WO2007104781A3 - Method for manufacturing of r-enantiomer of n-carbamoylmethyl-4-phenyl-2-pyrrolidone - Google Patents

Method for manufacturing of r-enantiomer of n-carbamoylmethyl-4-phenyl-2-pyrrolidone Download PDF

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Publication number
WO2007104781A3
WO2007104781A3 PCT/EP2007/052428 EP2007052428W WO2007104781A3 WO 2007104781 A3 WO2007104781 A3 WO 2007104781A3 EP 2007052428 W EP2007052428 W EP 2007052428W WO 2007104781 A3 WO2007104781 A3 WO 2007104781A3
Authority
WO
WIPO (PCT)
Prior art keywords
phenyl
carbamoylmethyl
enantiomer
pyrrolidone
manufacturing
Prior art date
Application number
PCT/EP2007/052428
Other languages
French (fr)
Other versions
WO2007104781A2 (en
Inventor
Grigory Veinberg
Maksim Vorona
Antons Lebedevs
Aleksandrs Chernobrovijs
Ivars Kalvinsh
Original Assignee
Grigory Veinberg
Maksim Vorona
Antons Lebedevs
Aleksandrs Chernobrovijs
Ivars Kalvinsh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grigory Veinberg, Maksim Vorona, Antons Lebedevs, Aleksandrs Chernobrovijs, Ivars Kalvinsh filed Critical Grigory Veinberg
Priority to EA200801977A priority Critical patent/EA015420B1/en
Publication of WO2007104781A2 publication Critical patent/WO2007104781A2/en
Publication of WO2007104781A3 publication Critical patent/WO2007104781A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for the preparation of R-enantiomer of N-carbamoylmethyl-4-phenyl-2- pyrrolidone by the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with haloacetic acid ester and the following conversion of intermediate N-alkoxycarbonylmethyl-4(R)- phenyl-2-pyrrolidinone into target product by the treatment with ammonia.
PCT/EP2007/052428 2006-03-16 2007-03-15 Method for manufacturing of r-enantiomer of n-carbamoylmethyl-4-phenyl-2-pyrrolidone WO2007104781A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EA200801977A EA015420B1 (en) 2006-03-16 2007-03-15 Method for manufacturing r-enantiomer of n-carbamoylmethyl-4-phenyl-2-pyrrolidone

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LVP-06-46 2006-03-16
LV060046A LV13631B (en) 2006-03-16 2006-03-16 Manufacturing method of n-carbamoylmethyl-4(r)-phenyl-2-pyrrolidinone

Publications (2)

Publication Number Publication Date
WO2007104781A2 WO2007104781A2 (en) 2007-09-20
WO2007104781A3 true WO2007104781A3 (en) 2007-11-29

Family

ID=38465622

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2007/052428 WO2007104781A2 (en) 2006-03-16 2007-03-15 Method for manufacturing of r-enantiomer of n-carbamoylmethyl-4-phenyl-2-pyrrolidone

Country Status (3)

Country Link
EA (1) EA015420B1 (en)
LV (1) LV13631B (en)
WO (1) WO2007104781A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010005380A1 (en) 2008-07-09 2010-01-14 Qunano Ab Nanostructured memory device
SE533531C2 (en) 2008-12-19 2010-10-19 Glo Ab Nanostructured device
CN103443023B (en) 2011-02-01 2016-04-20 昆南诺股份有限公司 For the nanowire device of electrified molecule

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144246A (en) * 1976-11-15 1979-03-13 Parke, Davis & Company Pyrrolidineacetic acid esters
SU1265191A1 (en) * 1984-06-27 1986-10-23 2-Ой Московский Ордена Ленина Государственный Медицинский Институт Им.Н.И.Пирогова Method of producing 4-phenylpyrrolidon-2-acetic-1-acid amide

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU797219A1 (en) * 1979-05-08 1995-07-25 Ленинградский государственный педагогический институт им.А.И.Герцена N-carbamoylmethyl-4-phenyl-2-pyrrolidone possessing hypotensive activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144246A (en) * 1976-11-15 1979-03-13 Parke, Davis & Company Pyrrolidineacetic acid esters
SU1265191A1 (en) * 1984-06-27 1986-10-23 2-Ой Московский Ордена Ленина Государственный Медицинский Институт Им.Н.И.Пирогова Method of producing 4-phenylpyrrolidon-2-acetic-1-acid amide

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
M GLOZMAN O ET AL: "The synthesis and antispasmodic activity of 4-phenylpyrrolidone-2-ace tamides", PHARMACEUTICAL CHEMISTRY JOURNAL, CONSULTANTS BUREAU, NAW YORK, NY, US, vol. 14, no. 11, November 1980 (1980-11-01), pages 776 - 780, XP008083570, ISSN: 0091-150X *

Also Published As

Publication number Publication date
EA200801977A1 (en) 2009-04-28
WO2007104781A2 (en) 2007-09-20
LV13631B (en) 2008-01-20
EA015420B1 (en) 2011-08-30

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