et procédés pour les utiliser - Google Patents
Dérivés d'indole tétracycliques et procédés pour les utiliser Download PDFInfo
- Publication number
- WO2009032123A3 WO2009032123A3 PCT/US2008/010147 US2008010147W WO2009032123A3 WO 2009032123 A3 WO2009032123 A3 WO 2009032123A3 US 2008010147 W US2008010147 W US 2008010147W WO 2009032123 A3 WO2009032123 A3 WO 2009032123A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treating
- indole derivatives
- tetracyclic indole
- viral infections
- preventing viral
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08795628A EP2197884A2 (fr) | 2007-08-29 | 2008-08-27 | Dérivés d'indole tétracycliques et procédés pour les utiliser |
US12/675,277 US20110104109A1 (en) | 2005-07-13 | 2008-08-27 | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
JP2010522933A JP5179585B2 (ja) | 2007-08-29 | 2008-08-27 | 四環系インドール誘導体およびその使用法 |
MX2010002316A MX2010002316A (es) | 2007-08-29 | 2008-08-27 | Derivados tetraciclicos de indol y su uso para el tratamiento o prevencion de infecciones virales. |
CN200880113543A CN101842376A (zh) | 2007-08-29 | 2008-08-27 | 四环吲哚衍生物及其用于治疗或预防病毒感染 |
AU2008295483A AU2008295483B2 (en) | 2007-08-29 | 2008-08-27 | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
CA2697451A CA2697451A1 (fr) | 2007-08-29 | 2008-08-27 | Derives d'indole tetracycliques et procedes pour les utiliser |
ZA2010/01391A ZA201001391B (en) | 2007-08-29 | 2010-02-25 | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96868407P | 2007-08-29 | 2007-08-29 | |
US60/968,684 | 2007-08-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009032123A2 WO2009032123A2 (fr) | 2009-03-12 |
WO2009032123A3 true WO2009032123A3 (fr) | 2009-06-11 |
Family
ID=40319417
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/010147 WO2009032123A2 (fr) | 2005-07-13 | 2008-08-27 | Dérivés d'indole tétracycliques et procédés pour les utiliser |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP2197884A2 (fr) |
JP (1) | JP5179585B2 (fr) |
KR (1) | KR20100061819A (fr) |
CN (1) | CN101842376A (fr) |
AR (1) | AR068109A1 (fr) |
AU (1) | AU2008295483B2 (fr) |
CA (1) | CA2697451A1 (fr) |
MX (1) | MX2010002316A (fr) |
TW (1) | TW200918536A (fr) |
WO (1) | WO2009032123A2 (fr) |
ZA (1) | ZA201001391B (fr) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5501251B2 (ja) | 2008-01-11 | 2014-05-21 | アルバニー モレキュラー リサーチ, インコーポレイテッド | Mch拮抗薬としての(1−アジノン)置換ピリドインドール類 |
JP5580814B2 (ja) * | 2008-06-13 | 2014-08-27 | メルク・シャープ・アンド・ドーム・コーポレーション | 3環式インドール誘導体およびその使用方法 |
ES2383273T3 (es) | 2008-07-23 | 2012-06-19 | F. Hoffmann-La Roche Ag | Compuestos heterocíclicos antivíricos |
JP2012503620A (ja) | 2008-09-26 | 2012-02-09 | エフ.ホフマン−ラ ロシュ アーゲー | Hcvを処置するためのピリンまたはピラジン誘導体 |
AU2010240888A1 (en) | 2009-04-25 | 2011-11-17 | F. Hoffmann-La Roche Ag | Heterocyclic antiviral compounds |
AU2010253791A1 (en) | 2009-05-29 | 2011-11-24 | Merck Sharp & Dohme Corp. | Antiviral compounds composed of three linked Aryl moieties to treat diseases such as Hepatitis C |
TWI428332B (zh) | 2009-06-09 | 2014-03-01 | Hoffmann La Roche | 雜環抗病毒化合物 |
CA2762675A1 (fr) | 2009-06-24 | 2010-12-29 | F. Hoffmann-La Roche Ag | Compose antiviral heterocyclique |
EP2448585B1 (fr) | 2009-07-01 | 2014-01-01 | Albany Molecular Research, Inc. | Antagonistes de mch-1 d azépino[b]indole et pyrido-pyrrolo-azépine azinone-substitué, procédés de préparation, et utilisation de ceux-ci |
WO2011003007A1 (fr) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Antagonistes de mch-1 dazabicycloalcane-indole et dazabicycloalcane-pyrrolo-pyridine, procédés de préparation, et utilisation de ceux-ci |
WO2011003012A1 (fr) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Antagonistes de mch-1 azapolycycles substitués par azinone, leurs procédés de fabrication et leur utilisation |
