WO2008009970A3 - Process for the preparation of montelukast - Google Patents

Process for the preparation of montelukast Download PDF

Info

Publication number
WO2008009970A3
WO2008009970A3 PCT/GB2007/002790 GB2007002790W WO2008009970A3 WO 2008009970 A3 WO2008009970 A3 WO 2008009970A3 GB 2007002790 W GB2007002790 W GB 2007002790W WO 2008009970 A3 WO2008009970 A3 WO 2008009970A3
Authority
WO
WIPO (PCT)
Prior art keywords
montelukast
preparation
formula
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
PCT/GB2007/002790
Other languages
French (fr)
Other versions
WO2008009970A2 (en
Inventor
Amir Avdagic
Juraj Jerkovic
Davorka Pavlicic
Original Assignee
Pliva Istrazivanje I Razvoj D
Mcleish Nicholas Alistair Maxw
Amir Avdagic
Juraj Jerkovic
Davorka Pavlicic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Istrazivanje I Razvoj D, Mcleish Nicholas Alistair Maxw, Amir Avdagic, Juraj Jerkovic, Davorka Pavlicic filed Critical Pliva Istrazivanje I Razvoj D
Priority to CA002658473A priority Critical patent/CA2658473A1/en
Priority to EP07766340A priority patent/EP2046750A2/en
Publication of WO2008009970A2 publication Critical patent/WO2008009970A2/en
Publication of WO2008009970A3 publication Critical patent/WO2008009970A3/en
Priority to IL196602A priority patent/IL196602A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

A process of preparing montelukast, or a pharmaceutically acceptable salt thereof, which process comprises reacting a protected intermediate of formula (II) as defined in the specification with a cyclopropyl intermediate.
PCT/GB2007/002790 2006-07-21 2007-07-23 Process for the preparation of montelukast WO2008009970A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002658473A CA2658473A1 (en) 2006-07-21 2007-07-23 Process
EP07766340A EP2046750A2 (en) 2006-07-21 2007-07-23 Process for the preparation of montelukast
IL196602A IL196602A0 (en) 2006-07-21 2009-01-20 Processes for the preparation of montelukast

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0614485.1 2006-07-21
GBGB0614485.1A GB0614485D0 (en) 2006-07-21 2006-07-21 Process

Publications (2)

Publication Number Publication Date
WO2008009970A2 WO2008009970A2 (en) 2008-01-24
WO2008009970A3 true WO2008009970A3 (en) 2008-04-10

Family

ID=37081006

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2007/002790 WO2008009970A2 (en) 2006-07-21 2007-07-23 Process for the preparation of montelukast

Country Status (5)

Country Link
EP (1) EP2046750A2 (en)
CA (1) CA2658473A1 (en)
GB (1) GB0614485D0 (en)
IL (1) IL196602A0 (en)
WO (1) WO2008009970A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2608369A1 (en) 2005-07-05 2007-01-11 Teva Pharmaceutical Industries Ltd. Purification of montelukast
EP1886998A1 (en) 2006-08-09 2008-02-13 Esteve Quimica, S.A. Purification process of montelukast and its amine salts
WO2011121091A1 (en) 2010-03-31 2011-10-06 Krka, D.D., Novo Mesto Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
HUP1000425A2 (en) 2010-08-11 2012-03-28 Richter Gedeon Nyrt Process for the production of montelukast sodium
WO2014081616A1 (en) * 2012-11-21 2014-05-30 Merck Sharp & Dohme Corp. Preparation of precursors for leukotriene antagonists
CN105541710B (en) * 2016-02-22 2018-06-19 齐鲁天和惠世制药有限公司 A kind of synthetic method of montelukast
CN105541711B (en) * 2016-02-22 2018-06-19 齐鲁天和惠世制药有限公司 A kind of preparation method of montelukast

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0480717A1 (en) * 1990-10-12 1992-04-15 Merck Frosst Canada Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
EP0737186A1 (en) * 1993-12-28 1996-10-16 Merck & Co. Inc. Process for the preparation of leukotriene antagonists

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0480717A1 (en) * 1990-10-12 1992-04-15 Merck Frosst Canada Inc. Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
EP0737186A1 (en) * 1993-12-28 1996-10-16 Merck & Co. Inc. Process for the preparation of leukotriene antagonists

Also Published As

Publication number Publication date
EP2046750A2 (en) 2009-04-15
GB0614485D0 (en) 2006-09-27
CA2658473A1 (en) 2008-01-24
IL196602A0 (en) 2009-11-18
WO2008009970A2 (en) 2008-01-24

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