WO2009032123A3 - Dérivés d'indole tétracycliques et procédés pour les utiliser - Google Patents
Dérivés d'indole tétracycliques et procédés pour les utiliser Download PDFInfo
- Publication number
- WO2009032123A3 WO2009032123A3 PCT/US2008/010147 US2008010147W WO2009032123A3 WO 2009032123 A3 WO2009032123 A3 WO 2009032123A3 US 2008010147 W US2008010147 W US 2008010147W WO 2009032123 A3 WO2009032123 A3 WO 2009032123A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- treating
- indole derivatives
- tetracyclic indole
- viral infections
- preventing viral
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/052—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being six-membered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2008295483A AU2008295483B2 (en) | 2007-08-29 | 2008-08-27 | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
CA2697451A CA2697451A1 (fr) | 2007-08-29 | 2008-08-27 | Derives d'indole tetracycliques et procedes pour les utiliser |
CN200880113543A CN101842376A (zh) | 2007-08-29 | 2008-08-27 | 四环吲哚衍生物及其用于治疗或预防病毒感染 |
JP2010522933A JP5179585B2 (ja) | 2007-08-29 | 2008-08-27 | 四環系インドール誘導体およびその使用法 |
MX2010002316A MX2010002316A (es) | 2007-08-29 | 2008-08-27 | Derivados tetraciclicos de indol y su uso para el tratamiento o prevencion de infecciones virales. |
EP08795628A EP2197884A2 (fr) | 2007-08-29 | 2008-08-27 | Dérivés d'indole tétracycliques et procédés pour les utiliser |
US12/675,277 US20110104109A1 (en) | 2005-07-13 | 2008-08-27 | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
ZA2010/01391A ZA201001391B (en) | 2007-08-29 | 2010-02-25 | Tetracyclic indole derivatives and their use for treating or preventing viral infections |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US96868407P | 2007-08-29 | 2007-08-29 | |
US60/968,684 | 2007-08-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2009032123A2 WO2009032123A2 (fr) | 2009-03-12 |
WO2009032123A3 true WO2009032123A3 (fr) | 2009-06-11 |
Family
ID=40319417
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/010147 WO2009032123A2 (fr) | 2005-07-13 | 2008-08-27 | Dérivés d'indole tétracycliques et procédés pour les utiliser |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP2197884A2 (fr) |
JP (1) | JP5179585B2 (fr) |
KR (1) | KR20100061819A (fr) |
CN (1) | CN101842376A (fr) |
AR (1) | AR068109A1 (fr) |
AU (1) | AU2008295483B2 (fr) |
CA (1) | CA2697451A1 (fr) |
MX (1) | MX2010002316A (fr) |
TW (1) | TW200918536A (fr) |
WO (1) | WO2009032123A2 (fr) |
ZA (1) | ZA201001391B (fr) |
Families Citing this family (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ586120A (en) | 2008-01-11 | 2012-07-27 | Albany Molecular Res Inc | (1-azinone) -substituted pyridoindoles as mch antagonists |
MX2010013630A (es) * | 2008-06-13 | 2010-12-21 | Schering Corp | Derivados triciclicos de indol y metodos de uso de los mismos. |
ES2383273T3 (es) | 2008-07-23 | 2012-06-19 | F. Hoffmann-La Roche Ag | Compuestos heterocíclicos antivíricos |
CN102164909A (zh) | 2008-09-26 | 2011-08-24 | 弗·哈夫曼-拉罗切有限公司 | 用于治疗hcv的吡啶或吡嗪衍生物 |
KR20120011880A (ko) | 2009-04-25 | 2012-02-08 | 에프. 호프만-라 로슈 아게 | 헤테로사이클릭 항바이러스성 화합물 |
EP2435424B1 (fr) | 2009-05-29 | 2015-01-21 | Merck Sharp & Dohme Corp. | Composés antiviraux de trois fractions d'aryle liées pour traiter des maladies telles que l'hépatite c |
TWI428332B (zh) | 2009-06-09 | 2014-03-01 | Hoffmann La Roche | 雜環抗病毒化合物 |
JP2012530751A (ja) | 2009-06-24 | 2012-12-06 | エフ.ホフマン−ラ ロシュ アーゲー | 複素環式の抗ウイルス性化合物 |
WO2011003021A1 (fr) | 2009-07-01 | 2011-01-06 | Albany Molecular Research, Inc. | Antagonistes de mch-1 azabicycloalcane-indoles et azabicycloalcane-pyrrolo-pyridines substitués par azinone, leurs procédés de fabrication et leur utilisation |
US8618299B2 (en) | 2009-07-01 | 2013-12-31 | Albany Molecular Research, Inc. | Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof |
JP2012532144A (ja) | 2009-07-01 | 2012-12-13 | アルバニー モレキュラー リサーチ, インコーポレイテッド | アジノン置換アゼピノ[b]インドールおよびピリド−ピロロ−アゼピンmch−1拮抗薬、ならびにその作製方法および使用 |
US8629158B2 (en) | 2009-07-01 | 2014-01-14 | Albany Molecular Research, Inc. | Azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof |
JP2013505218A (ja) | 2009-09-21 | 2013-02-14 | エフ.ホフマン−ラ ロシュ アーゲー | 複素環式抗ウイルス化合物 |
JP2013512246A (ja) | 2009-11-25 | 2013-04-11 | メルク・シャープ・アンド・ドーム・コーポレーション | ウイルス疾患治療に有用な縮合型三環式化合物およびその誘導体 |
WO2011087740A1 (fr) | 2009-12-22 | 2011-07-21 | Schering Corporation | Composés tricycliques fusionnés et leurs méthodes d'utilisation pour le traitement de maladies virales |
AU2011224698A1 (en) | 2010-03-09 | 2012-11-01 | Merck Sharp & Dohme Corp. | Fused Tricyclic Silyl Compounds and methods of use thereof for the treatment of viral diseases |
JP6132352B2 (ja) | 2010-05-02 | 2017-05-24 | エックスジェット エルティーディー. | セルフパージ、沈澱防止、および、ガス除去の構造を備えた印刷システム |
CA2805440A1 (fr) | 2010-07-26 | 2012-02-09 | Merck Sharp & Dohme Corp. | Composes de biphenylene substitue et procedes d'utilisation desdits composes pour le traitement de maladies virales |
WO2012041227A1 (fr) * | 2010-09-29 | 2012-04-05 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tétracycliques pour le traitement d'une infection par le virus de l'hépatite c |
EP2621279B1 (fr) | 2010-09-29 | 2018-04-04 | Merck Sharp & Dohme Corp. | Dérivés tétracycliques condensés et procédés d'utilisation de ceux-ci dans le traitement de maladies virales |
WO2012088124A2 (fr) | 2010-12-21 | 2012-06-28 | Albany Molecular Research, Inc. | Antagonistes de la mch-1 à base de tétrahydro-azacarboline, leurs procédés de fabrication et leurs utilisations |
WO2012088038A2 (fr) | 2010-12-21 | 2012-06-28 | Albany Molecular Research, Inc. | Antagonistes de mch-1 consistant en tétrahydro-carbolines substituées par pipérazinone, leurs procédés de fabrication et utilisations |
JP2014515023A (ja) | 2011-04-13 | 2014-06-26 | メルク・シャープ・アンド・ドーム・コーポレーション | 2’−置換ヌクレオシド誘導体およびウイルス疾患の処置のためのその使用方法 |
US9156872B2 (en) | 2011-04-13 | 2015-10-13 | Merck Sharp & Dohme Corp. | 2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
WO2013033900A1 (fr) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Composés hétérocycliques tétracycliques et leurs procédés d'utilisation pour le traitement de maladies virales |
WO2013033901A1 (fr) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Dérivés benzofuranes substitués par un hétérocycle et leurs procédés d'utilisation pour le traitement de maladies virales |
WO2013033899A1 (fr) | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Composés benzofuranes substitués et leur procédés d'utilisation pour le traitement de maladies virales |
US20140378416A1 (en) | 2011-09-14 | 2014-12-25 | Michael P. Dwyer | Silyl-containing heterocyclic compounds and methods of use thereof for the treatment of viral diseases |
AR092959A1 (es) | 2012-10-17 | 2015-05-06 | Merck Sharp & Dohme | Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales |
EP2909209B1 (fr) | 2012-10-17 | 2022-08-03 | Merck Sharp & Dohme LLC | Dérivés nucléosides à substitution 2'-cyano et leurs méthodes d'utilisation pour le traitement de maladies virales |
WO2014059902A1 (fr) | 2012-10-17 | 2014-04-24 | Merck Sharp & Dohme Corp. | Dérivés nucléosides substitués 2'-disubstitués et leurs procédés d'utilisation pour le traitement de maladies virales |
EP2919792B1 (fr) | 2012-11-19 | 2020-05-20 | Merck Sharp & Dohme Corp. | Dérivés de nucléoside à substitution alkynyle en position 2 pour le traitement de maladies virales |
EP3010512B1 (fr) | 2013-06-18 | 2017-12-27 | Merck Sharp & Dohme Corp. | Dérivés de nucléosides cycliques à substitution phosphonate et leurs méthodes d'utilisation pour le traitement de maladies virales |
