WO2007063506A2 - Composition de dentifrice exempte d'abrasif - Google Patents

Composition de dentifrice exempte d'abrasif Download PDF

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Publication number
WO2007063506A2
WO2007063506A2 PCT/IB2006/054510 IB2006054510W WO2007063506A2 WO 2007063506 A2 WO2007063506 A2 WO 2007063506A2 IB 2006054510 W IB2006054510 W IB 2006054510W WO 2007063506 A2 WO2007063506 A2 WO 2007063506A2
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WIPO (PCT)
Prior art keywords
zinc
dentifrice composition
composition
agents
mixtures
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PCT/IB2006/054510
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English (en)
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WO2007063506A3 (fr
Inventor
Xiaoli Wang
Lijiang Yang
Yun Wang
Ying Cheng
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The Procter & Gamble Company
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Publication date
Priority claimed from US11/545,266 external-priority patent/US20070122357A1/en
Application filed by The Procter & Gamble Company filed Critical The Procter & Gamble Company
Priority to JP2008538490A priority Critical patent/JP2009513695A/ja
Priority to AU2006321206A priority patent/AU2006321206A1/en
Priority to CA002631537A priority patent/CA2631537A1/fr
Priority to BRPI0619387-0A priority patent/BRPI0619387A2/pt
Priority to EP06832005A priority patent/EP1954238A2/fr
Publication of WO2007063506A2 publication Critical patent/WO2007063506A2/fr
Publication of WO2007063506A3 publication Critical patent/WO2007063506A3/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/55—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/25—Silicon; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a dentifrice composition which is substantially free of abrasive material, and which can still maintain the cleaning benefits of a regular toothpaste.
  • Dentifrice compositions such as toothpastes are routinely used by consumers as part of their oral care hygiene regimens. It is well known that oral care products can provide both therapeutic and cosmetic hygiene benefits to consumers.
  • Therapeutic benefits include, but are not limited to, caries prevention, gingivitis prevention, and hypersensitivity control.
  • Cosmetic benefits include, but are not limited to, control of plaque and calculus formulation, removal and prevention of tooth stain, tooth whitening, breath freshening, and mouth feel aesthetics such as fresh sensation or slippery sensory feel.
  • abrasive material such as silica has long been considered critical for delivering the above mentioned therapeutic and cosmetic benefits of a dentifrice composition.
  • Abrasive materials provide physical abrasion between toothbrush and teeth to clean plaque, stain, and calculus, while also build rheology and structure of the dentifrice for maintaining thermal stability of the overall formulation.
  • abrasive materials may also have certain negative effects to overall formulation.
  • the cost of silica itself is expensive.
  • silica adsorbs components in a typical dentifrice composition such as active agents, flavors, and foaming agents, thereby the concentrations of these components must be adjusted according to the foreseen loss by silica.
  • certain active agents such as cetylpyridinium chloride have poor compatibility with silica, and therefore cannot be included in a dentifrice composition, despite its known effectiveness.
  • the present invention is directed to a dentifrice composition
  • a dentifrice composition comprising:
  • composition is substantially free of abrasive material.
  • the present invention is further directed to a method of cleaning the teeth absent an abrasive.
  • the composition of the present invention comprises a hydrophilic clay material which swells or thickens with the presence of a polar solvent, and acts as a binder for the dentifrice composition.
  • the hydrophilic clay material may be any known that is safe and aesthetically acceptable for oral care use.
  • the hydrophilic clay material provides a suitable rheology for the present dentifrice composition of various product form, including brushing liquids, gels, and toothpaste, having a viscosity of from about 1 mPas to about 450,000 Pas as measured by Brookfield viscometer with T-E spindle.
  • the present dentifrice composition is a gel or toothpaste of suitable body and viscosity, the viscosity being from about 10,000 Pas to about 450,000 Pas, preferably from about 10,000 Pas to about 250,000 Pas. Additional binders may be added to provide such suitable rheology, as later discussed.
  • hydrophilic clay material provides the above mentioned suitable stability at relatively low level, and relatively low cost, without the existence of an abrasive material in the composition.
  • the hydrophilic clay material is preferably comprised, by weight of the entire composition, at from about 0.01% to about 10%, preferably from about 1% to about 5%.
  • Hydrophilic clay materials useful herein include natural and synthesized layered silicate minerals, fumed silicas, thickening precipitated silica, and mixtures thereof.
  • Layered silicate minerals may be naturally occurred, or synthesized to have magnesium substituted with certain portions of the mineral.
  • the fumed silicas are those that provide very little to no abrasive function having a particle size of smaller than about 5 ⁇ m, typically from about 1 nm to about 1 ⁇ m.
  • the thickening precipitated silica are those having a DOA value of at least about 150 m €/100g, preferably at least about 250 m €/100g, and having a particle size of about 1 ⁇ m to about 50 ⁇ m.
  • the thickening precipitated silica can be distinguished from abrasive silica material, due to its high oil absorbing capability, as defined by the DOA value. Such capability provides thickening property.
  • hydrophilic clay materials useful herein include synthesized layered magnesium silicate by the tradename LAPONITE series available from Rockwood Additives Limited and Southern Clay Company, fumed silica having an average particle size of about 12 nm by the tradename AEROSOL series and CAB-O-SIL available from Cabot & Degussa Corporation, amorphous precipitated silica by the tradename ZEODENT 165 from J. M. Huber Company and SYLOX 15 from Grace Davision, and precipitated silica by the tradename TIXOSIL from Rhodia.
  • LAPONITE series available from Rockwood Additives Limited and Southern Clay Company
  • fumed silica having an average particle size of about 12 nm by the tradename AEROSOL series and CAB-O-SIL available from Cabot & Degussa Corporation
  • ZEODENT 165 from J. M. Huber Company
  • SYLOX 15 from Grace Davision
  • precipitated silica by the tradename TIXOSIL from Rhodia.
