EA200801977A1 - METHOD OF OBTAINING N-CARBAMOILMETHYL-4R-Phenyl-2-pyrrolidone R-Enantiomer - Google Patents

METHOD OF OBTAINING N-CARBAMOILMETHYL-4R-Phenyl-2-pyrrolidone R-Enantiomer

Info

Publication number
EA200801977A1
EA200801977A1 EA200801977A EA200801977A EA200801977A1 EA 200801977 A1 EA200801977 A1 EA 200801977A1 EA 200801977 A EA200801977 A EA 200801977A EA 200801977 A EA200801977 A EA 200801977A EA 200801977 A1 EA200801977 A1 EA 200801977A1
Authority
EA
Eurasian Patent Office
Prior art keywords
phenyl
enantiomer
obtaining
carbamoilmethyl
pyrrolidone
Prior art date
Application number
EA200801977A
Other languages
Russian (ru)
Other versions
EA015420B1 (en
Inventor
Григорий Вейнберг
Максим Ворона
Антонс Лебедевс
Александрс Чернобровыйс
Иварс Калвиньш
Original Assignee
Акционерное Общество "Олайнфарм"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Акционерное Общество "Олайнфарм" filed Critical Акционерное Общество "Олайнфарм"
Publication of EA200801977A1 publication Critical patent/EA200801977A1/en
Publication of EA015420B1 publication Critical patent/EA015420B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyrrole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Способ получения R-энантиомера N-карбамоилметил-4-фенил-2-пирролидинона путем N-алкилирования 4(R)-фенил-2-пирролидинона эфирами галоуксусной кислоты и последующего преобразования промежуточного N-алкоксикарбонилметил-4(R)-фенил-2-пирролидинона в целевой продукт путем обработки аммиаком.The method of obtaining the N-carbamoylmethyl-4-phenyl-2-pyrrolidinone R-enantiomer by N-alkylation of 4 (R) -phenyl-2-pyrrolidinone with haloacetic acid esters and subsequent conversion of the intermediate N-alkoxycarbonylmethyl-4 (R) -phenyl-2- pyrrolidinone in the target product by treatment with ammonia.

EA200801977A 2006-03-16 2007-03-15 Method for manufacturing r-enantiomer of n-carbamoylmethyl-4-phenyl-2-pyrrolidone EA015420B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
LV060046A LV13631B (en) 2006-03-16 2006-03-16 Manufacturing method of n-carbamoylmethyl-4(r)-phenyl-2-pyrrolidinone
PCT/EP2007/052428 WO2007104781A2 (en) 2006-03-16 2007-03-15 Method for manufacturing of r-enantiomer of n-carbamoylmethyl-4-phenyl-2-pyrrolidone

Publications (2)

Publication Number Publication Date
EA200801977A1 true EA200801977A1 (en) 2009-04-28
EA015420B1 EA015420B1 (en) 2011-08-30

Family

ID=38465622

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801977A EA015420B1 (en) 2006-03-16 2007-03-15 Method for manufacturing r-enantiomer of n-carbamoylmethyl-4-phenyl-2-pyrrolidone

Country Status (3)

Country Link
EA (1) EA015420B1 (en)
LV (1) LV13631B (en)
WO (1) WO2007104781A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8212237B2 (en) 2008-07-09 2012-07-03 Qunano Ab Nanostructured memory device
SE533531C2 (en) 2008-12-19 2010-10-19 Glo Ab Nanostructured device
US20130306476A1 (en) 2011-02-01 2013-11-21 Qunano Ab Nanowire device for manipulating charged molecules

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4144246A (en) * 1976-11-15 1979-03-13 Parke, Davis & Company Pyrrolidineacetic acid esters
SU797219A1 (en) * 1979-05-08 1995-07-25 Ленинградский государственный педагогический институт им.А.И.Герцена N-carbamoylmethyl-4-phenyl-2-pyrrolidone possessing hypotensive activity
SU1265191A1 (en) * 1984-06-27 1986-10-23 2-Ой Московский Ордена Ленина Государственный Медицинский Институт Им.Н.И.Пирогова Method of producing 4-phenylpyrrolidon-2-acetic-1-acid amide

Also Published As

Publication number Publication date
LV13631B (en) 2008-01-20
WO2007104781A3 (en) 2007-11-29
EA015420B1 (en) 2011-08-30
WO2007104781A2 (en) 2007-09-20

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AZ BY KZ KG MD RU