WO2008081928A1 - ピラゾロピリミジン化合物 - Google Patents

ピラゾロピリミジン化合物 Download PDF

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Publication number
WO2008081928A1
WO2008081928A1 PCT/JP2007/075278 JP2007075278W WO2008081928A1 WO 2008081928 A1 WO2008081928 A1 WO 2008081928A1 JP 2007075278 W JP2007075278 W JP 2007075278W WO 2008081928 A1 WO2008081928 A1 WO 2008081928A1
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WO
WIPO (PCT)
Prior art keywords
pyrazolopyrimidine compound
disclosed
pyrazolopyrimidine
arthritides
syk
Prior art date
Application number
PCT/JP2007/075278
Other languages
English (en)
French (fr)
Inventor
Makoto Yagi
Hiroki Umemiya
Hajime Asanuma
Yusuke Oka
Rie Nishikawa
Keishi Hayashi
Takumi Okada
Takanori Shimizu
Shigetada Sasako
Original Assignee
Taisho Pharmaceutical Co., Ltd.
Nissan Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisho Pharmaceutical Co., Ltd., Nissan Chemical Industries, Ltd. filed Critical Taisho Pharmaceutical Co., Ltd.
Priority to US12/521,518 priority Critical patent/US20100298557A1/en
Priority to KR1020097013434A priority patent/KR20090103897A/ko
Priority to JP2008552181A priority patent/JPWO2008081928A1/ja
Priority to EP07860481A priority patent/EP2123654A4/en
Priority to CA002673965A priority patent/CA2673965A1/en
Publication of WO2008081928A1 publication Critical patent/WO2008081928A1/ja

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

【課題】Ｓｙｋ及び／又はＡｂｌ阻害作用に基づいたアレルギー性疾患、自己免疫疾患、関節炎又は癌などの疾病の予防・治療に有用な新規な化合物を提供することである。 【解決手段】 式(I)又は式(III)で表されるピラゾロピリミジン化合物、該化合物の互変異性体、立体異性体若しくはその薬学的に許容される塩又はそれらの溶媒和物を提供する。
PCT/JP2007/075278 2006-12-28 2007-12-28 ピラゾロピリミジン化合物 WO2008081928A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US12/521,518 US20100298557A1 (en) 2006-12-28 2007-12-28 Pyrazolopyrimidine compound
KR1020097013434A KR20090103897A (ko) 2006-12-28 2007-12-28 피라졸로피리미딘 화합물
JP2008552181A JPWO2008081928A1 (ja) 2006-12-28 2007-12-28 ピラゾロピリミジン化合物
EP07860481A EP2123654A4 (en) 2006-12-28 2007-12-28 pyrazolopyrimidine compound
CA002673965A CA2673965A1 (en) 2006-12-28 2007-12-28 Pyrazolopyrimidine compound

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006353781 2006-12-28
JP2006-353781 2006-12-28

Publications (1)

Publication Number Publication Date
WO2008081928A1 true WO2008081928A1 (ja) 2008-07-10

Family

ID=39588608

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/075278 WO2008081928A1 (ja) 2006-12-28 2007-12-28 ピラゾロピリミジン化合物

Country Status (8)

Country Link
US (1) US20100298557A1 (ja)
EP (1) EP2123654A4 (ja)
JP (1) JPWO2008081928A1 (ja)
KR (1) KR20090103897A (ja)
CN (1) CN101611035A (ja)
CA (1) CA2673965A1 (ja)
RU (1) RU2009128982A (ja)
WO (1) WO2008081928A1 (ja)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009026107A1 (en) * 2007-08-17 2009-02-26 Portola Pharmaceuticals, Inc. Protein kinase inhibitors
WO2009032703A1 (en) * 2007-08-28 2009-03-12 Irm Llc 2- (het) arylamino-6-aminopyridine derivatives and fused forms thereof as anaplastic lymphoma kinase inhibitors
WO2012057262A1 (ja) * 2010-10-28 2012-05-03 日本新薬株式会社 ピリジン誘導体及び医薬
EP2489663A1 (en) 2011-02-16 2012-08-22 Almirall, S.A. Compounds as syk kinase inhibitors
US8273754B2 (en) 2008-12-30 2012-09-25 Arqule, Inc. Substituted 1H-pyrazolo[3,4-D]pyrimidine-6-amine compounds
US8343961B2 (en) 2009-03-31 2013-01-01 Arqule, Inc. Substituted heterocyclic compounds
US8372858B2 (en) 2006-12-08 2013-02-12 Irm Llc Compounds and compositions as protein kinase inhibitors
JP2015529232A (ja) * 2012-09-20 2015-10-05 バイエル・ファルマ・アクティエンゲゼルシャフト 置換ピロロピリミジニルアミノ−ベンゾチアゾロン
US10913744B2 (en) 2015-02-13 2021-02-09 Dana-Farber Cancer Institute, Inc. LRRK2 inhibitors and methods of making and using the same