US9073925B2 (en) | 2009-07-01 | 2015-07-07 | Albany Molecular Research, Inc. | Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
JP2013505218A (ja) | 2009-09-21 | 2013-02-14 | エフ.ホフマン−ラ ロシュ アーゲー | 複素環式抗ウイルス化合物 |
AU2010324871A1 (en) | 2009-11-25 | 2012-06-14 | Merck Sharp & Dohme Corp. | Fused tricyclic compounds and derivatives thereof useful for the treatment of viral diseases |
AU2010341537A1 (en) | 2009-12-22 | 2012-08-09 | Merck Sharp & Dohme Corp. | Fused Tricyclic Compounds and methods of use thereof for the treatment of viral diseases |
SG183526A1 (en) | 2010-03-09 | 2012-09-27 | Merck Sharp & Dohme | Fused tricyclic silyl compounds and methods of use thereof for the treatment of viral diseases |
EP2566697B1 (fr) | 2010-05-02 | 2020-12-09 | Xjet Ltd. | Système d'impression pourvu de dispositifs de purge automatique, de prévention de dépôt et d'élimination d'émanations |
JP2013541499A (ja) | 2010-07-26 | 2013-11-14 | メルク・シャープ・エンド・ドーム・コーポレイション | 置換されたビフェニレン化合物およびウイルス性疾患の治療のためのその使用方法 |
EP2621932A4 (fr) * | 2010-09-29 | 2014-03-26 | Merck Sharp & Dohme | Composés hétérocycliques tétracycliques pour le traitement d'une infection par le virus de l'hépatite c |
AU2011314168A1 (en) | 2010-09-29 | 2013-04-04 | Merck Sharp & Dohme Corp. | Fused tetracycle derivatives and methods of use thereof for the treatment of viral diseases |
US8993765B2 (en) | 2010-12-21 | 2015-03-31 | Albany Molecular Research, Inc. | Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof |
US8697700B2 (en) | 2010-12-21 | 2014-04-15 | Albany Molecular Research, Inc. | Piperazinone-substituted tetrahydro-carboline MCH-1 antagonists, methods of making, and uses thereof |
US9156872B2 (en) | 2011-04-13 | 2015-10-13 | Merck Sharp & Dohme Corp. | 2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
BR112013026345A2 (pt) | 2011-04-13 | 2019-04-24 | Merck Sharp & Dohe Corp. | composto, composição farmacêutica, uso de um composto, e, método para tratar um paciente infectado com hcv |
WO2013033899A1 (fr) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Composés benzofuranes substitués et leur procédés d'utilisation pour le traitement de maladies virales |
WO2013033901A1 (fr) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Dérivés benzofuranes substitués par un hétérocycle et leurs procédés d'utilisation pour le traitement de maladies virales |
WO2013033900A1 (fr) * | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tétracycliques et leurs procédés d'utilisation pour le traitement de maladies virales |
EP2755981A4 (fr) | 2011-09-14 | 2015-03-25 | Merck Sharp & Dohme | Composés hétérocycliques contenant un silyle et méthodes d'utilisation desdits composés pour traiter les maladies virales |
AR092959A1 (es) | 2012-10-17 | 2015-05-06 | Merck Sharp & Dohme | Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales |
US9242988B2 (en) | 2012-10-17 | 2016-01-26 | Merck Sharp & Dohme Corp. | 2′-cyano substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
EP2909210A4 (fr) | 2012-10-17 | 2016-04-06 | Merck Sharp & Dohme | Dérivés nucléosides substitués 2'-disubstitués et leurs procédés d'utilisation pour le traitement de maladies virales |
RU2015123641A (ru) | 2012-11-19 | 2017-01-10 | Мерк Шарп И Доум Корп. | 2-алкинилзамещенные производные нуклеозидов, предназначенные для лечения вирусных заболеваний |
US9765107B2 (en) | 2013-06-18 | 2017-09-19 | Merck Sharp & Dohme Corp. | Cyclic phosphonate substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
WO2014205592A1 (fr) | 2013-06-24 | 2014-12-31 | Merck Sharp & Dohme Corp. | Composés hétérocycliques et leurs procédés d'utilisation pour le traitement de l'hépatite c |
WO2014205593A1 (fr) | 2013-06-24 | 2014-12-31 | Merck Sharp & Dohme Corp. | Composés de benzofurane substitués et leurs méthodes d'utilisation pour le traitement de maladies virales |
