WO2008084093A2 - Particles comprising active compounds - Google Patents

Particles comprising active compounds Download PDF

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Publication number
WO2008084093A2
WO2008084093A2 PCT/EP2008/050285 EP2008050285W WO2008084093A2 WO 2008084093 A2 WO2008084093 A2 WO 2008084093A2 EP 2008050285 W EP2008050285 W EP 2008050285W WO 2008084093 A2 WO2008084093 A2 WO 2008084093A2
Authority
WO
WIPO (PCT)
Prior art keywords
polymer
particle
enzyme
particles
modified
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/050285
Other languages
English (en)
French (fr)
Other versions
WO2008084093A3 (en
Inventor
Ole Simonsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novozymes AS
Original Assignee
Novozymes AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes AS filed Critical Novozymes AS
Priority to EP08701429A priority Critical patent/EP2129757A2/en
Priority to CN200880008046.0A priority patent/CN101636480B/zh
Priority to US12/521,658 priority patent/US20100323945A1/en
Priority to JP2009545185A priority patent/JP5209643B2/ja
Publication of WO2008084093A2 publication Critical patent/WO2008084093A2/en
Publication of WO2008084093A3 publication Critical patent/WO2008084093A3/en
Anticipated expiration legal-status Critical
Priority to US13/343,161 priority patent/US9499773B2/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/38—Products with no well-defined composition, e.g. natural products
    • C11D3/386—Preparations containing enzymes, e.g. protease or amylase
    • C11D3/38672—Granulated or coated enzymes
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/22—Carbohydrates or derivatives thereof
    • C11D3/222—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/20—Organic compounds containing oxygen
    • C11D3/22—Carbohydrates or derivatives thereof
    • C11D3/222—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin
    • C11D3/225—Natural or synthetic polysaccharides, e.g. cellulose, starch, gum, alginic acid or cyclodextrin etherified, e.g. CMC
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/16—Organic compounds
    • C11D3/37—Polymers
    • C11D3/3746—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C11D3/3769—(Co)polymerised monomers containing nitrogen, e.g. carbonamides, nitriles or amines
    • C11D3/3776—Heterocyclic compounds, e.g. lactam

Definitions

  • One object of the present invention is to provide particles comprising proteins in particular enzymes, with improved storage stability, for liquid compositions such as liquid detergents. It has surprisingly been found that it is possible to improve the storage stability of proteins such as enzymes by preparing polymer matrix particles comprising the enzyme.
  • Hydrophilic polymers may include but are not limited to polyvinylpyrrolidone, polyvinylalcohol, polyethyleneglycol, hydroxypropylcellulose, hydroxymethylcellulose, hydroxypropylmethylcellu- lose, gelatin, polyvinylmethylether, polymethyloxazoline, polyethyloxazoline, polyhydroxypropy- loxazoline, carrageenan, polyhydroxypropylmethacrylamide, polymethacrylamide, polydimethy- lacrylamide, polyhydroxypropylmethacrylate, polyhydroxyethylacrylate, hydroxymethylcellulose, hydroxyethylcellulose, polyethyleneglycol, polyaspartamide, polyethyleneoxide (PEO), and polysaccharides.
  • PEO polyethyleneoxide
  • the modified polymer may be selected from but is not limited to the group consisting of a hydrophobically modified polyvinyl pyrrolidone (PVP), hydrophobically modified polyvinyl alcohol (PVA), hydrophobically modified cellulose derivatives such as carboxymethyl cellulose, methyl cellulose and/or hydroxypropyl cellulose, car- rageenan, gum such as guar gum, gum benzoin, gum tragacanth, gum arabic and/or gum acacia, protein such as casein, gelatin and/or albumin.
  • PVP polyvinyl pyrrolidone
  • PVA hydrophobically modified polyvinyl alcohol
  • cellulose derivatives such as carboxymethyl cellulose, methyl cellulose and/or hydroxypropyl cellulose, car- rageenan
  • gum such as guar gum, gum benzoin, gum tragacanth, gum arabic and/or gum acacia
  • protein such as casein, gelatin and/or albumin.
  • the mole percent of monomer in the copolymer is as follows: about 10 to less than 50 mole percent cationic monomer; and greater than 50 to about 90 mole percent water insoluble, hydrophobic monomer. More specifically, the mole percent of monomers in the copolymer is from about 15 to about 25 mole percent cationic monomer; and from about 70 to about 85 mole percent water insoluble, hydrophobic monomer. Most specifically, the mole per- cent of monomers in the copolymer is from about 20 mole percent cationic monomer; and about 80 mole percent water insoluble, hydrophobic monomer.
  • Suitable laccases herein include those of bacterial or fungal origin. Chemically or genetically modified mutants are included. Examples of suitable laccases are those obtainable from a strain of Trametes, e.g., T. villosa or T. versicolor, or from a strain of Coprinus, e.g., C. cinereus, or from a strain of Myceliophthora, e.g., M. thermophila.
  • transglutaminases are described in WO 96/06931 (Novo Nordisk
  • Poly ethylene glycols PEG.
  • PEG waxes are commercially available having different molecular sizes, wherein PEG'S with low molecular sizes also have low melting points.
  • suitable PEG'S are PEG 1500, PEG 2000, PEG 3000, PEG 4000, PEG 6000, PEG 8000, PEG 9000 etc. e.g. from BASF (Pluriol E series) or from Clariant or from Ineos.
  • Derivatives of Poly ethylene glycols may also be used, polypropylene (e.g. polypropylen glycol Pluriol P series from BASF) or polyethylene or mixtures thereof. Derivatives of polypropylenes and polyethylenes may also be used.
  • the particles of the present invention may comprise one, two or more additional coating layers.
  • Emulsion process wherein an aqueous liquid enzyme containing solution is emulsified in a water immiscible liquid e.g. paraffinic oil.
  • a water immiscible liquid e.g. paraffinic oil.
  • various emulsifiers and surfactants are used.
  • the water from the droplet can subsequently be removed be distilliation, e.g. azeotropic distillation, or by spray drying the emulsion if the water immiscible liquid is volatile.
  • the liquid composition is a liquid detergent composition
  • the liquid composition may comprise a surfactant desolubilising electrolyte, said electrolyte being present in a concentration at which said surfactant forms a structure capable of stably suspending the enzyme/polymer particles and sufficient to prevent or inhibit dissolution of the water soluble polymer.
  • Other less preferred builders include potassium or lithium analogues of the above sodium salts.
  • the proportion of builder is typically from about 5% to about 40% by weight of the liquid detergent composition. Usually 10% to 35%, preferably 15-30%, more preferably 18 to 28%, most preferably 20 to 27%.
  • Mixtures of two or more builders are often employed, e.g. sodium tripolyphosphate with sodium silicate and/or sodium carbonate and/or with zeolite; or sodium nitrilotriacetate with sodium citrate.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Detergent Compositions (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
PCT/EP2008/050285 2007-01-11 2008-01-11 Particles comprising active compounds Ceased WO2008084093A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP08701429A EP2129757A2 (en) 2007-01-11 2008-01-11 Particles comprising active compounds
CN200880008046.0A CN101636480B (zh) 2007-01-11 2008-01-11 包含活性化合物的颗粒
US12/521,658 US20100323945A1 (en) 2007-01-11 2008-01-11 Particles Comprising Active Compounds
JP2009545185A JP5209643B2 (ja) 2007-01-11 2008-01-11 活性化合物を含む粒子
US13/343,161 US9499773B2 (en) 2007-01-11 2012-01-04 Enzyme particles comprising a vinyl pyrrolidone/vinyl acetate copolymer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200700039 2007-01-11
DKPA200700039 2007-01-11

