WO2007022682A1 - Pièce à valve et tube à valve pour réparer un vaisseau d’écoulement cardiaque - Google Patents

Pièce à valve et tube à valve pour réparer un vaisseau d’écoulement cardiaque Download PDF

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Publication number
WO2007022682A1
WO2007022682A1 PCT/CN2006/001598 CN2006001598W WO2007022682A1 WO 2007022682 A1 WO2007022682 A1 WO 2007022682A1 CN 2006001598 W CN2006001598 W CN 2006001598W WO 2007022682 A1 WO2007022682 A1 WO 2007022682A1
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WIPO (PCT)
Prior art keywords
tube
leaflet
valved
piece
inner liner
Prior art date
Application number
PCT/CN2006/001598
Other languages
English (en)
French (fr)
Inventor
Lei Jin
Original Assignee
Beijing Balance Medical Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CNB2005100826741A external-priority patent/CN100346754C/zh
Priority claimed from CNB2005100826737A external-priority patent/CN100405991C/zh
Application filed by Beijing Balance Medical Co. Ltd. filed Critical Beijing Balance Medical Co. Ltd.
Priority to EP06761373A priority Critical patent/EP1913899B1/en
Priority to JP2008519783A priority patent/JP4558075B2/ja
Priority to DE602006017383T priority patent/DE602006017383D1/de
Priority to US11/995,106 priority patent/US8267994B2/en
Publication of WO2007022682A1 publication Critical patent/WO2007022682A1/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2415—Manufacturing methods

