WO2008078350A3 - Process for the preparation of fluorophenylacetic acids and derivatives thereof - Google Patents

Process for the preparation of fluorophenylacetic acids and derivatives thereof Download PDF

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Publication number
WO2008078350A3
WO2008078350A3 PCT/IT2007/000860 IT2007000860W WO2008078350A3 WO 2008078350 A3 WO2008078350 A3 WO 2008078350A3 IT 2007000860 W IT2007000860 W IT 2007000860W WO 2008078350 A3 WO2008078350 A3 WO 2008078350A3
Authority
WO
WIPO (PCT)
Prior art keywords
derivatives
preparation
acids
fluorophenylacetic
fluorophenylacetic acids
Prior art date
Application number
PCT/IT2007/000860
Other languages
French (fr)
Other versions
WO2008078350A2 (en
Inventor
Alessandro Falchi
Mariano Stivanello
Siro Serafini
Original Assignee
Italiana Sint Spa
Alessandro Falchi
Mariano Stivanello
Siro Serafini
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Italiana Sint Spa, Alessandro Falchi, Mariano Stivanello, Siro Serafini filed Critical Italiana Sint Spa
Publication of WO2008078350A2 publication Critical patent/WO2008078350A2/en
Publication of WO2008078350A3 publication Critical patent/WO2008078350A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/317—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The object of the present invention is a process for the preparation of fluorophenylacetic acids and derivatives thereof, particularly of 2,4, 5-trifluorophenylacetic acid, starting from the corresponding mandelic acids.
PCT/IT2007/000860 2006-12-27 2007-12-10 Process for the preparation of fluorophenylacetic acids and derivatives thereof WO2008078350A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI20062508 ITMI20062508A1 (en) 2006-12-27 2006-12-27 PROCESS FOR THE PREPARATION OF FLUOROFENYLACETIC ACIDS AND THEIR DERIVATIVES
ITMI2006A002508 2006-12-27

Publications (2)

Publication Number Publication Date
WO2008078350A2 WO2008078350A2 (en) 2008-07-03
WO2008078350A3 true WO2008078350A3 (en) 2008-12-11

Family

ID=39402292

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IT2007/000860 WO2008078350A2 (en) 2006-12-27 2007-12-10 Process for the preparation of fluorophenylacetic acids and derivatives thereof

Country Status (2)

Country Link
IT (1) ITMI20062508A1 (en)
WO (1) WO2008078350A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013135674A1 (en) * 2012-03-12 2013-09-19 Syngenta Participations Ag Insecticidal 2-aryl-acetamide compounds
CN103012111B (en) * 2012-09-12 2016-01-13 衢州学院 A kind of preparation method of 2,4,5-trifluoro benzene acetic acid
EP3424927B1 (en) 2017-07-04 2019-04-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Efficient process for the preparation of sitagliptin through a very effective preparation of the intermediate 2,4,5-trifluorophenylacetic acid
CN107673951A (en) * 2017-08-18 2018-02-09 河南师范大学 A kind of high efficiency preparation method of 2,4,5 trifluoro benzene acetic acid
CN112457153B (en) * 2020-11-10 2022-09-09 台州臻挚生物科技有限公司 Industrial preparation method of 2,4, 5-trifluoro-phenylacetic acid

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4329497A (en) * 1978-02-20 1982-05-11 Diamalt Aktiengesellschaft Method for the production of 4-hydroxyphenylacetic acid
US6252090B1 (en) * 2000-08-29 2001-06-26 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
US20040068141A1 (en) * 2002-10-08 2004-04-08 Armstrong Joseph D. Process for the synthesis of trifluorophenylacetic acids
US20040077901A1 (en) * 2002-10-08 2004-04-22 Norihiro Ikemoto Process for the synthesis of trifluorophenylacetic acids

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4329497A (en) * 1978-02-20 1982-05-11 Diamalt Aktiengesellschaft Method for the production of 4-hydroxyphenylacetic acid
US6252090B1 (en) * 2000-08-29 2001-06-26 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
US20040068141A1 (en) * 2002-10-08 2004-04-08 Armstrong Joseph D. Process for the synthesis of trifluorophenylacetic acids
US20040077901A1 (en) * 2002-10-08 2004-04-22 Norihiro Ikemoto Process for the synthesis of trifluorophenylacetic acids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SUGITA ET AL., MOL. CRYST. LIQ. CRYST. SCI. TECHNOL. SECT. A., vol. 237, 1993, pages 399 - 406, XP009100680 *

Also Published As

Publication number Publication date
ITMI20062508A1 (en) 2008-06-28
WO2008078350A2 (en) 2008-07-03

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