WO2008133169A1 - N-(2-アミノ-1,2-ジシアノビニル)イミデート類、n-(2-アミノ-1,2-ジシアノビニル)ホルムアミジン、およびアミノイミダゾール誘導体の製造方法 - Google Patents
N-(2-アミノ-1,2-ジシアノビニル)イミデート類、n-(2-アミノ-1,2-ジシアノビニル)ホルムアミジン、およびアミノイミダゾール誘導体の製造方法 Download PDFInfo
- Publication number
- WO2008133169A1 WO2008133169A1 PCT/JP2008/057490 JP2008057490W WO2008133169A1 WO 2008133169 A1 WO2008133169 A1 WO 2008133169A1 JP 2008057490 W JP2008057490 W JP 2008057490W WO 2008133169 A1 WO2008133169 A1 WO 2008133169A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- production
- dicyanovinyl
- amino
- formamidine
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
- C07C257/12—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
- C07C257/04—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers
- C07C257/06—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers having carbon atoms of imino-carboxyl groups bound to hydrogen atoms, to acyclic carbon atoms, or to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08740560A EP2138480B1 (en) | 2007-04-19 | 2008-04-17 | Method for production of n-(2-amino-1,2-dicyanovinyl)imidates and method for production of aminoimidazole derivatives |
CN2008800120665A CN101663266B (zh) | 2007-04-19 | 2008-04-17 | N-(2-氨基-1,2-二氰基乙烯基)亚氨酸酯类、n-(2-氨基-1,2-二氰基乙烯基)甲脒和氨基咪唑衍生物的制造方法 |
AT08740560T ATE528283T1 (de) | 2007-04-19 | 2008-04-17 | Verfahren zur herstellung von n-(2-amino-1,2- dicyanovinyl)imidaten und verfahren zur herstellung von aminoimidazolderivaten |
US12/450,730 US8273899B2 (en) | 2007-04-19 | 2008-04-17 | Method for production of N-(2-amino-1,2-dicyanovinyl)imidates, method for production of N-(2-amino-1,2-dicyanovinyl)formamidine, and method for production of aminoimidazole derivatives |
KR1020117015448A KR101156497B1 (ko) | 2007-04-19 | 2008-04-17 | 아미노이미다졸 유도체의 제조 방법 |
KR1020097021314A KR101132590B1 (ko) | 2007-04-19 | 2008-04-17 | N-(2-아미노-1,2-디시아노비닐)이미데이트류의 제조 방법 |
KR1020117015447A KR101161602B1 (ko) | 2007-04-19 | 2008-04-17 | N-(2-아미노-1,2-디시아노비닐)포름아미딘의 제조 방법 |
US13/363,091 US8785654B2 (en) | 2007-04-19 | 2012-01-31 | Method for production of N-(2-amino-1,2-dicyanovinyl)imidates, method for production of N-(2-amino-1,2-dicyanovinyl)formamidine, and method for production of aminoimidazole derivatives |
US13/363,062 US8258333B2 (en) | 2007-04-19 | 2012-01-31 | Method for production of N-(2-amino-1,2-dicyanovinyl)imidates, method for production of N-(2-amino-1,2-dicyanovinyl)formamidine, and method for production of aminoimidazole derivatives |
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007111039A JP5064872B2 (ja) | 2007-04-19 | 2007-04-19 | N−(2−アミノ−1,2−ジシアノビニル)イミデート類の製造方法 |
JP2007-111039 | 2007-04-19 | ||
JP2007-111038 | 2007-04-19 | ||
JP2007111041A JP5112737B2 (ja) | 2007-04-19 | 2007-04-19 | アミノイミダゾール誘導体の製造方法 |
JP2007-111041 | 2007-04-19 | ||
JP2007111038A JP5004643B2 (ja) | 2007-04-19 | 2007-04-19 | N−(2−アミノ−1,2−ジシアノビニル)ホルムアミジンの製造方法 |