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/521,658 A-371-Of-International US20100323945A1 (en) 2007-01-11 2008-01-11 Particles Comprising Active Compounds
US13/343,161 Continuation US9499773B2 (en) 2007-01-11 2012-01-04 Enzyme particles comprising a vinyl pyrrolidone/vinyl acetate copolymer

Publications (2)

Publication Number Publication Date
WO2008084093A2 true WO2008084093A2 (en) 2008-07-17
WO2008084093A3 WO2008084093A3 (en) 2009-01-08

Family

ID=38055380

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/050285 Ceased WO2008084093A2 (en) 2007-01-11 2008-01-11 Particles comprising active compounds

Country Status (5)

Country Link
US (2) US20100323945A1 (enExample)
EP (1) EP2129757A2 (enExample)
JP (1) JP5209643B2 (enExample)
CN (1) CN101636480B (enExample)
WO (1) WO2008084093A2 (enExample)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101724621A (zh) * 2009-12-17 2010-06-09 北京凯泰新世纪生物技术有限公司 一种微载体固定化脂肪酶及其制备方法
WO2012140421A1 (en) * 2011-04-15 2012-10-18 Reckitt & Colman (Overseas) Limited Novel composite
WO2012140442A1 (en) * 2011-04-15 2012-10-18 Revolymer Limited Particles with hydroxyl vinylic copolymer coating sensitive to ionic strength
WO2015177077A1 (en) * 2014-05-22 2015-11-26 Unilever Plc Aqueous liquid detergent formulation comprising enzyme particles
WO2016023685A1 (en) * 2014-08-11 2016-02-18 Novozymes A/S Detergents and compositions with enzymatic polymer particles
US20160075976A1 (en) * 2013-05-03 2016-03-17 Novozymes A/S Microencapsulation of Detergent Enzymes
EP3173467A1 (en) * 2015-11-26 2017-05-31 The Procter & Gamble Company Cleaning compositions comprising enzymes
EP3243898A2 (en) 2016-05-09 2017-11-15 The Procter & Gamble Company Detergent composition comprising an oleic acid-transforming enzyme
EP3243896A1 (en) 2016-05-09 2017-11-15 The Procter and Gamble Company Detergent composition comprising a fatty acid decarboxylase
EP3243897A1 (en) 2016-05-09 2017-11-15 The Procter & Gamble Company Detergent composition comprising a fatty acid-transforming enzyme
CN109490274A (zh) * 2019-01-04 2019-03-19 齐鲁工业大学 一种用于研究酶在皮革中单向传质的实验装置及使用方法
EP2350250B2 (en) † 2008-11-03 2022-11-30 Danisco US Inc. Delivery system for co-formulated enzyme and substrate
EP3511404B1 (de) 2014-06-30 2024-12-18 Henkel AG & Co. KGaA Flüssiges reinigungsmittel enthaltend flüssige und feste enzymformulierungen

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IN2015KN00664A (enExample) * 2012-09-24 2015-07-17 Firmenich & Cie
AU2014324916B2 (en) 2013-09-27 2018-06-14 Rohm And Haas Company Ionic strength triggered disintegration of films and particulates
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US20150320033A1 (en) * 2014-05-12 2015-11-12 Thomas Michael Schultz Pre-Emergent Seed Coatings and Growth Stimulator Compositions
EP3446665B1 (en) 2014-10-06 2021-12-15 3M Innovative Properties Company Ion exchange absorbent systems, apparatuses
CN107896481B (zh) * 2015-05-18 2021-07-06 齐姆特罗尼克斯公司 磁力固定化的杀微生物酶
EP3307427B1 (en) * 2015-06-09 2023-08-16 Danisco US Inc. Osmotic burst encapsulates
CN108140848B (zh) 2015-07-15 2022-02-01 齐姆特罗尼克斯公司 自动化生物纳米催化剂生产
US12127557B2 (en) 2016-08-13 2024-10-29 Zymtronix Catalytic Systems, Inc. Magnetically immobilized biocidal enzymes and biocidal chemicals
CN108148827B (zh) * 2016-12-02 2022-09-23 丰益(上海)生物技术研发中心有限公司 固定化酶及其制备方法和用途

