WO2008136394A1 - ラクタム化合物の製造方法及びその製造中間体 - Google Patents

ラクタム化合物の製造方法及びその製造中間体 Download PDF

Info

Publication number
WO2008136394A1
WO2008136394A1 PCT/JP2008/058038 JP2008058038W WO2008136394A1 WO 2008136394 A1 WO2008136394 A1 WO 2008136394A1 JP 2008058038 W JP2008058038 W JP 2008058038W WO 2008136394 A1 WO2008136394 A1 WO 2008136394A1
Authority
WO
WIPO (PCT)
Prior art keywords
production
lactam compound
producing
therapeutic agent
production method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/058038
Other languages
English (en)
French (fr)
Inventor
Kouji Haga
Nobuhiro Yamanaka
Tsuyoshi Mita
Shigeo Hirasawa
Akinori Tatara
Junko Yamanaka
Kotaro Okado
Seiji Niwa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/JP2007/059545 external-priority patent/WO2008139576A1/ja
Priority claimed from PCT/JP2007/059540 external-priority patent/WO2008139574A1/ja
Priority claimed from PCT/JP2007/059544 external-priority patent/WO2008139575A1/ja
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Publication of WO2008136394A1 publication Critical patent/WO2008136394A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

　本発明は、ラクタム化合物の新規な製造法およびその製造中間体に関する。さらに詳しくは、本発明は、穏和で安全な条件で実施できる糖尿病治療薬あるいはその製造中間体としてのラクタム化合物の簡便な製造法、およびそのような製造法に有用な製造中間体に関する。
PCT/JP2008/058038 2007-04-27 2008-04-25 ラクタム化合物の製造方法及びその製造中間体 Ceased WO2008136394A1 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JPPCT/JP2007/059544 2007-04-27
JPPCT/JP2007/059545 2007-04-27
PCT/JP2007/059545 WO2008139576A1 (ja) 2007-04-27 2007-04-27 ラクタム化合物の製造方法及びその製造中間体
PCT/JP2007/059540 WO2008139574A1 (ja) 2007-04-27 2007-04-27 ラクタム化合物の結晶形およびその製造方法
PCT/JP2007/059544 WO2008139575A1 (ja) 2007-04-27 2007-04-27 経口投与用製剤
JPPCT/JP2007/059540 2007-04-27

Publications (1)

Publication Number Publication Date
WO2008136394A1 true WO2008136394A1 (ja) 2008-11-13

Family

ID=39943501

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/JP2008/058037 Ceased WO2008136393A1 (ja) 2007-04-27 2008-04-25 ラクタム化合物の結晶形およびその製造方法
PCT/JP2008/058036 Ceased WO2008136392A1 (ja) 2007-04-27 2008-04-25 経口投与用製剤
PCT/JP2008/058038 Ceased WO2008136394A1 (ja) 2007-04-27 2008-04-25 ラクタム化合物の製造方法及びその製造中間体

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/JP2008/058037 Ceased WO2008136393A1 (ja) 2007-04-27 2008-04-25 ラクタム化合物の結晶形およびその製造方法
PCT/JP2008/058036 Ceased WO2008136392A1 (ja) 2007-04-27 2008-04-25 経口投与用製剤

Country Status (1)

Country Link
WO (3) WO2008136393A1 (ja)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011002075A1 (ja) * 2009-07-02 2011-01-06 味の素株式会社 ラクタム化合物の製造方法およびその製造中間体
WO2011002076A1 (ja) * 2009-07-02 2011-01-06 味の素株式会社 ラクタム化合物の製造方法およびその製造中間体

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110009347A1 (en) 2009-07-08 2011-01-13 Yin Liang Combination therapy for the treatment of diabetes
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
LT2568988T (lt) 2010-05-11 2016-09-12 Janssen Pharmaceutica, N.V. Farmacinės kompozicijos, apimančios 1-(beta-d-gliukopiranozil)-2-tienilmetilbenzeno darinius kaip sglt inhibitorius
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US20170369494A1 (en) * 2014-12-22 2017-12-28 Ea Pharma Co., Ltd. Drug for treating disorders of corneal epithelium
JP6498158B2 (ja) * 2016-07-11 2019-04-10 ニプロ株式会社 口腔内崩壊錠

