WO2006125442A1 - Produit pharmaceutique comprenant un recipient - Google Patents

Produit pharmaceutique comprenant un recipient Download PDF

Info

Publication number
WO2006125442A1
WO2006125442A1 PCT/DK2006/000291 DK2006000291W WO2006125442A1 WO 2006125442 A1 WO2006125442 A1 WO 2006125442A1 DK 2006000291 W DK2006000291 W DK 2006000291W WO 2006125442 A1 WO2006125442 A1 WO 2006125442A1
Authority
WO
WIPO (PCT)
Prior art keywords
container
lid
pharmaceutical product
product according
liquid
Prior art date
Application number
PCT/DK2006/000291
Other languages
English (en)
Inventor
Kirsten Nielsen Tallerup
Original Assignee
Leo Pharma A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharma A/S filed Critical Leo Pharma A/S
Publication of WO2006125442A1 publication Critical patent/WO2006125442A1/fr

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/18—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages for discharging drops; Droppers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body
    • A61M35/003—Portable hand-held applicators having means for dispensing or spreading integral media
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D47/00—Closures with filling and discharging, or with discharging, devices
    • B65D47/04—Closures with discharging devices other than pumps
    • B65D47/06—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages
    • B65D47/12—Closures with discharging devices other than pumps with pouring spouts or tubes; with discharge nozzles or passages having removable closures
    • B65D47/127—Snap-on caps
    • B65D47/128—Snap-on caps with internal parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/87—Application Devices; Containers; Packaging

