WO2008133482A1 - Composition d'émulsion contenant une nanocapsule de céramide doublement stabilisée, son procédé de fabrication, et composition cosmétique la contenant - Google Patents
Composition d'émulsion contenant une nanocapsule de céramide doublement stabilisée, son procédé de fabrication, et composition cosmétique la contenant Download PDFInfo
- Publication number
- WO2008133482A1 WO2008133482A1 PCT/KR2008/002464 KR2008002464W WO2008133482A1 WO 2008133482 A1 WO2008133482 A1 WO 2008133482A1 KR 2008002464 W KR2008002464 W KR 2008002464W WO 2008133482 A1 WO2008133482 A1 WO 2008133482A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ceramide
- wax
- composition
- emulsion composition
- preparation
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 81
- 229940106189 ceramide Drugs 0.000 title claims abstract description 65
- YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 title claims abstract description 62
- CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 title claims abstract description 62
- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 title claims abstract description 62
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 title claims abstract description 62
- 239000000839 emulsion Substances 0.000 title claims abstract description 48
- 239000002537 cosmetic Substances 0.000 title claims abstract description 27
- 239000002088 nanocapsule Substances 0.000 title description 4
- 238000000034 method Methods 0.000 title description 3
- 238000004519 manufacturing process Methods 0.000 title description 2
- 239000002775 capsule Substances 0.000 claims abstract description 28
- 229920000642 polymer Polymers 0.000 claims abstract description 23
- 238000002360 preparation method Methods 0.000 claims abstract description 20
- 239000011159 matrix material Substances 0.000 claims abstract description 14
- 150000002632 lipids Chemical class 0.000 claims abstract description 13
- 239000007787 solid Substances 0.000 claims abstract description 5
- 239000001993 wax Substances 0.000 claims description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 239000006071 cream Substances 0.000 claims description 13
- 239000006210 lotion Substances 0.000 claims description 12
- 238000010438 heat treatment Methods 0.000 claims description 9
- 239000004615 ingredient Substances 0.000 claims description 8
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 8
- 229920001202 Inulin Polymers 0.000 claims description 6
- 229940029339 inulin Drugs 0.000 claims description 6
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 claims description 4
- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 claims description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 4
- 235000013871 bee wax Nutrition 0.000 claims description 4
- 239000012166 beeswax Substances 0.000 claims description 4
- 229920001400 block copolymer Polymers 0.000 claims description 4
- 229940074979 cetyl palmitate Drugs 0.000 claims description 4
- PXDJXZJSCPSGGI-UHFFFAOYSA-N hexadecanoic acid hexadecyl ester Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 3
- CNRDTAOOANTPCG-UHFFFAOYSA-N dodecyl carbamate Chemical compound CCCCCCCCCCCCOC(N)=O CNRDTAOOANTPCG-UHFFFAOYSA-N 0.000 claims description 3
- 230000001804 emulsifying effect Effects 0.000 claims description 3
- 239000000194 fatty acid Substances 0.000 claims description 3
- 229930195729 fatty acid Natural products 0.000 claims description 3
- 150000004665 fatty acids Chemical class 0.000 claims description 3
- 150000002191 fatty alcohols Chemical class 0.000 claims description 3
- -1 pack Substances 0.000 claims description 3
- 239000012165 plant wax Substances 0.000 claims description 3
- 229920002401 polyacrylamide Polymers 0.000 claims description 3
- 229920001610 polycaprolactone Polymers 0.000 claims description 3
- 229920001223 polyethylene glycol Polymers 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 239000000230 xanthan gum Substances 0.000 claims description 3
- 229920001285 xanthan gum Polymers 0.000 claims description 3
- 229940082509 xanthan gum Drugs 0.000 claims description 3
- 235000010493 xanthan gum Nutrition 0.000 claims description 3
- 239000006260 foam Substances 0.000 claims description 2
- 239000000499 gel Substances 0.000 claims description 2
- 235000011187 glycerol Nutrition 0.000 claims description 2
- 239000000118 hair dye Substances 0.000 claims description 2
- 239000002324 mouth wash Substances 0.000 claims description 2
- 229940051866 mouthwash Drugs 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 239000002453 shampoo Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 230000001256 tonic effect Effects 0.000 claims description 2
- 239000000606 toothpaste Substances 0.000 claims description 2