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044180A1 (en) * 2000-12-01 2002-06-06 Ajinomoto Co.,Inc. Lactam compounds and medicinal use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU761994C (en) * 1997-12-22 2004-01-08 Merck Sharp & Dohme Corp. Molecular dispersion composition with enhanced bioavailability
JP4327424B2 (ja) * 2000-05-15 2009-09-09 武田薬品工業株式会社 結晶の製造法
ITMI20011727A1 (it) * 2001-08-06 2003-02-06 Recordati Ind Chimica E Farma Solvati della lercanidipina cloridrato e nuove forme cristalline della lercanidipina cloridrato ottenute da essi
BRPI0407303A (pt) * 2003-02-07 2006-02-07 Ajinomoto Kk Composição farmacêutica
KR100882156B1 (ko) * 2003-08-08 2009-02-06 아지노모토 가부시키가이샤 나테글리니드 함유 제제
CA2544310A1 (en) * 2003-10-31 2005-05-12 Ajinomoto Co., Inc. New fused polycyclic compounds having a heterocyclic ring(s) and pharmaceutical use thereof
TW200616634A (en) * 2004-10-01 2006-06-01 Bristol Myers Squibb Co Crystalline forms and process for preparing spiro-hydantoin compounds
CN101166742B (zh) * 2005-04-28 2011-07-13 味之素株式会社 新型内酰胺化合物
WO2006132440A1 (ja) * 2005-06-09 2006-12-14 Takeda Pharmaceutical Company Limited 固形製剤

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002044180A1 (en) * 2000-12-01 2002-06-06 Ajinomoto Co.,Inc. Lactam compounds and medicinal use thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011002075A1 (ja) * 2009-07-02 2011-01-06 味の素株式会社 ラクタム化合物の製造方法およびその製造中間体
WO2011002076A1 (ja) * 2009-07-02 2011-01-06 味の素株式会社 ラクタム化合物の製造方法およびその製造中間体

Also Published As

Publication number Publication date
WO2008136392A1 (ja) 2008-11-13
WO2008136393A1 (ja) 2008-11-13

Similar Documents

Publication Publication Date Title
WO2008046581A3 (de) Substituierte tetrahydropyrrolopyrazin-verbindungen als inhibitoren der monoaminwiederaufnahme und deren verwendung in arzeimitteln
WO2007093627A3 (de) Biozide zusammensetzung
WO2007015017A3 (fr) Nouveaux derives de polyquinoleines et leur utilisation therapeutique
EP2133077A4 (en) DERIVATIVES OF AZABICYCLOOCTAN; PROCESS FOR THEIR PREPARATION AND THEIR USES AS AN INHIBITORS OF DIPEPTIDYLPEPTIDASE IV
WO2009092752A3 (de) Polyolefine mit isotaktischen strukturelementen, verfahren zu deren herstellung und deren verwendung
WO2008104306A3 (de) Substituierte 4-aryl-1,4-dihydro-1,6-naphthyridinamide und ihre verwendung
WO2010078900A3 (de) Neue aliphatisch substituierte pyrazolopyridine und ihre verwendung
ZA201001015B (en) (Carboxylalkylene-phenyl)-phenyl-oxalamides, method for the production thereof, and use of same as a medicament
IL204556A0 (en) (cyclopropyl-phenyl)-phenyl-oxalamides, method for the production thereof, and use of same as a medicament
WO2008121616A3 (en) Antibodies with decreased deamidation profiles
IL213112A (en) Nemphen hydrochloride dihydrate
WO2008017962A3 (en) Microcapsules with improved shells
WO2009068214A3 (de) Heteroaryl-substituierte piperidine
WO2009114601A3 (en) Preparation of lenalidomide
WO2007035629A3 (en) Process for the preparation of pyrimidinedione derivatives
WO2011073279A3 (fr) Procédé de traitement cosmétique impliquant un composé apte à condenser in situ
EP1908749A4 (en) PROCESS FOR PREPARING ISOCYANATE, ISOCYANATE MADE ACCORDING TO IT AND USE OF ISOCYANATE
WO2010009879A3 (en) Methods for producing paricalcitol
WO2010004197A3 (fr) Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
IL179758A (en) Substituted tetrahydro-2h-isoquinolin-1-one derivatives, method for the production thereof and use of the same as medicaments
WO2008035066A3 (en) Processes for the preparation of ciclesonide and its crystal form
WO2008151749A3 (de) Aktivierbare diagnostische und therapeutische verbindung
WO2009074247A8 (de) Neue 2-aryl-thiazol-4-carbonsäureamid-derivate, deren herstellung und verwendung als arzneimittel
WO2010102778A3 (de) Substituierte 3-aminoisoxazolopyridine als kcnq2/3 modulatoren
WO2008011433A3 (en) Styrenated terpene resin as well as methods of making and using the same

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08752112

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08752112

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP