WO2006127967A3 - Multifocal scanning microscopy systems and methods - Google Patents

Multifocal scanning microscopy systems and methods Download PDF

Info

Publication number
WO2006127967A3
WO2006127967A3 PCT/US2006/020372 US2006020372W WO2006127967A3 WO 2006127967 A3 WO2006127967 A3 WO 2006127967A3 US 2006020372 W US2006020372 W US 2006020372W WO 2006127967 A3 WO2006127967 A3 WO 2006127967A3
Authority
WO
WIPO (PCT)
Prior art keywords
mapmt
raster
specimen
methods
mmm
Prior art date
Application number
PCT/US2006/020372
Other languages
French (fr)
Other versions
WO2006127967A2 (en
Inventor
Karsten Bahlman
Ki-Hean Kim
Timothy Ragan
Peter T C So
Original Assignee
Massachusetts Inst Technology
Karsten Bahlman
Ki-Hean Kim
Timothy Ragan
Peter T C So
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Karsten Bahlman, Ki-Hean Kim, Timothy Ragan, Peter T C So filed Critical Massachusetts Inst Technology
Priority to EP06784478A priority Critical patent/EP1889111A2/en
Publication of WO2006127967A2 publication Critical patent/WO2006127967A2/en
Publication of WO2006127967A3 publication Critical patent/WO2006127967A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0052—Optical details of the image generation
    • G02B21/0076—Optical details of the image generation arrangements using fluorescence or luminescence
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/16—Microscopes adapted for ultraviolet illumination ; Fluorescence microscopes

Abstract

In the systems and methods of the present invention a multifocal multiphoton imaging system has a signal to noise ratio (SNR) that is reduced by over an order of magnitude at imaging depth equal to twice the mean free path scattering length of the specimen. An MMM (multi-photon multi-focal microscopy) system based on an area detector (120A) such as a multianode photomultiplier tube (MAPMT) that is optimized for high- speed tissue imaging. The specimen (105A) is raster- scanned with an array (151A,152A) of excitation light beams. The emission photons from the array of excitation foci are collected simultaneously by a MAPMT and the signals from each anode are detected using high sensitivity, low noise single photon counting circuits. An image is formed by the temporal encoding of the integrated signal with a raster scanning pattern. A deconvolution procedure taking account of the spatial distribution and the raster temporal encoding of collected photons can be used to improve decay coefficient . We demonstrate MAPMT-based MMM can provide significantly better contrast than CCD- based existing systems.
PCT/US2006/020372 2005-05-25 2006-05-25 Multifocal scanning microscopy systems and methods WO2006127967A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP06784478A EP1889111A2 (en) 2005-05-25 2006-05-25 Multifocal imaging systems and methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68460805P 2005-05-25 2005-05-25
US60/684,608 2005-05-25

Publications (2)

Publication Number Publication Date
WO2006127967A2 WO2006127967A2 (en) 2006-11-30
WO2006127967A3 true WO2006127967A3 (en) 2007-03-08

Family

ID=37075066

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/020372 WO2006127967A2 (en) 2005-05-25 2006-05-25 Multifocal scanning microscopy systems and methods

Country Status (3)

Country Link
US (2) US20070057211A1 (en)
EP (2) EP2703871A3 (en)
WO (1) WO2006127967A2 (en)

Families Citing this family (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7352029B2 (en) * 2005-04-27 2008-04-01 International Business Machines Corporation Electronically scannable multiplexing device
US20070057211A1 (en) 2005-05-25 2007-03-15 Karsten Bahlman Multifocal imaging systems and method
US7602488B2 (en) * 2006-06-12 2009-10-13 Neptec Optical Solutions, Inc. High-speed, rugged, time-resolved, raman spectrometer for sensing multiple components of a sample
WO2008104913A1 (en) * 2007-02-26 2008-09-04 Koninklijke Philips Electronics N.V. Method and device for optical analysis of a tissue
US20080262484A1 (en) * 2007-04-23 2008-10-23 Nlight Photonics Corporation Motion-controlled laser surface treatment apparatus
US20100167413A1 (en) * 2007-05-10 2010-07-01 Paul Lundquist Methods and systems for analyzing fluorescent materials with reduced autofluorescence
US7714303B2 (en) * 2007-05-10 2010-05-11 Pacific Biosciences Of California, Inc. Methods and systems for analyzing fluorescent materials with reduced authofluorescence
US20080277595A1 (en) * 2007-05-10 2008-11-13 Pacific Biosciences Of California, Inc. Highly multiplexed confocal detection systems and methods of using same
EP2150806A4 (en) * 2007-05-10 2013-01-02 Pacific Biosciences California Methods and systems for analyzing fluorescent materials with reduced autofluorescence
US8068899B2 (en) 2007-07-03 2011-11-29 The Board Of Trustees Of The Leland Stanford Junior University Method and system of using intrinsic-based photosensing with high-speed line scanning for characterization of biological thick tissue including muscle
US7566173B2 (en) * 2007-07-09 2009-07-28 Alcon, Inc. Multi-spot ophthalmic laser probe
US8105233B2 (en) * 2007-10-24 2012-01-31 Tarek Ahmed Nabil Abou El Kheir Endoscopic system and method for therapeutic applications and obtaining 3-dimensional human vision simulated imaging with real dynamic convergence
US8149319B2 (en) * 2007-12-03 2012-04-03 Ricoh Co., Ltd. End-to-end design of electro-optic imaging systems for color-correlated objects
US8594455B2 (en) * 2011-09-28 2013-11-26 The United States Of America As Represented By The Secretary Of The Army System and method for image enhancement and improvement
US20090185734A1 (en) * 2008-01-18 2009-07-23 Hemocue Ab Apparatus and method for analysis of particles in a liquid sample
US7943889B2 (en) * 2008-03-21 2011-05-17 Prairie Technologies, Inc. Apparatus for improving detection efficiency of multiphoton microscopy systems by focus compensation, pupil image division, and parallel pupil rearrangement
WO2009121067A1 (en) * 2008-03-28 2009-10-01 Volcano Corporation Method and apparatus for simultaneous hemoglobin reflectivity measurement
US8368897B2 (en) * 2008-08-22 2013-02-05 Ciencia, Inc. Versatile surface plasmon resonance analyzer with an integral surface plasmon resonance enhanced fluorescence mode
EP2340429B1 (en) 2008-10-14 2022-08-24 Tissuevision, Inc. Devices and methods for direct sampling analog time-resolved detection
EP2380038B1 (en) * 2008-12-22 2019-01-09 Koninklijke Philips N.V. Cmos imager
DE102009013147A1 (en) * 2009-03-05 2010-09-16 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for spectroscopy analysis e.g. Raman-spectroscopy, of surface or volume section of sample e.g. biological cell, in measuring arrangement, involves integrating radiations registered in focus volume over duration of measuring interval
EP2411818B1 (en) * 2009-03-23 2017-12-13 Neaspec GmbH Near field optical microscope
JP5727468B2 (en) * 2009-06-01 2015-06-03 バイオ−ラッド ラボラトリーズ，インコーポレイティド Calibration of imaging devices for biological / chemical samples
DE102009029831A1 (en) * 2009-06-17 2011-01-13 W.O.M. World Of Medicine Ag Apparatus and method for multi-photon fluorescence microscopy for obtaining information from biological tissue
JP2011022131A (en) * 2009-06-18 2011-02-03 Olympus Corp Medical diagnosis support device, image processing method, image processing program, and virtual microscope system
EP2454569B1 (en) * 2009-07-10 2014-12-24 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Emission detection for multi-photon microscopy
WO2011056658A1 (en) * 2009-10-27 2011-05-12 Duke University Multi-photon microscopy via air interface objective lens
WO2011066065A1 (en) * 2009-11-24 2011-06-03 Alcon Research, Ltd. Single-fiber multi-spot laser probe for ophthalmic endoillumination
JP5809163B2 (en) * 2009-12-15 2015-11-10 アルコン リサーチ， リミテッド Multi-spot laser probe
GB201001051D0 (en) 2010-01-22 2010-03-10 Fianium Ltd Optical sources
US8687055B2 (en) * 2010-03-16 2014-04-01 Eli Margalith Spectral imaging of moving objects with a stare down camera
US9529128B2 (en) * 2010-04-26 2016-12-27 Hewlett Packard Enterprise Development Lp Non-uniform grating
GB201007055D0 (en) * 2010-04-28 2010-06-09 Vib Vzw Method and apparatus for the imaging of a labelled sample
US8957956B2 (en) * 2010-06-09 2015-02-17 Honeywell International Inc. Method and system for iris image capture
US8903192B2 (en) 2010-10-14 2014-12-02 Massachusetts Institute Of Technology Noise reduction of imaging data
US8842168B2 (en) * 2010-10-29 2014-09-23 Sony Corporation Multi-view video and still 3D capture system
US8771978B2 (en) 2010-11-15 2014-07-08 Tissuevision, Inc. Systems and methods for imaging and processing tissue
JP5776992B2 (en) * 2010-11-22 2015-09-09 マックス−プランク−ゲゼルシャフト ツル フォルデルング デル ヴィッゼンシャフテン イー．ヴイ． STED microscopy, STED fluorescence correlation spectroscopy, and STED fluorescence microscope for pulse excitation, continuous deexcitation, and gate recording of spontaneous emission fluorescence
US20120257037A1 (en) * 2011-04-07 2012-10-11 Valerica Raicu High speed microscope with two-stage scanning for detection of rarities in samples
CA2832162C (en) * 2011-04-08 2019-05-14 British Columbia Cancer Agency Branch Apparatus and methods for multiphoton microscopy
