WO2008071169A3 - Verfahren zur herstellung spezifischer inhibitoren der 11beta-hydroxysteroid-dehydrogenase, insbesondere des typs 1, mit nor-oleanan- oder nor-ursan-grundgerüsten - Google Patents

Verfahren zur herstellung spezifischer inhibitoren der 11beta-hydroxysteroid-dehydrogenase, insbesondere des typs 1, mit nor-oleanan- oder nor-ursan-grundgerüsten Download PDF

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Publication number
WO2008071169A3
WO2008071169A3 PCT/DE2007/002218 DE2007002218W WO2008071169A3 WO 2008071169 A3 WO2008071169 A3 WO 2008071169A3 DE 2007002218 W DE2007002218 W DE 2007002218W WO 2008071169 A3 WO2008071169 A3 WO 2008071169A3
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WO
WIPO (PCT)
Prior art keywords
beta
hydroxysteroid dehydrogenase
oleanan
ursan
basic
Prior art date
Application number
PCT/DE2007/002218
Other languages
English (en)
French (fr)
Other versions
WO2008071169A2 (de
Inventor
Andreas Blum
Edmund Maser
Original Assignee
Uksh Schleswig Holstein
Andreas Blum
Edmund Maser
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102006058209A external-priority patent/DE102006058209A1/de
Priority claimed from DE102006058207A external-priority patent/DE102006058207A1/de
Application filed by Uksh Schleswig Holstein, Andreas Blum, Edmund Maser filed Critical Uksh Schleswig Holstein
Publication of WO2008071169A2 publication Critical patent/WO2008071169A2/de
Publication of WO2008071169A3 publication Critical patent/WO2008071169A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Abstract

Die Erfindung betrifft ein Verfahren zur Modifikation nicht-spezifisch wirkender Inhibitoren der 11beta-Hydroxysteroid-Dehydrogenase (11beta-HSD) mit pentacyclischem Grundgerüst des Oleanan- und Ursan-Typs, welches es ermöglicht, chemische Verbindungen herzustellen, die 11beta-Hydroxysteroid-Dehydrogenase hemmen und vorzugsweise im wesentlichen spezifisch die Isoform der 11beta-Hydroxysteroid-Dehydrogenase Typ 1 (11beta-HSD1) hemmen und dabei im wesentlichen keine hemmende Aktivität gegenüber der Isoform der 11beta-Hydroxysteroid-Dehydrogenase Typ 2 (11beta-HSD2) aufweisen. Des Weiteren betrifft die Erfindung neue chemische Verbindungen mit Nor-Oleanan- oder Nor-Ursan-Grundgerüst. Diese Inhibitoren wirken als im wesentlichen spezifische Inhibitoren der 11beta-HSD1 und sind damit etwa zur Behandlung und Vorbeugung etwa von Diabetes, Metabolischem Syndrom, Fettsucht, Dickleibigkeit, Übergewicht, Hyperlipoproteinämien, Hyperglykämie, Hyperinsulinämie, Arteriosklerose, Demenz, Depressionen, Osteroporese, Glaukom oder Viruserkrankungen geeignet.
PCT/DE2007/002218 2006-12-11 2007-12-10 Verfahren zur herstellung spezifischer inhibitoren der 11beta-hydroxysteroid-dehydrogenase, insbesondere des typs 1, mit nor-oleanan- oder nor-ursan-grundgerüsten WO2008071169A2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE102006058209A DE102006058209A1 (de) 2006-12-11 2006-12-11 Verfahren zur Darstellung spezifischer 11beta-Hydroxysteroid-Dehydrogenase hemmender Verbindungen aus Triterpenen mit Oleanan- und Ursan-Grundgerüst
DE102006058207A DE102006058207A1 (de) 2006-12-11 2006-12-11 Verfahren zur Herstellung spezifischer Inhibitoren der 11beta-Hydroxysteroid-Dehydrogenase Typ 1 mit Nor-Oleanan- oder Nor-Ursan-Grundgerüsten
DE102006058207.1 2006-12-11
DE102006058209.8 2006-12-11

Publications (2)

Publication Number Publication Date
WO2008071169A2 WO2008071169A2 (de) 2008-06-19
WO2008071169A3 true WO2008071169A3 (de) 2009-07-30

Family

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PCT/DE2007/002218 WO2008071169A2 (de) 2006-12-11 2007-12-10 Verfahren zur herstellung spezifischer inhibitoren der 11beta-hydroxysteroid-dehydrogenase, insbesondere des typs 1, mit nor-oleanan- oder nor-ursan-grundgerüsten

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WO (1) WO2008071169A2 (de)

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WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
CN102093462B (zh) * 2011-02-28 2012-11-21 贵州省中国科学院天然产物化学重点实验室 1α,2α-二羟基齐墩果酸的制备方法和应用
CN102070699B (zh) * 2011-02-28 2014-04-30 贵州省中国科学院天然产物化学重点实验室 三羟基取代五环三萜类化合物及其制备方法和应用
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (de) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridin-4-carbonsäureamidderivate als kinaseinhibitoren
CN103923158B (zh) * 2014-04-23 2017-03-29 贵州省中国科学院天然产物化学重点实验室 A环多氧化取代甘草次酸衍生物及其制备方法和用途
CN106172398B (zh) * 2014-04-28 2019-12-17 贵州省中国科学院天然产物化学重点实验室 A环三羟基取代五环三萜化合物在制药中的应用
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KR102284682B1 (ko) * 2019-03-08 2021-08-03 주식회사 제넨셀 병풀 추출물로부터 분리된 화합물을 유효성분으로 포함하는 망막 질환의 예방 또는 치료용 조성물

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