Definitions

  • the present invention relates to a pharmaceutical product comprising a container with a high-viscosity liquid pharmaceutical composition comprising a therapeutically active agent contained therein.
  • the pharmaceutical composition may be for the treatment of a dermatological disorder, such as e.g. psoriasis, and the container provides an improved dispenser for the high-viscosity liquid pharmaceutical composition.
  • Containers for liquid pharmaceutical compositions may include a dispenser for dispensing the pharmaceutical composition to e.g. a skin surface of a human being.
  • High-viscosity pharmaceutical compositions such as ointments for topical dermical use, are normally provided in a container, such as a bottle or tube, with a top opening through which the ointments may be expelled from the container under the action of gravity and/or by an operator applying a finger pressure to an outer surface of the walls of the container.
  • the top opening in such containers is usually provided in a dispensing section of the container, the dispensing section having a reduced diameter in comparison to the dimensions of body of the container, the transition between the container body and the dispensing section being as short as possible for reasons of compactness.
  • the dispensing section itself be as short as possible.
  • certain low-viscosity pharmaceutical compositions e.g. for nasal application, are provided in a container having an elongated dispensing section for reaching into patients' nostrils (nares).
  • Liquid pharmaceutical compositions for the treatment of psoriasis may be provided either as low-viscosity or as high-viscosity liquids in containers having short dispensing sections, e.g. usually shorter than 10 mm.
  • a pharmaceutical product including a high- viscosity liquid pharmaceutical composition and a container therefor, wherein the container facilitates application of the high-viscosity liquid composition.
  • liquid pharmaceutical compositions with a relatively high oil content of about 75% vol. or more contained in plastics containers have a tendency to penetrate into the containers.
  • This problem has, in particular, been observed in respect of containers made essentially from polyethylene. Such penetration is undesired, as it may reduce the storage stability of the pharmaceutical products to an unacceptably low level. It is thus another object of preferred embodiments of the present invention to provide a pharmaceutical product including a container and a liquid pharmaceutical composition with a high oil content, which does not suffer from the aforementioned problem of penetration.
  • the invention provides a pharmaceutical product comprising a container with a liquid pharmaceutical composition comprising a therapeutically active agent contained therein, the liquid having a viscosity of at least 400 mPas, the container comprising a body portion and a tapered dispensing section, the length of the tapered dispensing section being at least 25 mm, such as at least 30 mm or at least 50 mm.
  • the liquid pharmaceutical composition may be for the treatment of a dermatological disorder, e.g. psoriasis, such as a dermatological disorder occurring on the surface of the human scalp.
  • an elongated dispensing section having a length of at least 25 mm allows the liquid pharmaceutical composition to be applied to the skin portion of e.g. the human scalp, even to patients with abundant hair growth, as the dispensing section may reach through the hair to the skin surface for application without loss of pharmaceutical composition.
  • the dispensing section is tapered to define a narrow opening at a free end thereof, the pharmaceutical composition may be accurately applied to the desired treatment site.
  • the dispensing section has a significantly smaller diameter than the diameter of the body portion of the container, the smallest diameter of the dispensing section being e.g. less than 1/3 or less than 1/5 of the largest diameter of the body portion.
  • the viscosity of the liquid pharmaceutical composition may be at least 400 mPas, such as at least 500, 600, or 700 mPas, or 400-700 mPas, such as 550-650 mPas, such as 580-620 mPas.
  • the viscosity may suitably be determined by the cup/rotor method involving an NVl device on a Haake VT550 viscosimeter at 700 s "1 and 2O 0 C.
  • the transition between an inner side wall and a bottom surface of the container may be curved, whereby accumulation of liquid in the transition may be reduced.
  • the radius of curvature should not be excessive, e.g. approximately equal to 1/20 - 1/10 of the height of the body portion.
  • a lid for covering the dispensing section may be provided, the lid being preferably shaped and cross-sectionally dimensioned to conform to the shape and dimensions of the body portion.
  • the lid may thus also be essentially cylindrical with a diameter, which is essentially equal to the diameter of the container.
  • the container may suitably be placed upside down with the lid serving as a base support for the container, so that the liquid pharmaceutical composition may accumulate near the dispensing section in the container to facilitate a user's extraction of the liquid pharmaceutical composition.
  • the dispensing section as well as the pharmaceutical composition may be protected from contamination.
  • the lid has a textured or roughened outer surface portion to facilitate handling thereof, in particular for facilitating dismounting of the lid from the body portion.
  • the lid may be connected to the body portion via inner threads near a distal end of the lid engaging outer threads at the proximal end of the body portion of the container.
  • Other means for interconnecting the lid and the body portion are envisaged, e.g. a snap-fit.
  • the lid is preferably closed, so that the lid defines an inner end surface facing a tip of the tapered dispensing section, whereby the inner end surface of the lid may define means for providing a liquid tight seal between the tip of the dispensing section and the inner surface of the lid.
  • a protrusion may be provided at the inner surface of the lid for engaging the tip of the dispensing section.
  • the protrusion may be arranged centrally in a sleeve, which is w-shaped when seen in cross- section, with the protrusion engaging an outlet opening in the tip, and the peripheral portion of the sleeve engaging an outer surface portion of the dispensing section.
  • the w-shaped sleeve and/or the tip portion of the dispensing section may be made from an elastic material or provided with a packing material, such as a sealing ring of a rubber material.
  • a guide for the tip may be provided.
  • the guide may form a funnel- like member, which is open at its distal end and which is terminated by the sleeve and protrusion at its proximal end.
  • the funnel may e.g. be defined by a conical wall or by a plurality of mutually spaced ribs.
  • the container, and in particular the body portion thereof, may be flexible to ease expelling of the liquid pharmaceutical composition from the container.
  • the lid may be less flexible, i.e. more rigid, than the container.
  • the greater rigidity of the lid may be achieved by manufacturing the lid with a larger wall thickness than the wall thickness of the container and/or by a different choice of material for the lid.
  • the container and the lid may e.g. be manufactured from polyethylene, polypropylene, polyester, polystyrene, polyamide, or polyvinylchloride.
  • various types of polyethylene may be used, such as low-density polyethylene having a density of e.g. 0.910- 0.925 g/cm 3 , high-density polyethylene having a density of e.g. 0.941-0.965 g/cm 3 , or medium-density polyethylene having a density of 0.926-0.940 g/cm 3 , the aforementioned densities being according to information in W. Soroka, The Fundamentals of Packaging Technology, 3rd Ed., 2002, Institute of Packaging Professionals, Illinois, USA, p. 208
  • the liquid composition may typically comprise at least 75% vol. of oil, i.e. of a pharmaceutically acceptable oil, such as a mineral oil or paraffin. In most embodiments, the oil content is in the range of 75% to 85% vol. It has been found that the oil has a tendency to penetrate the container if the latter is made from polyethylene. Such penetration has a negative impact on the storage stability of the liquid composition.
  • One solution to this problem is to manufacture the container from a material different from polyethylene.
  • polyethylene has beneficial characteristics with respect to mechanical stability and flexibility
  • an alternative solution relying on polyethylene has been pursued. It has been found that the aforementioned problem of oil penetration does not occur when the container is essentially made from polyethylene of a high density.
  • the container in which the oil content is in the range of 75 to 85% vol., is preferably made from high-density polyethylene having a density of e.g. at least 0.941 g/cm 3 . Accordingly, it may be achieved that the degradation of the pharmaceutical composition remains below 10% at 25°C for a period of at least one year.
  • a seal may be provided between the lid and the body portion of the container, the seal being arranged such that it is irrevocably broken when the lid is removed from the body portion. Thereby, patients and physicians are ensured that a product which is believed to be new and non-contaminated has in fact not been opened.
  • the seal may e.g. be in the form of a plastic strip interconnecting the lid and the container, a heated spot at the interconnection between container and the lid, at which spot the lid is secured to the container, or a label adhesively joined to the lid and the container.
  • the seal may be in the form of a ring element at the distal end of the lid, the ring element engaging a lower portion of the threads of the container in such a way that the lid cannot be unscrewed from the lid, unless the connection between the ring element and the remainder of the lid is irrevocably broken.
  • the container has a volume for the liquid of at least 15 ml and at most 300 ml, such as 20-200 ml, such as 20-30 ml, 40-60 ml, 60-160 ml, 70-80 ml, 100-180 ml, or 140-170 ml.
  • the dispensing section may be connected to the body portion of the container by any appropriate means.
  • the body portion may have a reduced diameter section defining an opening of the container near its proximal end, and the dispensing section may define a mouth at its distal end, whereby the inner diameter of the opening of the container and the outer diameter of the mouth are such that the mouth is squeeze-fitted into the container.
  • one of the mouth of the dispensing section and the proximal end of the body of the container is barbed to securely engage the other one of the two parts.
  • the two parts may be made from different materials, e.g. materials of different rigidity and/or different density.
  • the container may essentially be made from high-density polyethylene
  • the mouth may essentially be made from low-density polyethylene, cf. the above definitions of high- and low-density polyethylene.
  • the invention provides a novel use of a container with a liquid pharmaceutical composition having a viscosity of at least 400 mPas contained therein and comprising a body portion and a tapered dispensing section having a length of at least 25 mm, the use comprising using the container as a dispensing device for the treatment of a dermatological disorder on the surface of the human scalp.