Definitions

  • the present invention relates to a prosthetic device for modifying or reconstructing an abnormal cardiac outflow tract, and more particularly to a valved patch for widening the heart outflow and a valved tube for replacing the entire main and pulmonary valve.
  • the second of congenital purpuric heart disease is pulmonary dysplasia, which requires reconstruction of the pulmonary artery with a pulmonary valve.
  • this type of surgery can be used: 1 Allogeneic aortic valve with a valve, but due to limited source of the same material There are many problems in storage and transportation; 2 porcine aortic valve and an artificial blood vessel; or 3 artificial mechanical valve and an artificial blood vessel.
  • the durability of the porcine aortic valve which is prone to fatigue and calcification, has been a concern, and the lifelong anticoagulation of mechanical flaps and the inevitable anticoagulant-related complications have not been well resolved.
  • the object of the present invention is to solve the deficiencies in the prior art and to provide a belt for widening the outflow tract of the heart.
  • the valve patch which has a widened outflow tract, better solves the reflux caused by pulmonary regurgitation, and more importantly, the leaflet of the patch can not only significantly improve the blood flow of the postoperative patient.
  • the unique structure gives the artificial leaflets excellent fatigue resistance and significantly improves the long-term quality of life of postoperative patients.
  • the present invention also provides a valved duct having good performance. Summary of the invention
  • a flap patch for repairing a heart outflow tract comprising an inner liner sheet, an outer liner support sheet and a leaflet, the inner liner sheet having an approximately semi-circular arc slit, the leaflet leaf
  • the edge slit is disposed between the inner liner sheet and the outer liner support sheet, and a natural petal pocket is formed between the upper edge of the leaflet and the inner liner sheet, and the suture line lining the edge along the slit edge of the inner liner sheet,
  • the lower edge of the leaflet and the outer lining support piece are sutured together, and the lower edge of the leaflet is fixed between the inner lining piece and the outer lining support piece.
  • the patch for repairing the heart is a single layer structure having only the inner liner from the upper portion of the upper edge of the leaflet; the inner liner is extended by 3.5 to 8.5 cm along the upper edge of the leaflet, and the outer liner is supported.
  • the inner lining piece Sewing together with the inner lining piece at the upper edge of the leaflet, the inner lining piece and the outer lining support piece extending downward along the lower edge of the leaflet by 1.5 to 6.5 cm; the inner lining piece, the leaflet leaflet and the outer lining support piece
  • the inner lining piece, the leaflet leaflet and the outer lining support piece The same tissue piece or the chemically modified heterogeneous tissue piece; the chemically modified heterogeneous tissue piece is an anti-calcification modified bovine pericardial piece; the lower edge of the leaflet is placed on the inner lining piece A portion of the portion between the outer liner and the outer support sheet is cut to make the lower edge of the leaflet smoother.
  • the utility model relates to a valved pipe for repairing a heart outflow tract, wherein the valved pipe is composed of an inner liner tube, three leaflets and an outer lining support tube, and the inner liner tube wall is provided with three approximately semicircular arc slits in a circumferential direction.
  • the lower edges of the three leaflets are respectively disposed between the inner liner tube and the outer liner support tube along three slits, and the suture line is along the edge of the inner liner tube slit, the inner liner tube, the three leaflet peripheral portions and the outer portion.
  • the lining support tube is sutured and fixed together, so that the upper edges of the three leaflets are symmetrically and smoothly aligned in the inner liner tube, and the inner liner tube and the outer lining support tube of the valved tube extend to the non-supported flap.
  • Lower pipe
  • the inner liner tube, the leaflet and the outer liner support tube are the same tissue piece or the chemically modified heterogeneous tissue piece; the chemically modified heterogeneous tissue piece is treated by anti-calcification modification a bovine pericardium; a portion of the periphery of the leaflet disposed between the inner and outer liners is cut with a plurality of slits to make the fixation suture more flat; the upper tube is a portion of the inner liner extending upward along the leaflet, without the stent
  • the under-valve tube is a portion of the inner liner tube and the outer liner support tube extending along the lower arc of the leaflet; the outer liner support tube is also sleeved with a rigid support structure made of medical polymer material or metal material.
