WO2006109898A1 - Composition antimicrobienne contenant un extrait naturel, des nanoparticules d'argent et une huile essentielle naturelle - Google Patents

Composition antimicrobienne contenant un extrait naturel, des nanoparticules d'argent et une huile essentielle naturelle Download PDF

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Publication number
WO2006109898A1
WO2006109898A1 PCT/KR2005/001015 KR2005001015W WO2006109898A1 WO 2006109898 A1 WO2006109898 A1 WO 2006109898A1 KR 2005001015 W KR2005001015 W KR 2005001015W WO 2006109898 A1 WO2006109898 A1 WO 2006109898A1
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WIPO (PCT)
Prior art keywords
oil
antimicrobial
weight
natural
nano silver
Prior art date
Application number
PCT/KR2005/001015
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English (en)
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WO2006109898A8 (fr
Inventor
Tae-Gon Kim
Original Assignee
Pion-Tech Co., Ltd
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Publication date
Application filed by Pion-Tech Co., Ltd filed Critical Pion-Tech Co., Ltd
Priority to PCT/KR2005/001015 priority Critical patent/WO2006109898A1/fr
Priority to JP2008505218A priority patent/JP2008534675A/ja
Publication of WO2006109898A1 publication Critical patent/WO2006109898A1/fr
Publication of WO2006109898A8 publication Critical patent/WO2006109898A8/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q13/00—Formulations or additives for perfume preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/77—Perfumes having both deodorant and antibacterial properties