- 229940034610 toothpaste Drugs 0.000 claims description 2
- 239000004632 polycaprolactone Substances 0.000 claims 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 1
- 239000008213 purified water Substances 0.000 claims 1
- 230000003020 moisturizing effect Effects 0.000 abstract description 25
- 239000002245 particle Substances 0.000 abstract description 15
- 230000002500 effect on skin Effects 0.000 abstract description 4
- 230000005923 long-lasting effect Effects 0.000 abstract description 4
- 230000002401 inhibitory effect Effects 0.000 abstract description 2
- 210000003491 skin Anatomy 0.000 description 33
- 230000000052 comparative effect Effects 0.000 description 19
- 230000036572 transepidermal water loss Effects 0.000 description 17
- 238000005259 measurement Methods 0.000 description 9
- 210000000434 stratum corneum Anatomy 0.000 description 9
- 230000000694 effects Effects 0.000 description 7
- 230000008859 change Effects 0.000 description 6
- 238000001704 evaporation Methods 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
- 210000002615 epidermis Anatomy 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 150000001783 ceramides Chemical class 0.000 description 3
- 238000005538 encapsulation Methods 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 230000008591 skin barrier function Effects 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000004909 Moisturizer Substances 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 230000004888 barrier function Effects 0.000 description 2
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical compound CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 210000004207 dermis Anatomy 0.000 description 2
- 239000003974 emollient agent Substances 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000001333 moisturizer Effects 0.000 description 2
- 230000000704 physical effect Effects 0.000 description 2
- 229920005862 polyol Polymers 0.000 description 2
- 150000003077 polyols Chemical class 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 230000005855 radiation Effects 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 230000036620 skin dryness Effects 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000035882 stress Effects 0.000 description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 229920000375 Poly(ethylene glycol)-block-poly(ε−caprolactone) methyl ether Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- IWWCATWBROCMCW-UHFFFAOYSA-N batyl alcohol Natural products CCCCCCCCCCCCCCCCCCOC(O)CO IWWCATWBROCMCW-UHFFFAOYSA-N 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 239000011449 brick Substances 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 229940082500 cetostearyl alcohol Drugs 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 235000004626 essential fatty acids Nutrition 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 238000011580 nude mouse model Methods 0.000 description 1
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- RECVMTHOQWMYFX-UHFFFAOYSA-N oxygen(1+) dihydride Chemical compound [OH2+] RECVMTHOQWMYFX-UHFFFAOYSA-N 0.000 description 1
- 238000003921 particle size analysis Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000001732 sebaceous gland Anatomy 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229960004274 stearic acid Drugs 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000000438 stratum basale Anatomy 0.000 description 1
- 210000000498 stratum granulosum Anatomy 0.000 description 1
- 210000000437 stratum spinosum Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 210000000106 sweat gland Anatomy 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/11—Encapsulated compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Definitions
- the inventors of the present invention have worked to develop an emulsion composition having superior stability with time in spite of high ceramide content, through double encapsulation of ceramide. They doubly encapsulated ceramide using an adequate combination of wax and polymer and, thereby, inhibited interactions between ceramide molecules and prevented gelling with time. Further, they intended to improve dermal delivery and adhesion to skin through nanoparticulation and improve value as cosmetics by improving and sustaining moisturizing effect.
- the present invention provides a preparation method of an emulsion composition containing a ceramide capsule, comprising: mixing ceramide, wax and polymer while heating and dispersing using a homogenizer to prepare a lipophilic mixture; and mixing aqueous ingredients while heating, and emulsifying the aqueous ingredients by slowly adding the lipophilic mixture to the aqueous ingredients.