  • the invention provides a novel use of a pharmaceutical product according to the first aspect of the invention in the preparation of a disposable medical dispensing device for the treatment of a dermatological disorder on the surface of the human scalp by application of the liquid pharmaceutical composition from the container to the surface of the scalp.
  • the invention provides a method for treating a dermatological disorder, comprising the steps of:
  • a pharmaceutical product comprising a container with a liquid contained therein, the liquid having a viscosity of at least 400 mPas, the container comprising a body portion and a tapered dispensing section having a length of at least 25 mm;
  • the invention provides a pharmaceutical product comprising:
  • liquid pharmaceutical composition comprising a therapeutically active agent contained in the container, the liquid pharmaceutical composition comprising at least 75% of oil; wherein the container is essentially made from high-density polyethylene.
  • the high-density polyethyelene as a material for the container reduces the problem of oil penetration into the container material and thus increases storage stability. It may thus be achieved that the degradation of the pharmaceutical composition remains below 10% at 25 0 C for a period of at least one year.
  • the high-density polyethylene in which the oil content is in the range of 75 to 85% vol., may have a density of at least 0.941 g/cm 3 , cf. the definitions of low- and high-density polyethylene given above in the description of the first aspect of the present invention.
  • the container may e.g. include a container as described herein with reference to the first aspect of the invention. It should be understood that parts or portions of the container other than the part or portion, which holds the liquid pharmaceutical composition, may be made from a material different from high-density polyethylene. For example, a dispensing section or a lid of the container may be made from other materials, such as low-density polyethylene.
  • the oil of the liquid composition is preferably a pharmaceutically acceptable oil, such as a mineral oil or paraffin.
  • the container may conveniently include a tapered dispensing section having a length of at least 25 mm to facilitate application of the liquid to, e.g., regions of abundant hair growth.
  • first, second, third and fourth apsects of the invention may be used in or applied to the product of the fifth aspect of the invention.
  • Fig. 1 is a perspective view of a first embodiment of the product of the present invention, including a lid;
  • Fig. 2 is a perspective view of the embodiment of Fig. 1, in which the lid has been removed;
  • Fig. 3 is a cross-sectional view through the embodiment of Figs. 1 and 2;
  • Fig. 4 is a cross-sectional view through a second embodiment of the product of the present invention.
  • Fig. 5 shows a detail of the lid of the embodiment of Fig. 4.
  • pharmaceutical product 100 comprises a body portion 102 and a lid 104, the lid defining outer ribs 106 for facilitated handling thereof.
  • the lid 104 is removed, thereby revealing a tapered dispensing section 108 defining a tip 110 with an opening 112, through which a liquid pharmaceutical composition in the container may be expelled.
  • the transition 114 between the body portion 102 and the dispensing section 108 defines a threaded section 116 for engagement of inner threads of the lid (cf. Fig. 3) and a reduced diameter section 118.
  • the body portion 102 and the lid 104 may e.g. be made from any of the materials cited in the above summary of the invention, e.g. low-, medium- or high-density polyethylene.
  • the engagement between the lid and the body portion is more clearly visible in Fig. 3, showing inner threads 120 on the lid engaging threads 116 of the body portion.
  • the hatched area 122 in Fig. 3 illustrates the level of liquid pharmaceutical composition contained in the body portion 102 when the container is full. It will be appreciated that the level liquid in the body does not extend into the reduced diameter section 118 of the container nor into the dispensing section 108.
  • the cylindrical inner wall is provided with a curvature 124 to facilitate emptying of the container.
  • the dispensing section 108 defines a mouth 126, which is squeeze-fitted into reduced diameter section 118 of the container.
  • an inner end surface 128 thereof defines a w- shaped sleeve 130 for engaging the tip 110 of the dispensing section.
  • the sleeve 130 has a central protrusion 132 for engaging the opening 112 in the tip of the dispensing section to provide a liquid-tight seal between the lid and the dispensing section.
  • An outer end surface 134 of the lid is flattened to allow for stable storage of the product when place upside down.
  • Figs. 4 and 5 illustate a second embodiment of a pharmaceutical product 200 comprising a body portion 202, a lid 204, a tapered dispensing section 208 with a tip 210 having an opening 212, thorugh which a liquid pharmaceutical composition may be expelled.
  • a threaded section 216 for engaging inner threads formed in the lid 204, and a reduced diameter section 218, which is reinforced by a collar portion 219 of increased wall thickness.
  • the dispensing section 208 defines a mouth 226, which is squeeze-fitted into the reduced diameter section 218.
  • a w-shaped sleeve 230 having a central protrusion 232 is provided for engaging the dispensing section, the sleeve 230 and protrusion 232 terminating a funnel-shaped portion 236.
  • the funnel-shaped portion 236 is formed as a spoke-and-hub element.
  • Table I includes examples of dimensions of embodiments of the product according to the invention.
  • the tapered dispensing section has a length of at least 25 mm, e.g. 30 - 35 mm.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

