JPS5659796A - Purification of ursodeoxycholic acid or chenodeoxycholic acid - Google Patents
Purification of ursodeoxycholic acid or chenodeoxycholic acidInfo
- Publication number
- JPS5659796A JPS5659796A JP13574379A JP13574379A JPS5659796A JP S5659796 A JPS5659796 A JP S5659796A JP 13574379 A JP13574379 A JP 13574379A JP 13574379 A JP13574379 A JP 13574379A JP S5659796 A JPS5659796 A JP S5659796A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- column
- ursodeoxycholic
- eluent
- chenodeoxycholic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: The titled compound that is used as a remedy for cholelithiasis is purified through a liquid chromatography where the porous particles of styrenedivinylbenzene copolymer is used as the stationary phase and a solvent with a specific solubility parameter is used as an eluent with industrial advantage.
CONSTITUTION: A crude product including ursodeoxycholic acid, chenodeoxychlolic acid, cholic acid, lithocholic acid, etc., is dissolved in methanol or the like to prepare the sample solution. Then, a column filled with porous particles of styrene- divinylbenzene copolymer as the stationary phase is connected to a liquid chromatography and a solvent with a solubility parameter of 11W17 such as methanol is passed through the column as an eluent. The sample solution is added to the column and eluted to give a chromatogram of ursodeoxycholic acid (1) and chenodeoxycholic acid (2) and they are obtained in pure form.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13574379A JPS5659796A (en) | 1979-10-19 | 1979-10-19 | Purification of ursodeoxycholic acid or chenodeoxycholic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13574379A JPS5659796A (en) | 1979-10-19 | 1979-10-19 | Purification of ursodeoxycholic acid or chenodeoxycholic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5659796A true JPS5659796A (en) | 1981-05-23 |
Family
ID=15158826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP13574379A Pending JPS5659796A (en) | 1979-10-19 | 1979-10-19 | Purification of ursodeoxycholic acid or chenodeoxycholic acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5659796A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008069152A (en) * | 2006-09-12 | 2008-03-27 | Dipharma Francis Srl | Process for preparing cholanic acid |
| KR100997675B1 (en) | 2008-12-30 | 2010-12-01 | (주)파마피아 | Method for manufacturing magnesium salt of chenodeoxycholic acid and ursodeoxycholic acid |
| CN103852554A (en) * | 2012-11-30 | 2014-06-11 | 山东阿如拉药物研究开发有限公司 | Quality detection method for Tibetan medicinal composition oxytropis itch-relieving preparation |
-
1979
- 1979-10-19 JP JP13574379A patent/JPS5659796A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008069152A (en) * | 2006-09-12 | 2008-03-27 | Dipharma Francis Srl | Process for preparing cholanic acid |
| KR100997675B1 (en) | 2008-12-30 | 2010-12-01 | (주)파마피아 | Method for manufacturing magnesium salt of chenodeoxycholic acid and ursodeoxycholic acid |
| CN103852554A (en) * | 2012-11-30 | 2014-06-11 | 山东阿如拉药物研究开发有限公司 | Quality detection method for Tibetan medicinal composition oxytropis itch-relieving preparation |
| CN103852554B (en) * | 2012-11-30 | 2015-11-18 | 山东金诃药物研究开发有限公司 | A kind of Tibetan medicinal composition whin disappears the quality determining method of preparation of itching |
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