EP1903050A3 - A process for the preparation of cholanic acids - Google Patents

A process for the preparation of cholanic acids Download PDF

Info

Publication number
EP1903050A3
EP1903050A3 EP20070113916 EP07113916A EP1903050A3 EP 1903050 A3 EP1903050 A3 EP 1903050A3 EP 20070113916 EP20070113916 EP 20070113916 EP 07113916 A EP07113916 A EP 07113916A EP 1903050 A3 EP1903050 A3 EP 1903050A3
Authority
EP
European Patent Office
Prior art keywords
preparation
cholanic acids
cholanic
acids
purity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
EP20070113916
Other languages
German (de)
French (fr)
Other versions
EP1903050A2 (en
EP1903050B1 (en
Inventor
Pietro Allegrini
Tiziano Scubla
Fausto Gorassini
Andrea Finco
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dipharma Francis SRL
Original Assignee
Dipharma Francis SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dipharma Francis SRL filed Critical Dipharma Francis SRL
Publication of EP1903050A2 publication Critical patent/EP1903050A2/en
Publication of EP1903050A3 publication Critical patent/EP1903050A3/en
Application granted granted Critical
Publication of EP1903050B1 publication Critical patent/EP1903050B1/en
Not-in-force legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/44—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with a hydroxy group on a condensed ring system having more than three rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation

Abstract

A process for the preparation of high purity cholanic acids, typically in purity equal to or higher than 99%.
EP07113916.6A 2006-09-12 2007-08-07 A process for the preparation of cholanic acids Not-in-force EP1903050B1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT001735A ITMI20061735A1 (en) 2006-09-12 2006-09-12 PROCEDURE FOR THE PREPARATION OF COLANIC ACIDS

Publications (3)

Publication Number Publication Date
EP1903050A2 EP1903050A2 (en) 2008-03-26
EP1903050A3 true EP1903050A3 (en) 2008-05-28
EP1903050B1 EP1903050B1 (en) 2015-09-16

Family

ID=39027512

Family Applications (1)

Application Number Title Priority Date Filing Date
EP07113916.6A Not-in-force EP1903050B1 (en) 2006-09-12 2007-08-07 A process for the preparation of cholanic acids

Country Status (6)

Country Link
US (1) US7982062B2 (en)
EP (1) EP1903050B1 (en)
JP (1) JP2008069152A (en)
KR (1) KR20080024092A (en)
ES (1) ES2550453T3 (en)
IT (1) ITMI20061735A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102617689B (en) * 2012-03-14 2013-11-06 江苏正大清江制药有限公司 Purification method of hyodeoxycholic acid
EP2857414A1 (en) 2013-10-03 2015-04-08 Prodotti Chimici E Alimentari Spa Polymorphous form of sodium hyodeoxycholate (NaHDC) and preparation process thereof
TR201909447T4 (en) * 2013-12-04 2019-07-22 Galmed Res & Development Ltd Aramkol salts.
US11571431B2 (en) 2013-12-04 2023-02-07 Galmed Research And Development Ltd Aramchol salts
US10849911B2 (en) 2015-06-10 2020-12-01 Galmed Research And Development Ltd. Low dose compositions of Aramachol salts
CN108236934A (en) * 2016-12-23 2018-07-03 西北大学 It is a kind of using cholic acid as the preparation and application of the mixed mode chromatograph packing material of aglucon

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5349074A (en) * 1992-03-11 1994-09-20 Erregierre Industria Chimica S.P.A. Process for pharmaceutical grade high purity hyodeoxycholic acid preparation

