WO2007068997A3 - Souche de thraustochytride sc1 produisant de l'acide docosahexaenoique (adh) - Google Patents

Souche de thraustochytride sc1 produisant de l'acide docosahexaenoique (adh) Download PDF

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Publication number
WO2007068997A3
WO2007068997A3 PCT/IB2005/003934 IB2005003934W WO2007068997A3 WO 2007068997 A3 WO2007068997 A3 WO 2007068997A3 IB 2005003934 W IB2005003934 W IB 2005003934W WO 2007068997 A3 WO2007068997 A3 WO 2007068997A3
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WO
WIPO (PCT)
Prior art keywords
dha
docosahexaenoic acid
organism
strain
producing
Prior art date
Application number
PCT/IB2005/003934
Other languages
English (en)
Other versions
WO2007068997A2 (fr
Inventor
Villo Morawala Patell
K R Rajyashri
Original Assignee
Avestha Gengraine Tech Pvt Ltd
Villo Morawala Patell
K R Rajyashri
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CNA200580052523XA priority Critical patent/CN101370929A/zh
Priority to AP2008004516A priority patent/AP2008004516A0/xx
Priority to CA002639071A priority patent/CA2639071A1/fr
Priority to EP05818740A priority patent/EP1963481A2/fr
Priority to BRPI0520823-8A priority patent/BRPI0520823A2/pt
Priority to PCT/IB2005/003934 priority patent/WO2007068997A2/fr
Application filed by Avestha Gengraine Tech Pvt Ltd, Villo Morawala Patell, K R Rajyashri filed Critical Avestha Gengraine Tech Pvt Ltd
Priority to MX2008007860A priority patent/MX2008007860A/es
Priority to AU2005339110A priority patent/AU2005339110A1/en
Priority to JP2008545118A priority patent/JP2009519032A/ja
Publication of WO2007068997A2 publication Critical patent/WO2007068997A2/fr
Publication of WO2007068997A3 publication Critical patent/WO2007068997A3/fr
Priority to IL192162A priority patent/IL192162A0/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11B—PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES
    • C11B1/00—Production of fats or fatty oils from raw materials
    • C11B1/10—Production of fats or fatty oils from raw materials by extracting
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/10—Protozoa; Culture media therefor
    • C12N1/105—Protozoal isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/12—Unicellular algae; Culture media therefor
    • C12N1/125—Unicellular algae isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/89—Algae ; Processes using algae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/90—Protozoa ; Processes using protozoa

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Botany (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)

Abstract

La présente invention concerne le criblage d'une souche inconnue de thraustochytride SC1 produisant des quantités significatives d'acide docosahexaénoïque (DAH) et accumulant également leurs acides gras intermédiaires respectifs en plus de l'DAH. Cet organisme a été isolé dans les mares de Goa au moyen de la technique d'appât au pollen ('pollen baiting'). L'invention concerne le profil d'acide gras et les séquences ribosomiques 18S de cet organisme, en indiquant sa phylogénie moléculaire. L'organisme toujours à l'étude peut être très important pour son utilisation dans la production commerciale d'ADH.
PCT/IB2005/003934 2005-12-16 2005-12-16 Souche de thraustochytride sc1 produisant de l'acide docosahexaenoique (adh) WO2007068997A2 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AP2008004516A AP2008004516A0 (en) 2005-12-16 2005-12-16 Docosahexaenoic acid (DHA) producing thraustochytrid strain-SC1
CA002639071A CA2639071A1 (fr) 2005-12-16 2005-12-16 Souche de thraustochytride sc1 produisant de l'acide docosahexaenoique (adh)
EP05818740A EP1963481A2 (fr) 2005-12-16 2005-12-16 Souche de thraustochytride sc1 produisant l acide docosahexaenoique (adh)
BRPI0520823-8A BRPI0520823A2 (pt) 2005-12-16 2005-12-16 variedade de traustoquitrìdeo -sc1 produtora de ácidodocosaexaenóico (dha)
PCT/IB2005/003934 WO2007068997A2 (fr) 2005-12-16 2005-12-16 Souche de thraustochytride sc1 produisant de l'acide docosahexaenoique (adh)
CNA200580052523XA CN101370929A (zh) 2005-12-16 2005-12-16 生产二十二碳六烯酸(dha)的破囊壶菌菌株-sc1
MX2008007860A MX2008007860A (es) 2005-12-16 2005-12-16 Cepa de thraustochytrido sc1 productora de acido docosahexaenoico (dha).
AU2005339110A AU2005339110A1 (en) 2005-12-16 2005-12-16 Docosahexaenoic acid (DHA) producing thraustochytrid strain - SC1
JP2008545118A JP2009519032A (ja) 2005-12-16 2005-12-16 ドコサヘキサエン酸（ｄｈａ）産生スラウストキトリウム菌株‐ｓｃ１
IL192162A IL192162A0 (en) 2005-12-16 2008-06-15 Docosahexaenoic acid (dha) producing thraustochytrid strain-sc1

