WO2007029834A1 - Composition alimentaire - Google Patents

Composition alimentaire Download PDF

Info

Publication number
WO2007029834A1
WO2007029834A1 PCT/JP2006/317922 JP2006317922W WO2007029834A1 WO 2007029834 A1 WO2007029834 A1 WO 2007029834A1 JP 2006317922 W JP2006317922 W JP 2006317922W WO 2007029834 A1 WO2007029834 A1 WO 2007029834A1
Authority
WO
WIPO (PCT)
Prior art keywords
extract
food composition
solid content
composition according
migratory fish
Prior art date
Application number
PCT/JP2006/317922
Other languages
English (en)
Japanese (ja)
Inventor
Motonaka Kuroda
Yoshizu Nozawa
Keiko Yamada
Original Assignee
Ajinomoto Co., Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co., Inc. filed Critical Ajinomoto Co., Inc.
Publication of WO2007029834A1 publication Critical patent/WO2007029834A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/60—Fish, e.g. seahorses; Fish eggs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L17/00—Food-from-the-sea products; Fish products; Fish meal; Fish-egg substitutes; Preparation or treatment thereof
    • A23L17/20—Fish extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Definitions

  • the present invention relates to a food composition, and more particularly, a food composition using a fish extract (fish extract) having anti-stress action and anti-fatigue action with reduced raw odor and bitterness. About.
  • fish extract fish extract
  • the food composition of the present invention has an anti-stress action using an extract of migratory fish as an active ingredient, which is effective when ingested by a person who feels mental fatigue or mental stress that is felt daily.
  • the anti-stress action referred to in the present invention means that it has either an anti-mental fatigue action that reduces or suppresses mental fatigue or an anti-stress action (in a narrow sense) that reduces stress.
  • anti-psychotic fatigue action and anti-stress action are collectively referred to as “anti-stress action (in a broad sense)” unless the meaning is different from the context.
  • the food composition of the present invention has an anti-fatigue action comprising an extract of migratory fish as an active ingredient, which is effective when used by a person who feels fatigue on the body and fatigue after exercise.
  • the anti-fatigue action referred to in the present invention means that it has either an anti-fatigue action that suppresses exercise fatigue or daily physical fatigue or a fatigue recovery action that promotes recovery from fatigue.
  • Examples of conventional anti-stress agents include pharmaceuticals containing tranquilizers.
  • pharmaceuticals containing tranquilizers are not appropriate for many consumers who feel mental fatigue or emotional dysfunction on a daily basis because they are too strong.
  • these existing foods are generally in the form of pharmaceuticals, and it was difficult to mix them with existing foods because of their sensory characteristics and physicochemical characteristics. If it is intended to be taken regularly in daily eating habits to prevent or reduce stress, it is desirable to be able to mix not only in the form of supplements but also in general foods. A dietary experience is considered preferable. From such a perspective, existing foods, pharmaceuticals, and supplement ingredients have limited applicability to food, so the development of more effective foods that are versatile as food and have a wealth of food experience. Has been desired.
  • anserine and carnosine which are abundant in seafood and livestock meat, activate ATPase.
  • Japanese Patent Application Laid-Open No. 2 0 2-1 7 3 4 4 2 seafood, chicken meat and livestock meat
  • the imidazole peptides, especially anserine, carnosine, and valenin, are specifically purified through ultrafiltration membranes from the low molecular fraction of the extract obtained from the above, and exercise ability is achieved by administration of at least one selected from these of It has been proposed that improvement and anti-fatigue effects are demonstrated. However, there is no mention of the effect of this composition on stress conditions such as mental fatigue.
  • JP-A-9 2 0 6 61 a composition containing an imidazole compound such as anserine, carnosine, or valenin reduces fatigue caused by excessive mental activity in humans. It has been shown to have an anti-mental fatigue effect that enhances concentration.
  • an extract containing an imidazole compound as a main component is, for example, a fraction separated from a boiled juice concentrate during fish processing using ultrafiltration and ion exchange resin (Examples in the same document).
  • the content of imidazole compound is 2% or more, preferably 10% or more, more preferably 50% or more, and particularly the content of anserine is 1% or more, It is preferably 5% or more, more preferably 20% or more (see paragraphs 0 0 14 to 0 0 15 of the same document).
  • This composition is expensive and may not be practical for a general food.
  • boiled juice concentrate at the time of fish processing generally has a strong raw odor and bitterness, and thus has a problem that it is difficult to take in normal food forms.
  • imidazole peptides particularly anserine, carnosine and valenin, are specifically purified through ultrafiltration membranes from low molecular fractions of extracts obtained from seafood, chicken, livestock, etc., and at least selected from these It has been proposed that one or more administrations can improve exercise ability and exert anti-fatigue effects. However, it does not show the fatigue recovery effect of the food composition of the present invention for mild exercise.
  • WO 2 0 0 4-0 3 2 6 5 2 reports that the fatigue after exercise is recovered by ingesting a migratory fish extract or a nutritional component having a similar composition.
  • the extract of migratory fish obtained in the invention described in this document has a strong bitter taste and raw odor, and taking the necessary intake 50 O mg (in terms of solid content) described in the invention is Because of its taste characteristics, it was difficult.