- FIG. 1 shows the result of particle size analysis in Example 1
- the capsule particle in the emulsion composition may have a nanosized diameter in the range from 10 to 1000 nm.
- the diameter is greater than 1000 nm, improvement of dermal delivery and adhesion to skin cannot be expected.
- a diameter smaller than 10 nm is not suited for commercialization of cosmetics because an expensive emulsifying apparatus is required, thereby, economical efficiency is low.
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
Abstract
L'invention concerne une composition d'émulsion contenant une particule de nanocapsule de céramide (10 à 1000 nm) stabilisée par double encapsulation avec une matrice de cire et un polymère, un procédé de préparation de la composition d'émulsion, et une composition cosmétique pour la peau contenant ladite composition d'émulsion. L'invention concerne plus particulièrement une composition d'émulsion présentant une stabilité supérieure dans le temps malgré la haute teneur en céramide, qui est atteinte par inhibition efficace de gélification entre les molécules de céramide par piégeage de la céramide dans une matrice de cire solide et par encapsulation de la matrice de cire au moyen d'un polymère. Selon la présente invention, le céramide, un composant lipidique de la peau présentant un excellent effet hydratant, est préparé sous forme d'émulsion stable par piégeage dans une particule de nanocapsule, qui assure une meilleure distribution dermique et une meilleure adhérence à la peau, ainsi qu'un effet hydratant de longue durée et amélioré.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2008800141500A CN101707900B (zh) | 2007-04-30 | 2008-04-30 | 含有双重稳定化的神经酰胺纳米胶囊的乳剂组合物，其生产方法，以及含有该组合物的化妆品组合物 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2007-0041831 | 2007-04-30 | ||
| KR1020070041831A KR100837558B1 (ko) | 2007-04-30 | 2007-04-30 | 이중으로 안정된 세라마이드 나노 캡슐 포함 에멀젼조성물, 그의 제조방법 및 이를 이용한 피부 화장료 조성물 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2008133482A1 true WO2008133482A1 (fr) | 2008-11-06 |
Family
ID=39771054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2008/002464 WO2008133482A1 (fr) | 2007-04-30 | 2008-04-30 | Composition d'émulsion contenant une nanocapsule de céramide doublement stabilisée, son procédé de fabrication, et composition cosmétique la contenant |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR100837558B1 (fr) |
| CN (1) | CN101707900B (fr) |
| WO (1) | WO2008133482A1 (fr) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011080741A2 (fr) | 2009-12-31 | 2011-07-07 | Sol-Gel Technologies Ltd. | Microcapsules à noyau stabilisé, procédé de leur préparation et utilisations de celles-ci |
| DE102011116069A1 (de) | 2011-10-18 | 2013-04-18 | Dr. Rimpler Gmbh | Lipidnanopartikeldispersion, Verfahren zu deren Herstellung sowie ihre Verwendung |
| EP2340805A3 (fr) * | 2009-12-14 | 2014-07-16 | Gabriele Blume | Système de support pour enfermer des matières actives et des huiles lipophiles en concentration élevée |
| EP2366374A3 (fr) * | 2010-02-12 | 2015-05-06 | ROVI Cosmetics International GmbH | Moyen de protection contre les UV pour la peau ou les cheveux doté d'une substance de filtre UV encapsulée dans un système porteur vésiculaire |