Related Child Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/450,730 A-371-Of-International US8273899B2 (en) | 2007-04-19 | 2008-04-17 | Method for production of N-(2-amino-1,2-dicyanovinyl)imidates, method for production of N-(2-amino-1,2-dicyanovinyl)formamidine, and method for production of aminoimidazole derivatives |
US13/363,062 Division US8258333B2 (en) | 2007-04-19 | 2012-01-31 | Method for production of N-(2-amino-1,2-dicyanovinyl)imidates, method for production of N-(2-amino-1,2-dicyanovinyl)formamidine, and method for production of aminoimidazole derivatives |
US13/363,091 Division US8785654B2 (en) | 2007-04-19 | 2012-01-31 | Method for production of N-(2-amino-1,2-dicyanovinyl)imidates, method for production of N-(2-amino-1,2-dicyanovinyl)formamidine, and method for production of aminoimidazole derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2008133169A1 true WO2008133169A1 (ja) | 2008-11-06 |
Family
ID=39925625
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/057490 WO2008133169A1 (ja) | 2007-04-19 | 2008-04-17 | N-(2-アミノ-1,2-ジシアノビニル)イミデート類、n-(2-アミノ-1,2-ジシアノビニル)ホルムアミジン、およびアミノイミダゾール誘導体の製造方法 |
Country Status (6)
Country | Link |
---|---|
US (3) | US8273899B2 (ja) |
EP (1) | EP2138480B1 (ja) |
KR (3) | KR101156497B1 (ja) |
CN (2) | CN102850238B (ja) |
AT (1) | ATE528283T1 (ja) |
WO (1) | WO2008133169A1 (ja) |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3778446A (en) * | 1971-07-23 | 1973-12-11 | Du Pont | 2-substituted-4,5-dicyanoimidazoles and their preparation from diaminomaleonitrile |
WO2001021592A1 (fr) | 1999-09-20 | 2001-03-29 | Nippon Soda Co., Ltd. | Procede de preparation de 4(5)-amino-5(4)-carboxamidoimidazoles et de leurs produits intermediaires |
JP2001151760A (ja) | 1999-11-19 | 2001-06-05 | Nippon Soda Co Ltd | 1h−4(5)−アミノイミダゾール−5(4)−カルボキサミドの製造方法 |
JP2001158776A (ja) | 1999-09-20 | 2001-06-12 | Nippon Soda Co Ltd | 1h−2−置換−4(5)−アミノ−5(4)−カルボキサミド−イミダゾールの製造方法 |
JP2001302609A (ja) | 2000-04-18 | 2001-10-31 | Nippon Soda Co Ltd | N−(2−アミノ−1,2−ジシアノビニル)ギ酸誘導体の製造方法 |
JP2002155059A (ja) | 2000-11-17 | 2002-05-28 | Nippon Soda Co Ltd | 4−アミノ−5−シアノイミダゾール誘導体及びその中間体の製造方法 |
JP2003246779A (ja) * | 2001-12-20 | 2003-09-02 | Nippon Soda Co Ltd | 4,5−ジアルコキシカルボニル又は4,5−ジシアノイミダゾールの製造方法 |
JP2004075610A (ja) | 2002-08-19 | 2004-03-11 | Nippon Soda Co Ltd | アミノイミダゾール化合物の製造方法 |
WO2004035529A1 (ja) | 2002-10-16 | 2004-04-29 | Nippon Soda Co.,Ltd. | N-(2-アミノ-1,2-ジシアノビニル)ホルムアミジンの製造方法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995003282A2 (en) * | 1993-07-26 | 1995-02-02 | Ciba-Geigy Ag | Process for the preparation of substituted 4,6-diamino-5-cyanopyrimidines |
-
2008
- 2008-04-17 EP EP08740560A patent/EP2138480B1/en not_active Not-in-force
- 2008-04-17 KR KR1020117015448A patent/KR101156497B1/ko active IP Right Grant
- 2008-04-17 KR KR1020097021314A patent/KR101132590B1/ko active IP Right Grant
- 2008-04-17 CN CN201210295851.4A patent/CN102850238B/zh not_active Expired - Fee Related