  • the liquid juice containing seafood extracts such as steamed juice produced during production is rich in taste ingredients, so it is processed into various extracts and seasonings after concentration.
  • these seafood extracts are rich in taste components, but often have a raw odor and Z or bitterness, which limits their use.
  • the present invention prevents, improves, reduces daily mental fatigue, mental insufficiency, and mental instability, and is ingested in a normal diet.
  • the first object is to provide a food composition having an anti-stress action.
  • the present invention provides a food having an anti-fatigue action, which can take a form that is easy to ingest in normal eating habits, and can prevent, reduce, or reduce the feeling of everyday fatigue and fatigue during exercise.
  • a second object is to provide a composition.
  • the present invention provides a method for removing the above-mentioned raw odor and bitterness, provides a fish extract with reduced raw odor and bitterness, and further provides a food composition using such a fish extract.
  • the third purpose is to provide it.
  • the present applicant has found a food composition having an anti-stress action, characterized by containing an extract of migratory fish as an active ingredient, and such a food composition.
  • the extract of the migratory fish is extracted from (i) boiled salmon broth, (mouth) (C) After heating and concentrating boiled salmon broth and / or steamed broth, add 2-20% diatomaceous earth to the extract solids It is characterized by being an extract obtained by filtration. (2) It is an extract obtained by hot water extraction of a nodule obtained from migratory fish.
  • Migratory nodules obtained from fish are subjected to enzymatic degradation with proteolytic enzymes and then extracted with hot water, or these extracts are (a) nominally Or (b) a reverse osmosis membrane having a nominal salt rejection of 10% or less, or a permeate obtained by treating with an ultrafiltration membrane having a molecular weight cut-off of 500 to 5, 000 Invented what is characterized by being a permeate obtained by treating with the above, and has already filed a patent application for this (Japanese Patent Application 2 0 0 6— 5 1 0 9 0 5).
  • an unpurified extract of migrating fish such as salmon can be used as an ultrafiltration membrane with a nominal molecular weight cut-off of 5,000 or less.
  • a refined extract of migratory fish obtained by treating with a reverse osmosis membrane having a nominal salt rejection of 10% or less and subjecting it to adsorbent treatment before or after the membrane treatment;
  • the weight of the component having a molecular weight of 1,00 or less in the solid content represents 80% or more of the total weight of the solid content, or per solid content That have a total bile acid content of 40 mo 1 e / 100 g or less have ease of drinking due to reduced raw odor and bitterness, and also have anti-stress action and anti-fatigue
  • the present invention relates to an unpurified extract of migratory fish such as persimmon belonging to Perciformes, Scombrina, ultrafiltration membranes having a nominal molecular weight of 5,000 or less, Z and nominal Migrating by treatment with a reverse osmosis membrane having a salt rejection of 10% or less and subjecting it to an adsorbent treatment selected from activated carbon, activated clay, etc. before and / or after the membrane treatment.
  • an adsorbent treatment selected from activated carbon, activated clay, etc. before and / or after the membrane treatment.
  • An anti-stress and anti-fatigue action food composition containing a purified fish extract as an active ingredient with reduced raw odor and bitterness, and such a food composition, So
  • the weight of the component having a molecular weight of 1,000 or less in the solid content of the solid content is 80% or more of the total weight of the solid content, or the total bile acid content per solid content is 40 ⁇ mo 1 e / 10 0g or less It relates to a product that has ease of drinking due to reduced raw odor and bitterness, and also has anti-stress action and anti-fatigue action.
  • the present invention provides that the migratory fish extract has a solid content weight of 1 in order to make it easy to ingest an effective amount of the above composition (solid extract weight of 0.5 to 1 meal).
  • Fig. 1 shows changes in the content of corticosterone by various koji extracts (Experimental example 2)
  • Figure 2 shows changes in G 0 T activity by various koji extracts (Experimental Example 2).
  • Fig. 3 shows the amount of spontaneous locomotor activity when various sputum extracts are administered (Experimental Example 3).
  • Figure 4 shows the swimming time of mice when various sputum extracts were administered (10 L / min condition) (Experimental Example 4).
  • FIG. 5 shows the swimming time of mice when various sputum extracts were administered (8 L / min condition) (Experimental Example 5).
  • Figure 6 shows the correlation between bile acids and bitterness and odor (Experimental Example 7).
  • Figure 7 shows the spontaneous locomotor activity of mice after administration of sputum extract before and after activated carbon treatment (Experimental Example 9) o [Best Mode for Carrying Out the Invention]
  • the migratory fish referred to in the present invention refers to fish that moves greatly for spawning, such as salmon, salmon, swordfish, salmon, salmon, salmon, herring, and burdock, and regularly according to the season.
  • Fish such as salmon, flounder, and flounder may be used.
  • Perciformes such as power, mackerel, grasshopper, managa, bluefin, bluefin tuna, bluefin tuna, bigeye tuna, swordfish, etc. It is a fish. This classification is based on the “Primary Color Fish Retrieval Pictorial Book (Revised 13th Edition)” (issued in Hokuryukan 1 989).
  • the unpurified extract of migratory fish used in the present invention is not particularly limited in its production method and can be obtained by a conventional method, but if it has the same composition, it is produced by a different production method. It may be an extract. However, from the viewpoint of production cost, boiled or steamed juices or their concentrates by-produced during the production of fishery foods such as canned migratory fish (power trout, tuna, mackerel, etc.) It is preferable to use this extract.