| WO2017112992A1 (fr) * | 2015-12-29 | 2017-07-06 | Natura Cosméticos S.A. | Composition de butylméthoxydibenzoylméthane, de diéthylaminohydroxybenzoylhexylbenzoate, d'éthylhexylsalycilate, d'homosalate et d'octrocrylène nanoencapsulée dans une nanostructure à film mince polymère |
| US10653899B2 (en) | 2009-12-31 | 2020-05-19 | Sol-Gel Technologies Ltd. | Core stabilized microcapsules, method of their preparation and uses thereof |
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| US12053546B2 (en) | 2011-06-29 | 2024-08-06 | Sol-Gel Technologies Ltd. | Stabilized topical formulations containing core-shell microcapsules |
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| KR102070557B1 (ko) * | 2019-06-25 | 2020-01-29 | 코스맥스 주식회사 | 세라마이드 함유 캡슐을 포함하는 화장료 조성물 |
| KR102278422B1 (ko) | 2019-10-02 | 2021-07-19 | 안호영 | 다중성분 폴리머 시스템을 이용한 유효성분 화합물의 나노 수준 캡슐화 제형을 포함하는 농약 조성물 |
| KR102394035B1 (ko) * | 2020-06-02 | 2022-05-04 | 코스맥스 주식회사 | 고압분산기를 이용한 세라마이드 함유 화장료 조성물 및 이의 제조방법 |
| KR20240015891A (ko) | 2022-07-28 | 2024-02-06 | 주식회사 수안향장 | 이중 매트릭스 캡슐의 제조방법 |
| KR20240075436A (ko) | 2022-11-22 | 2024-05-29 | 진홍종 | 이중 안정화 기술을 기반으로 하는 세라마이드 캡슐을 포함하는 나노에멀젼의 제조방법 및 이를 통해 제조된 세라마이드 캡슐을 포함하는 나노에멀젼 |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2340805A3 (fr) * | 2009-12-14 | 2014-07-16 | Gabriele Blume | Système de support pour enfermer des matières actives et des huiles lipophiles en concentration élevée |
| WO2011080741A2 (fr) | 2009-12-31 | 2011-07-07 | Sol-Gel Technologies Ltd. | Microcapsules à noyau stabilisé, procédé de leur préparation et utilisations de celles-ci |
| US10512796B2 (en) | 2009-12-31 | 2019-12-24 | Sol-Gel Technologies Ltd. | Core stabilized microcapsules, method of their preparation and uses thereof |
| US10653899B2 (en) | 2009-12-31 | 2020-05-19 | Sol-Gel Technologies Ltd. | Core stabilized microcapsules, method of their preparation and uses thereof |
| US11071878B2 (en) | 2009-12-31 | 2021-07-27 | Sol-Gel Technologies Ltd. | Core stabilized microcapsules, method of their preparation and uses thereof |
| US12070629B2 (en) | 2009-12-31 | 2024-08-27 | Sol-Gel Technologies Ltd. | Core stabilized microcapsules, method of their preparation and uses thereof |
| EP2366374A3 (fr) * | 2010-02-12 | 2015-05-06 | ROVI Cosmetics International GmbH | Moyen de protection contre les UV pour la peau ou les cheveux doté d'une substance de filtre UV encapsulée dans un système porteur vésiculaire |
| US12053546B2 (en) | 2011-06-29 | 2024-08-06 | Sol-Gel Technologies Ltd. | Stabilized topical formulations containing core-shell microcapsules |
| DE102011116069A1 (de) | 2011-10-18 | 2013-04-18 | Dr. Rimpler Gmbh | Lipidnanopartikeldispersion, Verfahren zu deren Herstellung sowie ihre Verwendung |
| WO2013057144A2 (fr) | 2011-10-18 | 2013-04-25 | Dr. Rimpler Gmbh | Dispersion aqueuse contenant une fraction de nanoparticules lipidiques, son procédé de préparation et son utilisation |
| WO2017112992A1 (fr) * | 2015-12-29 | 2017-07-06 | Natura Cosméticos S.A. | Composition de butylméthoxydibenzoylméthane, de diéthylaminohydroxybenzoylhexylbenzoate, d'éthylhexylsalycilate, d'homosalate et d'octrocrylène nanoencapsulée dans une nanostructure à film mince polymère |
Also Published As
| Publication number | Publication date |
|---|---|
| KR100837558B1 (ko) | 2008-06-12 |
| CN101707900B (zh) | 2013-02-06 |
| CN101707900A (zh) | 2010-05-12 |
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