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IB2005/003934 WO2007068997A2 (fr) 2005-12-16 2005-12-16 Souche de thraustochytride sc1 produisant de l'acide docosahexaenoique (adh)

Publications (2)

Publication Number Publication Date
WO2007068997A2 WO2007068997A2 (fr) 2007-06-21
WO2007068997A3 true WO2007068997A3 (fr) 2007-08-16

Family

ID=37890412

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/003934 WO2007068997A2 (fr) 2005-12-16 2005-12-16 Souche de thraustochytride sc1 produisant de l'acide docosahexaenoique (adh)

Country Status (9)

Country Link
EP (1) EP1963481A2 (fr)
JP (1) JP2009519032A (fr)
CN (1) CN101370929A (fr)
AU (1) AU2005339110A1 (fr)
BR (1) BRPI0520823A2 (fr)
CA (1) CA2639071A1 (fr)
IL (1) IL192162A0 (fr)
MX (1) MX2008007860A (fr)
WO (1) WO2007068997A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8921069B2 (en) 2005-06-07 2014-12-30 Dsm Nutritional Products Ag Eukaryotic microorganisms for producing lipids and antioxidants
US9222112B2 (en) 2011-07-21 2015-12-29 Dsm Ip Assets B.V. Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9023616B2 (en) 2006-08-01 2015-05-05 Dsm Nutritional Products Ag Oil producing microbes and method of modification thereof
PT2367950T (pt) 2008-12-01 2017-07-06 Univ Saarland Produção de ácidos gordos ómega-3 por mixobactérias
WO2010097809A2 (fr) * 2009-02-25 2010-09-02 V.B. Medicare Pvt. Ltd. Procédés perfectionnés de production par fermentation de l'acide docosahexaénoïque.
US8207363B2 (en) 2009-03-19 2012-06-26 Martek Biosciences Corporation Thraustochytrids, fatty acid compositions, and methods of making and uses thereof
CA2787344C (fr) 2010-01-19 2018-03-20 Dsm Ip Assets B.V. Micro-organismes produisant de l'acide eicosapentaenoique, compositions d'acides gras et leurs procedes de fabrication et d'utilisation
KR101147451B1 (ko) * 2010-05-04 2012-05-21 한국생명공학연구원 Ｔｈｒａｕｓｔｏｃｈｙｔｒｉｄ계 미세조류의 배양방법
EP2390343A1 (fr) 2010-05-31 2011-11-30 InterMed Discovery GmbH Production d'acides gras par l'expression hétérologue de groupes de gènes à partir de myxobactéries
US20140323569A1 (en) * 2011-07-21 2014-10-30 Krishna Raman Microbial oils enriched in polyunsaturated fatty acids
ES2762618T3 (es) 2013-01-18 2020-05-25 Kyowa Hakko Bio Co Ltd Microorganismos que producen ácido docosahexaenoico y utilización de los mismos
FR3001736B1 (fr) * 2013-02-06 2016-03-04 Roquette Freres Biomasse de la microalgue schizochytrium mangrovei et son procede de preparation
DK2970926T3 (en) 2013-03-13 2018-04-16 Dsm Nutritional Products Ag GENMANIPULATION OF MICROorganisms
CN103725617A (zh) * 2014-01-01 2014-04-16 北京大学深圳研究生院 一株富含甘油酯型DHA的破囊壶菌Aurantiochytrium sp.及其应用
AU2015263881B2 (en) * 2014-05-22 2020-06-18 Synthetic Genomics, Inc. Labyrinthulomycete strains for producing docosahexaenoic acid
US9890402B2 (en) 2015-01-24 2018-02-13 Indian Oil Corporation Limited Thraustochytrid based process for treating waste effluents
AR104042A1 (es) 2015-03-26 2017-06-21 Mara Renewables Corp Producción de alta densidad de biomasa y aceite utilizando glicerol en bruto
CA2991707C (fr) 2015-07-13 2023-08-01 MARA Renewables Corporation Amelioration du metabolisme de micro-algues de la xylose
US10851395B2 (en) 2016-06-10 2020-12-01 MARA Renewables Corporation Method of making lipids with improved cold flow properties
CN110168071A (zh) * 2016-12-22 2019-08-23 玛拉可再生能源公司 用于使用真核微生物产生富含dha、棕榈酸和蛋白质的生物质的方法
KR102100650B1 (ko) * 2018-06-29 2020-04-16 씨제이제일제당 주식회사 신규한 트라우즈토카이트리움 속 균주, 및 이를 이용한 다중불포화지방산 생산방법

