WO2008056450A1 - Agent diminuant le taux de graisse neutre dans le sang, agent augmentant le taux de cholésterol hdl et agent diminuant l'indice de rigidité artérielle - Google Patents

Agent diminuant le taux de graisse neutre dans le sang, agent augmentant le taux de cholésterol hdl et agent diminuant l'indice de rigidité artérielle Download PDF

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Publication number
WO2008056450A1
WO2008056450A1 PCT/JP2007/001231 JP2007001231W WO2008056450A1 WO 2008056450 A1 WO2008056450 A1 WO 2008056450A1 JP 2007001231 W JP2007001231 W JP 2007001231W WO 2008056450 A1 WO2008056450 A1 WO 2008056450A1
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WIPO (PCT)
Prior art keywords
agent
photosynthetic bacteria
neutral fat
concentration
blood
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PCT/JP2007/001231
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English (en)
Japanese (ja)
Inventor
Takaaki Maki
Miki Nishimura
Hirotada Tsujii
Original Assignee
Matsumoto Institute Of Microorganisms Co., Ltd.
Shinshu University
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Application filed by Matsumoto Institute Of Microorganisms Co., Ltd., Shinshu University filed Critical Matsumoto Institute Of Microorganisms Co., Ltd.
Priority to JP2008542993A priority Critical patent/JPWO2008056450A1/ja
Publication of WO2008056450A1 publication Critical patent/WO2008056450A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
    • A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
    • A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Definitions

  • Blood neutral fat concentration reducing agent HDL cholesterol concentration raising agent, and cardiovascular hardening index reducing agent
  • the present invention relates to blood neutral fat concentration reducing agents, arteriosclerosis index reducing agents, HDL cholesterol concentration raising agents, and neutral fat concentration reducing agents for improving meat quality or egg quality.
  • Hyperlipidemia is considered to be a particularly serious risk factor Ru.
  • Hyperlipidemia is caused by hypercholesterolemia with high cholesterol concentration, high triglyceride concentration, high triglyceride concentration, high triglyceride concentration, so-called bad cholesterol, low density lipoprotein (LDL).
  • high-density lipoprotein (HDL) which is a so-called good cholesterol, and is classified into types such as hypoHDLemia having a low concentration of cholesterol.
  • the development of hyperlipidemia causes arteriosclerosis and increases the risk of developing serious diseases such as heart disease and cerebrovascular disease as described above.
  • hyperlipidemia is caused not only by genetic abnormalities and aging, but also by lifestyle habits such as lack of exercise and eating disorder, and in particular, recent eating habits. Excessive intake of high-fat foods due to changes in Therefore, it is most important to improve lifestyle habits, such as reducing intake of fat, for treatment and prevention of hyperlipidemia, and voices wanting to supply meat and eggs with low neutral fat and cholesterol content. It is rising.
  • lifestyle habits such as reducing intake of fat, for treatment and prevention of hyperlipidemia, and voices wanting to supply meat and eggs with low neutral fat and cholesterol content. It is rising.
  • neutral fat and cholesterol concentrations in meat and eggs tend to rise.
  • Non-Patent Document 1 reports that the total cholesterol concentration in blood was reduced by feeding rats with photosynthetic bacteria.
  • Patent Document 1 describes a method for producing an egg low in cholesterol by feeding photosynthetic bacteria to laying hens.
  • Rhodobacter comprising the photosynthetic bacteria of the present invention
  • the genus Domonas belongs to a family of photosynthetic bacteria, a red non-sulfur bacterium (Ath i orhodaceae), and is present in most water environments such as paddy fields, rivers, coastal soils, sewage treatment plants, etc. It is an anaerobic and heterotrophic bacterium, and has been conventionally used for purification of waste water, feed for poultry and poultry, etc. It is also confirmed from the results of long-term rearing experiments using rats that there is no toxicity in the same red non-sulfur bacteria (Ath i orhodaceae) as Rhodopseudomonas (Rhodopseudomonas). In addition to these, photosynthetic bacteria are considered to be useful compared to soybeans and other plant components as described above because they are inexpensive and easy to use.
  • Patent Document 1 JP-A-62-269649
  • Non-Patent Document 1 Journals ⁇ Journal ⁇ ⁇ ⁇ Nutritional ⁇ ⁇ ⁇ ⁇ Science ⁇ • Journal of Science and Technology 1 990, 36, pp. 475 -483 Disclosure of the invention
  • VLDL Cholesterol has the effect of promoting arteriosclerosis, so even if the total cholesterol level in the blood is high, the risk of arteriosclerosis is not always high. Therefore, in recent years, as a criterion to determine the risk of hyperlipidemia rather than the total cholesterol concentration, triglyceride concentration and HDL cholesterol concentration, arteriosclerosis index indicating the ratio of good cholesterol and bad cholesterol is emphasized It has become. The effects of photosynthetic bacteria on them are unknown at all. Also, the effect of feeding photosynthetic bacteria on neutral fat concentration in meat or eggs is not known at all.
  • the first problem to be solved by the present invention is to provide an agent for reducing blood neutral fat concentration, HDL cholesterol concentration, which has excellent effects for preventing and improving arteriosclerosis and can be manufactured inexpensively. It is an object of the present invention to provide a raising agent, or an arteriosclerosis index reducing agent, and a second problem to be solved by the present invention is to provide a meat or egg having a low triglyceride concentration and a meat or egg therefor It is providing a neutral fat concentration reducing agent for quality improvement.
  • the inventors of the present invention conducted various studies on the effect of intake of photosynthetic bacteria, and found that photosynthetic bacteria have an effect of reducing triglyceride levels in blood and an effect of increasing HDL cholesterol concentration. And finding that it has an effect of reducing the arteriosclerosis index, and further, it is found that by administering photosynthetic bacteria to livestock and poultry, meat and eggs having a low neutral fat concentration can be obtained, and to complete the present invention. It has arrived.
  • the agent for reducing blood neutral fat concentration according to the present invention which was made to solve the above problems, is characterized in that it contains photosynthetic bacteria as an active ingredient. Furthermore, the present invention comprises a blood HDL cholesterol concentration raising agent, an arteriosclerosis index decreasing agent, and an animal meat quality improving agent for improving egg quality, characterized in that it contains photosynthetic bacteria as an active ingredient. Provide a concentration reducing agent.
  • the present invention further provides a method for lowering blood neutral fat concentration in the animal by orally administering photosynthetic bacteria to animals other than humans, a method for raising HDL cholesterol concentration, and a decrease in arteriosclerosis index. And a method of producing meat or eggs having a low neutral fat concentration.
  • the above-described agent for reducing blood neutral fat concentration, agent for increasing HDL cholesterol concentration, or agent for reducing arteriosclerosis index according to the present invention have an effect of improving lipid metabolism by the action of photosynthetic bacteria as an active ingredient, in particular, blood. It has the effect of lowering triglyceride levels, the effect of raising HDL cholesterol levels, or the effect of lowering the arteriosclerosis index. Therefore, these blood neutral fat concentration reducing agents, HDL cholesterol concentration raising agents, or arteriosclerosis index reducing agents improve lipid balance in blood to prevent arteriosclerosis and various diseases resulting therefrom. Or it can improve and greatly contribute to the health of humans or other animals.
  • the method of the present invention for reducing blood neutral fat concentration the method of raising HDL cholesterol concentration, or the method for reducing arteriosclerosis index
  • blood neutral fat due to the function of photosynthetic bacteria is the same as above.
