WO2008146888A1 - 光学活性１，２－ジオール類の製造に用いられる不斉酸化酵素 - Google Patents

光学活性１，２－ジオール類の製造に用いられる不斉酸化酵素 Download PDF

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Publication number
WO2008146888A1
WO2008146888A1 PCT/JP2008/059943 JP2008059943W WO2008146888A1 WO 2008146888 A1 WO2008146888 A1 WO 2008146888A1 JP 2008059943 W JP2008059943 W JP 2008059943W WO 2008146888 A1 WO2008146888 A1 WO 2008146888A1
Authority
WO
WIPO (PCT)
Prior art keywords
diol
optically active
oxidase
asymmetric
producing
Prior art date
Application number
PCT/JP2008/059943
Other languages
English (en)
French (fr)
Inventor
Kouji Nishikawa
Atsushi Nakagawa
Toshio Suzuki
Yoshiaki Nishiya
Original Assignee
Daiso Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiso Co., Ltd. filed Critical Daiso Co., Ltd.
Priority to JP2009516359A priority Critical patent/JP5175845B2/ja
Publication of WO2008146888A1 publication Critical patent/WO2008146888A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P9/00—Preparation of organic compounds containing a metal or atom other than H, N, C, O, S or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

　本発明は光学活性１，２-ジオール類の製法に使用される酵素、該酵素をコードする遺伝子およびそれらを利用した光学活性１，２-ジオール類の製法を提供する。具体的には不斉酸化酵素をコードする配列番号１の第１１２塩基～第２１８４塩基を含む遺伝子および配列番号５のアミノ酸配列を有する不斉酸化酵素を提供する。また、本発明の不斉酸化酵素を１，２-ジオール類の両エナンチオマー混合物もしくは一方のエナンチオマーと接触させて、他方のエナンチオマーを得る、光学活性１，２－ジオール類の製法を提供する。
PCT/JP2008/059943 2007-05-29 2008-05-29 光学活性１，２－ジオール類の製造に用いられる不斉酸化酵素 WO2008146888A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2009516359A JP5175845B2 (ja) 2007-05-29 2008-05-29 光学活性１，２−ジオール類の製造に用いられる不斉酸化酵素

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-141906 2007-05-29
JP2007141906 2007-05-29

Publications (1)

Publication Number Publication Date
WO2008146888A1 true WO2008146888A1 (ja) 2008-12-04

Family

ID=40075120

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/059943 WO2008146888A1 (ja) 2007-05-29 2008-05-29 光学活性１，２－ジオール類の製造に用いられる不斉酸化酵素

Country Status (2)

Country Link
JP (1) JP5175845B2 (ja)
WO (1) WO2008146888A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021129530A (ja) * 2020-02-20 2021-09-09 株式会社大阪ソーダ （ｓ）−３−ハロゲノ−２−メチル−１，２−プロパンジオールを製造する方法
WO2022259458A1 (ja) * 2021-06-10 2022-12-15 株式会社大阪ソーダ （ｓ）－３－ハロゲノ－２－メチル－１，２－プロパンジオールを製造する方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001149090A (ja) * 1999-11-29 2001-06-05 Daiso Co Ltd 微生物による（ｓ）−３−ハロゲノ−１，２−プロパンジオールの製法
JP2002253295A (ja) * 2000-12-26 2002-09-10 Daiso Co Ltd 微生物培養法によるｒ体１，２−プロパンジオールの製法
JP2006197803A (ja) * 2004-01-05 2006-08-03 Daiso Co Ltd 微生物を利用した光学活性３−クロロ−２−メチル−１，２−プロパンジオールの製造方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001149090A (ja) * 1999-11-29 2001-06-05 Daiso Co Ltd 微生物による（ｓ）−３−ハロゲノ−１，２−プロパンジオールの製法
JP2002253295A (ja) * 2000-12-26 2002-09-10 Daiso Co Ltd 微生物培養法によるｒ体１，２−プロパンジオールの製法
JP2006197803A (ja) * 2004-01-05 2006-08-03 Daiso Co Ltd 微生物を利用した光学活性３−クロロ−２−メチル−１，２−プロパンジオールの製造方法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FURUKAWA Y. ET AL.: "Kogaku Kassei Propanol Yudotai no Kogyoteki Seiho no Kaihatsu to Sono Oyo", JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN, vol. 65, no. 4, 1 April 2007 (2007-04-01), pages 308 - 319 *
KASAI N. ET AL.: "Biseibutsu ni yoru Kogaku Kassei C3 Gosei Unit no Kaihatsu", KAGAKU TO KOGYO, vol. 71, no. 11, 1997, pages 482 - 489 *
SUZUKI T. ET AL.: "Bio-ho ni yoru Kogaku Kassei 1,2-diol Gosei Unit no Kogyoteki Siesanho no Kaihatsu", FINE CHEMICALS, vol. 36, no. 5, 15 April 2007 (2007-04-15), pages 52 - 63 *
TOYAMA H. ET AL.: "Molecular cloning and structural analysis of quinohemoprotein alcohol dehydrogenase ADH-IIG from Pseudomonas putida HK5", J. MOL. BIOL., vol. 352, no. 1, 2005, pages 91 - 104, XP005014088 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021129530A (ja) * 2020-02-20 2021-09-09 株式会社大阪ソーダ （ｓ）−３−ハロゲノ−２−メチル−１，２−プロパンジオールを製造する方法
JP7014240B2 (ja) 2020-02-20 2022-02-01 株式会社大阪ソーダ （ｓ）－３－ハロゲノ－２－メチル－１，２－プロパンジオールを製造する方法
WO2022259458A1 (ja) * 2021-06-10 2022-12-15 株式会社大阪ソーダ （ｓ）－３－ハロゲノ－２－メチル－１，２－プロパンジオールを製造する方法

Also Published As

Publication number Publication date
JP5175845B2 (ja) 2013-04-03
JPWO2008146888A1 (ja) 2010-08-19

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