WO2008038119A2 - Composition contenant un complexe de coenzyme q10 et de cyclodextrines et son utilisation pour le traitement de pathologies du système nerveux central - Google Patents

Composition contenant un complexe de coenzyme q10 et de cyclodextrines et son utilisation pour le traitement de pathologies du système nerveux central Download PDF

Info

Publication number
WO2008038119A2
WO2008038119A2 PCT/IB2007/002820 IB2007002820W WO2008038119A2 WO 2008038119 A2 WO2008038119 A2 WO 2008038119A2 IB 2007002820 W IB2007002820 W IB 2007002820W WO 2008038119 A2 WO2008038119 A2 WO 2008038119A2
Authority
WO
WIPO (PCT)
Prior art keywords
composition according
treatment
production
cyclodextrin
drug
Prior art date
Application number
PCT/IB2007/002820
Other languages
English (en)
Other versions
WO2008038119A3 (fr
Inventor
Rosario Ammirante
Felice Piero Molinari
Federico Mauro Del Monte
Original Assignee
Rosario Ammirante
Felice Piero Molinari
Federico Mauro Del Monte
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rosario Ammirante, Felice Piero Molinari, Federico Mauro Del Monte filed Critical Rosario Ammirante
Publication of WO2008038119A2 publication Critical patent/WO2008038119A2/fr
Publication of WO2008038119A3 publication Critical patent/WO2008038119A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385—Concentrates of non-alcoholic beverages
    • A23L2/39—Dry compositions
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
    • A23L29/35—Degradation products of starch, e.g. hydrolysates, dextrins; Enzymatically modified starches
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A23L33/11—Plant sterols or derivatives thereof, e.g. phytosterols
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A23L33/155—Vitamins A or D
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
    • A23L5/10—General methods of cooking foods, e.g. by roasting or frying
    • A23L5/15—General methods of cooking foods, e.g. by roasting or frying using wave energy, irradiation, electrical means or magnetic fields, e.g. oven cooking or roasting using radiant dry heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to a composition comprising a complex of coenzyme QlO and cyclodextrins and the use thereof for the treatment of various diseases, in particular of neurodegenerative pathologic states of the central nervous system, more particu- larly of Parkinson's disease.
  • Parkinson's disease is a neurodegenerative pathology wherein the component of protein degradation of Sommering' s substantia nigra causes a functional alteration thereof.
  • This proteolytic stress therefore, results in a serious deficit in the production of dopamine, a cate- cholamin neurotransmitter involved in the nervous circuit of the nuclei of the base of telencephalon.
  • proteins having a struc- ture that is unsuitable to their function are destroyed by the ⁇ biquitin Proteasome System (USP) complex.
  • USP ⁇ biquitin Proteasome System
  • the degradation process for these proteins starts with the bond of a chain of ubiquitin molecules (a protein with 76 amino acids and MW of 8,500 Da) as signal for identification and degradation by a protea- some .
  • Ubiquitin monomers are activated during an ATP- dependant thioesterification by enzyme El of UPS complex.
  • Activated ubiquitin is transferred to enzyme E2, a specific carrier, and then bound with covalent bonds by enzyme E3 (a ubiquitin protein ligase) to free amino groups of the lysines of the proteins to be de-
  • UPS complex results in an accumulation of abnormal proteins, among which ⁇ -synuclein is crucial: in physiological conditions, this protein is involved in mechanisms of synaptic plasticity, since it manages the transport and exchange of vesicles in synaptic terminals.
  • oxidative stress belongs to a sequence of events leading to neuronal death: it acts in synergy with other malfunctions, among which mitochondrial de- ficits and alterations of UPS system of degradation of cell proteins.
  • Dopamine metabolism is responsible for the high levels of oxidative stress in substantia nigra: as a matter of fact, the degradation of this neurotransmitter by the enzyme monoamine oxidase produces hydrogen perox- ide (H 2 O 2 ) . This leads first to an increase in the formation of oxidized glutathione (GSSG) , which means a serious damage to the most important antioxidant system of the cell.
  • GSSG oxidized glutathione
  • nitric oxide causes iron to separate from ferritin, thus increasing the concentration of free iron in the cell.
  • This process does not only involve dopaminergic neurons, but also occurs in glial cells, which indeed express enzymes belonging to the class of monoamine oxidases .
  • glial cells which indeed express enzymes belonging to the class of monoamine oxidases .
  • the task of the present invention is to prepare a composition having an inhibitory effect on the progress of neurodegenerative pathologic states of the central nervous system and in particular in Parkinson' s disease (PD) .
  • an aim of the invention is to prepare a composition based on CoEnQlO, as active substance, complexed with cyclodextrins .
  • Neuroprotective treatments can be useful during the onset of PD. This would mean beginning the treatment in the initial stage of the disease.
  • Coenzyme QlO also known as ubiquinone or ubidecarenone
  • Coenzyme QlO is a physiological molecule with antioxidant properties to be found in all cell membranes, among which inner mitochondrial membranes, where it is part of the complex I of the so- called respiratory chain, involved in the production of energy by mitochondria.
  • US patent 6,861,447 B2 describes a method for producing complexes of coenzyme QlO and ⁇ - cyclodextrin by thermal or ultrasonic treatment.
  • International patent application WO 2005/111224 A2 describes water-soluble complexes of coenzyme QlO and ⁇ - cyclodextrin as well as a process for producing them, in which the temperature of ⁇ -cyclodextrin dissolution in water and of the following addition of coenzyme QlO is suitably controlled.
  • US patent application US 2006/0078549 describes a method for the therapeutic treatment of neurodegenerative diseases, of Huntington' s disease for instance, by administering a complex of coenzyme QlO and cyclo- dextrins .
  • preparations containing CoEQlO as active substance for single-dose administrations are available at present on the mar- ket .
  • Such preparations are therefore unsuitable for the treatment of neurodegenerative diseases as described above, which require quite high doses (300 mg/die to 1,200 mg/die) .