  • composition of the present invention comprises a phytic acid compound in an amount it provides effective cleaning to the teeth.
  • Phytic acid also known as myo-inositol hexaphosphate, or inositol hexaphosphoric acid, is a natural vegetable based biodegradable chelating agent in liquid form with chelating performance comparable to that of EDTA. Origin of vegetables from which phytic acid compounds can be found, include cereal grains, legumes, nuts oilseeds, pollen, spore, and organic soils.
  • the phytic acid compound herein can be phytic acid itself and/or its orally acceptable salts including, but not limited to, alkali metal salts and alkali earth metal salts.
  • Useful phytic acid salts include sodium phytate, potassium phytate, magnesium phytate, calcium phytate, stannous phytate, zinc phytate, copper phytate, ferrum phytate, and mixtures thereof.
  • the phytic acid compound provides good cleaning effect in the present abrasive free composition without consumer noticeable staining, and is compatible with the present polar solvent carrier, as well as a wide variety of oral care active ingredients. Without being bound by theory, it is believed that the phytic acid compound provides unique good cleaning due to its liquid form, by flowing between teeth. Such flowing is believed to provide cleaning in a way differently from solid abrasive materials. Further, it is believed that the phytic acid compound provides a positive effect for protecting tooth enamel from acid dissolution, and anti-tartar effect.
  • phytic acid compounds useful herein include phytic acid solution, sodium phytate, magnesium phytate, calcium phytate, and stannous phytate available from Sichuan Chengdu Yason, Shikishima Starch Manufacturing Company, and Nibbio. c) Oral Care Active
  • composition of the present invention comprises an oral care active which delivers the intended therapeutic oral care benefit.
  • Oral care actives useful herein include anti-calculus agents, stannous ion sources, fluoride ion sources, whitening agents, anti-microbial agents, anti- plaque agents, anti-inflammatory agents, nutrients, antioxidants, anti-viral agents, analgesic and anesthetic agents, zinc-containing layered material, and mixtures thereof.
  • Useful oral care agents herein include an anti-calculus agent, which in one embodiment may be present from about 0.05% to about 50%, by weight of the oral care composition, in another embodiment is from about 0.05% to about 25%.
  • the anti-calculus agent may be selected from the group consisting of polyphosphates (including pyrophosphates) and salts thereof; polyamino propane sulfonic acid (AMPS) and salts thereof; polyolefin sulfonates and salts thereof; polyvinyl phosphates and salts thereof; polyolefin phosphates and salts thereof; diphosphonates and salts thereof; phosphonoalkane carboxylic acid and salts thereof; polyphosphonates and salts thereof; polyvinyl phosphonates and salts thereof; polyolefin phosphonates and salts thereof; polypeptides; and mixtures thereof.
  • the salts are alkali metal salts.
  • Polyphosphates are generally employed as their wholly or partially neutralized water-soluble alkali metal salts such as potassium, sodium, ammonium salts, and mixtures thereof.
  • the inorganic polyphosphate salts include alkali metal (e.g. sodium) tripolyphosphate, tetrapolyphosphate, dialkyl metal (e.g. disodium) diacid, trialkyl metal (e.g. trisodium) monoacid, potassium hydrogen phosphate, sodium hydrogen phosphate, and alkali metal (e.g. sodium) hexametaphosphate, and mixtures thereof.
  • Polyphosphates larger than tetrapolyphosphate usually occur as amorphous glassy materials.
  • the pyrophosphate salts useful in the present invention include, alkali metal pyrophosphates, di-, tri-, and mono-potassium or sodium pyrophosphates, dialkali metal pyrophosphate salts, tetraalkali metal pyrophosphate salts, and mixtures thereof.
  • the pyrophosphate salt is selected from the group consisting of trisodium pyrophosphate, disodium dihydrogen pyrophosphate (Na2U2P2 ⁇ 7), dipotassium pyrophosphate, tetrasodium pyrophosphate (Na4P2U7), tetrapotassium pyrophosphate (K4P2O7), and mixtures thereof.
  • Polyolefin sulfonates include those wherein the olefin group contains 2 or more carbon atoms, and salts thereof.
  • Polyolefin phosphonates include those wherein the olefin group contains 2 or more carbon atoms.
  • Polyvinylphosphonates include polyvinylphosphonic acid.
  • Diphosphonates and salts thereof include azocycloalkane-2,2-diphosphonic acids and salts thereof, ions of azocycloalkane-2,2-diphosphonic acids and salts thereof, azacyclohexane-2,2- diphosphonic acid, azacyclopentane-2,2-diphosphonic acid, N-methyl-azacyclopentane-2,3- diphosphonic acid, EHDP (ethane- l-hydroxy-l,l,-diphosphonic acid), AHP (azacycloheptane- 2,2-diphosphonic acid), ethane-l-amino-l,l-diphosphonate, dichloromethane-diphosphonate, etc.
  • EHDP ethane- l-hydroxy-l,l,-diphosphonic acid
  • AHP azacycloheptane- 2,2-diphosphonic acid
  • ethane-l-amino-l,l-diphosphonate dichloromethane-
  • Phosphonoalkane carboxylic acid or their alkali metal salts include PPTA (phosphonopropane tricarboxylic acid), PBTA (phosphonobutane-l,2,4-tricarboxylic acid), each as acid or alkali metal salts.
  • Polyolefin phosphates include those wherein the olefin group contains 2 or more carbon atoms.
  • Other useful material include synthetic anionic polymers, including polyacrylates and copolymers of maleic anhydride or acid and methyl vinyl ether (e.g., Gantrez), as described, for example, in U.S.
