WO2009014176A1 - ペプチドの製造方法 - Google Patents

ペプチドの製造方法 Download PDF

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Publication number
WO2009014176A1
WO2009014176A1 PCT/JP2008/063280 JP2008063280W WO2009014176A1 WO 2009014176 A1 WO2009014176 A1 WO 2009014176A1 JP 2008063280 W JP2008063280 W JP 2008063280W WO 2009014176 A1 WO2009014176 A1 WO 2009014176A1
Authority
WO
WIPO (PCT)
Prior art keywords
peptide
deprotect
group
production
synthesis
Prior art date
Application number
PCT/JP2008/063280
Other languages
English (en)
French (fr)
Inventor
Daisuke Takahashi
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Priority to JP2009524509A priority Critical patent/JP5212371B2/ja
Publication of WO2009014176A1 publication Critical patent/WO2009014176A1/ja

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

　（Ｉ）Ｂｏｃ－ＮＨ基を含むペプチドを酸と反応させることにより脱保護した後、または（ＩＩ）Ｚ－ＮＨ基を含むペプチドを酸性条件下で接触還元に付すことにより脱保護した後に、反応混合物のｐＨを４～７に調整する工程を含むことを特徴とする、ワンポット合成可能なペプチドの液相合成法。
PCT/JP2008/063280 2007-07-25 2008-07-24 ペプチドの製造方法 WO2009014176A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009524509A JP5212371B2 (ja) 2007-07-25 2008-07-24 ペプチドの製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007193331 2007-07-25
JP2007-193331 2007-07-25

Publications (1)

Publication Number Publication Date
WO2009014176A1 true WO2009014176A1 (ja) 2009-01-29

Family

ID=40281424

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/063280 WO2009014176A1 (ja) 2007-07-25 2008-07-24 ペプチドの製造方法

Country Status (2)

Country Link
JP (1) JP5212371B2 (ja)
WO (1) WO2009014176A1 (ja)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012029794A1 (ja) 2010-08-30 2012-03-08 味の素株式会社 分岐鎖含有芳香族化合物
WO2019187468A1 (ja) * 2018-03-29 2019-10-03 株式会社カネカ ペプチドの製造方法
WO2019187469A1 (ja) * 2018-03-29 2019-10-03 株式会社カネカ 長鎖ペプチドの製造方法
JPWO2021002408A1 (ja) * 2019-07-02 2021-01-07
WO2021132545A1 (ja) * 2019-12-27 2021-07-01 中外製薬株式会社 ペプチド化合物の合成法
WO2021192488A1 (ja) * 2020-03-27 2021-09-30 株式会社カネカ アミド結合含有化合物の製造方法
CN114262358A (zh) * 2021-12-08 2022-04-01 苏州天马医药集团天吉生物制药有限公司 一种谷甘二肽的制备方法
CN116284206A (zh) * 2023-05-18 2023-06-23 杭州湃肽生化科技有限公司 一种树脂材料的洗涤方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06509821A (ja) * 1992-06-16 1994-11-02 シューラク、ギャリー　エイ ペプチドおよびペプチド誘導体の液相合成

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06509821A (ja) * 1992-06-16 1994-11-02 シューラク、ギャリー　エイ ペプチドおよびペプチド誘導体の液相合成

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CALPINO L.A. ET AL.: "Rapid, continuous solution-phase peptide synthesis: Application to peptides of pharmaceutical interest", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 7, 2003, pages 28 - 37 *
KISFALUDY L. ET AL.: "A novel and rapid peptide synthesis", TETRAHEDRON LETTERS, no. 19, 1974, pages 1785 - 1786 *
NOZAKI S. ET AL.: "Rapid peptide synthesis in liquid phase", BULL. CHEM. SOC. JPN., vol. 55, 1982, pages 2165 - 2168 *

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012029794A1 (ja) 2010-08-30 2012-03-08 味の素株式会社 分岐鎖含有芳香族化合物
US8546534B2 (en) 2010-08-30 2013-10-01 Ajinomoto Co., Inc. Branched chain-containing aromatic compound
US9499579B2 (en) 2010-08-30 2016-11-22 Ajinomoto Co., Inc. Branched chain-containing aromatic compound
US10711033B2 (en) 2010-08-30 2020-07-14 Ajinomoto Co., Inc. Branched chain-containing aromatic compound
WO2019187468A1 (ja) * 2018-03-29 2019-10-03 株式会社カネカ ペプチドの製造方法
WO2019187469A1 (ja) * 2018-03-29 2019-10-03 株式会社カネカ 長鎖ペプチドの製造方法
JPWO2021002408A1 (ja) * 2019-07-02 2021-01-07
JP7545690B2 (ja) 2019-07-02 2024-09-05 Ａｇｃ株式会社 ペプチド及びその製造方法
WO2021132545A1 (ja) * 2019-12-27 2021-07-01 中外製薬株式会社 ペプチド化合物の合成法
WO2021192488A1 (ja) * 2020-03-27 2021-09-30 株式会社カネカ アミド結合含有化合物の製造方法
CN115362144A (zh) * 2020-03-27 2022-11-18 株式会社钟化 含酰胺键化合物的制造方法
CN114262358A (zh) * 2021-12-08 2022-04-01 苏州天马医药集团天吉生物制药有限公司 一种谷甘二肽的制备方法
CN114262358B (zh) * 2021-12-08 2023-07-21 苏州天马医药集团天吉生物制药有限公司 一种谷甘二肽的制备方法
CN116284206A (zh) * 2023-05-18 2023-06-23 杭州湃肽生化科技有限公司 一种树脂材料的洗涤方法

Also Published As

Publication number Publication date
JPWO2009014176A1 (ja) 2010-10-07
JP5212371B2 (ja) 2013-06-19

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