  • such boiled juice or steamed juice or a concentrate thereof may be subjected to further concentration and purification treatment.
  • boiled salmon meat or steamed broth is heated and concentrated to about Brix 20 to 40 by a conventional method, after adding and mixing 1 to 20% diatomaceous earth with respect to the solid content, The filtered one can be mentioned.
  • the filtrate obtained in this manner may be subjected to protease treatment, or may be added with sugar and then heated to reduce the raw odor.
  • such an unpurified extract of migratory fish may be obtained by removing salt by electrodialysis or reverse osmosis filtration with a salt rejection of 25% or more.
  • the method for producing the migratory fish extract of the present invention with reduced raw odor and bitterness from such an unpurified extract of migratory fish is as follows.
  • the nominal molecular weight cut-off is 5, 000 or less, preferably 3, 000 or less, more preferably 2,
  • a membrane-treated permeate is obtained by treatment with an ultrafiltration membrane of 0 or less and / or a reverse osmosis membrane with a nominal salt rejection of 10% or less, preferably 5% or less.
  • the weight of the component having a molecular weight of 1,00 or less is 80% of the total solid weight. %, Preferably 90% or more.
  • YM-1 regenerated cellulose membrane manufactured by Mi 1 1 ipore
  • the extract is processed to obtain a permeate.
  • the concentrated solution is repeatedly washed with distilled water until the amount of low-molecular-weight mixture in the permeate is 1% or less of the initial permeate. That is, the low-molecular fraction present in the concentrate is removed as much as possible by water pushing, the solid content of the permeate fraction obtained in this way is measured, and the ratio of the original extract to the solid content is calculated. To do.
  • an ultrafiltration membrane with a molecular weight of 5,000 or less or a reverse osmosis membrane with a salt rejection of 10% or less is required. It is preferable to use and purify to some extent in advance.
  • either one of the film treatments may be performed, but both film treatments may be performed if necessary.
  • an ultrafiltration membrane having a molecular weight cut-off of 500 or more is known, but any membrane can be used as long as it satisfies the above conditions.
  • deodorization and decolorization treatment using an adsorbent is performed before and / or after the membrane treatment.
  • Adsorbent used at this time examples include activated carbon, activated clay, diatomaceous earth, and ion exchange resin, and it is preferable to use activated carbon from the viewpoint of cost and adsorption capacity.
  • the activated carbon can be activated carbon of any shape, such as granular activated carbon, powdered activated carbon, granular activated carbon.
  • the adsorbent treatment can also be performed before the film treatment.
  • bile acids Endo et al., which are known as components involved in bitterness and raw odor of seafood extracts in migratory fish extracts
  • “Nutrition and food” Vol.35, No.3, 181-187, 1982) is low. That is, the total bile acid content of migratory fish extract per solid content is not more than 40 mo 1 e / 100 g, preferably not more than 20 1mo 1 eZ 100 g, more preferably 10 ju o 1
  • An e / 100 g or less is an index indicating that it has ease of eating and drinking due to reduced raw odor and bitterness.
  • the bile acid mentioned here is C 2 4 -steroid, which is a metabolite of cholesterol, choleric acid, deoxycolic acid, chenodeoxycholic acid, lithocholic acid, ritokenocolic acid.
  • Free bile acids such as acids, and urine conjugates of the above free bile acids such as taurocholic acid and taurodeoxycolic acid. Including.
  • the total molar amount of these bile acids contained in the migratory fish extract per 100 g of migratory fish extract solids is shown as the total bile acid content.
  • Bile acids are preferably analyzed by a method such as high performance liquid chromatography (HPLC) or gas chromatography (GLC). A method for measuring total bile acid using 3-hyperhydroxysteroid dehydrogenase is widely used for estimation of bile acid content.
  • this measurement method can be applied to samples in which the type of bile acids contained in the sample is known in advance because the reactivity of the enzyme differs depending on the individual bile acids. If they are different, it is difficult to calculate the exact content, so it is preferable to quantify by the above HPLC method or GLC method.
  • an appropriate additive can be blended within a range not impeding the effects of the present invention.
  • Such additives include sugars (glucose, sucrose, starch, etc.), lipids (vegetable oil, fish oil, animal fats, etc.), proteins (soybean protein) that promote the anti-stress or anti-fatigue effects of migratory fish extracts.
  • Containing an effective amount of a purified extract of migratory fish obtained by the above method (solid extract weight per meal 0.3 g or more, preferably 1 to LO g) and easy to ingest
  • solid extract weight per meal 0.3 g or more, preferably 1 to LO g
  • easy to ingest In order to make the food composition in the form, it can be blended with the above-mentioned taste-masking ingredients, other nutritional ingredients, etc. and processed as follows.
  • the migratory fish extract according to the present invention further has a solid equivalent weight of 0.3 g or more per serving.
  • the extract solution is sterile so that the dissolved oxygen concentration is 1 O p pm or less (25 ° C). Fill to obtain the desired liquid food composition.
  • an aluminum voucher an aluminum can, a steel can, a paper pack that has been subjected to deoxidation treatment on the interior, a packaging material that has oxygen scavenging properties, and a packaging material that has oxygen barrier properties. Is preferred.
  • liquid food composition can provide the composition which can distribute
  • the dissolved oxygen concentration at 25 ° C is 5 ppm or less, preferably 3 ppm or less, and more preferably Need to be filled to 2 ppm or less.