  • Patent A, 621 ,911 as well as, e.g., polyamino propoane sulfonic acid (AMPS), zinc citrate trihydrate, polyphosphates (e.g., tripolyphosphate; hexametaphosphate), diphosphonates (e.g., EHDP; AHP), polypeptides (such as polyaspartic and polyglutamic acids), and mixtures thereof.
  • the oral care composition can include a polymer carrier, such as those described in U.S. Patent Nos. 6,682,722 and 6,589,512 and U.S. Application Nos. 10/424,640 and 10/430,617.
  • Useful oral care agents herein include a stannous ion source.
  • the stannous ions may be provided from stannous fluoride and/or other stannous salts.
  • Stannous fluoride has been found to help in the reduction of gingivitis, plaque, sensitivity, and in improved breath benefits.
  • the stannous ions provided in an oral composition will provide efficacy to a subject using the composition. Although efficacy could include benefits other than the reduction in gingivitis, efficacy is defined as a noticeable amount of reduction in in situ plaque metabolism.
  • Formulations providing such efficacy typically include stannous levels provided by stannous fluoride and/or other stannous salts ranging from about 3,000 ppm to about 15,000 ppm stannous ions in the total composition.
  • the stannous ion is present in an amount of from about 4,000 ppm to about 12,000 ppm, in one embodiment from about 5,000 ppm to about 10,000 ppm.
  • Other stannous salts include organic stannous carboxylates, such as stannous acetate, stannous gluconate, stannous oxalate, stannous malonate, stannous citrate, stannous ethylene glycoxide, stannous formate, stannous sulfate, stannous lactate, stannous tartrate, and the like.
  • stannous ion sources include, stannous halides such as stannous chlorides, stannous bromide, stannous iodide and stannous chloride dihydride.
  • the stannous ion source is stannous fluoride in another embodiment, stannous chloride dihydrate.
  • the combined stannous salts may be present in an amount of from about 0.001% to about 11%, by weight of the compositions.
  • the stannous salts may, in one embodiment, be present in an amount of from about 0.01% to about 7%, in another embodiment from about 0.1% to about 5%, and in another embodiment from about 1.5% to about 3%, by weight of the composition.
  • Useful oral care agents herein include a fluoride ion source to provide an anticaries effect.
  • a fluoride ion source to provide an anticaries effect.
  • these materials are inorganic fluoride salts, such as soluble alkali metal fluoride salts, for example, sodium fluoride, potassium fluoride, sodium monofluorophosphate and sodium hexafluorosilicate.
  • Alkali metal fluorides such as sodium fluoride, sodium monofluorophosphate, sodium hexafluorosilicate and mixtures thereof, are preferred.
  • the amount of fluorine-providing salt is generally present in the oral composition at a concentration of about 0.0 to about 3.0% by weight. Any suitable minimum amount of such salt may be used, but it is preferable to employ sufficient fluoride salt to release from about 50ppm to about 3500 ppm, preferably from about 300ppm to 2,000ppm, of fluoride ion. c-4) Whitening Agent
  • Useful oral care agents herein include a whitening agent
  • the actives suitable for whitening are selected from the group consisting of alkali metal and alkaline earth metal peroxides, metal chlorites, perborates inclusive of mono and tetrahydrates, perphoshates, percarbonates, peroxyacids, alkali metal and persulfates, such as ammonium, potassium, sodium and lithium persulfates, and combinations thereof.
  • Suitable peroxide compounds include hydrogen peroxide, urea peroxide, calcium peroxide, carbamide peroxide, magnesium peroxide, zinc peroxide, strontium peroxide and mixtures thereof. In one embodiment the peroxide compound is carbamide peroxide.
  • Suitable metal chlorites include calcium chlorite, barium chlorite, magnesium chlorite, lithium chlorite, sodium chlorite, and potassium chlorite.
  • Additional whitening actives may be hypochlorite and chlorine dioxide.
  • the chlorite is sodium chlorite.
  • the percarbonate is sodium percarbonate.
  • the persulfates are oxones. The level of these substances is dependent on the available oxygen or chlorine, respectively, that the molecule is capable of providing to bleach the stain.
  • the whitening agents may be present at levels from about 0.01% to about 40%, in another embodiment from about 0.1% to about 20%, in another embodiment form about 0.5% to about 10%, and in another embodiment from about 4% to about 7%, by weight of the composition.
  • Useful oral care agents herein include other anti-microbial agents.
  • Such agents may include, but are not limited to: 5-chloro-2-(2,4-dichlorophenoxy)-phenol, commonly referred to as triclosan; 8-hydroxyquinoline and its salts; copper II compounds, including, but not limited to, copper(II) chloride, copper(II) sulfate, copper(II) acetate, copper(II) fluoride and copper(II) hydroxide; phthalic acid and its salts including, but not limited to those disclosed in U.S. Pat.
  • 4,994,262 including magnesium monopotassium phthalate; chlorhexidine; alexidine; hexetidine; sanguinarine; benzalkonium chloride; salicylanilide; domiphen bromide; cetylpyridinium chloride (CPC); tetradecylpyridinium chloride (TPC); N-tetradecyl-4- ethylpyridinium chloride (TDEPC); octenidine; iodine; sulfonamides; bisbiguanides; phenolics; delmopinol, octapinol, and other piperidino derivatives; niacin preparations; zinc or stannous ion agents such as zinc oxide, zinc lactate and zinc citrate; nystatin; grapefruit extract; apple extract; thyme oil; thymol; antibiotics such as augmentin, amoxicillin, tetracycline, doxycycline, minocycline, metroni
  • Useful oral care agents herein include other anti-plaque agent such as dimethyl isosorbide, copper salts, strontium salts, magnesium salts or a dimethicone copolyol.