Citations (2)

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Publication number Priority date Publication date Assignee Title
US20040161831A1 (en) * 2002-12-27 2004-08-19 Fuji Photo Film Co., Ltd. Microorganism having an ability of producing docosahexaenoic acid and use thereof
WO2004087890A2 (fr) * 2003-03-31 2004-10-14 Council Of Scientific & Industrial Research Procede permettant d'augmenter les niveaux d'acides gras polyinsatures dans des protistes thraustochytrides

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Publication number Priority date Publication date Assignee Title
US20040161831A1 (en) * 2002-12-27 2004-08-19 Fuji Photo Film Co., Ltd. Microorganism having an ability of producing docosahexaenoic acid and use thereof
WO2004087890A2 (fr) * 2003-03-31 2004-10-14 Council Of Scientific & Industrial Research Procede permettant d'augmenter les niveaux d'acides gras polyinsatures dans des protistes thraustochytrides

Non-Patent Citations (2)

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Title
BOWLES R D ET AL: "Long-chain n-3 polyunsaturated fatty acid production by members of the marine protistan group the thraustochytrids: screening of isolates and optimisation of docosahexaenoic acid production", JOURNAL OF BIOTECHNOLOGY, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 70, no. 1-3, 30 April 1999 (1999-04-30), pages 193 - 202, XP004173399, ISSN: 0168-1656 *
SIJTSMA L ET AL: "Biotechnological production and applications of the omega-3 polyunsaturated fatty acid docosahexaenoic acid", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 64, no. 2, April 2004 (2004-04-01), pages 146 - 153, XP002428588, ISSN: 0175-7598 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8921069B2 (en) 2005-06-07 2014-12-30 Dsm Nutritional Products Ag Eukaryotic microorganisms for producing lipids and antioxidants
US9222112B2 (en) 2011-07-21 2015-12-29 Dsm Ip Assets B.V. Eicosapentaenoic acid-producing microorganisms, fatty acid compositions, and methods of making and uses thereof

Also Published As

Publication number Publication date
BRPI0520823A2 (pt) 2011-04-12
MX2008007860A (es) 2009-02-11
CA2639071A1 (fr) 2007-06-21
WO2007068997A2 (fr) 2007-06-21
EP1963481A2 (fr) 2008-09-03
AU2005339110A1 (en) 2007-06-21
JP2009519032A (ja) 2009-05-14
IL192162A0 (en) 2008-12-29
CN101370929A (zh) 2009-02-18

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