  • the food composition contains 0.3 g or more of the purified extract of migratory fish per meal in terms of solid content.
  • excipients, taste-masking ingredients, etc. are added to powder, granulate, or tablet to obtain the desired solid food composition.
  • Excipients used at this time include carbohydrates such as glucose, sucrose, trehalose, maltose, lactose, dextrin, starch, peptides such as gelatin, casein, and partial degradation products thereof, and proteins. Can be mentioned.
  • sucrose ingredients such as sucrose, aspartame, acesulfame K, sodium glutamate, and salt to impart functions as food (taste, texture, etc.).
  • means for powdering include spray drying, freeze drying, reduced pressure thin film drum drying, atmospheric pressure drum drying, and the like after the extract is concentrated as necessary.
  • the extract in order to ingest the extract without being influenced by the taste, the extract can be powdered by the above-mentioned means and then filled into a capsule.
  • a means for providing the extract in an easy-to-eat state it is also possible to add a component having a gelling action and provide it as a jelly-like food.
  • the gelling agent used at this time at least one of agar, gelatin, starches and gums is used. Also, at this time, in order to make it easier to ingest, It is preferable to add a taste ingredient such as aspartame, acesulfame K, sodium glutamate, and salt.
  • the food composition of the present invention thus produced can be put on the market as it is, that is, appropriately in the form of a liquid mixture, a powder mixture or the like. In addition, it can be used to impart a favorable taste to various foods. Examples of foods include, but are not limited to, liquid food compositions and powdered food compositions such as soup, miso soup, soup, and soup shown in the Examples below.
  • the dose (intake amount) of the food composition of the present invention will be described.
  • a salmon extract migratory fish extract
  • an anti-stress action and an anti-fatigue action were observed when the dose exceeded 38 O mg / kg in terms of solid content.
  • this dose is converted from animals to humans, it will be 0.3 g or more in terms of solid content per meal as 1 to 3 meals per adult human. If the amount is below this level, the effect cannot be expected.
  • the food composition of the present invention is mainly intended for healthy persons who feel mental fatigue on a daily basis.
  • the food composition of the present invention can also be effective when ingested by persons with mental illness or depression. Is possible.
  • a koji extract was prepared by the following method.
  • diatomaceous earth (“Radiolite # 700" manufactured by Showa Chemical Industry Co., Ltd.) is 5.0% of the extract solid content.
  • the mixture was filtered using a filter cloth, and desalted using an electrodialyzer (“Ashilyzer I” manufactured by Asahi Kasei Co., Ltd.) ( ⁇ extract A).
  • the soot extract A thus obtained was subjected to ultrafiltration membrane NTU-3250 ”(manufactured by Nitto Denko Corporation; fractionation using a nominal molecular weight cut off of 6,000, and a molecular weight of over 6,000.
  • Fraction 11 Fraction 11
  • a fraction with a molecular weight of 6,000 or less was subjected to ultrafiltration with a nominal molecular weight of 1,000 (Mi 11 ipo re Fractionation is performed using “Prep / Scale TFF6” (manufactured by Kogyo Co., Ltd.), a fraction having a molecular weight of 1,000 to 6,000 ( ⁇ extract C) and a fraction having a molecular weight of 1,000 or less ( ⁇ extract! )).
  • Prep / Scale TFF6 manufactured by Kogyo Co., Ltd.
  • ⁇ extract C fraction having a molecular weight of 1,000 to 6,000
  • ⁇ extract! fraction having a molecular weight of 1,000 or less
  • the content of corticosterone and the activity of glutamic acid / oxacin-acetic acid transaminase (hereinafter referred to as GOT) were determined according to conventional methods.
  • the group to which sputum extract A was administered showed lower values for both corticosterone content and GOT activity than the control group. That is, it was recognized that the stress index of the stress model mouse was reduced by administration of the sputum extract. From the above results, the koji extract It was confirmed to have a stress reducing effect. In addition, when ⁇ Extract D was administered, it showed a stronger stress reducing effect (corticosterone lowering effect and GOT activity lowering effect) than other fractions ( ⁇ extract B or ⁇ extract C). It was speculated that the main contributing component of the anti-stress effect of Extract A was a component with a molecular weight of 1,000 or less.
  • Experimental example 3 Fatigue recovery effect of various sputum extracts (Recovery of spontaneous momentum after exercise)
  • the fatigue recovery effect was confirmed when sputum extract A was administered.
  • the group to which cocoon extract C molecular weight 1,000 to 6,000 fraction
  • cocoon extract B molecular weight 6, There was no significant recovery of locomotor activity in the group administered 000 or more fractions.
  • the group that received sputum extract D fraction with a molecular weight of 1,000 or less
  • Figures 4A and 4B show the swimming times of the groups administered with various sputum extracts and distilled water.
  • * and ** indicate significant differences from the control group, * indicates p ⁇ 0. 05, and ** indicates p ⁇ 0. 01.
  • sputum extract A As shown in Fig. 4A, anti-fatigue effect (endurance extension effect) was confirmed when sputum extract A was administered.
  • sputum extract B fraction with molecular weight of 6,000 or more
  • sputum extract C molecular weight 000 to 6,000 fraction
  • mice (10 heads in each group) acclimated to swimming in a Kyoto Daimatsumoto-type momentum measuring water tank with a water supply of 8 L / min were treated with cocoon extract A or cocoon extract D prepared in Experimental Example 1. Oral administration was performed using a sonde so that the solid content was 0.86 g / kg body weight. After 1 hour, swimming was started and the limit swimming time was measured. This limit swimming time was used as an index of anti-fatigue effect.