  • the present invention for repairing a cardiac outflow tract with a valved patch and a valved valve leaflet sewed together with a lining piece/tube and an outer lining support piece/tube, and the lower edge of the leaflet is located in the lining piece/tube and outer Between the support piece/tube, the leaflet is not only fixed by the suture, so that the leaflet is firmer and can significantly improve the long-term therapeutic effect of the patient.
  • the part around the lower edge of the leaflet of the inner lining piece/tube and the outer lining support piece/tube has several incisions, which can make the suture more Leveling reduces stress concentration.
  • the leaflets and linings are treated with anti-calcification, which can effectively prevent premature calcification of the leaflets and linings.
  • valved patch and the valved tube are single layer above the upper edge of the leaflet, without the outer support piece/tube, which is easier to suture out of the channel.
  • repair the heart with a valve patch from the upper edge of the leaflet is a double layer, and the outer lining support tube has a rigid support structure, can be used to strengthen the right ventricle, to eliminate the right ventricular contraction is easy to appear abnormal move.
  • FIG. 1 is a schematic view showing an inner liner of a flap with a patch according to an embodiment of the present invention
  • FIG. 2 is a front elevational view showing a flap patch according to Embodiment 1 of the present invention.
  • FIG. 3 is a schematic structural view of a flapped patch according to Embodiment 1 of the present invention.
  • FIG. 4 is a schematic view showing the unfolding of the inner liner of the valved pipe according to the second embodiment of the present invention
  • Figure 5 is a schematic view showing the development of a valved tube according to Embodiment 2 of the present invention.
  • Figure 6 is a perspective view of a valved tube according to Embodiment 2 of the present invention.
  • Figure 7 is a schematic cross-sectional view of the A-A in Figure 5. detailed description
  • the embodiment of the present invention repairs a valved patch for a cardiac outflow tract comprising an inner lining piece 1, an outer lining support piece 2 and a leaflet 3 which are cut from a chemically modified bovine pericardium sheet.
  • the inner lining sheet 1 is cut with a semi-circular slit 4 (see FIG. 1), and the lower edge of the leaflet 3 is inserted between the inner lining sheet 1 and the outer lining support sheet 2 along the slit 4, and the leaflets 3 has a space between the inner lining sheet 1 and a petal pocket, and the inner lining sheet 1, the outer lining support sheet 2 and the leaflets 3 are sewn together by stitches 6 along the both edges of the slit 4.
  • the two slits 5 are cut in the lower edge portion between the inner lining sheet 1 and the outer lining support sheet 2, which can also effectively reduce stress concentration.
  • the valved patch is a single layer from the upper edge of the upper edge of the leaflet 3, has only the inner liner 1 and has a length of about 3.5 to 8.5 cm, and the patch is double-layered from the upper edge of the upper edge of the leaflet 3.
  • the inner lining piece 1 is simply cut into a desired shape, placed in the defect portion of the outflow tract, and sewn together with the outflow tract, which greatly saves the operation time. Since the leaflets 3 are placed between the inner liner and the outer liner support sheets, the connection is firmer, and the impact resistance to blood can be greatly enhanced.
  • the valved tubing for repairing the cardiac outflow tract comprises a liner tube piece 7 made of a chemically modified bovine pericardium sheet, an outer liner support tube piece 8 and three pieces.
  • the leaflet 9, which is unfolded in Fig. 4, is cut into three semicircular arc-shaped slits 10 side by side on the inner liner piece 7, and the lower edge of the leaflet 9 is passed along the slit 10 through the inner liner piece 7 and the outer lining
  • the inner circumference of the circular tube inner liner 7 is exactly the sum of the lengths of the upper edges of the three leaflets 9, and the three leaflets 9 and the inner liner 7 are no longer attached. Closed, is on.
  • the inner liner tube 7 and the outer liner support tube 8 of the valved pipe extend with upper and lower pipes 12, 13, and the lower pipe 13 is an extension of the inner liner pipe 7 and the outer liner support pipe 8 along the lower edge of the valve leaflet, generally l ⁇ 2cm, the upper pipe 6 is an extension of the inner liner 1 along the upper edge of the leaflet, generally 8 ⁇ 10cm, and the outer liner support tube 8 is sutured at the upper edge of the leaflet 9 with the inner liner 7 through the suture 11 together.
  • a support mesh made of medical polymer material or metal material may be disposed on the bellows pipe jacket.
  • the portion of the lower channel of the valved tube of the embodiment of the present invention can be matched with the outlet of the right heart outflow channel, and the valved tube is placed on the valved tube.
  • the tubing portion is anastomosed to the pulmonary artery trunk to complete the placement of the artificial valved tubing.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Prostheses (AREA)

