WO2007017895A3 - Compositions pharmaceutiques stabilisees de cephalosporines - Google Patents
Compositions pharmaceutiques stabilisees de cephalosporines Download PDFInfo
- Publication number
- WO2007017895A3 WO2007017895A3 PCT/IN2006/000160 IN2006000160W WO2007017895A3 WO 2007017895 A3 WO2007017895 A3 WO 2007017895A3 IN 2006000160 W IN2006000160 W IN 2006000160W WO 2007017895 A3 WO2007017895 A3 WO 2007017895A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cephalosporin
- oral pharmaceutical
- stability
- pharmaceutical compositions
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne des compositions pharmaceutiques orales de céphalosporines, et notamment du cefpodoxime, un procédé pour leur préparation et un procédé destiné à renforcer la stabilité de ces compositions pharmaceutiques orales. La composition pharmaceutique orale d'une céphalosporine est stable et présente une biodisponibilité adéquate, et comprend une céphalosporine ainsi que de l'amidon de maïs. Le procédé de préparation d'une composition pharmaceutique orale d'une céphalosporine consiste à réduire la taille de la céphalosporine et à la mélanger avec de l'amidon de maïs et un ou plusieurs excipients. Le procédé destiné à renforcer le profil de stabilité d'une céphalosporine dans une composition pharmaceutique consiste à mettre la céphalosporine en contact avec une dose renforçant la stabilité d'amidon de maïs présentant une teneur en humidité inférieure ou égale à 2 %. La suspension orale présente un profil de stabilité amélioré par comparaison avec une composition pharmaceutique en suspension orale comprenant ladite céphalosporine mais ne contenant pas d'amidon de maïs en dose renforçant la stabilité.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008509579A JP2008540403A (ja) | 2005-05-05 | 2006-05-05 | セファロスポリンの安定化経口用医薬組成物 |
EP06809918A EP1883393A2 (fr) | 2005-05-05 | 2006-05-05 | Compositions pharmaceutiques stabilisees de cephalosporines |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN556/MUM/2005 | 2005-05-05 | ||
IN556MU2005 | 2005-05-05 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2007017895A2 WO2007017895A2 (fr) | 2007-02-15 |
WO2007017895A3 true WO2007017895A3 (fr) | 2007-04-19 |
Family
ID=37672426
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IN2006/000160 WO2007017895A2 (fr) | 2005-05-05 | 2006-05-05 | Compositions pharmaceutiques stabilisees de cephalosporines |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1883393A2 (fr) |
JP (1) | JP2008540403A (fr) |
WO (1) | WO2007017895A2 (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TR201007107A1 (tr) * | 2010-08-25 | 2012-03-21 | Bi̇lgi̇ç Mahmut | Tat düzenleyici ajan içeren sefpodoksim proksetil formülasyonları. |
TR201007106A1 (tr) * | 2010-08-25 | 2012-03-21 | Bi̇lgi̇ç Mahmut | Sefpodoksim proksetil formülasyonları. |
TR201009167A2 (tr) * | 2010-11-05 | 2012-05-21 | Bi̇lgi̇ç Mahmut | Sefalosporin içeren farmasötik granüller. |
TR201009168A2 (tr) * | 2010-11-05 | 2012-05-21 | Bi̇lgi̇ç Mahmut | Suda dağılan sefpodoksim proksetil formülasyonları. |
JP2013147488A (ja) * | 2011-12-21 | 2013-08-01 | Taisho Pharmaceutical Co Ltd | 固形製剤 |
JP6449873B2 (ja) * | 2013-07-18 | 2019-01-09 | サンド・アクチエンゲゼルシヤフト | 抗生物質のドライシロップ製剤用の粉末混合物 |
CN103479589B (zh) * | 2013-09-22 | 2016-04-13 | 海南葫芦娃制药有限公司 | 头孢泊肟酯分散片及其制备方法 |
WO2017046756A1 (fr) * | 2015-09-18 | 2017-03-23 | Lupin Limited | Esters de céfixime proxétil et axétil |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1132583A (en) * | 1964-12-16 | 1968-11-06 | Glaxo Lab Ltd | Pharmaceutical compositions containing cephalosporins |
US3931404A (en) * | 1972-12-06 | 1976-01-06 | Hoechst Aktiengesellschaft | High dosage orally administrable cephalosporin antibiotic preparations |
US3945994A (en) * | 1973-02-08 | 1976-03-23 | Gist-Brocades N.V. | Novel acid compounds |
WO2002067943A1 (fr) * | 2001-02-27 | 2002-09-06 | Ranbaxy Laboratories Limited | Composition pharmaceutique orale de cefpodoxime-proxetil |
WO2004022727A1 (fr) * | 2002-09-06 | 2004-03-18 | Vri Biomedical Ltd | Bacterie probiotique : lactobacillus fermentum |
-
2006
- 2006-05-05 WO PCT/IN2006/000160 patent/WO2007017895A2/fr not_active Application Discontinuation
- 2006-05-05 EP EP06809918A patent/EP1883393A2/fr not_active Withdrawn
- 2006-05-05 JP JP2008509579A patent/JP2008540403A/ja not_active Withdrawn
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1132583A (en) * | 1964-12-16 | 1968-11-06 | Glaxo Lab Ltd | Pharmaceutical compositions containing cephalosporins |
US3931404A (en) * | 1972-12-06 | 1976-01-06 | Hoechst Aktiengesellschaft | High dosage orally administrable cephalosporin antibiotic preparations |
US3945994A (en) * | 1973-02-08 | 1976-03-23 | Gist-Brocades N.V. | Novel acid compounds |
WO2002067943A1 (fr) * | 2001-02-27 | 2002-09-06 | Ranbaxy Laboratories Limited | Composition pharmaceutique orale de cefpodoxime-proxetil |
WO2004022727A1 (fr) * | 2002-09-06 | 2004-03-18 | Vri Biomedical Ltd | Bacterie probiotique : lactobacillus fermentum |
Also Published As
Publication number | Publication date |
---|---|
JP2008540403A (ja) | 2008-11-20 |
WO2007017895A2 (fr) | 2007-02-15 |
EP1883393A2 (fr) | 2008-02-06 |
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