  • the dimethicone copolyol is selected from C12 to C20 alkyl dimethicone copolyols and mixtures thereof.
  • the dimethicone copolyol is cetyl dimethicone copolyol marketed under the Trade Name Abil EM90.
  • the dimethicone copolyol in one embodiment can be present in a level of from about 0.001% to about 25%, in another embodiment from about 0.01% to about 5%, and in another embodiment from about 0.1% to about 1.5% by weight of the composition.
  • Useful oral care agents herein include anti-inflammatory agents.
  • agents may include, but are not limited to, non-steroidal anti-inflammatory agents oxicams, salicylates, propionic acids, acetic acids and fenamates.
  • NSAIDs include but are not limited to ketorolac, flurbiprofen, ibuprofen, naproxen, indomethacin, diclofenac, etodolac, indomethacin, sulindac, tolmetin, ketoprofen, fenoprofen, piroxicam, nabumetone, aspirin, diflunisal, meclofenamate, mefenamic acid, oxyphenbutazone, phenylbutazone and acetaminophen.
  • NSAIDs such as ketorolac are claimed in U.S. Patent 5,626,838.
  • Suitable steroidal anti-inflammatory agents include corticosteroids, such as fluccinolone, and hydrocortisone.
  • Useful oral care agents herein include nutrients which improve the condition of the oral cavity.
  • Nutrients include minerals, vitamins, oral nutritional supplements, enteral nutritional supplements, and mixtures thereof.
  • Useful minerals include calcium, phosphorus, zinc, manganese, potassium and mixtures thereof.
  • Vitamins can be included with minerals or used independently. Suitable vitamins include Vitamins C and D, thiamine, riboflavin, calcium pantothenate, niacin, folic acid, nicotinamide, pyridoxine, cyanocobalamin, para-aminobenzoic acid, bioflavonoids, and mixtures thereof.
  • Oral nutritional supplements include amino acids, lipotropics, fish oil, and mixtures thereof.
  • Amino acids include, but are not limited to L- Tryptophan, L-Lysine, Methionine, Threonine, Levocarnitine or L- carnitine and mixtures thereof.
  • Lipotropics include, but are not limited to, choline, inositol, betaine, linoleic acid, linolenic acid, and mixtures thereof.
  • Fish oil contains large amounts of Omega-3 (N-3) polyunsaturated fatty acids, eicosapentaenoic acid and docosahexaenoic acid.
  • Enteral nutritional supplements include, but are not limited to, protein products, glucose polymers, corn oil, safflower oil, medium chain triglycerides.
  • Antioxidants are disclosed in texts such as Cadenas and Packer, The Handbook of Antioxidants, ⁇ 1996 by Marcel Dekker, Inc.
  • Antioxidants useful in the present invention include, but are not limited to, Vitamin E, ascorbic acid, Uric acid, carotenoids, Vitamin A, flavonoids and polyphenols, herbal antioxidants, melatonin, aminoindoles, lipoic acids and mixtures thereof.
  • C-IO Anti- Viral Agents
  • Useful oral care agents herein include an antiviral actives used to treat viral infections.
  • antiviral actives include, but are not limited to: phosphonoformic acid; cyosine derivatives; purine analogues, such as adenosine, guanosine and inosine analogues; pyrimidine bases, such as citidine and thymidine; amantadines; rimantadine HCl; ribavirin; zanamivir; oseltamivir phosphate; trifluridine; heterocyclic dyes; acyclovir; famciclovir; valacyclovir, cidofovir; ganciclovir; levimisole; idoxuridine; lipophilic ⁇ -ketones; and thiosemicarbazones.
  • Useful oral care agents herein include anti-pain or desensitizing agents.
  • Analgesics are agents that relieve pain by acting centrally to elevate pain threshold without disturbing consciousness or altering other sensory modalities.
  • Such agents may include, but are not limited to: strontium chloride; potassium nitrate; sodium fluoride; sodium nitrate; acetanilide; phenacetin; acertophan; thiorphan; spiradoline; aspirin; codeine; thebaine; levorphenol; hydromorphone; oxymorphone; phenazocine; fentanyl; buprenorphine; butaphanol; nalbuphine; pentazocine; natural herbs, such as gall nut; Asarum; Cubebin; Galanga; Scutellaria; Liangmianzhen; and Baizhi.
  • Anesthetic agents such as acetaminophen, sodium salicylate, trolamine salicylate, lidocaine and benzocaine may also be present.
  • topical analgesics such as acetaminophen, sodium salicylate, trolamine salicylate, lidocaine and benzocaine may also be present.
  • zinc-containing layered material which have effective anti-microbial and anti-gingivitis benefit due to high zinc lability.
  • Those zinc- containing layered materials particularly useful herein are those having a relative zinc lability of greater than about 25%, have an average particle size of less than about 20 microns, and have a high surface area.
  • the zinc-containing layered material herein is incorporated in compositions containing an anionic surfactant, as later discussed.
  • Zinc lability is a measure of the chemical availability of zinc ion. Soluble zinc salts that do not complex with other species in solution have a relative zinc lability, by definition, of 100%. The use of partially soluble forms of zinc salts and/or incorporation in a matrix with potential complexants generally lowers the zinc lability substantially below the defined 100% maximum. Labile zinc is maintained by choice of an effective zinc-containing layered material or formation of an effective zinc-containing layered material in-situ by known methods.
  • Zinc lability is assessed by combining a diluted zinc-containing solution or dispersion with the metallochromic dye xylenol orange (XO) and measurement of the degree of color change under specified conditions.
  • the magnitude of color formation is proportional to the level of labile zinc.
  • the procedure developed has been optimized for aqueous surfactant formulations but may be adapted to other physical product forms as well.