WO2015065817A1 (fr) | 2013-10-30 | 2015-05-07 | Merck Sharp & Dohme Corp. | Pseudopolymorphes d'un inhibiteur de la protéine ns5a du vhc et leurs utilisations |
US10899788B2 (en) | 2016-06-20 | 2021-01-26 | Merck Sharp & Dohme Corp. | Cyclic phosphate substituted nucleoside compounds and methods of use thereof for the treatment of viral diseases |
CN112898312B (zh) * | 2021-01-29 | 2021-11-12 | 湖南南新制药股份有限公司 | 一种稠合多环吡啶酮衍生物及其用途 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006020082A1 (fr) * | 2004-08-09 | 2006-02-23 | Bristol-Myers Squibb Company | Inhibiteurs de replication du hcv |
WO2006034337A2 (fr) * | 2004-09-23 | 2006-03-30 | Wyeth | Derives de carbazole et de cyclopentaindole destines a traiter une infection par le virus de l'hepatite c |
WO2007029029A2 (fr) * | 2005-09-09 | 2007-03-15 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Derives d'indole tetracycliques utilises comme agents antiviraux |
WO2007038209A2 (fr) * | 2005-09-23 | 2007-04-05 | Schering Corporation | Antagonistes du mglur1 tetracycliques fusionnes utilises en tant qu'agents therapeutiques |
-
2008
- 2008-08-27 AR ARP080103718A patent/AR068109A1/es not_active Application Discontinuation
- 2008-08-27 MX MX2010002316A patent/MX2010002316A/es not_active Application Discontinuation
- 2008-08-27 EP EP08795628A patent/EP2197884A2/fr not_active Withdrawn
- 2008-08-27 CA CA2697451A patent/CA2697451A1/fr not_active Abandoned
- 2008-08-27 KR KR1020107006704A patent/KR20100061819A/ko not_active Application Discontinuation
- 2008-08-27 CN CN200880113543A patent/CN101842376A/zh active Pending
- 2008-08-27 AU AU2008295483A patent/AU2008295483B2/en not_active Ceased
- 2008-08-27 WO PCT/US2008/010147 patent/WO2009032123A2/fr active Application Filing
- 2008-08-27 TW TW097132762A patent/TW200918536A/zh unknown
- 2008-08-27 JP JP2010522933A patent/JP5179585B2/ja not_active Expired - Fee Related
-
2010
- 2010-02-25 ZA ZA2010/01391A patent/ZA201001391B/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006020082A1 (fr) * | 2004-08-09 | 2006-02-23 | Bristol-Myers Squibb Company | Inhibiteurs de replication du hcv |
WO2006034337A2 (fr) * | 2004-09-23 | 2006-03-30 | Wyeth | Derives de carbazole et de cyclopentaindole destines a traiter une infection par le virus de l'hepatite c |
WO2007029029A2 (fr) * | 2005-09-09 | 2007-03-15 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Derives d'indole tetracycliques utilises comme agents antiviraux |
WO2007038209A2 (fr) * | 2005-09-23 | 2007-04-05 | Schering Corporation | Antagonistes du mglur1 tetracycliques fusionnes utilises en tant qu'agents therapeutiques |
Non-Patent Citations (1)
Title |
---|
R. SILVESTRI ET AL.: "Synthesis and biological evaluation of 5H-indolo [3,2-b][1,5]benzothiazepine derivatives, designed as conformationally constrained analogues of the human immunodeficiency virus type 1 reverse transcriptase inhibitor L-737126", ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, vol. 9, no. 2, 1998, pages 139 - 148, XP002523406 * |
Also Published As
Publication number | Publication date |
---|---|
EP2197884A2 (fr) | 2010-06-23 |
AU2008295483A1 (en) | 2009-03-12 |
CA2697451A1 (fr) | 2009-03-12 |
JP5179585B2 (ja) | 2013-04-10 |
JP2010537980A (ja) | 2010-12-09 |
ZA201001391B (en) | 2010-11-24 |
KR20100061819A (ko) | 2010-06-09 |
TW200918536A (en) | 2009-05-01 |
AR068109A1 (es) | 2009-11-04 |
AU2008295483B2 (en) | 2013-11-21 |
WO2009032123A2 (fr) | 2009-03-12 |
CN101842376A (zh) | 2010-09-22 |
MX2010002316A (es) | 2010-03-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2009032123A3 (fr) | Dérivés d'indole tétracycliques et procédés pour les utiliser | |
MX2010002317A (es) | Derivados de indol sustituidos y metodos para su utilizacion. | |