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US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
DK2300013T3 (en) 2008-05-21 2017-12-04 Ariad Pharma Inc PHOSPHORUS DERIVATIVES AS KINASE INHIBITORS
EP2365809B8 (en) 2008-11-12 2018-10-10 Ariad Pharmaceuticals, Inc. Pyrazinopyrazines and derivatives as kinase inhibitors
SI2516434T1 (sl) * 2009-12-23 2015-10-30 Takeda Pharmaceutical Company Limited Zliti heteroaromatski pirolidinoni kot inhibitorji SYK
JP2014501705A (ja) * 2010-11-01 2014-01-23 ポートラ ファーマシューティカルズ， インコーポレイテッド Ｓｙｋ調節剤としてのベンズアミドおよびニコチンアミド
TWI606049B (zh) * 2011-04-21 2017-11-21 原真股份有限公司 新穎激酶抑制劑
AU2012250517B2 (en) 2011-05-04 2016-05-19 Takeda Pharmaceutical Company Limited Compounds for inhibiting cell proliferation in EGFR-driven cancers
US9056873B2 (en) 2011-06-22 2015-06-16 Takeda Pharmaceutical Company Limited Substituted 6-aza-isoindolin-1-one derivatives
AU2013204563B2 (en) 2012-05-05 2016-05-19 Takeda Pharmaceutical Company Limited Compounds for inhibiting cell proliferation in EGFR-driven cancers
US9637491B2 (en) 2012-10-19 2017-05-02 Origenis Gmbh Pyrazolo[4,3-D]pyrimidines as kinase inhibitors
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
WO2015021149A1 (en) * 2013-08-06 2015-02-12 H. Lee Moffitt Cancer Center And Research Institute, Inc. Inhibitors of ack1/tnk2 tyrosine kinase
EP3142652B1 (en) 2014-05-14 2021-08-25 The Regents of the University of Colorado, a body corporate Heterocyclic hydroxamic acids as protein deacetylase inhibitors and dual protein deacetylase-protein kinase inhibitors and methods of use thereof
CN107406452B (zh) * 2015-01-23 2019-07-23 葛兰素史密斯克莱知识产权发展有限公司 吡唑并[3,4-d]嘧啶衍生物及其治疗利什曼病的用途
CN107383014B (zh) * 2017-06-21 2019-04-30 南方医科大学 一种1H-吡唑并[3,4-d]嘧啶类化合物及其制备方法和应用
EP3966207B1 (en) 2019-05-10 2023-11-01 Deciphera Pharmaceuticals, LLC Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof
LT3966206T (lt) 2019-05-10 2023-11-10 Deciphera Pharmaceuticals, Llc Heteroarilaminopirimidino amido autofagijos inhibitoriai ir jų naudojimo būdai
EP3983081A1 (en) 2019-06-17 2022-04-20 Deciphera Pharmaceuticals, LLC Aminopyrimidine amide autophagy inhibitors and methods of use thereof
CN116023380B (zh) * 2021-10-26 2024-01-23 沈阳药科大学 一类吡唑并嘧啶衍生物及制备方法和应用
CN115368366A (zh) * 2022-08-02 2022-11-22 江苏省中医药研究院 嘧啶并吡唑类化合物及其应用

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See also references of EP2123654A4

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8372858B2 (en) 2006-12-08 2013-02-12 Irm Llc Compounds and compositions as protein kinase inhibitors
US8957081B2 (en) 2006-12-08 2015-02-17 Irm Llc Compounds and compositions as protein kinase inhibitors
WO2009026107A1 (en) * 2007-08-17 2009-02-26 Portola Pharmaceuticals, Inc. Protein kinase inhibitors
US7705004B2 (en) 2007-08-17 2010-04-27 Portola Pharmaceuticals, Inc. Protein kinase inhibitors
WO2009032703A1 (en) * 2007-08-28 2009-03-12 Irm Llc 2- (het) arylamino-6-aminopyridine derivatives and fused forms thereof as anaplastic lymphoma kinase inhibitors
US8273754B2 (en) 2008-12-30 2012-09-25 Arqule, Inc. Substituted 1H-pyrazolo[3,4-D]pyrimidine-6-amine compounds
US8343961B2 (en) 2009-03-31 2013-01-01 Arqule, Inc. Substituted heterocyclic compounds
WO2012057262A1 (ja) * 2010-10-28 2012-05-03 日本新薬株式会社 ピリジン誘導体及び医薬
CN103298788A (zh) * 2010-10-28 2013-09-11 日本新药株式会社 吡啶衍生物及医药
EP2489663A1 (en) 2011-02-16 2012-08-22 Almirall, S.A. Compounds as syk kinase inhibitors
JP2015529232A (ja) * 2012-09-20 2015-10-05 バイエル・ファルマ・アクティエンゲゼルシャフト 置換ピロロピリミジニルアミノ−ベンゾチアゾロン
US10913744B2 (en) 2015-02-13 2021-02-09 Dana-Farber Cancer Institute, Inc. LRRK2 inhibitors and methods of making and using the same

Also Published As

Publication number Publication date
CN101611035A (zh) 2009-12-23
KR20090103897A (ko) 2009-10-01
CA2673965A1 (en) 2008-07-10
EP2123654A1 (en) 2009-11-25
RU2009128982A (ru) 2011-02-10
US20100298557A1 (en) 2010-11-25
JPWO2008081928A1 (ja) 2010-04-30
EP2123654A4 (en) 2011-05-11

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