  • the Applicants have faced the problem of providing preparations based on coenzyme QlO at high concentrations, having a high water solubility and a high pho- tostability, so as to enable the administration of the required dose also in a single step, preferably in liquid form or as water-soluble granules.
  • the present invention therefore re- lates to a composition
  • a composition comprising:
  • the present invention relates to a composition as defined above for use as a medicament.
  • the present invention relates to the use of a composition as defined above in the preparation of a drug for the treatment of neurodegenerative diseases of the central nervous system, in particular of Parkinson's disease (PD).
  • PD Parkinson's disease
  • the present invention relates to the use of a composition as defined above as food supplement .
  • Cyclodextrins are cyclic oligosaccharides containing at least 6 units of D- (+) -glucopyranose bound to one another with a ⁇ , 1-4 glucoside bond.
  • the three natural cyclodextrins ⁇ , ⁇ , ⁇ differ in ring size and solubility, ⁇ -cyclodextrin, ⁇ -cyclodextrin and ⁇ -cyclodextrin contain 6, 7 or 8 units of D- (+) -glucopyranose, re- spectively.
  • Cyclodextrins have the appearance of fine white, basically odourless powders, with a slight sweet taste.
  • ⁇ -cyclodextrin, ⁇ - cyclodextrin or ⁇ -cyclodextrin, or mixtures thereof can be used, ⁇ -cyclodextrin is particularly preferred.
  • Cyclodextrins have a stiff molecular structure of frusto-conical shape, with a central cavity whose size varies depending on the number of glucopyranose units present . Due to the arrangement of hydroxyl groups, the inside of the cavity is hydrophobic, whereas the outside is hydrophilic. This configuration allows cyclodextrins to house the host molecule of coenzyme QlO inside the cavity so as to form an inclusion complex ("host- guest" complex) .
  • the amount of coenzyme QlO in the composition according to the present invention is as a rule above 20% by weight, preferably of from 1% to 10% by weight, referred to the total weight of the composition.
  • the composition according to the present invention comprises from 40% to 100% by weight, more preferably from 50% to 90% by weight, of at least one cyclodex- trin, the percentage being expressed referred to the weight of coenzyme QlO.
  • the composition according to the present invention further comprises at least one carotene.
  • Carotene is preferably selected from: ⁇ -carotene, ⁇ - carotene, lycopene, or mixtures thereof. More preferably, carotene is ⁇ -carotene.
  • the composition according to the present invention comprises from 0.01% to 0.5% by weight of at least one carotene, more preferably from 0.05% to 0.3% by weight, the percentage being expressed referred to the total weight of the composition.
  • carotene As is known, carotenes are commonly marketed with a content of active substance of about 1-2%, the rest being made up of suitable additives and of carotene degradation products. Obviously, the above percentages refer to carotene that is actually present in the com- position.
  • composition according to the present invention solves the problems of solubility and photostability of coenzyme QlO as disclosed above, and is advantageous both for therapeutic use and for its technologi- cal properties, particularly for the flowability properties of the product.
  • composition in granular form has a controlled fri- -li ⁇
  • composition according to the present invention can comprise further pharmacologically acceptable excipi-
  • composition according to the present invention can include at least one com- io pound selected from: lactose, maltodextrins and lipoic acid.
  • the product is obtained by dividing the manufacturing process into two separate steps:
  • composition according to the present invention is used as inhibitor of neurodegenerative progress, in particular in Parkinson's disease.
  • the active substance acts by blocking the propagation of radical reaction, preventing the propagation thereof and therefore the lipoper- oxidation of cell membranes and thus cell death.
  • Such action is enhanced by the presence of carotene which, beyond having such chemical and physical characteristics as to improve the bioavailability and pho- tostability of coenzyme QlO, performs an antioxidant action and promotes the inhibition of mechanisms producing free radicals.
  • the end product can be portioned in suitable sealed containers so as to avoid any contamination from outside .
  • the product thus obtained has a duration not below 24 months in suitable conditions of temperature, humidity and package integrity.
  • composition according to the present invention can be used in several other diseases, such as: (a) mitochondrial diseases in general, with doses of coenzyme QlO of 1 mg/die to 10,000 mg/die;
  • cardiovascular diseases in which the oxidation of low density lipoproteins (LDL) is deemed to be the essential element for the development of atherosclero- sis, with doses of coenzyme QlO of 1 mg/die to 4,000 mg/die (it is believed that coenzyme QlO, thanks to its key role in energy production, contributes to the safeguard of vascular endothelium), such as: heart diseases in general, congestive heart failure, fatigue syndrome, dyspnea, essential hypertension, angina pectoris, surgical ischemiae;
  • LDL low density lipoproteins
  • I 5 carotene (commercial product distributed by A. C. E. F. with a titer of 1% and fine granulometry: 95% gets through a 80 mesh sieve) in such an amount as to obtain 0.1% by weight of ⁇ -carotene referred to the total weight of the composition.
  • S ⁇ concentration of coenzyme QlO (free and bound) ;
  • S w intrinsic solubility;
  • K f complexation constant;
  • L ⁇ concentration of binder.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Botany (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne une composition contenant : (a) un complexe de coenzyme Q10 et au moins une cyclodextrine; et (b) au moins un carotène. L'invention concerne également l'utilisation de ladite composition pour le traitement de diverses maladies, en particulier de maladies neurodégénératives du système nerveux central, spécialement la maladie de Parkinson (PD).
PCT/IB2007/002820 2006-09-29 2007-09-26 Composition contenant un complexe de coenzyme q10 et de cyclodextrines et son utilisation pour le traitement de pathologies du système nerveux central WO2008038119A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI2006A001874 2006-09-29
IT001874A ITMI20061874A1 (it) 2006-09-29 2006-09-29 Composizione per il trattamento degli stati patologici neurodegenerativi del sistema nervoso centrale ed in particolare nel morbo di parkinson