MX2010002319A (es) | Derivados indolicos 2,3 sustituidos para el tratamiento de infecciones virales. | |
MX2010005356A (es) | Derivados de indol 3-heterociclico sustituidos y metodos de uso de los mismos. | |
MX2010002318A (es) | Derivados azaindol 2,3-sustituidos para tratar infecciones virales. | |
MX2010005355A (es) | Derivados de indol sustituidos con 3-aminosulfonilo y metodos de uso de los mismos. | |
WO2008136815A3 (fr) | Dérivés indoliques annelés à cycle à 5 ou 6 éléments et leurs méthodes d'utilisation | |
TW200833662A (en) | 4,5-ring annulated indole derivatives and methods of use thereof | |
WO2008127364A3 (fr) | Composés antiviraux et utilisation de ceux-ci | |
IL250858A0 (en) | Tetracycline derivatives for the treatment of bacterial, viral and parasitic infections | |
WO2010062821A8 (fr) | Composés antiviraux, compositions, et procédés d’utilisation | |
WO2008115281A3 (fr) | Composés de traitement d'infections virales | |
WO2010014134A8 (fr) | Composés et compositions pharmaceutiques pour le traitement d'infections virales | |
CL2012001176A1 (es) | Compuestos derivados de bencimidazol-imidazol, inhibidores del virus de la hepatitis c (hcv); composición farmacéutica que los comprende; combinación farmacéutica; uso en la prevención o tratamiento de infección de hcv. | |
WO2008113011A3 (fr) | Purification de particules de type virus | |
IL187135A0 (en) | 2-amido-6-amino-8-oxopurine derivatives as toll-like receptor modulators for the treatment of cancer and viral infections, such as hepatitis c | |
MX2009011533A (es) | Productos quimicos, composiciones y metodos para tratamiento y prevencion de infecciones de virus orthopox y enfermedades asociadas. | |
AP2010005480A0 (en) | Small molecule inhibitors for the treatment or prevention of denque virus infection. | |
MX2012011222A (es) | Compuestos y composiciones farmaceuticas para el tratamiento de infecciones virales. | |
WO2009129246A3 (fr) | Compositions et leurs procédés de préparation et d'utilisation | |
WO2009105513A3 (fr) | Nouveaux composés et procédés pour la thérapie | |
EP1865967A4 (fr) | Composes, compositions et methodes de traitement d'infections virales et autres troubles medicaux | |
WO2011158039A8 (fr) | Dérivés d'uréido-pyrazole destinés à être utilisés dans le traitement d'infections par un rhinovirus | |
WO2009149179A3 (fr) | Procédés et dispositifs améliorés de thérapie antivirale | |
WO2008017346A3 (fr) | Utilisation de dérivés d'acide ascorbique pour la fonctionnalisation de matrices |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200880113543.7 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 08795628 Country of ref document: EP Kind code of ref document: A2 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 583388 Country of ref document: NZ Ref document number: 2008295483 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 204053 Country of ref document: IL |
|
WWE | Wipo information: entry into national phase |
Ref document number: 12010500407 Country of ref document: PH |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2697451 Country of ref document: CA |
|
ENP | Entry into the national phase |
Ref document number: 2010522933 Country of ref document: JP Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: MX/A/2010/002316 Country of ref document: MX |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 2008295483 Country of ref document: AU Date of ref document: 20080827 Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: PI 2010000803 Country of ref document: MY |
|
ENP | Entry into the national phase |
Ref document number: 20107006704 Country of ref document: KR Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2008795628 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 12675277 Country of ref document: US |