  • Fig. 5 shows the swimming time of the group to which sputum extract A, sputum extract D and distilled water were administered.
  • the anti-fatigue effect (endurance extension effect) was confirmed when sputum extract A was administered even under the condition of 8 L / min of water supply.
  • the group that received sputum extract D (fraction with a molecular weight of 1,00 or less) showed a longer swimming time than the sputum extract A administration group even under this condition. From this result, it is shown that the component with anti-fatigue effect (endurance extension effect) in the low molecular weight fraction contained in strawberry extract A (original extract before fractionation), especially the fraction with a molecular weight of 1,00 or less It was suggested that the group was enriched.
  • cocoon extract A (molecular weight of 1,000 or less fraction) obtained by fractionation under the conditions of fractional molecular weight of 1,00 or less Compared with A, the raw odor and bitterness are somewhat weak, but it is still difficult to ingest as it is.
  • Bile acids have been identified as components that exhibit the bitter taste and raw smell of seafood extracts (Endo et al., “Nutrition and Food” VoL 35, No. 3, 181-187, 1982). Bile acids were analyzed for the purpose of confirming whether or not the raw odor and bitterness of the sample obtained by treatment with activated charcoal in Experiment 6 were reduced. The analysis of bile acids was performed by separating the bile acids by HPLC and then reacting them through an immobilized enzyme column (3-hydroxysteroid dehydrogenase column) (Okuyama, Clinical Pathology Vo 1.29, No. 5). , 446-458, 1981). The analysis results obtained are shown in Table 2 below.
  • cocoon extract A (original extract), cocoon extract E (molecular weight 6, 000 0 or less) and cocoon extract D (molecular weight 1, 000 0 or less) It was also shown that the bile acid content (mo 1 e per 100 g of solid content) decreased by treatment with activated carbon. Also, as the amount of added activated carbon increased, the bile acid content was found to show a low value.
  • cocoon extract D (molecular weight 1, 0 0 0) was compared to the sample obtained by treating activated carbon for cocoon extract A (original extract) and cocoon extract E (molecular weight 6,00 0 or less).
  • the raw odor and bitterness of a 5% solid content solution of a strawberry extract with a bile acid content of 40/1110 16/100 or less in the solid content is “slightly felt”, so it is easy to eat, and
  • the bile acid content per extract solid content is preferably 40 mole / 100 g or less.
  • the raw odor and bitterness of a 5% solids solution of an extract with a bile acid content of 10 ⁇ 1 ⁇ 1 e / 100 g or less are ⁇ not felt at all '', it is easy to eat, has an anti-stress effect, and As a condition of the koji extract having anti-fatigue action, it is considered most preferable that the bile acid content per solid extract is 10 gm 01 eZ 100 g or less.
  • cocoon extract A original extract
  • cocoon extract E molecular weight of 6,000 or less
  • cocoon extract D molecular weight of 1,000 or less
  • “activated carbon V 6” was added to 2% of the liquid volume, mixed and stirred, and then filtered using filter paper “Toyo No. 2” to obtain various activated carbon treated soot extracts.
  • ⁇ Extract A was measured according to the ultrafiltration membrane “Milipore“ PM-5 ”(fractionated molecular weight 5,000)” or Asahi Kasei “Microza UF SEP — 1013” (fractionated molecular weight 3,000).
  • cocoon extract A original extract
  • cocoon extract E molecular weight 6,000 or less
  • cocoon extract D molecular weight of 1,000 or less
  • molecular weight of 3,000 or less both solid 5% solution
  • molecular weight of 5,000 or less were obtained by activated carbon treatment.
  • the extract had almost no bitterness and odor. Since the ratio of the molecular weight fraction of these extracts was 80% or more, the fraction of the molecular weight of 1,000 or less was used in order to reduce bitterness and raw odor by the method described above. 80% or more was considered preferable.
  • Part 1 Preparation of a powdered food composition having anti-stress and anti-fatigue effects
  • diatomaceous earth (“Radiolite # 700" manufactured by Showa Chemical Industry Co., Ltd.) is reduced to 5.0 After adding and mixing so that the content of the solution is 1%, it is filtered using a filter cloth and desalted using an electrodialyzer ("Asalyzer 1" manufactured by Asahi Kasei Co., Ltd.). Extract).
  • the solid content recovery rate of the permeate was measured using Millipore "YM-1 membrane” and found to be 98.0%. Furthermore, as a result of quantifying the bile acid contained in the extract, it was 6.0 mo 1 e (taurocolic acid 6.0 mol) per 100 g of the solid content.
  • Boiled boiled soup produced as a by-product during the production of bonito is heated and concentrated to about Bri x 30 by a conventional method, and then diatomaceous earth (“Radiolite # 700” manufactured by Showa Chemical Industry Co., Ltd.) is reduced to 5.0% of the solid extract After adding and mixing as such, filtration was performed using a filter cloth. 50 kg of this unrefined koji extract (25% solids) was added with 2.5 kg of “activated carbon V6”, stirred at 50 ° C. for 1.5 hours, and filtered using a Phil evening press. An activated carbon treated extract was obtained.
  • the activated charcoal-treated extract thus obtained was fractionated using an ultrafiltration membrane “Pr epZScal e TFF6” (Mi 11 ipore, nominal molecular weight cut off 1,000), and molecular weight less than 1,000. Fraction (solid content 12.0%) 45.0 kg was obtained. With respect to the extract thus obtained, the solid content recovery rate of the permeate was measured using “YM-1 membrane” manufactured by Mi 11 ipore, and found to be 96.8%. Furthermore, as a result of quantifying the bile acids contained in the above extract, 1.4 moles per 100 g of solid content (taurocholic acid 1.4 / mole) Met.
  • Example 3 Preparation of a powdered food composition having anti-stress and anti-fatigue effects (Part 3)