  • a spectrophotometer is used to quantify the color change at 572 nm, the wavelength of optimum color change for XO.
  • the spectrophotometer is set to zero absorbance at 572nm utilizing a product control as close in composition to the test product except excluding the potentially labile form of zinc.
  • the control and test products are then treated identically as follows.
  • a 50 ⁇ l product sample is dispensed into a jar and 95 ml of deaerated, distilled water are added and stirred. 5mL of a 23mg/mL xylenol orange stock solution at pH 5.0 is pipetted into the sample jar; this is considered time 0.
  • the pH is then adjusted to 5. 50+0.01 using dilute HCl or NaOH.
  • the 100% lability control is prepared in a matrix similar to the test products but utilizing a soluble zinc material (such as zinc sulfate) incorporated at an equivalent level on a zinc basis.
  • the absorbance of the 100% lability control is measured as above for the test materials.
  • the relative zinc lability is preferably greater than about 15%, more preferably greater than about 20%, and even more preferably greater than about 25%.
  • Zinc-containing layered structures are those with crystal growth primarily occurring in two dimensions. It is conventional to describe layer structures as not only those in which all the atoms are incorporated in well-defined layers, but also those in which there are ions or molecules between the layers, called gallery ions (A.F. Wells "Structural Inorganic Chemistry” Clarendon Press, 1975). Zinc-containing layered materials (ZLM's) may have zinc incorporated in the layers and/or be components of the gallery ions. Many ZLM' s occur naturally as minerals. Common examples include hydrozincite (zinc carbonate hydroxide), basic zinc carbonate, aurichalcite (zinc copper carbonate hydroxide), rosasite (copper zinc carbonate hydroxide) and many related minerals that are zinc-containing.
  • Natural ZLM' s can also occur wherein anionic layer species such as clay-type minerals (e.g., phyllosilicates) contain ion-exchanged zinc gallery ions. All of these natural materials can also be obtained synthetically or formed in situ in a composition or during a production process.
  • anionic layer species such as clay-type minerals (e.g., phyllosilicates) contain ion-exchanged zinc gallery ions. All of these natural materials can also be obtained synthetically or formed in situ in a composition or during a production process.
  • ZLM' s Another common class of ZLM' s, which are often, but not always, synthetic, is layered doubly hydroxides, which are generally represented by the formula [M2+l-xM3+x(OH)2]x+ Am-x/m-nH20 and some or all of the divalent ions (M2+) would be represented as zinc ions (Crepaldi, EL, Pava, PC, Tronto, J, Valim, JB J. Colloid Interfac. Sci. 2002, 248, 429-42).
  • hydroxy double salts can be prepared called hydroxy double salts (Morioka, H., Tagaya, H., Karasu, M, Kadokawa, J, Chiba, K Inorg. Chem. 1999, 38, 4211-6).
  • Zinc Carbonate Basic Cater Chemicals: Bensenville, IL, USA
  • Zinc Carbonate Shepherd Chemicals: Norwood, OH, USA
  • Zinc Carbonate CPS Union Corp.: New York, NY, USA
  • Zinc Carbonate Elementis Pigments: Durham, UK
  • Zinc Carbonate AC Zinc Carbonate AC
  • Basic zinc carbonate which also may be referred to commercially as "Zinc Carbonate” or “Zinc Carbonate Basic” or “Zinc Hydroxy Carbonate”, is a synthetic version consisting of materials similar to naturally occurring hydrozincite.
  • the idealized stoichiometry is represented by Zn5(OH)6(CO3)2 but the actual stoichiometric ratios can vary slightly and other impurities may be incorporated in the crystal lattice.
  • Polar Solvent Carrier a synthetic version consisting of materials similar to naturally occurring hydrozincite.
  • the idealized stoichiometry is represented by Zn5(OH)6(CO3)2 but the actual stoichiometric ratios can vary slightly and other impurities may be incorporated in the crystal lattice.
  • composition of the present invention comprises a polar solvent carrier for delivering the essential components, and for providing suitable rheology with the hydrophilic clay material.
  • the polar solvent also serves as solvent for incorporating water-soluble oral care actives and other components.
  • the polar solvent is comprised by weight of the entire composition at from about 1% to about 95%, preferably from about 30% to about 70%.
  • Polar solvents useful herein include water, polyhydric alcohols such as glycerin, 1,3- butylene glycol, propylene glycol, hexylene glycol, propane diol, ethylene glycol, diethylene glycol, dipropylene glycol, diglycerin, sorbitol, and other sugars which are in liquid form at ambient temperature. Also useful herein are water soluble alkoxylated nonionic polymers such as polyethylene glycol.
  • the present composition can comprise a relatively high level of water for providing a cost effective product.
  • water is comprised at from about 30% to about 95%, more preferably from about 50 % to about 70 % of the entire composition.
  • polar solvents herein include: glycerin available from Asahi Denka; propylene glycol with tradename LEXOL PG-865/855 available from Inolex, 1,2- PROPYLENE GLYCOL USP available from BASF; 1,3-butylene glycol available from Daisel Kagaku Kogyo; dipropylene glycol with the same tradename available from BASF; diglycerin with tradename DIGL YCEROL available from Solvay GmbH, polyethylene glycol with the tradename PEG 300 available from Doe Chemical Company, and sorbitol 70% solution available from Khalista (Liuzhou) Chemical Industries, Ltd. Free of Abrasive Material
  • the composition of the present invention is substantially free of abrasive material. Namely, the composition of the present invention has no abrasive material that is intentionally included. It has been surprisingly found that, the present composition can deliver the benefits of a regular dentifrice composition, including those which are typically attributed to the use of abrasive material, such as cleaning, stain removal, plaque removal, calculus removal, and others. Absence of abrasive material also accommodates inclusion of certain active agents such as cetylpyridinium chloride, which otherwise have poor compatibility with abrasive materials such as silica, and therefore cannot be included in a dentifrice composition. Further, due to the absence of abrasive material, various aesthetics for the dentifrice product may be pursued. For example, a composition of transparent appearance may be made.
