EP2150806A4 - Methods and systems for analyzing fluorescent materials with reduced autofluorescence - Google Patents

Methods and systems for analyzing fluorescent materials with reduced autofluorescence

Info

Publication number
EP2150806A4
EP2150806A4 EP08767652A EP08767652A EP2150806A4 EP 2150806 A4 EP2150806 A4 EP 2150806A4 EP 08767652 A EP08767652 A EP 08767652A EP 08767652 A EP08767652 A EP 08767652A EP 2150806 A4 EP2150806 A4 EP 2150806A4
Authority
EP
European Patent Office
Prior art keywords
systems
methods
fluorescent materials
analyzing fluorescent
reduced autofluorescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP08767652A
Other languages
German (de)
French (fr)
Other versions
EP2150806A1 (en
Inventor
Paul Lundquist
Cheng-Frank Zhong
Denis Zaccarin
Pegian Zhao
Stephen Turner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pacific Biosciences of California Inc
Original Assignee
Pacific Biosciences of California Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/901,273 external-priority patent/US20080277595A1/en
Application filed by Pacific Biosciences of California Inc filed Critical Pacific Biosciences of California Inc
Publication of EP2150806A1 publication Critical patent/EP2150806A1/en
Publication of EP2150806A4 publication Critical patent/EP2150806A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0004—Microscopes specially adapted for specific applications
    • G02B21/002—Scanning microscopes
    • G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
    • G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
EP08767652A 2007-05-10 2008-05-09 Methods and systems for analyzing fluorescent materials with reduced autofluorescence Withdrawn EP2150806A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US92861707P 2007-05-10 2007-05-10
US11/901,273 US20080277595A1 (en) 2007-05-10 2007-09-14 Highly multiplexed confocal detection systems and methods of using same
PCT/US2008/005953 WO2008140758A1 (en) 2007-05-10 2008-05-09 Methods and systems for analyzing fluorescent materials with reduced autofluorescence

Publications (2)

Publication Number Publication Date
EP2150806A1 EP2150806A1 (en) 2010-02-10
EP2150806A4 true EP2150806A4 (en) 2013-01-02

Family

ID=41382245

Family Applications (1)

Application Number Title Priority Date Filing Date
EP08767652A Withdrawn EP2150806A4 (en) 2007-05-10 2008-05-09 Methods and systems for analyzing fluorescent materials with reduced autofluorescence

Country Status (4)

Country Link
EP (1) EP2150806A4 (en)
AU (1) AU2008251861B2 (en)
CA (1) CA2687062C (en)
WO (1) WO2008140758A1 (en)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080277595A1 (en) * 2007-05-10 2008-11-13 Pacific Biosciences Of California, Inc. Highly multiplexed confocal detection systems and methods of using same
US9637380B2 (en) 2008-03-31 2017-05-02 Pacific Biosciences Of California, Inc. Nanoscale apertures having islands of functionality
EP2881736B1 (en) 2008-03-31 2017-06-07 Pacific Biosciences of California, Inc. Single polymerase molecule loading methods and compositions
US8247216B2 (en) 2008-09-30 2012-08-21 Pacific Biosciences Of California, Inc. Ultra-high multiplex analytical systems and methods
US8367159B2 (en) 2009-09-11 2013-02-05 Pacific Biosciences Of California, Inc. Methods for producing ZMWs with islands of functionality
WO2011031313A2 (en) 2009-09-11 2011-03-17 Pacific Biosciences Of California, Inc. Zero-mode waveguides with non-reflecting walls
EP2491370B1 (en) 2009-10-23 2023-03-01 Koninklijke Philips N.V. Device for monitoring a plurality of discrete fluorescence signals
WO2011139641A2 (en) * 2010-05-03 2011-11-10 The Regents Of The University Of California Wide-field lensless fluorescent imaging on a chip
WO2014194028A1 (en) * 2013-05-31 2014-12-04 Pacific Biosciences Of California, Inc Analytical devices having compact lens train arrays
EP3044538B1 (en) 2013-09-10 2021-06-30 BAE Systems PLC Optical surface roughness measurement
NL2020621B1 (en) * 2018-01-08 2019-07-15 Illumina Inc Multiplexing of an active sensor detector using structured illumination
EP3957982A1 (en) 2018-01-08 2022-02-23 Illumina, Inc. Devices for high-throughput sequencing with semiconductor-based detection
US11378544B2 (en) 2018-01-08 2022-07-05 Illumina, Inc. High-throughput sequencing with semiconductor-based detection
CN108181290B (en) * 2018-03-24 2020-07-10 王碧 Fluorescent quantitative analyzer
AU2020370160A1 (en) * 2019-10-21 2022-05-12 Illumina, Inc. Systems and methods for structured illumination microscopy
EP4379355A1 (en) * 2022-11-29 2024-06-05 Gnothis Holding AG High throughput analysis of single molecule events

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6055106A (en) * 1998-02-03 2000-04-25 Arch Development Corporation Apparatus for applying optical gradient forces
WO2003001178A2 (en) * 2001-06-20 2003-01-03 Arryx, Inc. Configurable dynamic three dimensional array
US20040126780A1 (en) * 2001-05-29 2004-07-01 Rudolf Rigler Use of optical diffraction elements in detection methods
US20060011859A1 (en) * 2004-07-16 2006-01-19 Ralf Wolleschensky Procedure for the optical acquisition of objects by means of a light raster microscope
US20060214106A1 (en) * 2005-03-01 2006-09-28 Ralf Wolleschensky Point scanning laser scanning microscope and methods for adjustment of a microscope

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU6068300A (en) * 1999-07-06 2001-01-22 Caliper Technologies Corporation Microfluidic systems and methods for determining modulator kinetics
US20030031596A1 (en) * 2001-08-09 2003-02-13 Yokogawa Electric Corporation Biochip reader and fluorometric imaging apparatus
US7476503B2 (en) * 2004-09-17 2009-01-13 Pacific Biosciences Of California, Inc. Apparatus and method for performing nucleic acid analysis
US20070057211A1 (en) * 2005-05-25 2007-03-15 Karsten Bahlman Multifocal imaging systems and method

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6055106A (en) * 1998-02-03 2000-04-25 Arch Development Corporation Apparatus for applying optical gradient forces
US20040126780A1 (en) * 2001-05-29 2004-07-01 Rudolf Rigler Use of optical diffraction elements in detection methods
WO2003001178A2 (en) * 2001-06-20 2003-01-03 Arryx, Inc. Configurable dynamic three dimensional array
US20060011859A1 (en) * 2004-07-16 2006-01-19 Ralf Wolleschensky Procedure for the optical acquisition of objects by means of a light raster microscope
US20060214106A1 (en) * 2005-03-01 2006-09-28 Ralf Wolleschensky Point scanning laser scanning microscope and methods for adjustment of a microscope

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
GOSCH M ET AL: "Parallel dual-color fluorescence cross-correlation spectroscopy using diffractive optical elements", JOURNAL OF BIOMEDICAL OPTICS SPIE USA, vol. 10, no. 5, September 2005 (2005-09-01), pages 54008 - 1, XP040213852, ISSN: 1083-3668 *
JOHANSSON M ET AL: "DESIGN, FABRICATION, AND EVALUATION OF A MULTICHANNEL DIFFRACTIVE OPTIC ROTARY JOINT", APPLIED OPTICS, OPTICAL SOCIETY OF AMERICA, WASHINGTON, DC; US, vol. 38, no. 8, 10 March 1999 (1999-03-10), pages 1302 - 1310, XP000823450, ISSN: 0003-6935, DOI: 10.1364/AO.38.001302 *
K SVOBODA ET AL: "Biological Applications of Optical Forces", ANNUAL REVIEW OF BIOPHYSICS AND BIOMOLECULAR STRUCTURE, vol. 23, no. 1, 1 June 1994 (1994-06-01), pages 247 - 285, XP055010743, ISSN: 1056-8700, DOI: 10.1146/annurev.bb.23.060194.001335 *
See also references of WO2008140758A1 *

Also Published As

Publication number Publication date
WO2008140758A1 (en) 2008-11-20
AU2008251861A1 (en) 2008-11-20
CA2687062C (en) 2016-04-12
EP2150806A1 (en) 2010-02-10
CA2687062A1 (en) 2008-11-20
AU2008251861B2 (en) 2014-03-20

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Inventor name: TURNER, STEPHEN

Inventor name: ZHAO, PEGIAN

Inventor name: ZACCARIN, DENIS

Inventor name: ZHONG, CHENG-FRANK

Inventor name: LUNDQUIST, PAUL

RIN1 Information on inventor provided before grant (corrected)

Inventor name: TURNER, STEPHEN

Inventor name: ZHAO, PEGIAN

Inventor name: ZACCARIN, DENIS

Inventor name: ZHONG, CHENG-FRANK

Inventor name: LUNDQUIST, PAUL

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