Publications (2)

Publication Number Publication Date
WO2008038119A2 true WO2008038119A2 (fr) 2008-04-03
WO2008038119A3 WO2008038119A3 (fr) 2008-11-06

Family

ID=39190249

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2007/002820 WO2008038119A2 (fr) 2006-09-29 2007-09-26 Composition contenant un complexe de coenzyme q10 et de cyclodextrines et son utilisation pour le traitement de pathologies du système nerveux central

Country Status (2)

Country Link
IT (1) ITMI20061874A1 (fr)
WO (1) WO2008038119A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU100797B1 (en) * 2018-05-15 2019-11-15 Univ Luxembourg 2-hydroxypropyl-beta-cyclodextrin for use in a method of treatment of a parkinsonian condition
FR3117339A1 (fr) 2020-12-16 2022-06-17 Naos Institute Of Life Science Utilisation des bactériorubérines et leurs dérivés glycosylés pour prévenir et traiter les maladies impliquant une dérégulation de l’agrégation des protéines, comme les maladies neurodégénératives

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011423A2 (fr) * 2002-07-29 2004-02-05 Hawaii Biotech, Inc. Analogues de carotenoides structuraux pour l'inhibition et la reduction de maladie
CN1634075A (zh) * 2004-10-28 2005-07-06 昆明翔昊科技有限公司 含番茄红素和辅酶q10的制剂及其制备方法
US7030102B1 (en) * 2003-05-06 2006-04-18 Bioactives, Llc Highly bioavailable coenzyme Q-10 cyclodextrin complex
EP1681053A1 (fr) * 2003-10-31 2006-07-19 Kaneka Corporation Composition contenant une coenzyme q reduite