  • Abrasive materials from which the present composition is substantially free of are defined as materials having a DOA value of no more than about 150 m €/100g, preferably no more than about 100 m €/100g, and having a particle size of from about 5 ⁇ m to about 50 ⁇ m. Abrasive materials herein can be distinguished herein from those materials useful as binders.
  • Abrasive materials from which the present composition is free of include: inorganic minerals such as silica gels and precipitates; aluminas; hydrated alumina, calcium carbonate, titanium dioxide, talc, calcium dioxide, and resinous abrasive materials such as particulate condensation products of urea and formaldehyde. Additional Binder Material
  • composition of the present invention may further comprise an additional binder material which further builds rheology to the composition, or provides certain mouth feel upon usage.
  • additional binder material is selected from those compatible with the hydrophilic clay material, and are included such that the total amount of hydrophilic clay material and additional binder material is from about 0.1% to about 10% of the entire composition, and provides a viscosity of from about 10,000 Pas to about 450,000 Pas, preferably from about 10,000 Pas to about 250,000 Pas.
  • Modified cellulose polymers are useful binder materials herein for building continuous structure to the composition.
  • Modified cellulose polymers useful herein include sodium carboxymethyl cellulose, polyvinylpyrrolidone, hydroxyethylpropylcellulose, hydroxybutyl methyl cellulose, hydroxypropy methyl cellulose, and hydroxyethyl cellulose.
  • Particularly useful commercially available materials include sodium carboxymethyl cellulose by the tradename BLANOSE series, OPTICEL 100, and AQUALON series from Hercules; hydroxyethylpropylcellulose by the tradename KLUCEL series from Hercules, hydroxypropy methyl cellulose by the tradename TF-E25 from YIXING CITY NO.8 CHEMICAL PLANT and by the tradename BENECEL series from Hercules.
  • Carboxyvinyl anionic polymers are useful binder materials herein for building a three dimentional structure in combination with the hydrophilic clay materials disclosed hereinabove.
  • Carboxyvinyl anionic polymers useful herein include those by the tradename of CARBOPOL series (or CARBOMER) such as CARBOPOL 956, 934, 940, 941, 1342, ETD 2020, ULTREZ 10" from Noveon Inc., CARBOPOL 934, 940, 974 P from B. F. Goodrich and SYNTHALEN K available from 3V Company.
  • Natural gum derived anionic polymers are useful binder materials herein for effectively adding viscosity. Natural gum derived anionic polymers useful herein in elude carrageenan, xanthan gum, gellan gum, and locust bean gum. Particularly useful commercially available materials include xanthan gum by the tradename KELDENT series available from CP Kelco, and by the tradename RHODICARE series from Rhodia; gellan gum by the tradename KELCOGEL series from CP Kelco; and locust bean gum by the tradename GELLOID LB series from FMC BioPolymer.
  • binder material also useful as binder material herein are starch and carrageenan.
  • Carrageenan is commercially available by tradename VISCARI series and GELCARIN series from FMC BioPolymer, by the tradename MEYPRO-SOL series from Meyhall AG, and by the tradename GENUVISCO series, GENU series and GENUTINE series from CP Kelco. Additional Components
  • composition of the present invention may include other additional components, which may be selected by the artisan according to the desired characteristics of the final product and which are suitable for rendering the composition more cosmetically or aesthetically acceptable or to provide them with additional usage benefits.
  • additional components generally are used individually at levels of no more than about 5% by weight of the composition.
  • Surfactants may be incorporated in the components of the present invention as an ingredient to aid in the thorough dispersion of the dentifrice throughout the oral cavity when applied thereto, as well as, to improve cosmetic acceptability and the foaming properties.
  • the surfactants which can be included in the present composition include anionic, nonionic or amphoteric compounds, anionic compounds being preferred.
  • anionic surfactants are higher alkyl sulfates such as potassium or sodium lauryl sulfate which is preferred, higher fatty acid monoglyceride monosulfates, such as the salt of the monosulfated monoglyceride of hydrogenated coconut oil fatty acids, alkyl sulfonates such as sodium dodecyl benzene sulfonate, higher fatty sulfoacetates, higher fatty acid esters of 1 ,2 dihydroxypropane sulfonate.
  • higher alkyl sulfates such as potassium or sodium lauryl sulfate which is preferred
  • higher fatty acid monoglyceride monosulfates such as the salt of the monosulfated monoglyceride of hydrogenated coconut oil fatty acids
  • alkyl sulfonates such as sodium dodecyl benzene sulfonate
  • higher fatty sulfoacetates higher fatty acid esters of 1 ,
  • water soluble nonionic surfactants are condensation products of ethylene oxide with various hydrogen-containing compounds that are reactive therewith and have long hydrophobic chains (e.g., aliphatic chains of about 12 of 20 carbon atoms), which condensation products contain hydrophilic polyoxyethylene moieties, such as condensation products of poly (ethylene oxide) with fatty acids, fatty alcohols, fatty amides and other fatty moieties, and with propylene oxide and polypropylene oxides, e.g., Pluronic materials such as Pluronic F127.
  • the surfactant can be present in the present composition at a concentration of from about 0.5 to about 10.0% by weight, preferably about 1 to about 2% by weight.
  • ingredients which may be incorporated in the dentifrice composition of the present invention include pigments, dyes, flavoring and sweetening materials.