DE102011105181A1 (en) * 2011-06-17 2012-12-20 Leica Microsystems Cms Gmbh Microscope and method for imaging fluorescence microscopy
US9095414B2 (en) * 2011-06-24 2015-08-04 The Regents Of The University Of California Nonlinear optical photodynamic therapy (NLO-PDT) of the cornea
WO2013103475A2 (en) * 2011-12-09 2013-07-11 Massachusetts Institute Of Technology Portable optical fiber probe-based spectroscopic scanner for rapid cancer diagnosis
US8520219B2 (en) * 2011-12-19 2013-08-27 Perceptron, Inc. Non-contact sensor having improved laser spot
DE102012201003A1 (en) * 2012-01-24 2013-07-25 Carl Zeiss Microscopy Gmbh Microscope and method for high-resolution 3-D fluorescence microscopy
TW201433296A (en) * 2013-02-21 2014-09-01 Univ Nat Taiwan A method for the observation, identification, and detection of blood cells
WO2013131062A1 (en) * 2012-03-02 2013-09-06 The Regents Of The University Of California System and method for time-resolved fluorescence imaging and pulse shaping
DE102012203736A1 (en) 2012-03-09 2013-09-12 Carl Zeiss Microscopy Gmbh Scanning microscope with spectral detection
DE102012204128B4 (en) * 2012-03-15 2023-11-16 Carl Zeiss Microscopy Gmbh High-resolution scanning microscopy
CN102798849B (en) * 2012-08-14 2014-03-26 中国科学院光电技术研究所 Method for eliminating spot centroid shift due to crosstalk
JP2014090401A (en) * 2012-10-05 2014-05-15 Canon Inc Imaging system and control method of the same
WO2014085911A1 (en) 2012-12-05 2014-06-12 Tornado Medical Systems, Inc. System and method for wide field oct imaging
US10245181B2 (en) 2012-12-21 2019-04-02 Alcon Research, Ltd. Grin fiber multi-spot laser probe
WO2014134314A1 (en) * 2013-03-01 2014-09-04 The Johns Hopkins University Light sources, medical devices, and methods of illuminating an object of interest
DE102013019348A1 (en) * 2013-08-15 2015-02-19 Carl Zeiss Microscopy Gmbh High-resolution scanning microscopy
DE102013019347A1 (en) * 2013-08-15 2015-02-19 Carl Zeiss Microscopy Gmbh High-resolution scanning microscopy
DE102013015933A1 (en) * 2013-09-19 2015-03-19 Carl Zeiss Microscopy Gmbh High-resolution scanning microscopy
DE102013015932A1 (en) * 2013-09-19 2015-03-19 Carl Zeiss Microscopy Gmbh High-resolution scanning microscopy
JP6203022B2 (en) * 2013-12-04 2017-09-27 オリンパス株式会社 Scanning microscope
US9820652B2 (en) 2013-12-09 2017-11-21 The Board Of Trustees Of The Leland Stanford Junior University Multi-photon microscope having an excitation-beam array
WO2015100421A1 (en) * 2013-12-24 2015-07-02 Tissuevision, Inc. Multi-foci multiphoton imaging systems and methods
US10083507B2 (en) 2014-04-07 2018-09-25 Mimo Ag Method for the analysis of image data representing a three-dimensional volume of biological tissue
EP3132073B1 (en) 2014-04-14 2021-06-30 SRI International Portable nucleic acid analysis system and high-performance microfluidic electroactive polymer actuators
WO2015160844A1 (en) * 2014-04-17 2015-10-22 The Regents Of The University Of California Parallel acquisition of spectral signals from a 2-d laser beam array
DE102014105759A1 (en) * 2014-04-24 2015-10-29 Sick Ag Camera and method for detecting a moving stream of objects
US9282237B2 (en) 2014-07-17 2016-03-08 Schlage Lock Company Llc Multifocal iris recognition device
US9844314B2 (en) * 2014-07-28 2017-12-19 Novartis Ag Increased depth of field microscope and associated devices, systems, and methods
US10261298B1 (en) * 2014-12-09 2019-04-16 The Board Of Trustees Of The Leland Stanford Junior University Near-infrared-II confocal microscope and methods of use
WO2016106350A1 (en) 2014-12-23 2016-06-30 Bribbla Dynamics Llc Confocal inspection system having non-overlapping annular illumination and collection regions
WO2016109355A1 (en) 2014-12-23 2016-07-07 Bribbla Dynamics Llc Optical inspection system and method including accounting for variations of optical path length within a sample
US10718931B2 (en) 2014-12-23 2020-07-21 Apple Inc. Confocal inspection system having averaged illumination and averaged collection paths
JP6300739B2 (en) * 2015-01-20 2018-03-28 浜松ホトニクス株式会社 Image acquisition apparatus and image acquisition method
JP6539052B2 (en) 2015-01-20 2019-07-03 浜松ホトニクス株式会社 Image acquisition apparatus and image acquisition method
FR3032528A1 (en) * 2015-02-06 2016-08-12 Commissariat Energie Atomique METHOD FOR CORRECTING A RETROFILE SIGNAL BY A SAMPLE AND ASSOCIATED DEVICE
CN111855621B (en) 2015-02-24 2023-11-10 国立大学法人东京大学 Dynamic high-speed high-sensitivity imaging device and imaging method
US10788403B2 (en) 2015-03-11 2020-09-29 Tissuevision, Inc. Systems and methods for serial staining and imaging
WO2016189522A1 (en) 2015-05-28 2016-12-01 Leukodx, Ltd. System and apparatus for blind deconvolution of flow cytometer particle emission
JP6891130B2 (en) * 2015-06-02 2021-06-18 ライフ テクノロジーズ コーポレーション Systems and methods for generating structured lighting images
EP4148416A1 (en) 2015-09-01 2023-03-15 Apple Inc. System for taking a measurement and method for taking a measurement of a sample using a device
DE102015217908A1 (en) * 2015-09-18 2017-03-23 Robert Bosch Gmbh lidar
US9992477B2 (en) 2015-09-24 2018-06-05 Ouster, Inc. Optical system for collecting distance information within a field
DE102015116598A1 (en) 2015-09-30 2017-03-30 Carl Zeiss Microscopy Gmbh Method and microscope for high-resolution imaging by means of SIM
WO2017073737A1 (en) 2015-10-28 2017-05-04 国立大学法人東京大学 Analysis device
WO2020206362A1 (en) * 2019-04-04 2020-10-08 Inscopix, Inc. Multi-modal microscopic imaging
US10386300B2 (en) * 2015-12-21 2019-08-20 Verily Life Sciences Llc Spectrally and spatially multiplexed fluorescent probes for in situ cell labeling
JP7245051B2 (en) 2016-03-08 2023-03-23 エンスペクトラ・ヘルス・インコーポレイテッド Non-invasive detection of skin diseases
JP6722883B2 (en) 2016-04-01 2020-07-15 国立大学法人浜松医科大学 Image acquisition apparatus and image acquisition method
WO2017184420A1 (en) * 2016-04-21 2017-10-26 Bribbla Dynamics Llc Optical system for reference switching
WO2017192896A1 (en) * 2016-05-06 2017-11-09 Uwm Research Foundation, Inc. Snapshot optical tomography system and method of acquiring an image with the system
EP4160319A1 (en) 2016-08-15 2023-04-05 Osaka University Electromagnetic wave phase/amplitude generation device, electromagnetic wave phase/amplitude generation method, and electromagnetic wave phase/amplitude generation program
DE102016119730A1 (en) 2016-10-17 2018-04-19 Carl Zeiss Microscopy Gmbh Optical group for detection light for a microscope, method for microscopy and microscope
US20190301980A1 (en) 2016-11-18 2019-10-03 Tissuevision, Inc. Automated tissue section capture, indexing and storage system and methods
IT201600117339A1 (en) * 2016-11-21 2018-05-21 Crestoptics S P A APPARATUS AS A SUPER-RESOLUTION FOR FLUORESCENT ANALYSIS OF THE EYE BACKGROUND
GB201701691D0 (en) * 2017-02-01 2017-03-15 Illumina Inc System and method with reflective fiducials
US11896944B2 (en) 2017-02-01 2024-02-13 Illumina, Inc. System and method with fiducials responding to multiple excitation frequencies
GB201701688D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials in non-recliner layouts
GB201701689D0 (en) 2017-02-01 2017-03-15 Illumia Inc System and method with fiducials of non-closed shapes
GB201701686D0 (en) 2017-02-01 2017-03-15 Illunina Inc System & method with fiducials having offset layouts
US10473766B2 (en) * 2017-03-13 2019-11-12 The Charles Stark Draper Laboratory, Inc. Light detection and ranging (LiDAR) system and method
WO2018201082A1 (en) 2017-04-28 2018-11-01 Zebra Medical Technologies, Inc. Systems and methods for imaging and measurement of sarcomeres
US10481385B2 (en) * 2017-05-11 2019-11-19 Kaiser Optical Systems Inc. Endoscopic immersion probe end optics for laser spectroscopy
GB2563435A (en) * 2017-06-16 2018-12-19 The Univ Court Of The Univ Of St Andrews Three-photon light sheet imaging
US11169092B2 (en) * 2017-07-11 2021-11-09 Hamamatsu Photonics K.K. Sample observation device and sample observation method
EP3655748B1 (en) 2017-07-18 2023-08-09 Perimeter Medical Imaging, Inc. Sample container for stabilizing and aligning excised biological tissue samples for ex vivo analysis
EP3688446A2 (en) 2017-09-29 2020-08-05 Apple Inc. Resolve path optical sampling architectures
US11041756B2 (en) * 2017-10-20 2021-06-22 Charted Scientific Inc. Method and apparatus of filtering light using a spectrometer enhanced with additional spectral filters with optical analysis of fluorescence and scattered light from particles suspended in a liquid medium using confocal and non confocal illumination and imaging
JP7287961B2 (en) * 2017-12-12 2023-06-06 アレン インスティテュート System, apparatus and method for simultaneous multi-plane imaging
WO2019118582A2 (en) * 2017-12-12 2019-06-20 Trustees Of Boston University Multi-z confocal imaging system
EP3731726A4 (en) 2017-12-27 2021-10-27 Ethicon LLC Hyperspectral imaging in a light deficient environment
WO2019148024A1 (en) 2018-01-26 2019-08-01 Park Jong Kang Systems and methods to reduce scattering in temporal focusing multiphoton microscopy
GB201804951D0 (en) * 2018-03-27 2018-05-09 Pxyl Ltd Improved non-linear optical microscope
JP7078815B2 (en) * 2018-03-28 2022-06-01 秀和 三村 X-ray imaging method and X-ray imaging device
JP7369385B2 (en) 2018-06-13 2023-10-26 シンクサイト株式会社 Methods and systems for cytometry
JP6953632B2 (en) * 2018-07-09 2021-10-27 オリンパス株式会社 Optical analyzers, optical analysis methods and trained models
DE102018216370B4 (en) * 2018-09-25 2020-06-18 Siemens Healthcare Gmbh Providing an annotated medical image data set for radiotherapy planning of a patient
CN109557653B (en) * 2018-12-20 2021-06-29 浙江大学 Differential confocal microscopic imaging method and device based on algorithm recovery
CN109668869A (en) * 2018-12-28 2019-04-23 中国科学院长春光学精密机械与物理研究所 A kind of hand-held reflection Confocal laser-scanning microscopy detection device
CN109656014B (en) * 2019-01-31 2024-03-19 北京超维景生物科技有限公司 Multipath fluorescence collection device and three-dimensional nonlinear laser scanning cavity endoscope
US11516374B2 (en) 2019-06-05 2022-11-29 Synaptics Incorporated Under-display image sensor
US11280675B2 (en) 2019-06-18 2022-03-22 Ruolin Li Method, system and apparatus for a Raman spectroscopic measurement system
KR20220024561A (en) 2019-06-19 2022-03-03 라이프 테크놀로지스 홀딩스 프리베이트 리미티드 Biological Analysis Devices and Systems
US11925328B2 (en) 2019-06-20 2024-03-12 Cilag Gmbh International Noise aware edge enhancement in a pulsed hyperspectral imaging system
US11432706B2 (en) 2019-06-20 2022-09-06 Cilag Gmbh International Hyperspectral imaging with minimal area monolithic image sensor
US11412152B2 (en) 2019-06-20 2022-08-09 Cilag Gmbh International Speckle removal in a pulsed hyperspectral imaging system
US11700995B2 (en) 2019-06-20 2023-07-18 Cilag Gmbh International Speckle removal in a pulsed fluorescence imaging system
US11540696B2 (en) 2019-06-20 2023-01-03 Cilag Gmbh International Noise aware edge enhancement in a pulsed fluorescence imaging system
US11550057B2 (en) 2019-06-20 2023-01-10 Cilag Gmbh International Offset illumination of a scene using multiple emitters in a fluorescence imaging system
US11903563B2 (en) 2019-06-20 2024-02-20 Cilag Gmbh International Offset illumination of a scene using multiple emitters in a fluorescence imaging system
US11516388B2 (en) 2019-06-20 2022-11-29 Cilag Gmbh International Pulsed illumination in a fluorescence imaging system
US20200397246A1 (en) 2019-06-20 2020-12-24 Ethicon Llc Minimizing image sensor input/output in a pulsed hyperspectral, fluorescence, and laser mapping imaging system
US11937784B2 (en) 2019-06-20 2024-03-26 Cilag Gmbh International Fluorescence imaging in a light deficient environment
US10841504B1 (en) 2019-06-20 2020-11-17 Ethicon Llc Fluorescence imaging with minimal area monolithic image sensor
US11291358B2 (en) 2019-06-20 2022-04-05 Cilag Gmbh International Fluorescence videostroboscopy of vocal cords
US11076747B2 (en) 2019-06-20 2021-08-03 Cilag Gmbh International Driving light emissions according to a jitter specification in a laser mapping imaging system
US11237270B2 (en) 2019-06-20 2022-02-01 Cilag Gmbh International Hyperspectral, fluorescence, and laser mapping imaging with fixed pattern noise cancellation
US11213194B2 (en) 2019-06-20 2022-01-04 Cilag Gmbh International Optical fiber waveguide in an endoscopic system for hyperspectral, fluorescence, and laser mapping imaging
US11398011B2 (en) 2019-06-20 2022-07-26 Cilag Gmbh International Super resolution and color motion artifact correction in a pulsed laser mapping imaging system
US11931009B2 (en) 2019-06-20 2024-03-19 Cilag Gmbh International Offset illumination of a scene using multiple emitters in a hyperspectral imaging system
US11898909B2 (en) 2019-06-20 2024-02-13 Cilag Gmbh International Noise aware edge enhancement in a pulsed fluorescence imaging system
US20200397239A1 (en) 2019-06-20 2020-12-24 Ethicon Llc Offset illumination of a scene using multiple emitters in a fluorescence imaging system
US11674848B2 (en) 2019-06-20 2023-06-13 Cilag Gmbh International Wide dynamic range using a monochrome image sensor for hyperspectral imaging
US11533417B2 (en) 2019-06-20 2022-12-20 Cilag Gmbh International Laser scanning and tool tracking imaging in a light deficient environment
US11716543B2 (en) 2019-06-20 2023-08-01 Cilag Gmbh International Wide dynamic range using a monochrome image sensor for fluorescence imaging
US11622094B2 (en) 2019-06-20 2023-04-04 Cilag Gmbh International Wide dynamic range using a monochrome image sensor for fluorescence imaging
US11471055B2 (en) 2019-06-20 2022-10-18 Cilag Gmbh International Noise aware edge enhancement in a pulsed fluorescence imaging system
US11187658B2 (en) 2019-06-20 2021-11-30 Cilag Gmbh International Fluorescence imaging with fixed pattern noise cancellation
US11671691B2 (en) 2019-06-20 2023-06-06 Cilag Gmbh International Image rotation in an endoscopic laser mapping imaging system
US11793399B2 (en) 2019-06-20 2023-10-24 Cilag Gmbh International Super resolution and color motion artifact correction in a pulsed hyperspectral imaging system
US11758256B2 (en) 2019-06-20 2023-09-12 Cilag Gmbh International Fluorescence imaging in a light deficient environment
US11147436B2 (en) 2019-06-20 2021-10-19 Cilag Gmbh International Image rotation in an endoscopic fluorescence imaging system
US11633089B2 (en) 2019-06-20 2023-04-25 Cilag Gmbh International Fluorescence imaging with minimal area monolithic image sensor
US11412920B2 (en) 2019-06-20 2022-08-16 Cilag Gmbh International Speckle removal in a pulsed fluorescence imaging system
US11624830B2 (en) 2019-06-20 2023-04-11 Cilag Gmbh International Wide dynamic range using a monochrome image sensor for laser mapping imaging
US11389066B2 (en) 2019-06-20 2022-07-19 Cilag Gmbh International Noise aware edge enhancement in a pulsed hyperspectral, fluorescence, and laser mapping imaging system
US11360028B2 (en) 2019-06-20 2022-06-14 Cilag Gmbh International Super resolution and color motion artifact correction in a pulsed hyperspectral, fluorescence, and laser mapping imaging system
US11284785B2 (en) 2019-06-20 2022-03-29 Cilag Gmbh International Controlling integral energy of a laser pulse in a hyperspectral, fluorescence, and laser mapping imaging system
CN110441311B (en) * 2019-07-22 2021-10-08 中国科学院上海光学精密机械研究所 Multi-axis and multi-focus lens for multi-object plane imaging
US11153513B2 (en) * 2019-08-19 2021-10-19 Synaptics Incorporated Light source for camera
WO2021076148A1 (en) * 2019-10-18 2021-04-22 Google Llc Diffractive optical elements for large-field image display
DE102019129932B4 (en) * 2019-11-06 2023-12-21 Technische Universität Braunschweig Optical detection device and method for operating an optical detection device
US11076080B2 (en) 2019-12-05 2021-07-27 Synaptics Incorporated Under-display image sensor for eye tracking
CN111693545B (en) * 2020-06-02 2022-12-13 哈尔滨工程大学 Composite structure array probe for testing lath and optical fiber white light interference device
CN112051247B (en) * 2020-08-21 2022-10-18 杭州电子科技大学 Lens-free imaging device based on laminated imaging and phase recovery method thereof
KR20230043191A (en) 2020-09-09 2023-03-30 애플 인크. Optical system for noise mitigation
WO2022056385A1 (en) 2020-09-14 2022-03-17 Singular Genomics Systems, Inc. Methods and systems for multidimensional imaging
US20220139743A1 (en) * 2020-11-04 2022-05-05 Tokyo Electron Limited Optical Sensor for Inspecting Pattern Collapse Defects
CN113126205B (en) * 2021-04-20 2022-08-02 电子科技大学 Sectional type plane imaging system and method based on optical switch
CN113390850B (en) * 2021-06-02 2022-06-21 复旦大学 Gastric Raman femtosecond picosecond image mapping method based on U-shaped convolution neural network
CN113624666B (en) 2021-09-07 2022-09-23 清华大学 Stream type imaging system based on dot matrix laser scanning
FR3127048A1 (en) * 2021-09-10 2023-03-17 Universite de Bordeaux Optical microscope and method for high resolution optical microscopy with increased field of view
CN113820035B (en) * 2021-09-28 2023-09-15 应急管理部天津消防研究所 Femtosecond laser filament remote non-contact temperature measurement device and measurement method
WO2023211772A1 (en) * 2022-04-25 2023-11-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Lens array based imaging system with improved field of view
US20230371813A1 (en) * 2022-05-17 2023-11-23 EyeQ Technologies, Inc. Three-dimensional ocular endoscope device and methods of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6028306A (en) * 1997-05-14 2000-02-22 Olympus Optical Co., Ltd. Scanning microscope
US20040125372A1 (en) * 2002-10-17 2004-07-01 Walla Peter Jomo Multi-parameter fluorimetric analysis in a massively parallel multi-focal arrangement and the use thereof

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4960330A (en) 1985-07-16 1990-10-02 Kerschmann Russell L Image recording apparatus
IL88359A (en) 1988-11-10 1993-06-10 Cubital Ltd Method and apparatus for volumetric digitization of 3-dimensional objects
JP2659429B2 (en) * 1989-03-17 1997-09-30 株式会社日立製作所 Photoacoustic signal detection method and apparatus, and semiconductor element internal defect detection method
US5109149A (en) * 1990-03-15 1992-04-28 Albert Leung Laser, direct-write integrated circuit production system
US5156019A (en) 1990-11-19 1992-10-20 Mccormick James B Frozen tissue sectioning apparatus and method
US5233197A (en) * 1991-07-15 1993-08-03 University Of Massachusetts Medical Center High speed digital imaging microscope
JP3343276B2 (en) * 1993-04-15 2002-11-11 興和株式会社 Laser scanning optical microscope
FR2705917B1 (en) 1993-06-02 1995-09-08 Tabone Herve Aspiration microtome, especially for histological and similar work.
EP0627643B1 (en) * 1993-06-03 1999-05-06 Hamamatsu Photonics K.K. Laser scanning optical system using axicon
US5483055A (en) * 1994-01-18 1996-01-09 Thompson; Timothy V. Method and apparatus for performing an automatic focus operation for a microscope
US5633695A (en) * 1995-08-14 1997-05-27 Canon Kabushiki Kaisha Beam steering optical system and method and ophthalmic apparatus using same having spaced apart irradiation and observation paths
WO1998002851A1 (en) 1996-07-12 1998-01-22 Advanced Pathology Systems, Inc. Image recording with optical sectioning
US6020591A (en) * 1997-07-11 2000-02-01 Imra America, Inc. Two-photon microscopy with plane wave illumination
US6248988B1 (en) * 1998-05-05 2001-06-19 Kla-Tencor Corporation Conventional and confocal multi-spot scanning optical microscope
US6603537B1 (en) 1998-08-21 2003-08-05 Surromed, Inc. Optical architectures for microvolume laser-scanning cytometers
US6392795B2 (en) * 1998-08-28 2002-05-21 Olympus Optical Co., Ltd. Microscope with a dynamic damper
JP3099063B2 (en) 1998-12-28 2000-10-16 大阪大学長 Multiphoton microscope
DE19904592C2 (en) 1999-02-05 2001-03-08 Lavision Gmbh Beam splitter device
JP2000292705A (en) 1999-04-05 2000-10-20 Olympus Optical Co Ltd Scanning microscope
US6387653B1 (en) 1999-04-09 2002-05-14 Culterra, Llc Apparatus and method for automatically producing tissue slides
US6449039B1 (en) * 1999-07-28 2002-09-10 Thermo Noran Inc. Laser scanning fluorescence microscopy with compensation for spatial dispersion of fast laser pulses
US7217573B1 (en) * 1999-10-05 2007-05-15 Hitachi, Ltd. Method of inspecting a DNA chip
US7003143B1 (en) 1999-11-02 2006-02-21 Hewitt Charles W Tomographic microscope for high resolution imaging and method of analyzing specimens
US6623977B1 (en) * 1999-11-05 2003-09-23 Real-Time Analyzers, Inc. Material for surface-enhanced Raman spectroscopy, and SER sensors and method for preparing same
AU2839601A (en) 1999-12-02 2001-06-12 Evotec Oai Ag High rate screening method and device for optically detecting samples
AU782452B2 (en) 1999-12-13 2005-07-28 Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The High-throughput tissue microarray technology and applications
US6423960B1 (en) 1999-12-31 2002-07-23 Leica Microsystems Heidelberg Gmbh Method and system for processing scan-data from a confocal microscope
US7127573B1 (en) * 2000-05-04 2006-10-24 Advanced Micro Devices, Inc. Memory controller providing multiple power modes for accessing memory devices by reordering memory transactions
US7209287B2 (en) * 2000-09-18 2007-04-24 Vincent Lauer Confocal optical scanning device
AU2002232892B2 (en) 2000-10-24 2008-06-26 Intrexon Corporation Method and device for selectively targeting cells within a three -dimensional specimen
JP2004515779A (en) * 2000-12-15 2004-05-27 ザ ジェネラル ホスピタル コーポレーション Indirect imaging
US7110118B2 (en) 2000-12-19 2006-09-19 Trustees Of Boston University Spectral imaging for vertical sectioning
US7274446B2 (en) 2001-04-07 2007-09-25 Carl Zeiss Jena Gmbh Method and arrangement for the deep resolved optical recording of a sample
DE10118355B4 (en) 2001-04-12 2005-07-21 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Method and apparatus for multiphoton excitation of a sample
US7155076B2 (en) * 2001-06-15 2006-12-26 The Regents Of The University Of California Target molecules detection by waveguiding in a photonic silicon membrane
US6785432B2 (en) * 2001-06-15 2004-08-31 The Regents Of The University Of California Target molecules detection by waveguiding in a photonic silicon membrane
DE10151217B4 (en) 2001-10-16 2012-05-16 Carl Zeiss Microlmaging Gmbh Method for operating a laser scanning microscope
EP1461592B1 (en) 2001-12-05 2019-04-10 The J. David Gladstone Institutes Robotic microscopy systems
JP4632634B2 (en) * 2002-03-27 2011-02-16 オリンパス株式会社 Confocal microscope apparatus and observation method using confocal microscope apparatus
US7738945B2 (en) 2002-04-19 2010-06-15 University Of Washington Method and apparatus for pseudo-projection formation for optical tomography
US7197193B2 (en) 2002-05-03 2007-03-27 Creatv Microtech, Inc. Apparatus and method for three dimensional image reconstruction
AU2003272667A1 (en) * 2002-09-26 2004-04-19 Bio Techplex Corporation Method and apparatus for screening using a waveform modulated led
US7038848B2 (en) 2002-12-27 2006-05-02 Olympus Corporation Confocal microscope
JP4239166B2 (en) * 2002-12-27 2009-03-18 関西ティー・エル・オー株式会社 Multilayer observation type optical microscope and multilayer observation unit
DE10300091A1 (en) 2003-01-04 2004-07-29 Lubatschowski, Holger, Dr. microtome
WO2004070653A2 (en) * 2003-01-31 2004-08-19 Discovery Partners International Image analysis system and method
GB0308852D0 (en) * 2003-04-16 2003-05-21 Lingvitae As Method
DE10327531B4 (en) * 2003-06-17 2006-11-30 Leica Microsystems Cms Gmbh Method for measuring fluorescence correlations in the presence of slow signal fluctuations
DE10327486B4 (en) * 2003-06-17 2006-07-20 Leica Microsystems Cms Gmbh Device for determining directional transport processes
JP2005017127A (en) 2003-06-26 2005-01-20 Institute Of Physical & Chemical Research Interferometer and shape measuring system
DE10335471A1 (en) * 2003-08-02 2005-03-03 Leica Microsystems Heidelberg Gmbh Detector and method for detecting weak fluorescent radiation with a microscope system
US7372985B2 (en) 2003-08-15 2008-05-13 Massachusetts Institute Of Technology Systems and methods for volumetric tissue scanning microscopy
EP1656680B1 (en) * 2003-08-22 2010-09-15 SECRETARY, DEPARTMENT OF ATOMIC ENERGY, Government of India Apparatus and method for transport of microscopic object(s)
EP2259050A3 (en) 2003-08-26 2010-12-22 Blueshift Biotechnologies, Inc. Time dependent fluorescence measurements
DE10339311B4 (en) * 2003-08-27 2006-04-27 Leica Microsystems Cms Gmbh System and method for setting a fluorescence spectral measurement system for microscopy
US20060211752A1 (en) 2004-03-16 2006-09-21 Kohn Leonard D Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression
JP4593141B2 (en) 2004-03-26 2010-12-08 オリンパス株式会社 Optical scanning observation device
DE602005007403D1 (en) 2004-03-25 2008-07-24 Olympus Corp Scanning confocal microscope
US7170675B2 (en) * 2004-05-19 2007-01-30 Celloptic, Inc. Method and system for wide-field multi-photon microscopy having a confocal excitation plane
US7919325B2 (en) * 2004-05-24 2011-04-05 Authentix, Inc. Method and apparatus for monitoring liquid for the presence of an additive
WO2005123909A2 (en) 2004-06-09 2005-12-29 The Board Of Trustees Of The Leland Stanford Junior University Isolation and characterization of muscle regenerating cells
US7677289B2 (en) 2004-07-08 2010-03-16 President And Fellows Of Harvard College Methods and apparatuses for the automated production, collection, handling, and imaging of large numbers of serial tissue sections
DE102004034970A1 (en) 2004-07-16 2006-02-02 Carl Zeiss Jena Gmbh Scanning microscope and use
DE102004034962A1 (en) * 2004-07-16 2006-02-16 Carl Zeiss Jena Gmbh Microscope with increased resolution
EP1789828B1 (en) * 2004-09-14 2017-12-20 Yeda Research And Development Co., Ltd. Microscope system and method
US20070258122A1 (en) 2004-10-06 2007-11-08 Bc Cancer Agency Computer-Tomography Microscope and Computer-Tomography Image Reconstruction Methods
KR100624454B1 (en) 2004-12-23 2006-09-18 삼성전기주식회사 Hybrid lens unit and hybrid lens array
US7382464B2 (en) 2005-01-20 2008-06-03 Carl Zeiss Meditec, Inc. Apparatus and method for combined optical-coherence-tomographic and confocal detection
US7767414B1 (en) 2005-04-20 2010-08-03 The Board Of Trustees Of The Leland Stanford Junior University Optical imaging of molecular characteristics of biological specimen
US20070057211A1 (en) 2005-05-25 2007-03-15 Karsten Bahlman Multifocal imaging systems and method
KR20080023292A (en) 2005-05-27 2008-03-13 더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 Optical coherence tomographic detection of cells and compositions
US8355776B2 (en) 2005-05-27 2013-01-15 Board Of Regents, The University Of Texas System Hemoglobin contrast in magneto-motive optical doppler tomography, optical coherence tomography, and ultrasound imaging methods and apparatus
US7801590B2 (en) 2005-05-27 2010-09-21 Board Of Regents, The University Of Texas System Optical coherence tomographic detection of cells and killing of the same
US7329860B2 (en) 2005-11-23 2008-02-12 Illumina, Inc. Confocal imaging methods and apparatus
ATE529732T1 (en) 2006-10-30 2011-11-15 Ventana Med Syst Inc THIN FILM APPARATUS AND METHOD
GB2477648B (en) 2008-08-29 2013-02-20 Lee H Angros In situ heat induced antigen recovery and staining apparatus and method
US8771978B2 (en) * 2010-11-15 2014-07-08 Tissuevision, Inc. Systems and methods for imaging and processing tissue