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2758120A (en) * 1953-02-27 1956-08-07 Canada Packers Ltd Preparation of hyodesoxycholic acid
US3006927A (en) * 1960-05-27 1961-10-31 Riedel De Haen Ag Method of making hyodesoxycholic acid
GB1532413A (en) * 1974-12-23 1978-11-15 Union International Co Ltd Chenodeoxycholic acid
DE2404102C2 (en) * 1974-01-25 1975-11-06 Schering Ag, 1000 Berlin Und 4619 Bergkamen Process for purifying crude chenodeoxycholic acid
FR2446293A1 (en) * 1978-12-11 1980-08-08 Roussel Uclaf PROCESS OF PURIFICATION OF CHENODESOXYCHOLIC ACID
IT1165251B (en) * 1979-07-12 1987-04-22 Blasinachim Spa METHOD OF FURIFICATION OF CHENODESOXICOLIC ACID
JPS5659796A (en) * 1979-10-19 1981-05-23 Sekisui Chem Co Ltd Purification of ursodeoxycholic acid or chenodeoxycholic acid
JPS57163397A (en) * 1981-03-31 1982-10-07 Sekisui Chem Co Ltd Purification of chenodeoxycholic acid
JPS59139399A (en) * 1983-01-31 1984-08-10 Showa Denko Kk Production of ursodeoxycholic acid
US5236930A (en) * 1989-11-13 1993-08-17 Mitbushi Gas Chemical Company, Inc. Oxazopyrroloquinolines and use of oxazopyrroloquinolines
JP4263817B2 (en) * 1999-07-29 2009-05-13 丸善製薬株式会社 Antibacterial agent
JP4456321B2 (en) * 2002-07-12 2010-04-28 株式会社ファンケル Lipase inhibitor
JP2005247767A (en) * 2004-03-04 2005-09-15 Japan Science & Technology Agency Anti-babesia agent extracted from arcangelisia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5349074A (en) * 1992-03-11 1994-09-20 Erregierre Industria Chimica S.P.A. Process for pharmaceutical grade high purity hyodeoxycholic acid preparation

Also Published As

Publication number Publication date
ES2550453T3 (en) 2015-11-10
EP1903050A2 (en) 2008-03-26
US20080064888A1 (en) 2008-03-13
EP1903050B1 (en) 2015-09-16
US7982062B2 (en) 2011-07-19
JP2008069152A (en) 2008-03-27
KR20080024092A (en) 2008-03-17
ITMI20061735A1 (en) 2008-03-13

Similar Documents

Publication Publication Date Title
EP2194119A3 (en) Production of fatty acids and derivatives thereof
EP2840131A3 (en) Production of fatty acids and derivatives thereof
DK3872058T3 (en) Process for the preparation of 2,3,3,3 tetrahydrofluoropropene
SG138520A1 (en) Tripentyl citrates and their use
WO2006066014A3 (en) Backplane design for display panels and processes for their manufacture
HK1137990A1 (en) Thienyl-containing glycopyranosyl derivatives as antidiabetics
PL2059513T3 (en) Process for the preparation of 1,2,4-oxadiazole benzoic acids
EP2178891B8 (en) Phosphonous acids, salts and esters, methods for the production thereof, and use of same
EP1637167A3 (en) New injectable formulations containing progesterone
ZA200800729B (en) A crystalline form of the zoledronic acid, a process to obtain it and the pharmaceutical composition comprising it
IL223126A (en) Method for the preparation of acetic acid 4,5-diacetoxy-tetrahydro-furan-2-ylmethyl ester and its stereoisomers
EP1903050A3 (en) A process for the preparation of cholanic acids
WO2008140641A3 (en) Pure paliperidone and processes for preparing thereof
EP3037401A3 (en) 14-hydroxy-docosahexaenoic acid compounds
IL180311A0 (en) Process for the preparation of 4,4-difluoro-3-oxobutanoic acid esters
WO2007029087A3 (en) Controlled release multiple unit formulations
WO2008021346A3 (en) Pure paliperidone and processes for preparing thereof
WO2008073863A3 (en) Preparation and utility of substituted allylamines
WO2008049920A3 (en) Il-21 variants
WO2007013043A3 (en) Processes for the preparation of 7-amino-3-vinyl cephalosporanic acid
WO2008068413A3 (en) Method for preparing acetyl,docosahexaenoyl-glycerophosphocholine and use thereof for the delivery of polyunsaturated fatty acids
AU2007270897A8 (en) Novel process for the preparation of bisphosphonic acids
EP2025663A4 (en) Novel carboxylic acid compound, use thereof, and process for producing the same
EP1996192A4 (en) Process for the preparation of 3,4-disubstituted-thiazolidin-2-ones
WO2007045353A3 (en) Combined preparation of o-acetylsalicylic acid salts

