WO2009022642A1 - 新規なイソキノリン化合物の塩及びその結晶 - Google Patents

新規なイソキノリン化合物の塩及びその結晶 Download PDF

Info

Publication number
WO2009022642A1
WO2009022642A1 PCT/JP2008/064289 JP2008064289W WO2009022642A1 WO 2009022642 A1 WO2009022642 A1 WO 2009022642A1 JP 2008064289 W JP2008064289 W JP 2008064289W WO 2009022642 A1 WO2009022642 A1 WO 2009022642A1
Authority
WO
WIPO (PCT)
Prior art keywords
crystal
novel salt
isoquinoline compound
compound
hydroxymethylpyrrolidin
Prior art date
Application number
PCT/JP2008/064289
Other languages
English (en)
French (fr)
Inventor
Masakazu Fujio
Toshihiko Tanaka
Hisao Takayanagi
Hiroyuki Satoh
Takanori Ito
Original Assignee
Mitsubishi Tanabe Pharma Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corporation filed Critical Mitsubishi Tanabe Pharma Corporation
Priority to EP08792346.2A priority Critical patent/EP2184282B1/en
Priority to US12/672,784 priority patent/US8309573B2/en
Priority to ES08792346.2T priority patent/ES2514517T3/es
Priority to AU2008287831A priority patent/AU2008287831B2/en
Priority to JP2009528110A priority patent/JP5282037B2/ja
Priority to CA2695973A priority patent/CA2695973C/en
Publication of WO2009022642A1 publication Critical patent/WO2009022642A1/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

　（Ｒ）－３－［２－（２－ヒドロキシメチルピロリジン－１－イル）エチル］－５－メチル－２Ｈ－イソキノリン－１－オンの新規な塩形態を提供する。 　（Ｒ）－３－［２－（２－ヒドロキシメチルピロリジン－１－イル）エチル］－５－メチル－２Ｈ－イソキノリン－１－オン　１リン酸はフリー体や１塩酸塩２水和物と比較して、化学的に安定で、高い溶解性を有し、湿度に対して重量変化が少ない化合物であり、医薬品の原薬として優れた化合物である。
PCT/JP2008/064289 2007-08-10 2008-08-08 新規なイソキノリン化合物の塩及びその結晶 WO2009022642A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP08792346.2A EP2184282B1 (en) 2007-08-10 2008-08-08 Novel salt of isoquinoline compound and crystal thereof
US12/672,784 US8309573B2 (en) 2007-08-10 2008-08-08 Salt of isoquinoline compound and crystal thereof
ES08792346.2T ES2514517T3 (es) 2007-08-10 2008-08-08 Nueva sal de compuesto de isoquinolina y cristal de la misma
AU2008287831A AU2008287831B2 (en) 2007-08-10 2008-08-08 Novel salt of isoquinoline compound and crystal thereof
JP2009528110A JP5282037B2 (ja) 2007-08-10 2008-08-08 新規なイソキノリン化合物の塩及びその結晶
CA2695973A CA2695973C (en) 2007-08-10 2008-08-08 Novel salt of isoquinoline compound and crystal thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007208693 2007-08-10
JP2007-208693 2007-08-10

Publications (1)

Publication Number Publication Date
WO2009022642A1 true WO2009022642A1 (ja) 2009-02-19

Family

ID=40350695

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/064289 WO2009022642A1 (ja) 2007-08-10 2008-08-08 新規なイソキノリン化合物の塩及びその結晶

Country Status (7)

Country Link
US (1) US8309573B2 (ja)
EP (1) EP2184282B1 (ja)
JP (1) JP5282037B2 (ja)
AU (1) AU2008287831B2 (ja)
CA (1) CA2695973C (ja)
ES (1) ES2514517T3 (ja)
WO (1) WO2009022642A1 (ja)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017517532A (ja) * 2014-06-11 2017-06-29 ギリアド ファーマセット エルエルシー 抗ウイルス化合物の固体形態

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX367614B (es) 2012-01-20 2019-08-28 Del Mar Pharmaceuticals Uso de hexitoles sustituidos que incluyen dianhidrogalactitol y analogos para tratar enfermedad neoplasica y celulas madre de cancer que incluyen glioblastoma multiforme y meduloblastoma.
CN105492011A (zh) 2013-04-08 2016-04-13 丹尼斯·M·布朗 不理想给药化学化合物的治疗增效
CN105764501A (zh) 2013-07-26 2016-07-13 现代化制药公司 改善比生群治疗效益的组合物
AU2015240465B2 (en) 2014-04-04 2020-02-27 Del Mar Pharmaceuticals Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004031171A1 (ja) 2002-10-01 2004-04-15 Mitsubishi Pharma Corporation イソキノリン化合物及びその医薬用途
JP2007208693A (ja) 2006-02-02 2007-08-16 Toshiba Corp 通信装置、通信システム、通信方法および通信プログラム

