WO2008071171A1 - Dispositif de perfusion de médicaments commandé par ordinateur avec obtention à différents instants de valeurs de mesure dans une boucle de régulation - Google Patents

Dispositif de perfusion de médicaments commandé par ordinateur avec obtention à différents instants de valeurs de mesure dans une boucle de régulation Download PDF

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Publication number
WO2008071171A1
WO2008071171A1 PCT/DE2007/002223 DE2007002223W WO2008071171A1 WO 2008071171 A1 WO2008071171 A1 WO 2008071171A1 DE 2007002223 W DE2007002223 W DE 2007002223W WO 2008071171 A1 WO2008071171 A1 WO 2008071171A1
Authority
WO
WIPO (PCT)
Prior art keywords
sodium
potassium
computer
glucose
insulin
Prior art date
Application number
PCT/DE2007/002223
Other languages
German (de)
English (en)
Inventor
Hendrik Lehnert
Daniel Pittasch
Edgar Kanneberg
Ralf Lobmann
Original Assignee
Endocrine Technologies Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Endocrine Technologies Gmbh filed Critical Endocrine Technologies Gmbh
Priority to EP07856074A priority Critical patent/EP2122522A1/fr
Priority to DE112007003346T priority patent/DE112007003346A5/de
Publication of WO2008071171A1 publication Critical patent/WO2008071171A1/fr

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
    • G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
    • G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection

Definitions

  • the invention relates to a device for computer-controlled infusion of drugs in the context of intensive monitoring and intensive therapy with discrete-time measurement value in a control loop and the integration of an external sensor determination intensive medical necessary parameters.
  • Devices, devices and methods for the computer-controlled infusion of drugs with the regulation in humans can be made to scientific and clinical issues are well known, the known devices and methods are adapted to the equipment and performance profile of each task.
  • devices and methods for the regulation of, for example, glucose are known, whose devices consist essentially of the components infusion pump for insulin, infusion pump for glucose, a measuring device for determining the blood glucose level and a computer unit for implementing the method for glucose regulation.
  • Such devices are available for use as a controlled insulin pump for the administration of insulin or as combined infusion devices for the administration of insulin and glucose.
  • the blood glucose is measured either non-invasively spectroscopically, minimally invasive via the glucose determination of the interstitial fluid or via an implanted sensor minimally invasive or directly bloody.
  • these known devices have the disadvantage that problems and inaccurate results can occur if the integrated measuring devices fail to determine the blood glucose level or the measurement accuracy is impaired by drift or other factors, since the accuracy of the measured values determined directly affects the quality the regulation of blood glucose levels.
  • DE 198 44 252 A 1 relates to a modular device for computer-controlled insulin and glucose infusion, which is designed as an appliance unit, which consists of a commercial industrial personal computer with running on the equally commercial operating system user program and free replaceable and controllable peripheral components for blood glucose determination and continuous administration of insulin and glucose relates.
  • the user program running on the operating system is subdivided into software modules, which perform the tasks for the analysis and independent integration as well as for the control and monitoring of the peripheral components.
  • This solution describes the manual venous blood glucose value generation integrated in an open-loop system with computer-controlled, automated control for insulin and glucose infusion for quasi-continuous blood glucose control.
  • the device is only suitable for regulating insulin and glucose infusion, a further determination of intensive medical parameters, such as sodium and potassium and their regulation in the context of intensive care and intensive care are not possible with this solution presented.
  • the device should be designed in such a way that an additional, short-term available determination of further parameters for the intensive monitoring is available within the scope of an intensive monitoring or therapy.
  • the state of development of blood sugar and blood mineral measurement technology allows the use of high-precision measuring instruments, which are validated by laboratory use and interlaboratory tests and provide higher measurement accuracy and greater stability of the expected measurement results.
  • a discrete-time determination of blood sodium and blood potassium is carried out in combination with high-precision measuring instruments which calibrate themselves for the determination of glucose and irisulm. This is done at certain measurement intervals, which are adapted to the experimental conditions such that there are short measurement intervals in a first time range and subsequently, after modeling could be validated, the measurement intervals by the accumulation of data and modeling of the current sodium potassium -Regulation system can be extended.
  • a recovery of the necessary parameters is time-discrete in short quasi-equivalent time intervals, but they may be different according to the respective test requirements and conditions. Also, not all of the mentioned measured values need to be determined at the same time intervals.
  • the intervals for obtaining the measured value of the individual parameters are specified by the experimenter or physician and can be adapted to the current requirements during the examination.
  • the data are accumulated, rules for the description of the individual control systems for sodium and potassium are derived and the necessary parameters are estimated, as they are used for the regulation of the parameters. a certain level over a longer period are necessary.
  • the necessary parameters are obtained at longer intervals and their regulation then takes place according to the model for regulation created in the first time range.
  • the device according to the invention is designed as a mineral measuring device, which is connected to the device for potassium infusion and Nalriuminfusion and which is coupled in parallel with a commercial computer unit, this mineral meter is also connectable in the combination as a device via the corresponding interface to Rechnerereinhe ⁇ t.
  • the computer unit a standard computer unit, consists of an industrial PC, a laptop, pocket PC, industrial workstation or panel computer. Whenever a new measured value has been determined with the external sensor continuously connected to the patient, the automatic transmission to the computer unit and to the process sequence software takes place.
  • the procedural software evaluates the received measured value in conjunction with the history of the already stored measured values, and for the period between the real measured value readings, measured values are determined which are fed to the control algorithm for calculating the necessary infusion quantities.
  • the program system allows the integration of new software modules to apply new scientific methods for sodium and potassium regulation.
  • the program on which the computer unit operates is variably configurable so that the attached device and measurements taken by it are used to determine and regulate the values for the sodium and potassium potassium.
  • the device created is for use in the intensive care application for the regulation of sodium and potassium levels at a presettable level for the treatment of disorders of the mineral balance after intensive care operations and therapy in emergency situations (eg cardiac arrhythmia, severe exciscose, the water and mineral balance relevant hormone / regulatory disorders), further for computer-aided, automated glucose regulation with a similar field of application for the regulation to a presettable level for the therapy of disorders of the glucose balance after intensive care interventions and therapy in emergency situations (eg diabetic coma).
  • emergency situations eg cardiac arrhythmia, severe exciscose, the water and mineral balance relevant hormone / regulatory disorders
  • the created device for computer-controlled sodium, potassium, insulin and glucose infusion with time-discrete blood sugar, sodium and Kaüummesswert forung and interpolated variable blood sugar, sodium and potassium measurement and additional diagnostic value recovery is also advantageous for the hitensiv monitoring necessary parameters. It is also advantageous that with the presented device highly accurate, self-calibrating Läborieri can be used and by appropriate choice of appropriate merpolation algorithms for the necessary spaces, the time intervals of the discrete measurements the trial and treatment conditions can be customized.
  • Figure 1 is a schematic representation, a block diagram of the device with direct assignment of the injection devices for potassium and sodium to the computer unit and in
  • FIG. 2 shows a further embodiment of the device created in a schematic representation, a block diagram of the associated combination injection devices for potassium and insulin and for sodium and glucose to the computer unit.
  • Figure 1 results in a training variant of the created device 1, which consists of a computer unit 2 and is formed with an operating system 3, which is directly connected to the hardware interface 8 of the computer unit 2.
  • the operating system 3 is further provided with a peripheral controller 13, a peripheral data exchange 14, a process control controller 15 and an information processing with visualization 16.
  • the computer unit 2 is equipped with a screen and also connected via the hardware interface 8 with a printer 12.
  • the entire device 1 includes a sensor unit 5 as well as an injection device 6 for potassium and an injection device 7 for sodium, which functionally are in operative connection.
  • the sensor unit 5 is connected directly to the hardware interface 8 via an interface 17. Analogously, the connections between the injection device 6 for potassium and the injection device 7 for sodium are connected to the sensor unit 5 via the interfaces 10. The connection of the injection devices 6, 7 to the respective examination object takes place via the interfaces 9.
  • the injection devices 6, 7 are designed as combined devices 18, 19, the injection device 18 for potassium and insulin, and the injection device 19 for sodium and glucose.
  • the units of the device 1 shown in FIGS. 1 and 2 are designed in the sense of a closed-loop system for controlled potassium, sodium, insulin and glucose infusion and consist of a computer unit 2 (an industrial PC, a laptop, a computer) Pocket PC, a panel computer or an industrial workstation) with an operating system 3 and user software 4 arranged thereon and the peripheral devices 6, 7, 18, 19 with integrated external combined sensors for determining the blood gases, glucose, lactate , Bilirubin, sodium, potassium, calcium, chloride and hemoglobin concentration in the form of a sensor unit 5.
  • the application software 4 contains the individual modules, which realizes the process control and control and with the peripheral devices, the injection devices 6, 7. 18, 19, via standard installed hardware interfaces 8 of the computer unit 2 is connected.
  • the connections to the respective examination object are established via the interfaces 9.
  • the glucose regulation according to the described and illustrated embodiment is used for precise adjustment of the blood sugar level to a presettable level for scientific clamp tests.
  • the process software 4 determines from the operator inputs which amount of insulin must be given over the experimental period and then controls the necessary variable glucose supply in order to achieve and maintain the desired value.
  • the measurement of sodium, potassium and glucose initially takes place in short, equidistant time intervals.
  • the user software 4 thereby automatically initiates the blood collection and measured value determination by means of the sensor unit 5, depending on the measuring intervals predefined by the user.