  • a concentration lowering effect, an HDL cholesterol concentration raising effect, or an arteriosclerosis index lowering effect can be obtained. Therefore, by applying the present invention to animals other than human, for example, livestock and poultry, the health of the livestock and the like can be promoted, and the productivity can be improved. Further, according to the agent for reducing meat or egg quality, and the method for producing meat or egg of the present invention, the concentration of neutral fat in meat or egg which is a product of the livestock or the like is reduced. It becomes possible.
  • the type of photosynthetic bacteria used in the present invention is not particularly limited, and one or more photosynthesis selected from Rhodococcus spp. Rhodococcus spp. Rhodospirillum sp. It is desirable to use bacteria, and furthermore, Rhodobacter capsulatus.
  • cells of photosynthetic bacteria can be used as they are, it is preferable to use those in which the cell wall of the photosynthetic bacteria is broken so that components in the cells act more effectively.
  • the cell wall crushing method is not particularly limited. For example, crushing by lysozyme treatment and ultrasonic treatment, crushing by French press, mechanical crushing using silica sand and mortar, and the like can be considered.
  • the photosynthetic bacteria according to the present invention be in the form of a dry powder in view of storage stability and ease of handling.
  • the dry powder of photosynthetic bacteria may be formed into particles or attached to a suitable carrier.
  • the agent for reducing blood neutral fat concentration, the agent for increasing HDL cholesterol concentration and the agent for reducing arteriosclerosis index obtained as described above may be taken as it is, but it may be mixed in foods, beverages, etc. Eating and drinking can be more easily consumed.
  • the present invention is applied to animals other than humans, it can be easily ingested by mixing photosynthetic bacteria into feed.
  • the blending amount of photosynthetic bacteria is preferably 0.01 to 5 wt ⁇ 1 ⁇ 2 of the whole feed. When the amount is less than 0.01 wt ⁇ 1 ⁇ 2, the effect is sufficient If 5 wt ⁇ 1 ⁇ 2 is exceeded, no significant increase in the effect can be expected, which is not preferable in view of cost.
  • animals other than human beings include livestock such as cows, pigs, horses, goats and sheep, poultry such as chickens, facils, chicks and ostriches, cultured fish and shellfish such as puri and red sea bream or dogs
  • livestock such as cows, pigs, horses, goats and sheep
  • poultry such as chickens, facils, chicks and ostriches
  • cultured fish and shellfish such as puri and red sea bream or dogs
  • a pet such as a cat or a snail, and in particular, in the method of producing meat or egg according to the present invention, it means livestock, poultry, or cultured fish and shellfish.
  • flax oil calcium oil, kapok oil cake, or a mixture thereof may be orally administered.
  • meat containing a high content of primary linolenic acid, lecithin, vitamin E, etc. having the function of lowering cholesterol levels can be obtained by adding calcium diamfatty acid fatty acid calcium or kapok oil syrup to feed. By feeding them with photosynthetic bacteria, more functional meat or eggs can be obtained.
  • a photosynthetic bacteria strain Dossius domonas ⁇ Pulsed Tris (ATGG1 1 1 68) was shake cultured under microaerobic light conditions of 1500 LUX, and lyophilized using maltodextrin and skim milk. The composition of the lyophilized powder is shown in Table 1.
  • Main component is corn starch
  • control section a standard feed without adding photosynthetic bacteria is continuously fed as it is (hereinafter referred to as "control section"), and in the remaining two sections, the above standard feed is replaced with sucrose instead of sucrose.
  • Freeze-dried powders of photosynthetic bacteria were added to give a ratio of photosynthetic bacteria of 0.2 wt% to the total feed, and 2. O wt% to give them (following, these were added) Each of them was called “0.2% addition zone” and “2.0% addition zone”, and both were combined and called “photosynthetic bacteria addition zone” and bred for 4 weeks with free intake.
  • T_Gho serum total cholesterol
  • HDL_Gho HDL cholesterol
  • triglycerides TG
  • glucose concentrations Enzymatically determined using a commercially available reagent kit (Cholesterol E-Test, HDL-Cholesterol E-Test, triglyceride E-Test, Glucose GI I-Test: Wako Pure Chemical Industries, Ltd.) .
  • organ samples were taken on the final day of the test period, and cholesterol was measured in the same manner. The concentration was determined from the absorbance using a spectrophotometer (SP-810: from Metertek) for all analysis.
  • Table 3 shows weight gain, food consumption, food intake efficiency, specific body weight of organs, and excretory substance volume during the test period.
  • Table 7 shows the weight of laying hens
  • Table 8 shows feed intake
  • Table 9 shows average egg laying rate, average egg weight, and feed efficiency. 7] Growth of laying hens (g)
  • the concentrations of triglyceride, total cholesterol and HDL cholesterol in blood in each group were measured by the same method as in Example 1, and the results are shown in Table 10, Table 11, and Table 12.
  • the arteriosclerosis index at the end of the test period Table 13 shows the results of measurement of cholesterol concentration in breast meat and peach meat obtained from each section.
  • the arteriosclerosis index at the end of the test showed a decreasing tendency in the order of the control, 0.01% addition, 0.02% addition, and 0.04% addition, and 0.04% addition It showed a significantly lower value than the control. Further, as shown in Table 14, regarding cholesterol in breast meat and peach meat, a decreasing tendency was observed in the order of the control, 0.01% addition, 0.02% addition, and 0.04% addition.
  • triglyceride and cholesterol concentrations in egg yolk tend to decrease in the order of control, 0.01% addition, 0.02% addition, and 0.04% addition.
  • the 0.04% addition showed significantly lower values than the control.
  • eggs obtained from laying hens in the photosynthetic bacteria-added area have a yellowing degree of egg yolk compared with that in the control area (Kara 1 fan No. 9). While the fan No. 13 shows a significantly higher value, the yolk weight, eggshell weight, eggshell thickness, eggshell thickness and egg yolk index tend to increase depending on the added amount of photosynthetic bacteria, and the Howe unit showing the viscosity of concentrated egg white (Haugh unit) The index also showed an upward trend. Egg yolk weight, eggshell weight, eggshell thickness, yolk index etc.
  • Haugh unit 100 log (H + 7.57 ⁇ 1.7W 0.37)
  • W egg weight
  • H egg white height
  • Egg Yolk Index Height of Egg Yolk Width of Egg Yolk
  • the action of photosynthetic bacteria can lower the concentration of neutral fat in blood and increase the concentration of HDL cholesterol.
  • An effect or an effect to reduce the arteriosclerosis index can be obtained.
  • by feeding photosynthetic bacteria to livestock and poultry it is possible to improve lipid metabolism of the livestock and the like, and to produce meat and eggs having a low neutral fat concentration.

