WO2009001805A1 - 新規なｎ結合型人工シアロ糖鎖含有ポリマーおよびその製造方法 - Google Patents

新規なｎ結合型人工シアロ糖鎖含有ポリマーおよびその製造方法 Download PDF

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Publication number
WO2009001805A1
WO2009001805A1 PCT/JP2008/061429 JP2008061429W WO2009001805A1 WO 2009001805 A1 WO2009001805 A1 WO 2009001805A1 JP 2008061429 W JP2008061429 W JP 2008061429W WO 2009001805 A1 WO2009001805 A1 WO 2009001805A1
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WO
WIPO (PCT)
Prior art keywords
formula
sugar chain
sialo
containing polymer
same
Prior art date
Application number
PCT/JP2008/061429
Other languages
English (en)
French (fr)
Inventor
Taiichi Usui
Takeomi Murata
Takashi Suzuki
Ilpal Jwa
Yusuke Ohba
Tomoki Hamamoto
Toshitada Noguchi
Original Assignee
National University Corporation Shizuoka University
Shizuoka Prefectural Universities Corporation
Yamasa Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National University Corporation Shizuoka University, Shizuoka Prefectural Universities Corporation, Yamasa Corporation filed Critical National University Corporation Shizuoka University
Priority to JP2009520586A priority Critical patent/JP5360497B2/ja
Priority to US12/666,482 priority patent/US8450441B2/en
Publication of WO2009001805A1 publication Critical patent/WO2009001805A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7012—Compounds having a free or esterified carboxyl group attached, directly or through a carbon chain, to a carbon atom of the saccharide radical, e.g. glucuronic acid, neuraminic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/04—Preparatory processes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
    • C08G69/10—Alpha-amino-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/40—Polyamides containing oxygen in the form of ether groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polyamides (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

合成収率が高く実用的な方法で合成でき、インフルエンザウイルスの感染阻害活性が向上されたシアロ糖鎖含有ポリマーおよびその製造方法を提供する。下記構造式（Ｉ）で表され、γ－ポリグルタミン酸に末端にアミノ基とカルボキシル基を有する化合物をリンカーとしてシアロ糖鎖を結合させたＮ結合型シアロ糖鎖含有ポリマー。 式（Ｉ） （式中、Ｚは水酸基又は式（ＩＩ）で表される残基を意味し、ｎは１０以上の整数を示す。ただし、いずれか１以上のＺは式（ＩＩ）で表される残基である。） 式（ＩＩ） （式中、Ｘは水酸基又はアセチルアミノ基、Ｙ１及びＹ２は水酸基又はＮ－アセチルノイラミン酸残基、Ｌは炭化水素を意味し、ｍは０又は１もしくは２の整数を示す。ただし、Ｙ１とＹ２は同一でない。）
PCT/JP2008/061429 2007-06-28 2008-06-24 新規なｎ結合型人工シアロ糖鎖含有ポリマーおよびその製造方法 WO2009001805A1 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2009520586A JP5360497B2 (ja) 2007-06-28 2008-06-24 新規なｎ結合型人工シアロ糖鎖含有ポリマーおよびその製造方法
US12/666,482 US8450441B2 (en) 2007-06-28 2008-06-24 Synthetic N-linked sialo-glycan-containing polymer and method for producing the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-170079 2007-06-28
JP2007170079 2007-06-28

Publications (1)

Publication Number Publication Date
WO2009001805A1 true WO2009001805A1 (ja) 2008-12-31

Family

ID=40185619

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/061429 WO2009001805A1 (ja) 2007-06-28 2008-06-24 新規なｎ結合型人工シアロ糖鎖含有ポリマーおよびその製造方法

Country Status (3)

Country Link
US (1) US8450441B2 (ja)
JP (1) JP5360497B2 (ja)
WO (1) WO2009001805A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011108471A1 (ja) * 2010-03-04 2011-09-09 国立大学法人静岡大学 ウィルス阻害剤
WO2014136931A1 (ja) * 2013-03-08 2014-09-12 雪印メグミルク株式会社 感染防御剤

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021535150A (ja) * 2018-09-04 2021-12-16 エコール ポリテクニーク フェデラル デ ローザンヌ （イーピーエフエル） 殺ウイルス性ナノ粒子及びインフルエンザウイルスに対するその使用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10310610A (ja) * 1997-05-09 1998-11-24 Snow Brand Milk Prod Co Ltd シアリルラクトース結合ポリスチレン誘導体及びその用途
JP2002514186A (ja) * 1996-10-02 2002-05-14 シンテゾーメ ゲゼルシャフト フュア メッド．ビオフェミー ミット．ベシュレンクター．ハフツンク． ウイルス性細胞接着阻害剤としての複合糖質
JP2003073397A (ja) * 2001-08-30 2003-03-12 Wakamoto Pharmaceut Co Ltd 合成ムチン
WO2007026669A1 (ja) * 2005-09-02 2007-03-08 Shizuoka Prefectural Universities Corporation ウイルスレセプター糖鎖認識特異性の判別方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079353A (en) * 1987-12-02 1992-01-07 Chembiomed, Ltd. Sialic acid glycosides, antigens, immunoadsorbents, and methods for their preparation
US5742738A (en) * 1988-05-20 1998-04-21 John R. Koza Simultaneous evolution of the architecture of a multi-part program to solve a problem using architecture altering operations
CA2239296A1 (en) * 1996-10-02 1998-04-09 Syntesome Gesellschaft Fur Med. Biochemie M.B.H. Glycoconjugates as virus cell adhesion inhibitors
US6766348B1 (en) * 1999-08-03 2004-07-20 Worldcom, Inc. Method and system for load-balanced data exchange in distributed network-based resource allocation
US20030120824A1 (en) * 2001-05-03 2003-06-26 Scott Shattuck System supporting object-oriented constructs in ECMAScript

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002514186A (ja) * 1996-10-02 2002-05-14 シンテゾーメ ゲゼルシャフト フュア メッド．ビオフェミー ミット．ベシュレンクター．ハフツンク． ウイルス性細胞接着阻害剤としての複合糖質
JPH10310610A (ja) * 1997-05-09 1998-11-24 Snow Brand Milk Prod Co Ltd シアリルラクトース結合ポリスチレン誘導体及びその用途
JP2003073397A (ja) * 2001-08-30 2003-03-12 Wakamoto Pharmaceut Co Ltd 合成ムチン
WO2007026669A1 (ja) * 2005-09-02 2007-03-08 Shizuoka Prefectural Universities Corporation ウイルスレセプター糖鎖認識特異性の判別方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
OGATA ET AL.: "Chemoenzymatic synthesis of artificial glycopolypeptides containing multivalent sialyloligosaccharides with a gamma-polyglutamic acid backbone and their effect on inhibition of infection by influenza viruses", BIOORG. MED. CHEM., vol. 15, no. 3, 1 February 2007 (2007-02-01), pages 1383 - 1393, XP005823079 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011108471A1 (ja) * 2010-03-04 2011-09-09 国立大学法人静岡大学 ウィルス阻害剤
WO2014136931A1 (ja) * 2013-03-08 2014-09-12 雪印メグミルク株式会社 感染防御剤
JP2014172862A (ja) * 2013-03-08 2014-09-22 Snow Brand Milk Products Co Ltd 感染予防剤

Also Published As

Publication number Publication date
JPWO2009001805A1 (ja) 2010-08-26
US20100168366A1 (en) 2010-07-01
JP5360497B2 (ja) 2013-12-04
US8450441B2 (en) 2013-05-28

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