  • the activated charcoal-treated extract thus obtained was fractionated using an ultrafiltration membrane “ROMICON PM-1” (manufactured by Komatsugawa Kako Co., Ltd., nominal molecular weight cut-off 1, 00), and a fraction having a molecular weight of 1,000 or less. 44 to 0 kg was obtained (solid content 12.5%). With respect to the extract thus obtained, the solid content recovery rate of the permeate was measured using “YM-1 membrane” manufactured by Millipore Corporation, and found to be 95.0%. Furthermore, as a result of quantifying the bile acid contained in the above extract, it was 4.5 mo 1 e (taurocholic acid 4.5 mole) per 100 g of solid content.
  • diatomaceous earth (“Radiolite # 700” manufactured by Showa Chemical Industry Co., Ltd.) is 5.0% of the solid extract After adding and mixing so that it became, it filtered using the filter cloth. Add 2.5 kg of “activated carbon V6” to 50 kg of unrefined koji extract (solid content 25%) of this filtrate. The mixture was stirred at C for 1.5 hours and filtered using a filter press to obtain an activated carbon-treated extract.
  • the activated charcoal-treated extract thus obtained was fractionated using an ultrafiltration membrane “Microza UFSEP-1013” (manufactured by Asahi Kasei Co., Ltd., nominal molecular weight 3,000) and having a molecular weight of 3,000 or less. Fraction (solid 15.2%) 45.0 kg was obtained. With respect to the extract thus obtained, the solid content recovery rate of the permeate was measured using Mi 11 ipor “YM-1 membrane” and found to be 82.4%. Furthermore, as a result of quantifying the bile acid contained in the extract, it was 8.2 zmo 1 e (taurocholic acid 8.2 zmole) per 100 g of solid content.
  • diatomaceous earth (“Radiolite # 700" manufactured by Showa Chemical Industry Co., Ltd.) is added to the solid content of 5.0. After adding and mixing so that the content of the solution is 1%, it is filtered using a filter cloth and desalted using an electrodialyzer ("Asalyzer 1" manufactured by Asahi Kasei Co., Ltd.). Extract).
  • Example 8 Preparation of koji extract granules (granular food composition)
  • Example 1 Preparation of jelly-like cocoon extract food (jelly-like food composition)
  • Liquid of koji extract obtained in Example 2 (permeate of ultrafiltration treatment, solid content 12.0%) 50 parts by weight, water 150 parts by weight, aspartame (manufactured by Ajinomoto Co.) To 2 parts by weight and 2.0 parts by weight of sodium glutamate, 4.0 parts by weight of gelatin (manufactured by Nitta Gelatin Co., Ltd.) was added, dissolved by heating, and then filled in 100 g of an aluminum container, then at 10 ° C. 1 5 minutes sterilization under pressure and cooling to obtain a jelly-like koji extract food. The weight of solid content of persimmon extract contained in each food composition was 2.1 g.
  • Example 1 1 Preparation of jelly-like koji extract food (jelly-like food composition)
  • Liquid of koji extract obtained in Example 2 100 parts by weight, water 100 parts by weight, aspartame (manufactured by Ajinomoto Co.) 0.2 parts by weight and sodium glutamate 2.0 parts by weight Add 0.5 parts by weight of gelatin (made by Nitta Gelatin Co., Ltd.), heat-dissolve, fill 100 g in an aluminum container, perform autoclaving at 120 ° C for 15 minutes, cool, A jelly-like koji extract food was obtained. The weight of the solid extract of persimmon extract contained in this food composition was 2.42.
  • Example 12 Preparation of soup-like food composition (liquid food composition)
  • Liquid of koji extract obtained in Example 2 (permeate of ultrafiltration treatment, solid content: 12.0%) 10 kg, concentrated soy sauce 6 kg, and sodium glutamate (“MSG-RC” manufactured by Ajinomoto Co., Inc.) 0 1kg was mixed and dissolved.
  • the liquid thus obtained was heat sterilized at 120 ° C. for 60 seconds, then purged with nitrogen, and aseptically filled into aluminum pouches every 40 g, to obtain the liquid packaged food of the present invention.
  • the weight of solid content of persimmon extract per serving (1 bag) of the obtained food was 2.98 g.
  • the dissolved oxygen concentration of this liquid composition was 0.9 ppm.
  • Example 13 Preparation of a powdered miso soup-like food composition (powdered food composition)
  • Powdered miso soup-like food powder was obtained by mixing 6.0 kg of the koji extract powder obtained in Example 2 and 7.5 kg of powdered miso (manufactured by Hanamaruki). Each 13.5g of this powder was filled into an aluminum pouch to obtain a powdered miso soup-like packaged food. The weight of the koji extract solids contained in one serving of this composition was 3.0.
  • Example 14 Preparation of powder soup-like food composition (powdered food composition)
  • Powder of koji extract obtained in Example 3 1.0 kg, powdered soy sauce (manufactured by Yamasa Co., Ltd.) 2.4 3 ⁇ 4: crushed and mixed 0.7 kg of salt, 0.3 kg of granulated sugar and 0.2 kg of powdered sake A powdered soup-like food was obtained.
  • the powder thus obtained was filled in 23 g each in an aluminum pouch to obtain a packaged powder soup-like food composition.
  • the weight of the solid extract of cocoon extract contained in one meal (1 bag) of this composition was 2.5 g.
  • Example 15 Preparation of a powdered soup-like food composition (powdered food composition)
  • Koji extract powder obtained in Example 2 1.0 kg, onion extract powder (manufactured by Nikken Foods) 0.2 kg, cabbage extract powder 0.1] £, salt 0.5 kg, white paper powder Powdered soup-like food was obtained by grinding 0.02 kg, sodium glutamate (FC) 0.3 kg, granulated sugar 0.3 kg and sodium inosinate (TRI) 0.03 kg. 7.0 g of the powder thus obtained was filled in an aluminum pouch bag to obtain a packaged powder soup-like food composition. In addition, the weight of the solid content of the koji extract contained in one meal (one bag) of this composition was 1.5 g.
  • Food composition with anti-stress action that can prevent or reduce stress-induced conditions such as mental fatigue, mental fatigue or mental failure, or mental instability Things can be provided easily.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Polymers & Plastics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Food Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