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Abstract

L'invention concerne un agent diminuant le taux de graisse neutre dans le sang, un agent augmentant le taux de cholestérol HDL, un agent diminuant l'indice de rigidité artérielle ou un agent diminuant le taux de graisse neutre pour améliorer la qualité d'une viande ou d'un œuf, lesquels agents comprennent un poudre séchée d'une bactérie phototrophe ayant une paroi cellulaire rompue en tant qu'ingrédient actif. L'agent diminuant le taux de graisse neutre dans le sang, l'agent augmentant le taux de cholestérol HDL ou l'agent diminuant l'indice de rigidité artérielle ont un excellent effet prophylactique et un effet améliorant sur l'artériosclérose et peuvent être produits à faible coût. L'agent diminuant le taux de graisse neutre pour améliorer la qualité d'une viande ou d'un œuf peut être administré à un animal de ferme ou similaire pour produire une viande ou un œuf ayant une teneur en graisse neutre faible.
PCT/JP2007/001231 2006-11-09 2007-11-09 Agent diminuant le taux de graisse neutre dans le sang, agent augmentant le taux de cholésterol hdl et agent diminuant l'indice de rigidité artérielle WO2008056450A1 (fr)

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JP2008542993A JPWO2008056450A1 (ja) 2006-11-09 2007-11-09 血中中性脂肪濃度低下剤、ｈｄｌコレステロール濃度上昇剤、及び動脈硬化指数低下剤

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JP2006304544 2006-11-09
JP2006-304544 2006-11-09