Definitions

  • the present invention relates to a composition containing grapefruit, purslane (
  • Houttuyniae Herba Houttuynia cordata Thunb extracts as natural extracts, nano silver and natural essential oils, and having excellent antimicrobial activity.
  • microorganisms include Staphylococcus aureus causing skin suppuration and resident skin flora such as Staphylococcus epidermis, Propioni- bacterium acnes and Pityrosporum ovale.
  • Dermatophytes invade the stratum corneum of hairs and skin, causing superficial mycoses.
  • Dermatophytes causing superficial mycoses mention may be made of Microsporum, Trichophyton and Epodermophyton which are pathogens causing trichophytosis.
  • Candida albicans causes skin candidiasis and chronic skin/mucosal candidiasis.
  • Such fungi cause superficial mycoses leading to various lesions due to their parasitic nature and proliferation on corneous tissues of the skin.
  • a causative agent that causes granulomatous lesions on other skin and subcutaneous tissues mention may be made of the pathogenic fungi Sporothrix schenckii .
  • the present invention has been made in view of the above problems, and it is an object of the present invention to provide an antimicrobial composition containing natural extracts, nano silver and natural essential oils, and having excellent antimicrobial activity against bacteria and fungi such as Staphylococcus aureus, resident skin flora and Dermatophytes.
  • an antimicrobial composition comprising 10 to 30% by weight of natural extracts containing a 1:1:1 mixture (w/w) of grapefruit, purslane (Portulaca oleracea L.) and Houttuyniae Herba (Houttuynia cordata Thunb) extracts, 1 to 5% by weight of nano silver having a concentration of 50 to 1,000 ppm, 5 to 30% by weight of a mixture of natural essential oils and the balance of ethanol.
  • the antimicrobial composition in accordance with the present invention exhibits excellent antimicrobial activity against bacteria and fungi such as Staphylococcus aureus, resident skin flora and Dermatophytes, and is suitable for preparation of formulations comprising the antimicrobial composition and having antimicrobial activity, such as hand cleaning agents, aromatic fragrances and herbal gels. Best Mode for Carrying Out the Invention
  • the present invention employs grapefruit, purslane (Portulaca oleracea L.) and
  • Houttuyniae Herba (Houttuynia cordata Thunb) as natural extracts. Grapefruit belongs to the Citrus family, and is slightly larger than an adult fist with a smooth and light yellow skin. Fruit flesh of grapefruit is very soft, succulent and white. Grapefruit tastes slightly bitter. Grapefruit seed extract (GSE) kills microorganisms by blockage of amino acid supply in cell tissues and decomposition and elution of low molecular weight intracellular substances, and thus are receiving a great deal of attention as a multipurpose and non-toxic bacteriostatic agent from the medical world, for application thereof as sterile antimicrobial agents, natural antibiotics, and the like.
  • GSE Grapefruit seed extract
  • Minimal inhibitory concentrations of GSE on various microorganisms are, respectively, 10 to 500 ppm for bacteria, 250 to 1,000 ppm for fungi, and 100 to 250 ppm for yeast.
  • grapefruit seed extract exerts anti-proliferative activity on bacteria, for example, at a concentration of 50 ppm for the genus Vibrio, and at a concentration of more than 30 ppm for Bacillus cereus and Staphylococcus aureus, and exhibits sterilizing effects at a concentration of more than 50 ppm for Vibrio vulnificus.
  • GSE grapefruit seed extract
  • Houttuyniae Herba which is an ingredient of natural extracts constituting an antimicrobial composition in accordance with the present invention, is a perennial herbaceous plant belonging to the Saururaceae family.
  • Herba are white and soft, and extend horizontally, while its main stem on the ground has no leaves or trichomes, grows to 20 to 50 cm tall and has several longitudinal cords.
  • Herba has a pungent fish odor when its leaves are crushed, so it is also named "Yu Xing Cao" in Chinese and oriental medicine (yu is fish, xing means fishy smell, and cao is the general term for herbs), and is also called a deca-medicine (multi-cure drug) because it is believed to cure 10 kinds of diseases.
  • Houttuyniae Herba including roots, leaves and stems thereof is utilized as a medicine for treating or alleviating dropsy, syphilis, cystitis, metritis, lumps in the breast, pulmonary abscesses, otitis media, palsy, pneumonia, dermatitis, hepatitis and hypertension, as a cardiotonic/ antipyretic drug, for promoting urination, and for ameliorating gonorrhea, urethritis and the like.
  • Houttuyniae Herba is one of the most famous folk medicines and a juice of green leaves thereof is therapeutically effective for treatment of purulent inflammation, furuncles, wounds, and the like via application thereof to affected parts, and also effectively removes sore toxic pathogenic factors and promotes urination.
  • 30 g of decocted Houttuyniae Herba is used internally for treatment of gonorrhea and urethritis.
  • decocted Houttuyniae Herba is used in washing to treat hemorrhoids and scabies and is used for bathing (Korean Medicinal Plant Dictionary).
  • Herba juice is applied to affected parts for treatment of athlete's foot, hemorrhoids, snake bites and lacquer poisoning. It is effective for alleviation of fever, detoxification, and treatment of dysuria and eczema. In addition, it is also good for healing wounds, cleaning the face, as an insecticide, and for treatment of skin diseases and gastric diseases.