L'invention concerne une composition alimentaire qui comporte un extrait purifié dont l'ingrédient actif est un poisson migrateur. L'extrait purifié est produit par la préparation d'un extrait non purifié d'un poisson migrateur, comme la bonite à ventre rayé appartenant à l'ordre Perciformes, au sous-ordre Scombrina, et par le traitement de l'extrait non purifié au moyen d'une membrane d'ultrafiltration membrane dont le poids moléculaire nominal du seuil de coupure est égal ou inférieur à 5 000 et/ou d'une membrane d'osmose inverse dont le coefficient nominal d'interception du sel est égal ou inférieur à 10 %, où l'extrait non purifié est soumis au traitement d'un matériau adsorbant sélectionné à parti de carbone activé, de terre activée et similaire avant et/ou après le traitement au moyen d'une membrane. Dans l'extrait purifié ou dans une partie de celui-ci dont la teneur en constituants aux poids moléculaires égaux ou inférieurs à 1 000 est égale ou supérieure à 80 % du total de la teneur en solides de l'extrait purifié, dont la teneur totale en acide biliaire est égal ou inférieur à 40 μmoles par 100 g de la teneur en solides de l'extrait ou de sa fraction.
PCT/JP2006/317922 2005-09-09 2006-09-04 Composition alimentaire WO2007029834A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP2005262185 2005-09-09
JP2005262184 2005-09-09
JP2005-262184 2005-09-09
JP2005-262185 2005-09-09
JP2005262183 2005-09-09
JP2005-262183 2005-09-09