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004031171A1 (ja) 2002-10-01 2004-04-15 Mitsubishi Pharma Corporation イソキノリン化合物及びその医薬用途
JP2007208693A (ja) 2006-02-02 2007-08-16 Toshiba Corp 通信装置、通信システム、通信方法および通信プログラム

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
C.G WERMUTH, HIROSHI NAGASE (TRANSLATOR): "Saishin Soyaku Kagaku Gekan", 25 September 1999, pages: 347 - 365 *
See also references of EP2184282A4

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017517532A (ja) * 2014-06-11 2017-06-29 ギリアド ファーマセット エルエルシー 抗ウイルス化合物の固体形態
JP2019070057A (ja) * 2014-06-11 2019-05-09 ギリアド ファーマセット エルエルシー 抗ウイルス化合物の固体形態

Also Published As

Publication number Publication date
EP2184282A4 (en) 2011-08-03
CA2695973A1 (en) 2009-02-19
EP2184282B1 (en) 2014-10-08
AU2008287831B2 (en) 2013-05-23
US20110130419A1 (en) 2011-06-02
EP2184282A1 (en) 2010-05-12
US8309573B2 (en) 2012-11-13
AU2008287831A1 (en) 2009-02-19
JP5282037B2 (ja) 2013-09-04
ES2514517T3 (es) 2014-10-28
JPWO2009022642A1 (ja) 2010-11-18
CA2695973C (en) 2012-12-04

Similar Documents

Publication Publication Date Title
WO2008022777A3 (de) Verfahren zum herstellen von 3-dihalomethyl-pyrazol-4-carbonsäurederivaten
MX342309B (es) Derivados de [1,2,3]traizolo[4,5-d]pirimidina como agonistas del receptor canabinoide 2.
WO2010089768A3 (en) Bortezumib containing pharmaceutical composition
BRPI0716598A2 (pt) Derivados de (hetero) arilsulfonamida de n-biarila úteis no tratamento de doenças medidas por interações de linfócitos
JO2807B1 (en) A new process for the synthesis of ivabradine and its addition salts with pharmaceutically acceptable acid.
MY153985A (en) Aminotriazole derivatives as alx agonists
MX2009011579A (es) Pirimidinonas como moduladores de caseina cinasa ii (ck2).
WO2014045162A8 (en) ALKYL-SUBSTITUTED HEXAHYDROPYRANO[3,4-d] [1,3]THIAZIN-2-AMINE COMPOUNDS
ZA201103727B (en) Sulfoximine-substituted anilinopyrimidine derivatives as cdk inhibitors, the production thereof, and use as medicine
WO2011009938A3 (en) Stambomycin and derivatives, their production and their use as drugs
HK1162494A1 (en) Sulfone-substituted anilinopyrimidine derivatives as cdk inhibitors, the production thereof, and use as a medicine cdk
WO2008136393A1 (ja) ラクタム化合物の結晶形およびその製造方法
MX2011011011A (es) Preparacion solida.
WO2009153461A3 (fr) Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro-2h-3- benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
IN2012DN00765A (ja)
WO2009022642A1 (ja) 新規なイソキノリン化合物の塩及びその結晶
MY150014A (en) New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
MY152557A (en) 3-aminocyclopentanecarboxamides as chemokine receptor modulators
FI20080351A0 (fi) Prosessi matalan lääkepitoisuuden tabletin valmistamiseksi
WO2008009970A3 (en) Process for the preparation of montelukast
MX2013008256A (es) Derivados novedosos de tetrahidroquinolina.
MX2011011716A (es) Derivados de isoquinolina novedosos.
SG165254A1 (en) New process for the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
WO2009071691A3 (de) Oxindol-derivate und ihre verwendung als medikament
NO20073440L (no) Prosess for fremstilling av candesartan

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08792346

Country of ref document: EP

Kind code of ref document: A1

WWE Wipo information: entry into national phase

Ref document number: 2009528110

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2695973

Country of ref document: CA

Ref document number: 12672784

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2008287831

Country of ref document: AU

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2008792346

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2008287831

Country of ref document: AU

Date of ref document: 20080808

Kind code of ref document: A