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004011423A2 (fr) * 2002-07-29 2004-02-05 Hawaii Biotech, Inc. Analogues de carotenoides structuraux pour l'inhibition et la reduction de maladie
US7030102B1 (en) * 2003-05-06 2006-04-18 Bioactives, Llc Highly bioavailable coenzyme Q-10 cyclodextrin complex
EP1681053A1 (fr) * 2003-10-31 2006-07-19 Kaneka Corporation Composition contenant une coenzyme q reduite
CN1634075A (zh) * 2004-10-28 2005-07-06 昆明翔昊科技有限公司 含番茄红素和辅酶q10的制剂及其制备方法

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU100797B1 (en) * 2018-05-15 2019-11-15 Univ Luxembourg 2-hydroxypropyl-beta-cyclodextrin for use in a method of treatment of a parkinsonian condition
WO2019219741A1 (fr) * 2018-05-15 2019-11-21 Université Du Luxembourg 2-hydroxypropyl-bêta-cyclodextrine destinée à être utilisée dans une méthode de traitement d'un état parkinsonien
FR3117339A1 (fr) 2020-12-16 2022-06-17 Naos Institute Of Life Science Utilisation des bactériorubérines et leurs dérivés glycosylés pour prévenir et traiter les maladies impliquant une dérégulation de l’agrégation des protéines, comme les maladies neurodégénératives
WO2022129407A1 (fr) 2020-12-16 2022-06-23 Naos Institute Of Life Science Utilisation des bactériorubérines et leurs dérivés glycosylés pour prévenir et traiter les maladies impliquant une dérégulation de l'agrégation des protéines, comme les maladies neurodégénératives

Also Published As

Publication number Publication date
ITMI20061874A1 (it) 2006-12-29
WO2008038119A3 (fr) 2008-11-06

Similar Documents

Publication Publication Date Title
US10342822B2 (en) Method of producing physiological and therapeutic levels of nitric oxide through an oral delivery system
US11633448B2 (en) Controlled-release and stratified cyclodextrin inclusion complex vehicles
JP5144274B2 (ja) リポ酸含有シクロデキストリン複合体の使用
JP5847721B2 (ja) 高水溶性２−ヒドロキシプロピル−ベータシクロデキストリンを有効成分として含有する、肥満疾患の予防および治療用組成物
US11896598B2 (en) Appetite suppressant compositions and methods thereof
US20190046598A1 (en) Controlled-release and stratified cyclodextrin inclusion complex vehicles
EP2065045B1 (fr) Anti-oxydant destiné à la prévention et au traitement de maladies liées au stress oxydatif
WO2008038119A2 (fr) Composition contenant un complexe de coenzyme q10 et de cyclodextrines et son utilisation pour le traitement de pathologies du système nerveux central
Lee et al. Medicinal Benefits, Biological and Nanoencapsulation Functions of Riboflavin with its Toxicity Profile-A Narrative Review
JP2012506429A (ja) 真性糖尿病及びその共存症の処置に有用である、水に不溶な安定なＲ−（＋）−α−リポ酸塩
CA3074541C (fr) Compositions de suppression de l`appetit et methodes connexes
WO2012014746A1 (fr) Complexe d'acide α-lipoïque
WO2022108479A1 (fr) Combinaison pour réduire le stress oxydatif dans le corps et maintenir des fonctions hépatiques
EP3231296B1 (fr) Utilisation d'une composition comprenant de l'acide alpha-lipoïque
Madhavi et al. A study on the bioavailability of a novel sustained-release coenzyme Q10-β-cyclodextrin complex
KR20200107809A (ko) 자일리톨 및/또는 효소처리 스테비아로 피복된 복합비타민 과립제
Chandur et al. Characterization of Liquid Oral Containing Lycopene Phytosomes for Improved Absorption
CN115701985A (zh) 具有硫胺素的二氢槲皮素制剂
KR101026864B1 (ko) 고 수용성 ２―하이드록시프로필―베타사이클로덱스트린을 유효성분으로 함유하는 비만 질환 예방 및 치료용 조성물
WO2023233165A1 (fr) Composition et procédé
WO2014185761A1 (fr) Nouvelle composition du 3,4-diaminopyridine pour le traitement de la fatigabilite musculaire associee a des troubles neurovegetatifs

Legal Events

Date Code Title Description
NENP Non-entry into the national phase in:

Ref country code: DE

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 07825195

Country of ref document: EP

Kind code of ref document: A2

122 Ep: pct application non-entry in european phase

Ref document number: 07825195

Country of ref document: EP

Kind code of ref document: A2