Publications (1)

Publication Number Publication Date
WO2007029834A1 true WO2007029834A1 (fr) 2007-03-15

Family

ID=37835948

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2006/317922 WO2007029834A1 (fr) 2005-09-09 2006-09-04 Composition alimentaire

Country Status (1)

Country Link
WO (1) WO2007029834A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010094112A (ja) * 2008-10-20 2010-04-30 Ito En Ltd 野菜汁の呈味改善方法及び野菜汁の製造方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0920661A (ja) * 1995-07-04 1997-01-21 Suntory Ltd 学習能力向上組成物
JPH0920660A (ja) * 1995-07-04 1997-01-21 Suntory Ltd 抗ストレス組成物
JPH09252712A (ja) * 1996-03-25 1997-09-30 Kikkoman Corp 濃厚抽出液の製造方法及び装置
JP2001029042A (ja) * 1999-07-19 2001-02-06 Nikken Foods Co Ltd 食用天然カルノシン含有組成物
JP2002173442A (ja) * 2000-12-04 2002-06-21 Yaizu Suisankagaku Industry Co Ltd 抗疲労組成物
JP2002338473A (ja) * 2001-05-15 2002-11-27 Yaizu Suisankagaku Industry Co Ltd 抗疲労組成物
JP2003189825A (ja) * 2001-12-26 2003-07-08 Ajinomoto Co Inc 風味の改善された魚介類エキスおよびその製造方法
WO2004032652A1 (fr) * 2002-10-11 2004-04-22 Ajinomoto Co., Inc. Compositions alimentaires de recuperation de la fatigue

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0920661A (ja) * 1995-07-04 1997-01-21 Suntory Ltd 学習能力向上組成物
JPH0920660A (ja) * 1995-07-04 1997-01-21 Suntory Ltd 抗ストレス組成物
JPH09252712A (ja) * 1996-03-25 1997-09-30 Kikkoman Corp 濃厚抽出液の製造方法及び装置
JP2001029042A (ja) * 1999-07-19 2001-02-06 Nikken Foods Co Ltd 食用天然カルノシン含有組成物
JP2002173442A (ja) * 2000-12-04 2002-06-21 Yaizu Suisankagaku Industry Co Ltd 抗疲労組成物
JP2002338473A (ja) * 2001-05-15 2002-11-27 Yaizu Suisankagaku Industry Co Ltd 抗疲労組成物
JP2003189825A (ja) * 2001-12-26 2003-07-08 Ajinomoto Co Inc 風味の改善された魚介類エキスおよびその製造方法
WO2004032652A1 (fr) * 2002-10-11 2004-04-22 Ajinomoto Co., Inc. Compositions alimentaires de recuperation de la fatigue

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KIKUCHI K. ET AL.: "Katsuo Nijiru kara Erareru Anserine Ganyu Funmatsu, 'Marine Active', no Tokusei to Kino", NEW FOOD INDUSTRY, vol. 43, no. 9, 2001, pages 15 - 20, XP003009728 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010094112A (ja) * 2008-10-20 2010-04-30 Ito En Ltd 野菜汁の呈味改善方法及び野菜汁の製造方法

Similar Documents

Publication Publication Date Title
Jinap et al. Glutamate. Its applications in food and contribution to health
JP6796487B2 (ja) 環状ジペプチド高含有組成物
JP2003235512A (ja) 呈味性が改善されたアミノ酸含有組成物
JP7108521B2 (ja) 体内ｂｄｎｆ量増加促進用組成物
JP4931352B2 (ja) 鉄補給剤及びその利用
JP2006273850A (ja) 血中乳酸値上昇抑制組成物及びそれを含有する飲食品
WO2017026429A1 (fr) Agent favorisant la synthèse du muscle
JP2009286703A (ja) Ｄ−タガトースを有効成分とする体脂肪蓄積改善剤およびメタボリックシンドローム改善剤
JP5224680B2 (ja) 抗疲労剤
JPH04278061A (ja) 栄養食品
JPWO2005087022A1 (ja) 抗ストレス作用を有する食品組成物
JP2009112227A (ja) カプサイシン含有飲料
JP6942113B2 (ja) アミノ酸含有組成物
WO2006115153A1 (fr) Composition alimentaire ayant un effet d'amelioration de l'etat cutane
Datta et al. An overview on monosodium glutamate: Its direct and indirect effects
WO2007029834A1 (fr) Composition alimentaire
JP7044306B2 (ja) ロイシン血中濃度上昇促進剤及びその用途
CN113115883A (zh) 蛋白肽固体饮料及其制备方法和应用
JP2006136262A (ja) 液体調味料
JP2007006874A (ja) 飲食物ベース組成物
JP2006314316A (ja) 液体調味料の製造方法
JP2007228963A (ja) 血流改善作用を有する食品組成物
JP5297867B2 (ja) モロヘイヤ抽出物を含有する抗疲労剤又は体力向上剤
JP4948056B2 (ja) 疲労の予防又は改善剤
JP2006197878A (ja) 血圧降下作用を有する食品組成物

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06797748

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP