WO2008152758A1 - リョウキョウ由来の悪性腫瘍治療薬 - Google Patents

リョウキョウ由来の悪性腫瘍治療薬 Download PDF

Info

Publication number
WO2008152758A1
WO2008152758A1 PCT/JP2008/000055 JP2008000055W WO2008152758A1 WO 2008152758 A1 WO2008152758 A1 WO 2008152758A1 JP 2008000055 W JP2008000055 W JP 2008000055W WO 2008152758 A1 WO2008152758 A1 WO 2008152758A1
Authority
WO
WIPO (PCT)
Prior art keywords
therapeutic agent
hydrogen atom
malignant tumor
tumor derived
alpinia officinarum
Prior art date
Application number
PCT/JP2008/000055
Other languages
English (en)
French (fr)
Inventor
Takashi Suzuki
Ken Yasukawa
Keiichi Tabata
Original Assignee
Nihon University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon University filed Critical Nihon University
Priority to JP2009519139A priority Critical patent/JP5201603B2/ja
Publication of WO2008152758A1 publication Critical patent/WO2008152758A1/ja

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　本発明は、新たな悪性腫瘍治療薬を提供するものである。 　一般式（１） （式中、Ｒ１は水素原子、ヒドロキシ基又はメトキシ基を示し；Ｒ２は水素原子又はヒドロキシ基を示し；Ｒ３は水素原子又はヒドロキシ基を示し；Ｒ４は水素原子又はメトキシ基を示し；破線はその部分が二重結合になっていてもよいことを示し；Ｒ５は水素原子又は式（ａ） （式中、矢印は結合部位を示し、Ｒ１、Ｒ２、Ｒ３、Ｒ４及び破線は前記と同じ） で示される基を示す） で表される化合物を有効成分とする悪性腫瘍治療薬。
PCT/JP2008/000055 2007-06-11 2008-01-21 リョウキョウ由来の悪性腫瘍治療薬 WO2008152758A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009519139A JP5201603B2 (ja) 2007-06-11 2008-01-21 リョウキョウ由来の悪性腫瘍治療薬

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007154106 2007-06-11
JP2007-154106 2007-06-11

Publications (1)

Publication Number Publication Date
WO2008152758A1 true WO2008152758A1 (ja) 2008-12-18

Family

ID=40129373

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/000055 WO2008152758A1 (ja) 2007-06-11 2008-01-21 リョウキョウ由来の悪性腫瘍治療薬

Country Status (2)

Country Link
JP (1) JP5201603B2 (ja)
WO (1) WO2008152758A1 (ja)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07206669A (ja) * 1994-01-14 1995-08-08 Nikken Food Kk チロシナーゼ阻害活性剤
CN1359694A (zh) * 2000-12-18 2002-07-24 马庆发 花椒等系列中药流浸膏
US20050215635A1 (en) * 2004-03-08 2005-09-29 Rafi M Mohamed Diarylheptanoid compounds and uses thereof
JP2005535626A (ja) * 2002-06-24 2005-11-24 リサーチ　ディベロップメント　ファンデーション クルクミンによるヒト多発性骨髄腫の治療
US20060276536A1 (en) * 2004-02-12 2006-12-07 Vander Jagt David L Cancer treatment using curcumin derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07206669A (ja) * 1994-01-14 1995-08-08 Nikken Food Kk チロシナーゼ阻害活性剤
CN1359694A (zh) * 2000-12-18 2002-07-24 马庆发 花椒等系列中药流浸膏
JP2005535626A (ja) * 2002-06-24 2005-11-24 リサーチ　ディベロップメント　ファンデーション クルクミンによるヒト多発性骨髄腫の治療
US20060276536A1 (en) * 2004-02-12 2006-12-07 Vander Jagt David L Cancer treatment using curcumin derivatives
US20050215635A1 (en) * 2004-03-08 2005-09-29 Rafi M Mohamed Diarylheptanoid compounds and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE CAPLUS [online] accession no. STN Database accession no. (2007:980336) *
FAN G.-J. ET AL.: "Platelet-activating factor (PAF) receptor binding antagonists from Alpinia officinarum", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 17, no. 24, 2007, pages 6720 - 6722, XP022339561 *
WEBER W.M. ET AL.: "Anti-oxidant activities of curcumin and related enones", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 13, no. 11, 2005, pages 3811 - 3820, XP004873539 *

Also Published As

Publication number Publication date
JPWO2008152758A1 (ja) 2010-08-26
JP5201603B2 (ja) 2013-06-05

Similar Documents

Publication Publication Date Title
WO2009031644A1 (ja) 抗真菌医薬組成物
WO2009031642A1 (ja) 医薬組成物
WO2004014322A3 (en) Immunomodulatory compositions, methods of making, and methods of use thereof
WO2009142571A8 (en) Phenyl and benzodioxinyl substituted indazoles derivatives
MX2009004096A (es) Metabolitos de talarozol.
WO2010026436A3 (en) 1,3, 4, 6, 7, 11b-hexahydro-benzo[alpha]quinolizines for the treatment of hyperkinetic movement and related disorders
HK1113352A1 (en) Chemical compounds
TW200800963A (en) Chemical compounds
HK1114375A1 (en) Chemical compounds
WO2008070129A3 (en) Compositions and methods for the treatment of inflammatory disease
WO2010071783A8 (en) Thiazoles as cannabinoid receptor ligands
WO2004106293A3 (en) Oxazolyl - and thiazolyl - purine based tricyclic compounds.
WO2009051244A1 (ja) 複素環化合物
EP1935893A4 (en) TOTAL SYNTHESIS OF PLADIENOLIDE B AND PLADIENOLIDE D
WO2006060189A3 (en) Curable silicone compositions incorporating a fluorescent detection system
WO2008017381A8 (de) Arylaminoaryl-alkyl-substituierte imidazolidin-2,4-dione, verfahren zu ihrer herstellung, diese verbindungen enthaltende arzneimittel und ihre verwendung
DK1606242T3 (da) Azidfri fremgangsmåde til fremstilling af 1,2-diaminoforbindelser
WO2011058027A3 (en) N-9-substituted purine compounds, compositions and methods of use
WO2008126858A1 (ja) アミド化合物の製造方法
TW200510317A (en) Caspase inhibitors and uses thereof
MY141233A (en) Enantiomers of selected fused heterocyclics and uses thereof
ATE491475T1 (de) Konjugate enthaltend gm-csf und ein polymer
WO2008008700A3 (en) Substituted cyclopentane derivatives as therapeutic agents
WO2005117543A3 (en) N-sulfonylcarboximidamide apoptosis promoters
WO2005077902A3 (en) Methods for the synthesis of pyridoxamine

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08702796

Country of ref document: EP

Kind code of ref document: A1

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
ENP Entry into the national phase

Ref document number: 2009519139

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08702796

Country of ref document: EP

Kind code of ref document: A1