  • Herba exhibits advantageous effects such as regeneration of skin tissues, healing of wounds, antibacterial and antifungal properties, and anti- oxidative effects and blood circulation promoting effects, thus preventing skin aging.
  • purslane (Portulaca oleracea L.) is non-toxic and non-irritative and thus displays excellent therapeutic effects for treatment of skin diseases such as furuncles and edema. Therefore, purslane has been widely used as a medicinal substance, and has been frequently ingested by ancient people as a non-toxic food for achieving longevity.
  • purslane is pounded and applied to affected parts, or affected parts are washed with juice thereof, for external use, or purslane is decocted for drinking. Purslane is also used as antivenin as well as for treatment of insect bites and also heals various diseases which are accompanied by formation of pus and festering of wounds.
  • Purslane is edible in the form of cooked potherbs without adverse side effects even when large amounts thereof are ingested. Such medicinal effects of purslane enable to effectively remove adverse side effects which may result from skin diseases or cosmetic-causing troubles due to use of cosmetic or other environmental factors.
  • the antimicrobial composition employs a 1:1:1 mixture (w/w) of grapefruit, purslane (Portulaca oleracea L.) and Houttuyniae Herba (Houttuynia cordata Thunb) extracts as the natural extracts.
  • the amount of the natural extracts used herein is within the range of 10 to 30% by weight, and preferably 1 to 5% by weight.
  • the amount of the natural extracts is less than 10% by weight, it is impossible to obtain desired antimicrobial effects due to decreased efficiency of active ingredients.
  • the amount of the natural extract is greater than 30% by weight, synergism between nano silver and natural essential oils is inhibited. Therefore, it is preferred to use the natural extracts within the above-mentioned range.
  • nano silver when it is formed into nano particles, silver displays strong sterilizing and antimicrobial properties. Research indicates that silver can sterilize about 650 species of bacteria and viruses and silver is also known to exert excellent effects on fungi. In addition, nano silver is totally harmless to humans while exhibiting sterilizing power several tens of times stronger than chlorine-based sterilizers. Generally, high- purity nano silver is accepted to be harmless to humans even when taken internally. It is hypothesized that such antimicrobial action of nano silver is effected by the following three action mechanisms.
  • antimicrobial and sterilizing actions of silver as a metal may be mentioned. Unlike other metals or conventional silver, it can be assumed that nano silver, which has a small size of less than 10 nm, can be ingested by microorganisms having a size of about 100 nm to 200 nm and therefore bacteria die from respiratory disorder and metabolism disorder due to uptake of nano silver. Further, it is believed that, in antimicrobial agents utilizing any other inorganic carriers, antimicrobial metal ions (for example, Ag + , Zn + and Cu + ) dissociated from inorganic carriers bind to cell membranes and proteins such as enzymes, thereby inhibiting energy metabolism of cells.
  • antimicrobial metal ions for example, Ag + , Zn + and Cu +
  • nano silver used herein has a particle size of 5 nm to 20 nm.
  • the antimicrobial composition of the present invention contains 1 to 5% by weight of nano silver at a concentration of 50 to 1,000 ppm and preferably 3 to 5% by weight. Where the content of nano silver is less than the above-mentioned range, antimicrobial effects are lowered. In contrast, where the content of nano silver is greater than the above- mentioned range, problems associated with compatibility such as precipitation of silver due to saturation will occur. Therefore, it is preferred to use nano silver within the above-mentioned range.
  • aromatherapy is a branch of various traditional therapies, originated and developed from the discovery of the fact that flowers, leaves, roots and stems of plants have beneficial effects on sprit and body of humans, in ancient Egypt, China, India, and the like countries.
  • Essential oils play an important role in life cycles and germination processes of plants and have certain actions against diseases, and therefore have been believed as hormones or vitality necessary for survival of plants and have been used in religious rituals, wound healing and for cosmesis.
  • Eucalyptus is a tall evergreen tree of the Myrtaceae family, a characteristic component of Australian flora. Oil extracted from leaves of the eucalyptus tree has analgesic, antimicrobial and antiviral effects.
  • German chamomile is a plant of the Compositae family native to the Mediterranean coast. Oil extracted from flower petals of German chamomile has been used for more than 2,000 years as a household medicine in Europe. German chamomile oil contains azulene, a powerful antimicrobial and anti-inflammatory agent, and thus is effective in treating skin inflammatory conditions such as acne, eczema, diaper eczema and burn.
  • Cedar wood is a coniferous tree of the family Cupressaceae. Oil extracted from cedar wood was used for preservation of corpses or as cosmetic in ancient Egyptian. In addition, the odor of cedar wood oil repels ants, moths and other harmful insects and has antimicrobial, insecticidal and disinfecting actions.
  • Cinnamon is a tropical tree of the Lauraceae family, and oil extracted from leaves and branches thereof has excellent antimicrobial activity effectively acting on most bacteria.
  • Bergamot is a citrus tree of the Rutaceae family, and oil extracted from peels thereof has disinfecting effects and therefore is therapeutically effective against eczema, psoriasis, acne, seborrhea of skin and scalp, varicella and shingles and serves to effectively repel insects.
  • Lemon is a tree of the Rutaceae family, and oil extracted from peels thereof has disinfecting, antimicrobial and anti-oxidative action and is known to inactivate Mycobacterium tuberculosis even with a 0.2 dilution thereof.
  • Cypress is an evergreen tree of the family Cupressaceae, and oil extracted from leaves thereof has insect-repelling and antimicrobial effects.
  • Lemon grass is an aromatic tropical grass of the Poaceae family,and oil extracted from leaves thereof has antimicrobial, anti-oxidative and antifungal action.
  • Juniper berry is a coniferous evergreen tree of the family Cupressaceae, and oil extracted from berries thereof has antimicrobial and disinfecting action and thus is used in after-shave lotions.
  • Tea tree is a shrub of the Myrtaceae family, and oil extracted from leaves and twigs thereof has excellent antimicrobial, antibacterial, antiviral and disinfecting action against infection with all species of bacteria.
  • Peppermint is an aromatic herb of the Lamiaceae family, and oil extracted from leaves and flowering branch tips thereof is therapeutically effective against bronchial diseases and has anti-inflammatory,antimicrobial, antiphlogistic and antiviral effects.
  • Rosemary is an evergreen perennial shrub belonging to the Labiatae family, and oil extracted from flowers thereof has antibacterial, antifungal, disinfecting and insect repellent action.
  • Sandalwood is a small evergreen tree belonging to the Santalaceae family, and oil extracted from dried duramen of sandalwood has antimicrobial and disinfecting action.
  • Ginger is a medicinal perennial herb belonging to the Zingiberaceae family, and oil extracted from dried roots thereof has bactericidal, antimicrobial and anti-oxidative effects.
  • Lavender is a shrub of the Lamiaceae family, and oil extracted from flowers thereof is known to have the most popular and broad antimicrobial, sedative and antiinflammatory action.
  • thyme is an evergreen tree of the Lamiaceae family, and oil extracted from leaves and flower thereof has antimicrobial, anti-oxidative, antiseptic, sterilizing, detoxifying and parasite-repelling effects.
  • the antimicrobial composition of the present invention contains, as mentioned above, at least one natural essential oil selected from the group consisting of eucalyptus oil, German chamomile oil, cedar wood oil, cinnamon oil, bergamot oil, lemon oil, cypress oil, lemon grass oil, juniper berry oil, tea tree oil, peppermint oil, rosemary oil, sandalwood oil, ginger oil, lavender oil and thyme oil.
  • the amount of the natural essential oil used herein is within the range of 5 to 30% by weight, and preferably 5 to 15% by weight. Where the content of the natural essential oil is less than 5% by weight, antimicrobial activity is disadvantageously decreased. In contrast, where the content of the natural essential oil is greater than 30% by weight, the strong odor of the essential oil may cause customer dissatisfaction. Therefore, it is preferred to add the natural essential oil within the above-mentioned range. Mode for the Invention
  • composition ratio of ingredients given in Table 1 below an antimicrobial composition containing grapefruit, purslane (Portulaca oleracea L.) and Houttuyniae Herba (Houttuynia cordata Thunb) extracts, nano silver having a concentration of 1,000 ppm and an essential oil consisting of cinnamon oil, tea tree oil and lemon oil was prepared.
  • a base solution a 1:2 mixture of 1,3-butylene glycol and ethanol was used.
  • Example 6 In order to examine antimicrobial effects exhibited by natural extracts alone, the same procedure was carried out as in Example 1, except that an antimicrobial composition was prepared according to the composition and ratio of constituent ingredients given in Table 1 below. Diameters of clear zones appearing on the paper discs were measured. The results (antimicrobial effects) are shown in Table 3 below.
  • Example 2 In order to examine antimicrobial effects exhibited by nano silver alone, the same procedure as in Example 1 was employed, except that an antimicrobial composition was prepared according to the composition and ratio of constituent ingredients given in Table 1 below. Diameters of clear zones appearing on the paper discs were measured. The results (antimicrobial effects) are shown in Table 3 below.
  • Comparative Example 3 In order to examine antimicrobial effects exhibited by natural essential oil alone, the same procedure as in Example 1 was employed, except that an antimicrobial composition was prepared according to the composition and ratio of constituent ingredients given in Table 1 below. Diameters of clear zones appearing on the paper discs were measured. The results (antimicrobial effects) are shown in Table 3 below.
  • Example 1 exhibited broader clear zones than Comparative Examples 1 through 3, thus representing that the antimicrobial composition of the present invention has antimicrobial activity superior to natural extracts alone, nano silver alone and essential oils alone, respectively. Therefore, it can be said that combination of these ingredients exerts superior antimicrobial effects via synergistic effects therebetween.