- 2008-04-17 WO PCT/JP2008/057490 patent/WO2008133169A1/ja active Application Filing
- 2008-04-17 KR KR1020117015447A patent/KR101161602B1/ko active IP Right Grant
- 2008-04-17 AT AT08740560T patent/ATE528283T1/de not_active IP Right Cessation
- 2008-04-17 CN CN2012102958548A patent/CN102850277A/zh active Pending
- 2008-04-17 US US12/450,730 patent/US8273899B2/en active Active
-
2012
- 2012-01-31 US US13/363,091 patent/US8785654B2/en not_active Expired - Fee Related
- 2012-01-31 US US13/363,062 patent/US8258333B2/en active Active
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3778446A (en) * | 1971-07-23 | 1973-12-11 | Du Pont | 2-substituted-4,5-dicyanoimidazoles and their preparation from diaminomaleonitrile |
WO2001021592A1 (fr) | 1999-09-20 | 2001-03-29 | Nippon Soda Co., Ltd. | Procede de preparation de 4(5)-amino-5(4)-carboxamidoimidazoles et de leurs produits intermediaires |
JP2001158776A (ja) | 1999-09-20 | 2001-06-12 | Nippon Soda Co Ltd | 1h−2−置換−4(5)−アミノ−5(4)−カルボキサミド−イミダゾールの製造方法 |
JP2001151760A (ja) | 1999-11-19 | 2001-06-05 | Nippon Soda Co Ltd | 1h−4(5)−アミノイミダゾール−5(4)−カルボキサミドの製造方法 |
JP2001302609A (ja) | 2000-04-18 | 2001-10-31 | Nippon Soda Co Ltd | N−(2−アミノ−1,2−ジシアノビニル)ギ酸誘導体の製造方法 |
JP2002155059A (ja) | 2000-11-17 | 2002-05-28 | Nippon Soda Co Ltd | 4−アミノ−5−シアノイミダゾール誘導体及びその中間体の製造方法 |
JP2003246779A (ja) * | 2001-12-20 | 2003-09-02 | Nippon Soda Co Ltd | 4,5−ジアルコキシカルボニル又は4,5−ジシアノイミダゾールの製造方法 |
JP2004075610A (ja) | 2002-08-19 | 2004-03-11 | Nippon Soda Co Ltd | アミノイミダゾール化合物の製造方法 |
WO2004035529A1 (ja) | 2002-10-16 | 2004-04-29 | Nippon Soda Co.,Ltd. | N-(2-アミノ-1,2-ジシアノビニル)ホルムアミジンの製造方法 |
Non-Patent Citations (5)
Title |
---|
ALVES M.J. ET AL.: "Synthesis of 5-Amino-4-(cyanoformidioyl)1H-imidazole: a Reactive Intermediate for the Synthesis of 6-Carbamoyl-1,2-dihydropurines and 6-Carbamoylpurines", J. CHEM. SOC. PERKIN TRANS. 1, no. 6, 1990, pages 1705 - 1712, XP002234628 * |
B. L. BOOTH ET AL., J. CHEM. SOC. PERKIN TRANS., 1990, pages 1705 |
B. L. BOOTH ET AL., J. CHEM. SOC. PERKIN TRANS., 1992, pages 2120 |
B. L. BOOTH ET AL., J. CHEM. SOC. PERKIN TRANS., 1995, pages 669 |
STEPHEN J.J.: "1-Alkylation of 4,5-Dicyanoimidazole by Ortho Esters", SYNTHESIS, no. 1, 1991, pages 75 - 78, XP008122470 * |
Also Published As
Publication number | Publication date |
---|---|
US8273899B2 (en) | 2012-09-25 |
KR101161602B1 (ko) | 2012-07-03 |
KR20090122988A (ko) | 2009-12-01 |
US20120130083A1 (en) | 2012-05-24 |
CN102850238A (zh) | 2013-01-02 |
KR20110086191A (ko) | 2011-07-27 |
EP2138480A1 (en) | 2009-12-30 |
US20120142957A1 (en) | 2012-06-07 |
ATE528283T1 (de) | 2011-10-15 |
CN102850277A (zh) | 2013-01-02 |
KR20110086770A (ko) | 2011-07-29 |
US20100087655A1 (en) | 2010-04-08 |
EP2138480A4 (en) | 2010-06-09 |
KR101132590B1 (ko) | 2012-04-10 |
CN102850238B (zh) | 2015-08-19 |
KR101156497B1 (ko) | 2012-06-18 |