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008115055A2 (fr) * 2007-03-19 2008-09-25 Ipstar B.V. Rhodospirillum et phaeospirillium dans des aliments pour animaux dans le but d'obtenir des produits d'alimentation avec un taux réduit de cholestérol
JP2013133312A (ja) * 2011-12-27 2013-07-08 Tropical Plant Resources Institute Inc 非アルコール性脂肪性肝疾患および／または非アルコール性脂肪肝炎の治療薬
WO2023009000A1 (fr) 2021-07-29 2023-02-02 Semilla Health B.V. Aliment pour volailles permettant d'abaisser le taux de cholestérol dans les jaunes d'oeufs
WO2023214591A1 (fr) * 2022-05-06 2023-11-09 Ｓｙｍｂｉｏｂｅ株式会社 Aliment aquacole

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JPS51107966A (fr) * 1975-03-12 1976-09-24 Asahimatsu Koridofu Kk
JPS62269649A (ja) * 1986-05-16 1987-11-24 Kobayashi Kankyo Kagaku Kenkyusho:Kk 光合成細菌によるビタミン強化鶏卵の生産法
JPH07255387A (ja) * 1994-03-24 1995-10-09 Morinaga Milk Ind Co Ltd 食用家禽用飼料及び該飼料を用いる食用家禽の飼養方 法
JPH1066519A (ja) * 1996-04-26 1998-03-10 Suomen Rehu Oy 食用鶏卵、その鶏卵を生産するための方法およびそのための雌鶏用飼料
JP2004099447A (ja) * 2002-09-04 2004-04-02 Kyowa Hakko Kogyo Co Ltd コレステロール低減化ペプチド
JP2004283110A (ja) * 2003-03-24 2004-10-14 Nisshin Oillio Ltd 畜肉改質剤、畜肉改質用飼料、改質された畜肉及び畜肉の改質方法
JP2006513176A (ja) * 2002-12-12 2006-04-20 ネーデルランドセ オルガニサティエ フォール トエゲパストナトールヴェテンシャッペリク オンデルゾエク ティエヌオー コレステロールを低下させる調製物、食品サプリメントおよび食品、ならびにそれらの製造法

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JPS62269649A (ja) * 1986-05-16 1987-11-24 Kobayashi Kankyo Kagaku Kenkyusho:Kk 光合成細菌によるビタミン強化鶏卵の生産法
JPH07255387A (ja) * 1994-03-24 1995-10-09 Morinaga Milk Ind Co Ltd 食用家禽用飼料及び該飼料を用いる食用家禽の飼養方 法
JPH1066519A (ja) * 1996-04-26 1998-03-10 Suomen Rehu Oy 食用鶏卵、その鶏卵を生産するための方法およびそのための雌鶏用飼料
JP2004099447A (ja) * 2002-09-04 2004-04-02 Kyowa Hakko Kogyo Co Ltd コレステロール低減化ペプチド
JP2006513176A (ja) * 2002-12-12 2006-04-20 ネーデルランドセ オルガニサティエ フォール トエゲパストナトールヴェテンシャッペリク オンデルゾエク ティエヌオー コレステロールを低下させる調製物、食品サプリメントおよび食品、ならびにそれらの製造法
JP2004283110A (ja) * 2003-03-24 2004-10-14 Nisshin Oillio Ltd 畜肉改質剤、畜肉改質用飼料、改質された畜肉及び畜肉の改質方法

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008115055A2 (fr) * 2007-03-19 2008-09-25 Ipstar B.V. Rhodospirillum et phaeospirillium dans des aliments pour animaux dans le but d'obtenir des produits d'alimentation avec un taux réduit de cholestérol
WO2008115055A3 (fr) * 2007-03-19 2009-07-16 Ipstar B V Rhodospirillum et phaeospirillium dans des aliments pour animaux dans le but d'obtenir des produits d'alimentation avec un taux réduit de cholestérol
JP2013133312A (ja) * 2011-12-27 2013-07-08 Tropical Plant Resources Institute Inc 非アルコール性脂肪性肝疾患および／または非アルコール性脂肪肝炎の治療薬
WO2023009000A1 (fr) 2021-07-29 2023-02-02 Semilla Health B.V. Aliment pour volailles permettant d'abaisser le taux de cholestérol dans les jaunes d'oeufs
WO2023214591A1 (fr) * 2022-05-06 2023-11-09 Ｓｙｍｂｉｏｂｅ株式会社 Aliment aquacole

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