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6028306A (en) * 1997-05-14 2000-02-22 Olympus Optical Co., Ltd. Scanning microscope
US20040125372A1 (en) * 2002-10-17 2004-07-01 Walla Peter Jomo Multi-parameter fluorimetric analysis in a massively parallel multi-focal arrangement and the use thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KIM DAEKEUN ET AL.: "Optical biopsy in high-speed handheld miniaturized multifocal multiphoton microscopy", PROGR. BIOMED. OPT. IMAGING PROC. SPIE; PROGRESS IN BIOMEDICAL OPTICS AND IMAGING - PROCEEDINGS OF SPIE; MULTIPHOTON MICROSCOPY IN THE BIOMEDICAL SCIENCES V 2005, vol. 5700, March 2005 (2005-03-01), pages 14 - 22, XP002403958 *
KIM DAEKEUN ET AL: "High speed handheld multiphoton multifoci microscopy", PROC SPIE INT SOC OPT ENG; PROCEEDINGS OF SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING; PROGRESS IN BIOMEDICAL OPTICS AND IMAGING - MULTIPHOTON MICROSCOPY IN THE BIOMEDICAL SCIENCES IV 2004, vol. 5323, 2004, pages 267 - 272, XP002403959 *
LEVEQUE-FORT S ET AL: "Fluorescence lifetime imaging with a multifocal two-photon microscope", PROCEEDINGS OF THE SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING SPIE-INT. SOC. OPT. ENG USA, vol. 5323, no. 1, 2004, pages 99 - 107, XP002403957, ISSN: 0277-786X *
LEVEQUE-FORT S ET AL: "Time-resolved multifocal multiphoton microscopy", PROC SPIE INT SOC OPT ENG; PROCEEDINGS OF SPIE - THE INTERNATIONAL SOCIETY FOR OPTICAL ENGINEERING 2003, vol. 5139, 2003, pages 173 - 179, XP002403956 *