  • a striped product is obtained in accordance with the present invention wherein colorants of contrasting colors are incorporated in each of the components used in the practice of the present invention, the colorants being pharmacologically and physiologically nontoxic when used in the suggested amounts.
  • Colorants used in the present invention include both pigments and dyes.
  • Pigments useful in the present invention include non-toxic, water insoluble inorganic pigments such as titanium dioxide and chromium oxide greens, ultramarine blues and pinks and ferric oxides as well as water insoluble dye lakes prepared by extending calcium or aluminum salts of FD&C dyes on alumina such as FD&C Green #1 lake, FD&C Blue #2 lake, FD&C R&D #30 lake, FD&C #5 Yellow and FD&C # Yellow 15 lake, The concentration of the dye in the present composition is no more than about 3% by weight.
  • the pigments herein are distinguished from the abrasive materials, which the present composition is substantially free from, as pigments herein have a particle size in the range of from 100 to about 1000 microns, preferably from about 250 to about 500 microns. When present, the pigments are included in the present composition at from about 0.5% to about 3% by weight.
  • flavoring or sweetening material may also be incorporated in the components of the present invention.
  • suitable flavoring constituents are flavoring oils, e.g., oils of spearmint, peppermint, wintergreen, sassafras, clove, sage, eucalyptus, marjoram, cinnamon. Lemon, and orange, and methyl salicylate.
  • suitable sweetening agents include sucrose, lactose, maltose, sorbitol, xylitol, sodium cyclamate, perillartine, and sodium saccharin.
  • flavor and sweetening agents may together comprise from 0.01% to 5% by weight or more of the preparations.
  • compositions for Examples 1-5 are formed by the following components using the method of preparation described herein.
  • Sorbitol 70% solution available from Khalista (Liuzhou) Chemicals
  • Glycerin Glycerin, available from Asahi Denka
  • Carbopol Carbomer 956, available from Noveon, Inc.
  • Xanthan Gum KELDENT, available from CP Kelco Inc.
  • Carrageenan GELCARIN TP911 available from FMC Corporation food ingredients division *10 Synthesized Layered Magnesium Silicate 0.2% Fluoride: LAPONITE DF, available from
  • Tetrasodium Pyrophosphate Sodium Pyrophosphate, Tetra (anhydrous), available from
  • Tribasic Sodium Phosphate TSP, available from Jiangsu Jiangyin Phosph Chemicals *19 Sodium Phytate 20% Solution: available from Sichuan Chengdu Yason *20 Sodium Saccharin: available from Suzhou Fine Chemical *21 Stannous Fluoride: SnF2, available from Hashimoto *22 Triclosan: available from Ciba-Geigy Chemicals Ltd. *23 Cetylpyridinium Chloride: available from Cambrex company *24 Zinc Carbonate: available from Bruggemann Chemical Method of Preparation
  • the dentifrice compositions of Examples 1 - 10 may be made by any method known to one skilled in the art, and are suitably prepared as follows.
  • the hydrophilic clay material (component numbers 10-13) is dissolved in part of water in a container at room temperature, using Propeller Mixer mix until homogeneous.
  • sorbitol solution component number 2
  • glycerin component number 3
  • polyethylene glycol component number 4
  • sodium hydroxide solution component number 15
  • dye and pigment component number 14
  • flavor and surfactant component number 5
  • component number 5 All remaining components except flavor and surfactant (component number 5) are added to main mix pot.
  • the pot is hermetically closed, vacuum is built to around lOOmmhg, homogenizer is turned at a rotation rate of 2400 to 3500rpm. The obtained mixture is further de-aerated.
  • the obtained product is pumped out of the container and delivered to a primary packaging such as laminate tube.
  • Example compositions herein have many benefits suitable for a dentifrice product. All compositions provide lower abrasion to teeth surface, and are safer to teeth enamel compared to toothpastes containing abrasive material. All compositions provide soft mouth feel, and easier dispersion, and improved approach in the between-teeth area compared to toothpastes containing abrasive material. All compositions provide better consumer noticeability of flavor as compared to toothpastes containing abrasive material and the same level of the same flavor. Further, all compositions can be manufactured at an economical cost. The compositions of Examples 1-5 provide anti-caries, anti-plaque, whitening, and anti-calculus benefit.
  • compositions of Examples 6-7 provide anti-caries, anti-plaque, whitening, anti-calculus, and anti-gingivitis benefit.
  • compositions of Examples 8-9 provide anti-caries, anti-plaque, whitening, anti-calculus, and anti-microbial benefit.
  • the composition of Example 10 provides anti-caries, anti-plaque, and anti-calculus benefit.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition de dentifrice qui comprend : (a) un matériau argileux hydrophile ; (b) un composé d'acide phytique ; (c) une dose efficace d'un agent actif de soin buccal ; et (d) un excipient de type solvant polaire. La composition de l'invention est sensiblement exempte d'abrasif.