L'invention concerne un produit pharmaceutique (100) comprenant un récipient (102 ; 104) contenant une composition pharmaceutique liquide à haute viscosité (122) renfermant un agent thérapeutique actif, destiné au traitement d'un trouble dermatologique, par exemple, tel que le psoriasis du cuir chevelu. Le récipient comprend une section de distribution évasée (108) d'une longueur d'au moins 25 mm. Un capuchon (104) protège la section de distribution, ce bouchon formant un joint étanche au liquide lorsqu'il entre en prise avec l'extrémité (110) de la section de distribution. Une partie inférieure, interne, du récipient, est incurvée de façon que le récipient puisse être vidé plus facilement. Le liquide peut être composés d'au moins 75 % d'huile et le récipient peut être fabriqué principalement à partir de polyéthylène haute densité afin de réduire la pénétration d'huile dans le matériau dont est constitué le récipient.
PCT/DK2006/000291 2005-05-26 2006-05-26 Produit pharmaceutique comprenant un recipient WO2006125442A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US68455205P 2005-05-26 2005-05-26
US60/684,552 2005-05-26
EP05076229.3 2005-05-26
EP05076229 2005-05-26

Publications (1)

Publication Number Publication Date
WO2006125442A1 true WO2006125442A1 (fr) 2006-11-30

Family

ID=36698892

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2006/000291 WO2006125442A1 (fr) 2005-05-26 2006-05-26 Produit pharmaceutique comprenant un recipient

Country Status (1)

Country Link
WO (1) WO2006125442A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2098460A1 (fr) * 2008-03-08 2009-09-09 Jürgen Schmidt Distributeur de produits pouvant s'écouler
FR2953694A1 (fr) * 2009-12-15 2011-06-17 Oreal Dispositif de conditionnement et d'application a effet de froid.
BE1022296B1 (nl) * 2015-02-02 2016-03-14 Oystershell Nv Inrichting voor de topicale behandeling van epidermaal weefsel en samenstellingen hiervoor
US10123966B2 (en) 2013-05-16 2018-11-13 The Procter And Gamble Company Hair thickening compositions and methods of use
JP2021024590A (ja) * 2019-07-31 2021-02-22 日本クロージャー株式会社 容器内容液を滴下吐出する包装材

Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2519740A (en) * 1948-02-06 1950-08-22 Call George Richard Combination conventional and ball point tooth comb
GB739626A (en) * 1953-02-05 1955-11-02 Foxboro Co Improvements in liquid dispensing containers
GB854879A (en) * 1956-04-10 1960-11-23 British Xylonite Co Ltd Improvements in the manufacture of shaped containers
US4067975A (en) * 1975-08-04 1978-01-10 Yu Ruey J Treatment of psoriasis with 6-aminonicotinamide and thionicotinamide
CH602125A5 (en) * 1975-09-10 1978-07-31 Jean Jost Scalp treatment fluid applicator
US4209027A (en) * 1974-06-21 1980-06-24 Shila Morganroth Hair treatment devices and packaging therefor
US4235889A (en) * 1979-04-25 1980-11-25 Pharmazeutische Fabrik Evers & Co. Therapeutic agent for the external treatment of psoriasis, tinea and eczemas
EP0320131A1 (fr) * 1987-11-25 1989-06-14 The Procter & Gamble Company Dispositif pour l'application de liquides sur la tête
EP0475426A1 (fr) * 1990-09-14 1992-03-18 Terumo Kabushiki Kaisha Applicateur pour liquides visqueux
WO1994007454A1 (fr) * 1992-10-01 1994-04-14 De-Novo International Pty Ltd Composition topique et utilisation de ladite composition pour assurer la repousse des cheveux et/ou pour empecher la chute des cheveux
US5848598A (en) * 1998-06-22 1998-12-15 Walz; David K. Hair treatment dispensing container
FR2777867A1 (fr) * 1998-04-23 1999-10-29 Oreal Ensemble pour le conditionnement et l'application dosee d'un produit fluide
US6043202A (en) * 1998-03-06 2000-03-28 Eriksen; Karla S. Shampoo compositions and oil compositions and methods for treatment of cradle cap
US6105828A (en) * 1998-04-22 2000-08-22 Atrion Medical Products, Inc. Non-bubble forming dropper tip
WO2001070181A1 (fr) * 2000-03-17 2001-09-27 Pr Originals, L.L.C. Procede et preparation pour le traitement et la prevention de l'alopecie
DE10125958A1 (de) * 2000-06-10 2001-12-13 Wella Ag Behälter
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WO2006006047A1 (fr) * 2004-07-02 2006-01-19 Natura Cosmeticos S.A. Composition cosmetique comprenant une fraction lipidique d'origine vegetale et un agent anti-cristallisation