US8258333B2 (en) | 2012-09-04 |
US8785654B2 (en) | 2014-07-22 |
EP2138480B1 (en) | 2011-10-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2005076990A3 (en) | Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors | |
WO2008017670A8 (en) | Pyrrolo [3, 2 -d] pyrimidines as dpp-iv inhibitors for the treatment of diabetes mellitus | |
WO2007065942A3 (en) | Bis-heterocyclic imidazolyl compounds | |
NZ596025A (en) | [4-(6-halo-7-substituted-2,4-dioxo-1,4-dihydro-2h-quinazolin-3-yl)-phenyl]-5-chloro-thiophen-2-yl-sulfonylureas and forms and methods related thereto | |
WO2008022777A3 (de) | Verfahren zum herstellen von 3-dihalomethyl-pyrazol-4-carbonsäurederivaten | |
MX2010001137A (es) | Procesopara preparar 5-fluoro-1h-pirazol[3,4-b]piridin-3-amina y derivados del mismo. | |
TW200716105A (en) | Imidazole compounds | |
WO2009122436A3 (en) | An improved process for the preparation of morphinane analogues | |
WO2011038185A3 (en) | Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors | |
WO2010091877A3 (en) | Process for producing ambrisentan | |
NZ588488A (en) | Method for producing an intermediate product of dabigatran etexilate | |
WO2009066735A1 (ja) | 2-アザアダマンタン類の製造方法 | |
PH12015500160A1 (en) | Method of producing 4-[5-(pyridin-4-yl)-1h-1,2,4-triazole-3-yl]pyridin-2-carbonitrile, and intermediary thereof | |
TW200640830A (en) | Process for the preparation of intermediates | |
WO2007018807A3 (en) | Methods and intermediates for the synthesis of porphyrins | |
MX2011008348A (es) | Proceso para producir derivado heterociclico sustituido con fenilo a traves de acoplamiento usando catalizador de metal de transicion. | |
WO2006122020A3 (en) | Process for production of 4-biphenylyazetidin-2-ones | |
WO2008133169A1 (ja) | N-(2-アミノ-1,2-ジシアノビニル)イミデート類、n-(2-アミノ-1,2-ジシアノビニル)ホルムアミジン、およびアミノイミダゾール誘導体の製造方法 | |
MX2012006721A (es) | Nuevos derivados de dioxolano y dioxano y un procedimiento para su preparacion. | |
PL2118058T3 (pl) | Sposób wytwarzania 5-benzyloksy-2-(4-benzyloksyfenylo)-3-metylo-1H-indolu | |
EP1967509A4 (en) | PROCESS FOR PRODUCING PRIMARY AMINO COMPOUND | |
WO2009025238A1 (ja) | キナゾリン誘導体の製造方法 | |
WO2012072548A3 (de) | Verfahren zur quervernetzung von polyamiden | |
TW200635914A (en) | Process for preparing substituted thiophenesulfonyl isocyanates | |
EP2348010A4 (en) | METHOD FOR PRODUCING A TETRAFLUOR COMPOUND |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200880012066.5 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 08740560 Country of ref document: EP Kind code of ref document: A1 |
|
ENP | Entry into the national phase |
Ref document number: 20097021314 Country of ref document: KR Kind code of ref document: A |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2008740560 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 6065/CHENP/2009 Country of ref document: IN |
|
NENP | Non-entry into the national phase |
Ref country code: DE |