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medical Informatics (AREA)
  • Primary Health Care (AREA)
  • Public Health (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • External Artificial Organs (AREA)

Abstract

L'invention concerne un dispositif de perfusion de médicaments commandé par ordinateur avec obtention à différents instants de valeurs de mesure dans une boucle de régulation, pour les soins intensifs ainsi que les thérapies intensives, configuré sous la forme d'une unité de calcul (2) dotée d'un système d'exploitation (3) et d'un logiciel d'utilisateur (4) au moyen duquel, en plus de la perfusion de glucose et d'insuline commandée par ordinateur avec obtention de valeurs de mesure sur le glucose et l'insuline et détermination des valeurs de mesure sur le glucose et l'insuline ainsi que détermination de valeurs de mesure de diagnostic, on réalise une perfusion de sodium et potassium commandée par ordinateur avec obtention à différents instants de valeurs de mesure du sodium et du potassium et détermination des valeurs de mesure interpolées et variables du sodium et du potassium ainsi qu'une détermination de valeurs de mesure de diagnostic. Ledit dispositif comprend un appareil (6) d'injection de potassium et un appareil (7) d'injection de sodium ou un appareil (18) d'injection combinée de potassium et d'insuline et un appareil (19) d'injection combinée de sodium et de glucose sont reliés par des interfaces (10) à l'interface électronique (8) de l'unité de calcul (2).
PCT/DE2007/002223 2006-12-14 2007-12-11 Dispositif de perfusion de médicaments commandé par ordinateur avec obtention à différents instants de valeurs de mesure dans une boucle de régulation WO2008071171A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP07856074A EP2122522A1 (fr) 2006-12-14 2007-12-11 Dispositif de perfusion de médicaments commandé par ordinateur avec obtention à différents instants de valeurs de mesure dans une boucle de régulation
DE112007003346T DE112007003346A5 (de) 2006-12-14 2007-12-11 Einrichtung zur computergesteuerten Infusion von Arzneistoffen mit zeitdiskreter Messwertgewinnung in einem Regelkreis

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102006059019A DE102006059019A1 (de) 2006-12-14 2006-12-14 Einrichtung zur computergesteuerten Infusion von Arzneistoffen mit zeitdiskreter Messwertgewinnung in einem Regelkreis
DE102006059019.8 2006-12-14

Publications (1)

Publication Number Publication Date
WO2008071171A1 true WO2008071171A1 (fr) 2008-06-19

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2007/002223 WO2008071171A1 (fr) 2006-12-14 2007-12-11 Dispositif de perfusion de médicaments commandé par ordinateur avec obtention à différents instants de valeurs de mesure dans une boucle de régulation

Country Status (3)

Country Link
EP (1) EP2122522A1 (fr)
DE (2) DE102006059019A1 (fr)
WO (1) WO2008071171A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107252508A (zh) * 2009-09-18 2017-10-17 F·霍夫曼-拉罗氏股份公司 用于根据用户参数对单次剂量进行量化的装置、系统和方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19844252A1 (de) * 1998-09-26 2000-03-30 Hendrik Lehnert Modulare Vorrichtung zur computergesteuerten Insulin- und Glukoseinfusion
US20020065509A1 (en) * 2000-01-21 2002-05-30 Lebel Ronald J. Microprocessor controlled ambulatory medical apparatus with hand held communication device
US6572542B1 (en) * 2000-03-03 2003-06-03 Medtronic, Inc. System and method for monitoring and controlling the glycemic state of a patient
US20060047538A1 (en) * 2004-08-25 2006-03-02 Joseph Condurso System and method for dynamically adjusting patient therapy

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19844252A1 (de) * 1998-09-26 2000-03-30 Hendrik Lehnert Modulare Vorrichtung zur computergesteuerten Insulin- und Glukoseinfusion
US20020065509A1 (en) * 2000-01-21 2002-05-30 Lebel Ronald J. Microprocessor controlled ambulatory medical apparatus with hand held communication device
US6572542B1 (en) * 2000-03-03 2003-06-03 Medtronic, Inc. System and method for monitoring and controlling the glycemic state of a patient
US20060047538A1 (en) * 2004-08-25 2006-03-02 Joseph Condurso System and method for dynamically adjusting patient therapy

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107252508A (zh) * 2009-09-18 2017-10-17 F·霍夫曼-拉罗氏股份公司 用于根据用户参数对单次剂量进行量化的装置、系统和方法

Also Published As

Publication number Publication date
DE112007003346A5 (de) 2009-11-19
DE102006059019A1 (de) 2008-06-19
EP2122522A1 (fr) 2009-11-25

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