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

AK Designated contracting states

Kind code of ref document: A2

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR MK YU

PUAL Search report despatched

Free format text: ORIGINAL CODE: 0009013

AK Designated contracting states

Kind code of ref document: A3

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

AX Request for extension of the european patent

Extension state: AL BA HR MK RS

17P Request for examination filed

Effective date: 20081104

AKX Designation fees paid

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

17Q First examination report despatched

Effective date: 20090206

GRAP Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOSNIGR1

INTG Intention to grant announced

Effective date: 20150520

GRAS Grant fee paid

Free format text: ORIGINAL CODE: EPIDOSNIGR3

GRAA (expected) grant

Free format text: ORIGINAL CODE: 0009210

AK Designated contracting states

Kind code of ref document: B1

Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LI LT LU LV MC MT NL PL PT RO SE SI SK TR

REG Reference to a national code

Ref country code: GB

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: CH

Ref legal event code: EP

REG Reference to a national code

Ref country code: IE

Ref legal event code: FG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: REF

Ref document number: 749745

Country of ref document: AT

Kind code of ref document: T

Effective date: 20151015

Ref country code: CH

Ref legal event code: NV

Representative=s name: ISLER AND PEDRAZZINI AG, CH

REG Reference to a national code

Ref country code: DE

Ref legal event code: R096

Ref document number: 602007043119

Country of ref document: DE

REG Reference to a national code

Ref country code: ES

Ref legal event code: FG2A

Ref document number: 2550453

Country of ref document: ES

Kind code of ref document: T3

Effective date: 20151110

REG Reference to a national code

Ref country code: NL

Ref legal event code: MP

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: FI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: GR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20151217

REG Reference to a national code

Ref country code: LT

Ref legal event code: MG4D

REG Reference to a national code

Ref country code: AT

Ref legal event code: MK05

Ref document number: 749745

Country of ref document: AT

Kind code of ref document: T

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: NL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: EE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: IS

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160116

Ref country code: SK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: CZ

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: RO

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: PL

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: PT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20160118

Ref country code: AT

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

REG Reference to a national code

Ref country code: DE

Ref legal event code: R097

Ref document number: 602007043119

Country of ref document: DE

PLBE No opposition filed within time limit

Free format text: ORIGINAL CODE: 0009261

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: NO OPPOSITION FILED WITHIN TIME LIMIT

26N No opposition filed

Effective date: 20160617

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DK

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: SI

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BE

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MC

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

GBPC Gb: european patent ceased through non-payment of renewal fee

Effective date: 20160807

REG Reference to a national code

Ref country code: FR

Ref legal event code: ST

Effective date: 20170428

REG Reference to a national code

Ref country code: IE

Ref legal event code: MM4A

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: IE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20160807

Ref country code: FR

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20160831

Ref country code: GB

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20160807

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: LU

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20160807

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: CH

Payment date: 20170811

Year of fee payment: 11

Ref country code: ES

Payment date: 20170904

Year of fee payment: 11

Ref country code: DE

Payment date: 20170821

Year of fee payment: 11

PGFP Annual fee paid to national office [announced via postgrant information from national office to epo]

Ref country code: LV

Payment date: 20170825

Year of fee payment: 11

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CY

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

Ref country code: HU

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT; INVALID AB INITIO

Effective date: 20070807

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: MT

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20160831

Ref country code: TR

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: BG

Free format text: LAPSE BECAUSE OF FAILURE TO SUBMIT A TRANSLATION OF THE DESCRIPTION OR TO PAY THE FEE WITHIN THE PRESCRIBED TIME-LIMIT

Effective date: 20150916

REG Reference to a national code

Ref country code: DE

Ref legal event code: R119

Ref document number: 602007043119

Country of ref document: DE

REG Reference to a national code

Ref country code: CH

Ref legal event code: PL

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: CH

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180831

Ref country code: LV

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180807

Ref country code: LI

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180831

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: DE

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20190301

REG Reference to a national code

Ref country code: ES

Ref legal event code: FD2A

Effective date: 20190918

PG25 Lapsed in a contracting state [announced via postgrant information from national office to epo]

Ref country code: ES

Free format text: LAPSE BECAUSE OF NON-PAYMENT OF DUE FEES

Effective date: 20180808