Description

修复心脏流出道用带瓣补片和带瓣管道 技术领域
本发明涉及改建或重构异常心脏流出道的修补器械， 特别涉及用于加宽心脏流 出道的带瓣补片和用于置换整个主、 肺动脉瓣的带瓣管道。 背景技术
用人造器官替代发生病变的心脏组织是治疗先天性心脏病的常用治疗方法。 以先天性紫绀型心脏病为例， 其病变之一是其右室流道狭窄， 心外科医生通常 需要采用自体心包片或用牛心包补片作为修补材料以加宽或重建流出道， 然而， 多 数患者因伴有肺动脉瓣关闭不全或无肺动脉瓣而导致右心负荷加重， 极大地影响了 患者术后治疗效果， 为此， 某些心外科医生不得不在手术过程中自行于补片材料上 缝上一个瓣叶， 此举虽能改善术后效果但因牢固性有限， 或材料发生钙化等导致长 期结果不能令人满意。 此外， 也有部分有条件的医生采用同种异体主动脉瓣或同种 异体肺动脉瓣， 作为右室流出道修补或替代。 虽然可以收到较好临床效果， 但因同 种材料的来源有限， 其储存、 运输都存在诸多问题。
先天性紫绀型心脏病病变之二是肺动脉发育不良， 需要重建带有肺动脉瓣的肺 动脉管道， 通常这类手术中可使用： ①同种异体主动脉带瓣管道， 但因同种材料的 来源有限， 其储存、 运输都存在诸多问题； ②猪主动脉瓣和一段人工血管； 或③人 工机械瓣和一段人工血管。猪主动脉瓣其瓣叶组织易发生疲劳和钙化其耐久性一直 令人担忧， 而机械瓣需要终身抗凝以及不可避免的抗凝相关并发症至今未能得到很 好的解决。 发明目的
本项发明的目的是解决现有技术中的不足， 提供一种用于加宽心脏流出道的带 瓣补片， 这种带瓣补片在加宽流出道的同时较好地解决肺动脉瓣关闭不全所引起的 返流， 更重要的是补片的瓣叶不仅可以明显改善术后患者血流动力学， 同时， 特有 的结构所赋予人工瓣叶具有极好的耐疲劳性， 显著提高术后患者远期生活质量。 依 据与这种带瓣补片类 的缝制结构， 本发明还提供了一种性能良好的带瓣管道。 发明内容
为达到发明目的， 本发明所釆取的技术方案是：
一种修复心脏流出道用带瓣补片， 所述带瓣补片包括内衬片、 外衬支撑片和 瓣叶， 所述内衬片上具有一个近似半圆弧形狭缝， 所述瓣叶下缘沿狭缝穿设于内衬 片与外衬支撑片之间， 且瓣叶上沿与内衬片之间构成一个自然的瓣兜， 缝线沿内衬 片狭缝边缘将内衬片、 瓣叶下缘和外衬支撑片三者缝合在一起， 瓣叶下缘被固定在 内衬片、 外衬支撑片之间。
其中， 所述修复心脏用带瓣补片自瓣叶上缘以上部分为只具有内衬片的单层结 构； 所述内衬片沿瓣叶上缘上延 3.5〜8.5cm， 外衬支撑片与内衬片于瓣叶上缘处缝 合在一起， 所述内衬片和外衬支撑片沿瓣叶下缘向下延长 1.5〜6.5cm; 所述内衬片、 瓣叶和外衬支撑片为同种组织片或经化学改性处理的异种组织片； 所述经化学改性 处理的异种组织片为经抗钙化改性处理的牛心包片； 所述瓣叶下缘置于内衬片和外 衬支撑片之间的部分切有数个切口， 以使瓣叶下缘缝合更加平整。
一种修复心脏流出道用带瓣管道， 所述带瓣管道由内衬管、 三片瓣叶和外衬支 撑管构成， 内衬管壁周向一圈设有三个近似半圆弧形狭缝， 所述三片瓣叶下缘分别 沿三个狭缝穿设于内衬管与外衬支撑管之间， 缝线沿内衬管狭缝边缘将内衬管、 三 片瓣叶周边部分和外衬支撑管缝合固定在一起， 使三片瓣叶的上沿对称、 平整地对 合于内衬管内， 所述带瓣管道的内衬管、 外衬支撑管两端延伸为无支架瓣上、 下管 道。 其中， 所述内衬管、 瓣叶和外衬支撑管为同种组织片或经化学改性处理的异种 组织片； 所述经化学改性处理的异种组织片为经抗钙化改性处理的牛心包片； 所述 瓣叶周边置于内、 外衬管之间的部分切有数个切口， 以使固定缝合更加平整； 所述 上管道为内衬管沿瓣叶向上延伸的部分， 无支架瓣下管道为内衬管和外衬支撑管沿 瓣叶下弧延伸的部分； 所述外衬支撑管外还套设由医用高分子材料或金属材料制成 的刚性支撑结构。
本发明所能产生的有益效果是：
1、 本发明修复心脏流出道用带瓣补片和带瓣管道的瓣叶与内衬片 /管和外衬支 撑片 /管缝合在一起， 且瓣叶下缘位于内衬片 /管和外衬支撑片 /管之间， 免除了仅靠 缝线固定瓣叶， 使瓣叶的牢固性更好， 可以显著提高患者术后远期治疗效果。