PCT/IB2006/054510 2005-11-29 2006-11-29 Composition de dentifrice exempte d'abrasif WO2007063506A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2008538490A JP2009513695A (ja) 2005-11-29 2006-11-29 研磨材を含まない歯磨剤組成物
AU2006321206A AU2006321206A1 (en) 2005-11-29 2006-11-29 Dentifrice composition free of abrasive material
CA002631537A CA2631537A1 (fr) 2005-11-29 2006-11-29 Composition de dentifrice exempte d'abrasif
BRPI0619387-0A BRPI0619387A2 (pt) 2005-11-29 2006-11-29 composição dentifrìcia isenta de material abrasivo
EP06832005A EP1954238A2 (fr) 2005-11-29 2006-11-29 Composition de dentifrice exempte d'abrasif

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US74053805P 2005-11-29 2005-11-29
US60/740,538 2005-11-29
US75140505P 2005-12-16 2005-12-16
US60/751,405 2005-12-16
US11/545,266 US20070122357A1 (en) 2005-11-29 2006-10-10 Dentifrice composition
US11/545,266 2006-10-10

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WO2007063506A3 WO2007063506A3 (fr) 2007-10-11

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KR (1) KR20080063528A (fr)
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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007076001A2 (fr) * 2005-12-20 2007-07-05 The Procter & Gamble Company Compositions pour soins buccaux contenant du zinc et du phytate
WO2010058522A1 (fr) * 2008-11-19 2010-05-27 花王株式会社 Procédé d’élimination d’un produit solide formé sur la surface des dents
JP2010120880A (ja) * 2008-11-19 2010-06-03 Kao Corp 口腔用組成物
JP2010150225A (ja) * 2008-11-19 2010-07-08 Kao Corp 歯の表面に生成した固形生成物除去用組成物
US8580234B2 (en) 2008-11-19 2013-11-12 Kao Corporation Method for removing solid product formed on surfaces of teeth
WO2014102032A1 (fr) 2012-12-27 2014-07-03 Unilever N.V. Composition de soin buccal comportant un adduit d'argile et un agent antibactérien
US9168213B2 (en) 2011-04-08 2015-10-27 Kao Corporation Oral composition
US10098829B2 (en) 2011-06-02 2018-10-16 Colgate-Palmolive Company Low water metal ion dentifrice

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130216485A1 (en) * 2010-11-04 2013-08-22 Colgate-Palmolive Company Dentifrice Composition with Reduced Astringency
JP5625818B2 (ja) * 2010-11-30 2014-11-19 ライオン株式会社 歯磨剤組成物
JP2012240966A (ja) * 2011-05-19 2012-12-10 Lion Corp 有機無機複合増粘体及びその調製方法並びにゲル状化粧料又は外用剤用基材
JP5765407B2 (ja) * 2013-11-28 2015-08-19 ライオン株式会社 歯磨剤組成物
WO2020058321A1 (fr) * 2018-09-18 2020-03-26 Inositec Ag Inhibiteurs de cristallisation d'oxalate de calcium pour troubles rénaux
JP2020100596A (ja) * 2018-12-25 2020-07-02 ライオン株式会社 口腔バイオフィルム除去剤及び口腔用組成物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2153673A (en) * 1984-02-01 1985-08-29 Colgate Palmolive Co Dentifrice containing dual sources of fluoride
WO2002002060A2 (fr) * 2000-06-30 2002-01-10 The Procter & Gamble Company Compositions orales
US20040223941A1 (en) * 2003-03-18 2004-11-11 Schwartz James Robert Composition comprising zinc-containing layered material with a high relative zinc lability

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2153673A (en) * 1984-02-01 1985-08-29 Colgate Palmolive Co Dentifrice containing dual sources of fluoride
WO2002002060A2 (fr) * 2000-06-30 2002-01-10 The Procter & Gamble Company Compositions orales
US20040223941A1 (en) * 2003-03-18 2004-11-11 Schwartz James Robert Composition comprising zinc-containing layered material with a high relative zinc lability

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
"The penguin dictionary of chemistry" 1990, PENGUIN BOOKS , UK , XP002434359 Clay page 101 *
DATABASE CAPLUS [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 1992, SUNSTAR, INC.: XP002434064 retrieved from STN Database accession no. 1992:241752 *
DATABASE REGISTRY [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 16 November 1984 (1984-11-16), "Zeodent 118" XP002434070 retrieved from STN Database accession no. RN 7631-86-9 *
DATABASE REGISTRY [Online] CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; 16 November 1984 (1984-11-16), "Zeodent 165" XP002434069 retrieved from STN Database accession no. RN 7631-86-9 *
HUBER CORPORATION: "Working with the Essential Elements" INTERNET ARTICLE, [Online] 2004, XP002434262 Retrieved from the Internet: URL:www.prochem.ch/html/forum/Oral%20Care_ FINAL.pdf>> [retrieved on 2007-05-18] *
MICHAEL AND IRENE ASH: "Hanbook of Cosmetic and Personal Care Additive" 2002, SYNAPSE INFORMATION RESOURCES INC. , NY 1 , XP002433735 Laponite D page 411, left-hand column *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007076001A2 (fr) * 2005-12-20 2007-07-05 The Procter & Gamble Company Compositions pour soins buccaux contenant du zinc et du phytate
WO2007076001A3 (fr) * 2005-12-20 2007-09-07 Procter & Gamble Compositions pour soins buccaux contenant du zinc et du phytate
WO2010058522A1 (fr) * 2008-11-19 2010-05-27 花王株式会社 Procédé d’élimination d’un produit solide formé sur la surface des dents
JP2010120880A (ja) * 2008-11-19 2010-06-03 Kao Corp 口腔用組成物
JP2010150225A (ja) * 2008-11-19 2010-07-08 Kao Corp 歯の表面に生成した固形生成物除去用組成物
US8580234B2 (en) 2008-11-19 2013-11-12 Kao Corporation Method for removing solid product formed on surfaces of teeth
US9168213B2 (en) 2011-04-08 2015-10-27 Kao Corporation Oral composition
US10098829B2 (en) 2011-06-02 2018-10-16 Colgate-Palmolive Company Low water metal ion dentifrice
WO2014102032A1 (fr) 2012-12-27 2014-07-03 Unilever N.V. Composition de soin buccal comportant un adduit d'argile et un agent antibactérien

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KR20080063528A (ko) 2008-07-04
CA2631537A1 (fr) 2007-06-07
AU2006321206A1 (en) 2007-06-07
BRPI0619387A2 (pt) 2011-10-04
WO2007063506A3 (fr) 2007-10-11
EP1954238A2 (fr) 2008-08-13

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