WO2014205593A1 (fr) | 2013-06-24 | 2014-12-31 | Merck Sharp & Dohme Corp. | Composés de benzofurane substitués et leurs méthodes d'utilisation pour le traitement de maladies virales |
WO2014205592A1 (fr) | 2013-06-24 | 2014-12-31 | Merck Sharp & Dohme Corp. | Composés hétérocycliques et leurs procédés d'utilisation pour le traitement de l'hépatite c |
WO2015065817A1 (fr) | 2013-10-30 | 2015-05-07 | Merck Sharp & Dohme Corp. | Pseudopolymorphes d'un inhibiteur de la protéine ns5a du vhc et leurs utilisations |
EP3471737A4 (fr) | 2016-06-20 | 2019-12-25 | Merck Sharp & Dohme Corp. | Composés nucléosides cycliques à substitution phosphate et leurs procédés d'utilisation pour le traitement de maladies virales |
CN112898312B (zh) * | 2021-01-29 | 2021-11-12 | 湖南南新制药股份有限公司 | 一种稠合多环吡啶酮衍生物及其用途 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006020082A1 (fr) * | 2004-08-09 | 2006-02-23 | Bristol-Myers Squibb Company | Inhibiteurs de replication du hcv |
WO2006034337A2 (fr) * | 2004-09-23 | 2006-03-30 | Wyeth | Derives de carbazole et de cyclopentaindole destines a traiter une infection par le virus de l'hepatite c |
WO2007029029A2 (fr) * | 2005-09-09 | 2007-03-15 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Derives d'indole tetracycliques utilises comme agents antiviraux |
WO2007038209A2 (fr) * | 2005-09-23 | 2007-04-05 | Schering Corporation | Antagonistes du mglur1 tetracycliques fusionnes utilises en tant qu'agents therapeutiques |
-
2008
- 2008-08-27 JP JP2010522933A patent/JP5179585B2/ja not_active Expired - Fee Related
- 2008-08-27 EP EP08795628A patent/EP2197884A2/fr not_active Withdrawn
- 2008-08-27 WO PCT/US2008/010147 patent/WO2009032123A2/fr active Application Filing
- 2008-08-27 TW TW097132762A patent/TW200918536A/zh unknown
- 2008-08-27 AR ARP080103718A patent/AR068109A1/es not_active Application Discontinuation
- 2008-08-27 KR KR1020107006704A patent/KR20100061819A/ko not_active Application Discontinuation
- 2008-08-27 CA CA2697451A patent/CA2697451A1/fr not_active Abandoned
- 2008-08-27 AU AU2008295483A patent/AU2008295483B2/en not_active Ceased
- 2008-08-27 MX MX2010002316A patent/MX2010002316A/es not_active Application Discontinuation
- 2008-08-27 CN CN200880113543A patent/CN101842376A/zh active Pending
-
2010
- 2010-02-25 ZA ZA2010/01391A patent/ZA201001391B/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006020082A1 (fr) * | 2004-08-09 | 2006-02-23 | Bristol-Myers Squibb Company | Inhibiteurs de replication du hcv |
WO2006034337A2 (fr) * | 2004-09-23 | 2006-03-30 | Wyeth | Derives de carbazole et de cyclopentaindole destines a traiter une infection par le virus de l'hepatite c |
WO2007029029A2 (fr) * | 2005-09-09 | 2007-03-15 | Istituto Di Ricerche Di Biologia Molecolare P. Angeletti Spa | Derives d'indole tetracycliques utilises comme agents antiviraux |
WO2007038209A2 (fr) * | 2005-09-23 | 2007-04-05 | Schering Corporation | Antagonistes du mglur1 tetracycliques fusionnes utilises en tant qu'agents therapeutiques |
Non-Patent Citations (1)
Title |
---|
R. SILVESTRI ET AL.: "Synthesis and biological evaluation of 5H-indolo [3,2-b][1,5]benzothiazepine derivatives, designed as conformationally constrained analogues of the human immunodeficiency virus type 1 reverse transcriptase inhibitor L-737126", ANTIVIRAL CHEMISTRY & CHEMOTHERAPY, vol. 9, no. 2, 1998, pages 139 - 148, XP002523406 * |
Also Published As
Publication number | Publication date |
---|---|
EP2197884A2 (fr) | 2010-06-23 |
AU2008295483A1 (en) | 2009-03-12 |
MX2010002316A (es) | 2010-03-22 |
AU2008295483B2 (en) | 2013-11-21 |
JP5179585B2 (ja) | 2013-04-10 |
ZA201001391B (en) | 2010-11-24 |
CA2697451A1 (fr) | 2009-03-12 |
AR068109A1 (es) | 2009-11-04 |
WO2009032123A2 (fr) | 2009-03-12 |
CN101842376A (zh) | 2010-09-22 |
JP2010537980A (ja) | 2010-12-09 |
KR20100061819A (ko) | 2010-06-09 |
TW200918536A (en) | 2009-05-01 |
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