2、 瓣叶与内衬片 /管和外衬支撑片 /管缝合时， 夹于内衬片 /管和外衬支撑片 /管 的瓣叶下缘周边的部分有数个切口， 可使缝合更平整， 减少了应力集中现象。
3、 瓣叶与内衬片均经过抗钙化处理， 可有效地防止瓣叶和内衬片过早发生钙 化。
4、 带瓣补片和带瓣管道自瓣叶上缘以上部分为单层， 无外衬支撑片 /管， 更加 易于流出道的缝合。
5、 修复心脏用带瓣补片自瓣叶上缘以下的部分为双层， 且外衬支撑管外具有 刚性支撑结构， 可以有针对加固右心室， 以消除右室收缩时易出现的反常博动。 附图说明
图 1为本发明实施例 1带瓣补片的内衬片示意图；
图 2为本发明实施例 1带瓣补片的正面示意图；
图 3为本发明实施例 1带瓣补片的结构示意图
图 4为本发明实施例 2带瓣管道内衬管展开示意图； 图 5为本发明实施例 2带瓣管道展开示意图；
图 6为本发明实施例 2带瓣管道立体图；
图 7为图 5中 A— A截面示意图。 具体实施方式
实施例 1
参阅图 2、 图 3， 本发明实施例修复心脏流出道用带瓣补片包括由经过化学改性 处理的牛心包片裁切制成的内衬片 1、 外衬支撑片 2和瓣叶 3， 内衬片 1上裁切有一半 圆弧形的狭缝 4 (参阅图 1 )， 瓣叶 3的下缘沿狭缝 4塞于内衬片 1、 外衬支撑片 2之间， 且瓣叶 3与内衬片 1之间具有一定的空间， 形成一瓣兜， 内衬片 1、 外衬支撑片 2和瓣 叶 3通过沿狭缝 4的两边缘的缝线 6缝合在一起。为使缝合平整，在瓣叶 3置于内衬片 1、 外衬支撑片 2之间的下缘部分， 裁切两个切口 5， 这样也可以有效地减少应力集中现 象。通常，带瓣补片自瓣叶 3上缘以上部分为单层，只具有内衬片 1，且长度约为 3.5〜 8.5cm, 补片自瓣叶 3上缘以下的部分均为双层， 具有内衬片 1和外衬支撑片 2， 其长 度约为 1.5〜6.5cm。
手术过程中， 只需将内衬片 1裁成所需形状， 置于流出道缺损部分， 并与流出 道缝合在一起， 大大节约了手术时间。 由于瓣叶 3置于内衬片、 外衬支撑片之间， 连接更为牢固， 可大大加强对血液的抗冲击能力。
实施例 2
参阅图 4、 图 5， 本发明实施例修复心脏流出道用带瓣管道包括由经过化学改 性处理的牛心包片裁切制成的内衬管片 7、 外衬支撑管片 8和三片瓣叶 9， 其展开 图 4中， 内衬管片 7上并排裁切有三个半圆弧形的狭缝 10， 瓣叶 9的下缘沿狭缝 10穿设于内衬管片 7和外衬管支撑片 8之间，且瓣叶 9贴合于内衬管片 7上， 内衬 管片 7、 外衬支撑管片 8和瓣叶 9通过沿狭缝 10的两边缘的缝线 11缝合在一起。 参阅图 5、 图 6、 图 7， 带瓣管道， 圆管形内衬管 7内径周长恰好为三个瓣叶 9上缘 长度之和， 三片瓣叶 9与内衬管 7不再贴合， 处于开启状态。 带瓣管道的内衬管 7 和外衬支撑管 8两端延伸有上、 下管道 12、 13， 下管道 13为内衬管 7和外衬支撑 管 8沿瓣叶下缘延长部分， 一般为 l〜2cm， 上管道 6为内衬管 1沿瓣叶上边缘延 长部分，一般为 8〜10cm，且外衬支撑管 8于瓣叶 9上缘处与内衬管 7通过缝线 11 缝合在一起。 瓣叶与内衬管、 外衬支撑管缝合时， 夹于内衬管、 外衬支撑管的瓣叶 下缘周边的部分有数个切口， 可使缝合更平整， 减少了应力集中现象。
手术过程中， 只需将瓣下管道 13边缘与右室流出道出口吻合， 瓣上管道与肺 动脉干吻合。 由于瓣叶 9置于内衬管与外衬支持管之间， 连接平整、 牢固， 可大大 增强抗血液冲击的能力。 为了加强带瓣管道的刚性， 在带瓣管道较长时， 可以在带 瓣管道外套设一医用高分子材料或金属材料制成的支撑网。
此外， 在 Ross手术中， 将肺动脉瓣连同部分肺动脉一起植入到主动脉瓣位置 后， 可以将本发明实施例的带瓣管道下管道部分与右心流出道出口吻合， 而将带瓣 管道上管道部分与肺动脉主干吻合以完成人工带瓣管道的置入。

Claims

权利要求
1、 一种修复心脏流出道用带瓣补片， 其特征在于： 所述带瓣补片包括内衬片、 外衬支撑片和瓣叶， 所述内衬片上具有一个近似半圆弧形狭缝， 所述瓣叶下缘沿狭 缝穿设于内衬片与外衬支撑片之间，且瓣叶上沿与内衬片之间构成一个自然的瓣兜， 缝线沿内衬片狭缝边缘将内衬片、 瓣叶下缘和外衬支撑片三者缝合在一起， 瓣叶下 缘被固定在内衬片、 外衬支撑片之间。
2、 根据权利要求 1所述的一种修复心脏流出道用带瓣补片， 其特征在于： 所 述修复心脏用带瓣补片自瓣叶上缘以上部分为只具有内衬片的单层结构。
3、 根据权利要求 1或 2所述的一种修复心脏流出道用带瓣补片， 其特征在于： 所述内衬片沿瓣叶上缘延设 3.5〜8.5cm， 外衬支撑片与内衬片于瓣叶上缘处缝合在 一起， 所述内衬片、 外衬支撑片沿瓣叶下缘延设 1.5〜6.5cm。
4、 根据权利要求 1 所述的一种修复心脏流出道用带瓣补片， 其特征在于： 所 述内衬片、 瓣叶和外衬支撑片为同种组织片或经化学改性处理的异种组织片。
5、 根据权利要求 1所述的一种修复心脏流出道用带瓣补片， 其特征在于： 所 述经化学改性处理的异种组织片为经抗钙化改性处理的牛心包片。
6、 根据权利要求 1所述的一种修复心脏流出道用带瓣补片， 其特征在于： 所 述瓣叶下缘置于内衬片、 外衬支撑片之间的部分切有数个切口， 以使瓣叶下缘缝合 更加平整。
7、 一种修复心脏流出道用带瓣管道， 其特征在于： 所述带瓣管道由内衬管、 三片瓣叶和外衬支撑管构成， 内衬管壁周向一圈设有三个近似半圆弧形狭缝， 所述 三片瓣叶下缘分别沿三个狭缝穿设于内衬管与外衬支撑管之间， 缝线沿内衬管狭缝 边缘将内衬管、 三片瓣叶周边部分和外衬支撑管缝合固定在一起， 使三片瓣叶的上 沿对称、 平整地对合于内衬管内， 所述带瓣管道的内衬管、 外衬支撑管两端延伸为 上管道和下管道。
8、 根据权利要求 7所述的一种修复心脏流出道用带瓣管道， 其特征在于： 所 述内衬管、 瓣叶和外衬支撑管为同种组织片或经化学改性处理的异种组织片。
9、 根据权利要求 8所述的一种修复心脏流出道用带瓣管道， 其特征在于： 所 述经化学改性处理的异种组织片为经抗钙化改性处理的牛心包片。
10、 根据权利要求 7所述的一种修复心脏流出道用带瓣管道， 其特征在于： 所 述瓣叶周边置于内、 外衬管之间的部分切有数个切口， 以使固定缝合更加平整。
11、 根据权利要求 7所述的一种修复心脏流出道用带瓣管道， 其特征在于： 所 述上管道为内衬管沿瓣叶向上延伸的部分， 下管道为内衬管和外衬支撑管沿瓣叶下 弧延伸的部分。
12、 根据权利要求 7所述的一种修复心脏流出道用带瓣管道， 其特征在于： 所 述外衬支撑管外还套设由医用高分子材料或金属材料制成的刚性支撑结构。
PCT/CN2006/001598 2005-07-08 2006-07-07 Pièce à valve et tube à valve pour réparer un vaisseau d’écoulement cardiaque WO2007022682A1 (fr)

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EP06761373A EP1913899B1 (en) 2005-07-08 2006-07-07 A valved patch and a valved tube for repairing a cardiac outflow vessel
JP2008519783A JP4558075B2 (ja) 2005-07-08 2006-07-07 心臓の流出路の修復に用いられる弁付きパッチおよび弁付きチューブ
DE602006017383T DE602006017383D1 (de) 2005-07-08 2006-07-07 Klappenstück und schlauch mit ventilklappe zur rep
US11/995,106 US8267994B2 (en) 2005-07-08 2006-07-07 Mono cusped patch and valved conduit for repairing cardiac outflow tract

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CNB2005100826741A CN100346754C (zh) 2005-07-08 2005-07-08 无支架人工生物瓣
CN200510082673.7 2005-07-08
CN200510082674.1 2005-07-08
CNB2005100826737A CN100405991C (zh) 2005-07-08 2005-07-08 心脏流出道带瓣补片

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106473840A (zh) * 2016-12-07 2017-03-08 复旦大学附属儿科医院 手工缝制带瓣外管道及该管道缝制用的模具和缝制方法