Also Published As

Publication number Publication date
US10598597B2 (en) 2020-03-24
EP2703871A2 (en) 2014-03-05
US20180202935A1 (en) 2018-07-19
US20070057211A1 (en) 2007-03-15
EP1889111A2 (en) 2008-02-20
EP2703871A3 (en) 2014-09-03
WO2006127967A2 (en) 2006-11-30

Similar Documents

Publication Publication Date Title
WO2006127967A3 (en) Multifocal scanning microscopy systems and methods
US7601963B2 (en) High-resolution depth-of-interaction PET detector
CN102549381B (en) Optical distance-measuring device
Korpar et al. Study of TOF PET using Cherenkov light
US10488251B2 (en) Method for improving the dynamic range of a device for detecting light
JP2017501402A (en) High resolution fluorescence microscope with structured excitation light
Suhling et al. Wide-field time-correlated single photon counting-based fluorescence lifetime imaging microscopy
EP2487704A3 (en) Detection method for use in charged-particle microscopy
Hirvonen et al. Photon counting phosphorescence lifetime imaging with TimepixCam
CN110392847A (en) The increased spatial resolution of X-ray detector on photon counting edge
RU2011153725A (en) VISUALIZATION SYSTEM WITH AN ARRAY FROM MANY DETECTORS
WO2009047328A3 (en) Combination of single photon emission computed tomography and optical imaging detector
JP2022519397A (en) High resolution depth coded PET detector with pseudo-prism guide array
JP6999751B2 (en) Segmented detector for charged particle beam devices
Lee et al. High-resolution time-of-flight PET detector with 100 ps coincidence time resolution using a side-coupled phoswich configuration
US20060215264A1 (en) Apparatus for the detection of photons of a light beam
Vinke et al. Optimization of digital time pickoff methods for LaBr 3-SiPM TOF-PET detectors
Long et al. Effects of fixed pattern noise on single molecule localization microscopy
US20180031479A1 (en) Systems and methods for particle tracking using spatiotemporal offset light beams
US9184034B2 (en) Photomultiplier tube with extended dynamic range
Podgorski et al. Fast non‐negative temporal deconvolution for laser scanning microscopy
Adamczewski-Musch et al. Single photon test bench for series tests of HAMAMATSU H12700 MAPMTs
Krstajić et al. Improving TCSPC data acquisition from CMOS SPAD arrays
Aykac et al. New approach to obtain high resolution using conventional block designs in PET
US20140147836A1 (en) Methods and apparatus for imaging molecules in living systems

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2006784478

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: RU