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* Cited by examiner, † Cited by third party
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GB739626A (en) * 1953-02-05 1955-11-02 Foxboro Co Improvements in liquid dispensing containers
GB854879A (en) * 1956-04-10 1960-11-23 British Xylonite Co Ltd Improvements in the manufacture of shaped containers
US4209027A (en) * 1974-06-21 1980-06-24 Shila Morganroth Hair treatment devices and packaging therefor
US4067975A (en) * 1975-08-04 1978-01-10 Yu Ruey J Treatment of psoriasis with 6-aminonicotinamide and thionicotinamide
CH602125A5 (en) * 1975-09-10 1978-07-31 Jean Jost Scalp treatment fluid applicator
US4235889A (en) * 1979-04-25 1980-11-25 Pharmazeutische Fabrik Evers & Co. Therapeutic agent for the external treatment of psoriasis, tinea and eczemas
EP0320131A1 (fr) * 1987-11-25 1989-06-14 The Procter & Gamble Company Dispositif pour l'application de liquides sur la tête
EP0475426A1 (fr) * 1990-09-14 1992-03-18 Terumo Kabushiki Kaisha Applicateur pour liquides visqueux
WO1994007454A1 (fr) * 1992-10-01 1994-04-14 De-Novo International Pty Ltd Composition topique et utilisation de ladite composition pour assurer la repousse des cheveux et/ou pour empecher la chute des cheveux
US6043202A (en) * 1998-03-06 2000-03-28 Eriksen; Karla S. Shampoo compositions and oil compositions and methods for treatment of cradle cap
US6105828A (en) * 1998-04-22 2000-08-22 Atrion Medical Products, Inc. Non-bubble forming dropper tip
FR2777867A1 (fr) * 1998-04-23 1999-10-29 Oreal Ensemble pour le conditionnement et l'application dosee d'un produit fluide
US5848598A (en) * 1998-06-22 1998-12-15 Walz; David K. Hair treatment dispensing container
US20020176732A1 (en) * 2000-01-07 2002-11-28 Closure Medical Corporation Adhesive applicators with improved applicator tips
WO2001070181A1 (fr) * 2000-03-17 2001-09-27 Pr Originals, L.L.C. Procede et preparation pour le traitement et la prevention de l'alopecie
DE10125958A1 (de) * 2000-06-10 2001-12-13 Wella Ag Behälter
WO2006006047A1 (fr) * 2004-07-02 2006-01-19 Natura Cosmeticos S.A. Composition cosmetique comprenant une fraction lipidique d'origine vegetale et un agent anti-cristallisation

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Title
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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2098460A1 (fr) * 2008-03-08 2009-09-09 Jürgen Schmidt Distributeur de produits pouvant s'écouler
FR2953694A1 (fr) * 2009-12-15 2011-06-17 Oreal Dispositif de conditionnement et d'application a effet de froid.
WO2011073898A3 (fr) * 2009-12-15 2012-01-05 L'oreal Dispositif de conditionnement et d'application à effet froid
US10123966B2 (en) 2013-05-16 2018-11-13 The Procter And Gamble Company Hair thickening compositions and methods of use
BE1022296B1 (nl) * 2015-02-02 2016-03-14 Oystershell Nv Inrichting voor de topicale behandeling van epidermaal weefsel en samenstellingen hiervoor
JP2021024590A (ja) * 2019-07-31 2021-02-22 日本クロージャー株式会社 容器内容液を滴下吐出する包装材
JP7351666B2 (ja) 2019-07-31 2023-09-27 日本クロージャー株式会社 容器内容液を滴下吐出する包装材

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