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Abstract

L'invention concerne une composition contenant des extraits naturels de pamplemousse, de pourpier (Portulaca oleracea L.) et de Herba Houttuyniae (Houttuyniae cordata Thunb), des nanoparticules d'argent et des huiles essentielles naturelles, et qui présente une excellente activité antimicrobienne. Cette composition comprend de 10 à 30 % en poids d'extraits naturels contenant un mélange 1:1:1 (en poids) d'extraits de pamplemousse, de pourpier (Portulaca oleracea L.) et de Herba Houttuyniae (Houttuyniae cordata Thunb), de 1 à 5 % en poids de nanoparticules d'argent selon une concentration de 50 à 1000 ppm, de 5 à 30 % en poids d'un mélange d'huiles essentielles naturelles, le reste étant de l'éthanol. Cette composition présente une excellente activité antimicrobienne contre les bactéries et les champignons tels que Staphylococcus aureus, la flore cutanée résidente et Dermatophytes, et convient pour préparer des formulations comprenant une composition antimicrobienne et qui présentent une activité antibactérienne telles que des agents de nettoyage des mains, des parfums aromatiques et des gels à base d'herbes.
PCT/KR2005/001015 2005-04-09 2005-04-09 Composition antimicrobienne contenant un extrait naturel, des nanoparticules d'argent et une huile essentielle naturelle WO2006109898A1 (fr)

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PCT/KR2005/001015 WO2006109898A1 (fr) 2005-04-09 2005-04-09 Composition antimicrobienne contenant un extrait naturel, des nanoparticules d'argent et une huile essentielle naturelle
JP2008505218A JP2008534675A (ja) 2005-04-09 2005-04-09 天然抽出物、ナノシルバー、および天然エッセンシャルオイルを含有する抗菌剤組成物

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GB2444029A (en) * 2006-11-27 2008-05-28 Marnich Hygiene Ltd A naturally based anti-bacterial solution used in a hand spray
GB2444233A (en) * 2006-12-01 2008-06-04 Amtul Saleem Akhtar Nappy rash treatment with essential oil composition
NL1036275C2 (nl) * 2008-12-03 2009-09-29 Desiree Snijders-Driessen Bacterie- en schimmeldodende crème voor paarden en honden bestaande uit laurinezuur, caprinezuur, capron-capryl, lavendula officinalis, spygium, teatree olie en colloïdaal zilver werkzaam tegen schimmels, staart- en maaneczeem en andere jeukende huidaandoeningen.
US7700137B1 (en) 2007-07-18 2010-04-20 Kiani Iraj E Anti-viral compositions and method
US7850998B2 (en) 2007-07-18 2010-12-14 Kiani Iraj E Method of treating viral conditions
WO2009149369A3 (fr) * 2008-06-05 2011-04-07 Davidson Richard E Compositions de traitement de l’acné comportant une nanoparticule d’argent et utilisations
US20110212197A1 (en) * 2008-05-16 2011-09-01 Insignion Holdings Limited Plant Extract and Its Therapeutic Use
JP2013501779A (ja) * 2009-08-14 2013-01-17 株式会社アモーレパシフィック 天然抽出物含有組成物
US8637094B2 (en) 2007-07-18 2014-01-28 Iraj E. Kiani Composition and method for treating viral conditions
US9693941B2 (en) 2011-11-03 2017-07-04 Conopco, Inc. Liquid personal wash composition
US10028989B2 (en) 2010-08-05 2018-07-24 Alpinia Laudanum Institute Of Phytopharmaceutical Sciences Ag Composition comprising Retinol, a precursor or a reaction product of it and a plant extract from at least one Chamomilla plant for the treatment of cancer
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WO2021139194A1 (fr) * 2020-01-06 2021-07-15 浙江神英科技股份有限公司 Agent antibactérien végétal nanométrique pour désinfectant pour les mains et son procédé de préparation
CN113728922A (zh) * 2021-09-16 2021-12-03 贵州师范大学 一种鱼腥草种植苗制备方法
CN113994983A (zh) * 2021-09-29 2022-02-01 华南农业大学 一种紫外杀菌增效剂葡萄柚精油及其应用
WO2023073447A1 (fr) * 2021-10-29 2023-05-04 Unilabs Asesoría E Investigación S.A.S. Formulations biocides comprenant des huiles essentielles ou des extraits végétaux et des métaux lourds

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JP5026205B2 (ja) * 2007-09-18 2012-09-12 日本メナード化粧品株式会社 毛髪用組成物
MX2011004155A (es) 2008-10-20 2011-05-23 Unilever Nv Una composicion antimicrobiana.
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