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8556960B2 (en) * 2008-11-06 2013-10-15 Cook Medical Technologies Llc Frameless vascular valve
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US10507101B2 (en) 2014-10-13 2019-12-17 W. L. Gore & Associates, Inc. Valved conduit
EP3310267A4 (en) * 2015-12-15 2019-07-31 Meril Life Sciences Pvt Ltd SINGLE TISSUE SHEETS OF A PROSTHETIC VALVE
CN108882981B (zh) 2016-01-29 2021-08-10 内奥瓦斯克迪亚拉公司 用于防止流出阻塞的假体瓣膜
WO2018090148A1 (en) 2016-11-21 2018-05-24 Neovasc Tiara Inc. Methods and systems for rapid retraction of a transcatheter heart valve delivery system
US11523940B2 (en) 2017-03-17 2022-12-13 W. L. Gore & Associates, Inc. Delivery aids for glaucoma shunts
CA3073834A1 (en) 2017-08-25 2019-02-28 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
CA3078607C (en) 2017-10-31 2022-07-26 W.L. Gore & Associates, Inc. Valved conduit
USD977642S1 (en) 2018-10-29 2023-02-07 W. L. Gore & Associates, Inc. Pulmonary valve conduit
US11737872B2 (en) 2018-11-08 2023-08-29 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
US11678983B2 (en) 2018-12-12 2023-06-20 W. L. Gore & Associates, Inc. Implantable component with socket
CA3135753C (en) 2019-04-01 2023-10-24 Neovasc Tiara Inc. Controllably deployable prosthetic valve
EP3952792A4 (en) 2019-04-10 2023-01-04 Neovasc Tiara Inc. HEART VALVE PROSTHESIS WITH NATURAL BLOOD FLOW
AU2020279750B2 (en) 2019-05-20 2023-07-13 Neovasc Tiara Inc. Introducer with hemostasis mechanism
AU2020295566B2 (en) 2019-06-20 2023-07-20 Neovasc Tiara Inc. Low profile prosthetic mitral valve

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5509930A (en) * 1993-12-17 1996-04-23 Autogenics Stentless heart valve
WO2000023008A2 (en) * 1998-10-20 2000-04-27 Tissue Engineering, Inc. Cardiovascular components for transplantation and methods of making thereof
US20020072794A1 (en) 2000-12-11 2002-06-13 Shlomo Gabbay Implantable patch prosthesis having one or more cusps for improved competency and method for using same
US20020091441A1 (en) 2001-01-05 2002-07-11 Guzik Donald S. Focused beam cutting of materials
WO2002087474A1 (en) 2001-05-01 2002-11-07 Imperial Medical Devices Limited Valve prosthesis
US6733525B2 (en) * 2001-03-23 2004-05-11 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of use

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK229077A (da) * 1977-05-25 1978-11-26 Biocoating Aps Hjerteklapprotese samt fremgangsmaade til fremstilling heraf
CH672247A5 (zh) * 1986-03-06 1989-11-15 Mo Vysshee Tekhnicheskoe Uchil
US5545215A (en) * 1994-09-14 1996-08-13 Duran; Carlos G. External sigmoid valve complex frame and valved conduit supported by the same
US20030032102A1 (en) * 1997-09-18 2003-02-13 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
US5925063A (en) * 1997-09-26 1999-07-20 Khosravi; Farhad Coiled sheet valve, filter or occlusive device and methods of use
JP4230118B2 (ja) * 1999-01-26 2009-02-25 エドワーズ ライフサイエンシーズ コーポレイション 可撓性心臓弁
US6602286B1 (en) * 2000-10-26 2003-08-05 Ernst Peter Strecker Implantable valve system
US6936067B2 (en) * 2001-05-17 2005-08-30 St. Jude Medical Inc. Prosthetic heart valve with slit stent

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5509930A (en) * 1993-12-17 1996-04-23 Autogenics Stentless heart valve
WO2000023008A2 (en) * 1998-10-20 2000-04-27 Tissue Engineering, Inc. Cardiovascular components for transplantation and methods of making thereof
US20020072794A1 (en) 2000-12-11 2002-06-13 Shlomo Gabbay Implantable patch prosthesis having one or more cusps for improved competency and method for using same
US20020091441A1 (en) 2001-01-05 2002-07-11 Guzik Donald S. Focused beam cutting of materials
US6733525B2 (en) * 2001-03-23 2004-05-11 Edwards Lifesciences Corporation Rolled minimally-invasive heart valves and methods of use
WO2002087474A1 (en) 2001-05-01 2002-11-07 Imperial Medical Devices Limited Valve prosthesis

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1913899A4

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106473840A (zh) * 2016-12-07 2017-03-08 复旦大学附属儿科医院 手工缝制带瓣外管道及该管道缝制用的模具和缝制方法

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EP1913899A1 (en) 2008-04-23
JP2009500088A (ja) 2009-01-08

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