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Cited By (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2350250B2 (en) † 2008-11-03 2022-11-30 Danisco US Inc. Delivery system for co-formulated enzyme and substrate
CN101724621A (zh) * 2009-12-17 2010-06-09 北京凯泰新世纪生物技术有限公司 一种微载体固定化脂肪酶及其制备方法
WO2012140421A1 (en) * 2011-04-15 2012-10-18 Reckitt & Colman (Overseas) Limited Novel composite
WO2012140442A1 (en) * 2011-04-15 2012-10-18 Revolymer Limited Particles with hydroxyl vinylic copolymer coating sensitive to ionic strength
US20140171327A1 (en) * 2011-04-15 2014-06-19 Revolymer (U.K.) Limited Novel composite
US20160075976A1 (en) * 2013-05-03 2016-03-17 Novozymes A/S Microencapsulation of Detergent Enzymes
CN106488972B (zh) * 2014-05-22 2020-05-05 荷兰联合利华有限公司 包含酶颗粒的水性液体洗涤剂制剂
CN106488972A (zh) * 2014-05-22 2017-03-08 荷兰联合利华有限公司 包含酶颗粒的水性液体洗涤剂制剂
WO2015177077A1 (en) * 2014-05-22 2015-11-26 Unilever Plc Aqueous liquid detergent formulation comprising enzyme particles
EP3511404B1 (de) 2014-06-30 2024-12-18 Henkel AG & Co. KGaA Flüssiges reinigungsmittel enthaltend flüssige und feste enzymformulierungen
WO2016023685A1 (en) * 2014-08-11 2016-02-18 Novozymes A/S Detergents and compositions with enzymatic polymer particles
EP3173467A1 (en) * 2015-11-26 2017-05-31 The Procter & Gamble Company Cleaning compositions comprising enzymes
WO2017091674A1 (en) * 2015-11-26 2017-06-01 The Procter & Gamble Company Liquid detergent compositions comprising protease and encapsulated lipase
EP3243898A2 (en) 2016-05-09 2017-11-15 The Procter & Gamble Company Detergent composition comprising an oleic acid-transforming enzyme
EP3511403A1 (en) 2016-05-09 2019-07-17 The Procter & Gamble Company Detergent composition
EP3540037A1 (en) 2016-05-09 2019-09-18 The Procter & Gamble Company Detergent composition comprising a oleate 10s lipoxygenase
EP3540036A1 (en) 2016-05-09 2019-09-18 The Procter & Gamble Company Detergent composition comprising a fatty acid lipoxygenase
EP3556834A1 (en) 2016-05-09 2019-10-23 The Procter & Gamble Company Detergent composition comprising a fatty acid decarboxylase
EP3556835A1 (en) 2016-05-09 2019-10-23 The Procter & Gamble Company Detergent composition comprising a fatty acid decarboxylase
EP3243897A1 (en) 2016-05-09 2017-11-15 The Procter & Gamble Company Detergent composition comprising a fatty acid-transforming enzyme
EP3243896A1 (en) 2016-05-09 2017-11-15 The Procter and Gamble Company Detergent composition comprising a fatty acid decarboxylase
CN109490274A (zh) * 2019-01-04 2019-03-19 齐鲁工业大学 一种用于研究酶在皮革中单向传质的实验装置及使用方法

Also Published As

Publication number Publication date
JP5209643B2 (ja) 2013-06-12
WO2008084093A3 (en) 2009-01-08
CN101636480A (zh) 2010-01-27
US20120108491A1 (en) 2012-05-03
EP2129757A2 (en) 2009-12-09
US20100323945A1 (en) 2010-12-23
CN101636480B (zh) 2014-04-09
US9499773B2 (en) 2016-11-22
JP2010515800A (ja) 2010-05-13

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