WO2006098603A2 - Composition comprising isoorientin for suppressing histamine - Google Patents

Composition comprising isoorientin for suppressing histamine Download PDF

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Publication number
WO2006098603A2
WO2006098603A2 PCT/KR2006/000984 KR2006000984W WO2006098603A2 WO 2006098603 A2 WO2006098603 A2 WO 2006098603A2 KR 2006000984 W KR2006000984 W KR 2006000984W WO 2006098603 A2 WO2006098603 A2 WO 2006098603A2
Authority
WO
WIPO (PCT)
Prior art keywords
isoorientin
extract
histamine
aloe
bamboo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2006/000984
Other languages
English (en)
French (fr)
Other versions
WO2006098603A3 (en
Inventor
Sung-Sick Woo
Dong-Seon Kim
Seon-Gil Do
Young-Chul Lee
Mi-Sun Oh
Ji-Min Cha
Tae-Hyung Jo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Unigen Inc
Original Assignee
Unigen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unigen Inc filed Critical Unigen Inc
Priority to EP06716434A priority Critical patent/EP1863498A2/en
Priority to JP2008501819A priority patent/JP2008533131A/ja
Priority to BRPI0608546-6A priority patent/BRPI0608546A2/pt
Priority to AU2006223734A priority patent/AU2006223734B2/en
Priority to CA002601046A priority patent/CA2601046A1/en
Priority to US11/908,927 priority patent/US20080214658A1/en
Publication of WO2006098603A2 publication Critical patent/WO2006098603A2/en
Publication of WO2006098603A3 publication Critical patent/WO2006098603A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H39/00—Devices for locating or stimulating specific reflex points of the body for physical therapy, e.g. acupuncture
    • A61H39/04—Devices for pressing such points, e.g. Shiatsu or Acupressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/01—Constructive details
    • A61H2201/0157—Constructive details portable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/01—Constructive details
    • A61H2201/0192—Specific means for adjusting dimensions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2201/00—Characteristics of apparatus not provided for in the preceding codes
    • A61H2201/16—Physical interface with patient
    • A61H2201/1683—Surface of interface
    • A61H2201/169—Physical characteristics of the surface, e.g. material, relief, texture or indicia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61H—PHYSICAL THERAPY APPARATUS, e.g. DEVICES FOR LOCATING OR STIMULATING REFLEX POINTS IN THE BODY; ARTIFICIAL RESPIRATION; MASSAGE; BATHING DEVICES FOR SPECIAL THERAPEUTIC OR HYGIENIC PURPOSES OR SPECIFIC PARTS OF THE BODY
    • A61H2205/00—Devices for specific parts of the body
    • A61H2205/06—Arms
    • A61H2205/065—Hands
    • A61H2205/067—Fingers

Definitions

  • Histamine can be found in almost all tissues of animal, and is even present in various kinds
  • N-methyltransferase N-methyltransferase
  • N-methylhistamine N-methylimidazole
  • H 1 receptor functions as neurotransmitter. It is known that H 1 receptor is highly distributed in
  • Fig. 2 is 13 C-NMR spectrum of isoorientin
  • the present invention provides a pharmaceutical
  • the aloe extract comprising isoorientin is any organic solvent thereof.
  • the aloe extract comprising isoorientin is any organic solvent thereof.
  • composition of the present invention may be orally
  • the amount of histamine released in each sample was measured by using the

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Molecular Biology (AREA)
  • Rehabilitation Therapy (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
PCT/KR2006/000984 2005-03-18 2006-03-17 Composition comprising isoorientin for suppressing histamine Ceased WO2006098603A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
EP06716434A EP1863498A2 (en) 2005-03-18 2006-03-17 Composition comprising isoorientin for suppressing histamine
JP2008501819A JP2008533131A (ja) 2005-03-18 2006-03-17 イソオリエンチンを含むヒスタミン抑制用組成物
BRPI0608546-6A BRPI0608546A2 (pt) 2005-03-18 2006-03-17 composição farmacêutica, e, uso de isoorientina derivada naturalmente
AU2006223734A AU2006223734B2 (en) 2005-03-18 2006-03-17 Composition comprising isoorientin for suppressing histamine
CA002601046A CA2601046A1 (en) 2005-03-18 2006-03-17 Composition comprising isoorientin for suppressing histamine
US11/908,927 US20080214658A1 (en) 2005-03-18 2006-03-17 Composition Comprising Isoorientin for Suppressing Histamine

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2005-0022772 2005-03-18
KR1020050022772A KR100720973B1 (ko) 2005-03-18 2005-03-18 천연물 유래 아이소오리엔틴을 포함하는 히스타민 억제용약학 조성물

Publications (2)

Publication Number Publication Date
WO2006098603A2 true WO2006098603A2 (en) 2006-09-21
WO2006098603A3 WO2006098603A3 (en) 2006-11-30

Family

ID=36992143

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2006/000984 Ceased WO2006098603A2 (en) 2005-03-18 2006-03-17 Composition comprising isoorientin for suppressing histamine

Country Status (9)

Country Link
US (1) US20080214658A1 (cg-RX-API-DMAC7.html)
EP (1) EP1863498A2 (cg-RX-API-DMAC7.html)
JP (1) JP2008533131A (cg-RX-API-DMAC7.html)
KR (1) KR100720973B1 (cg-RX-API-DMAC7.html)
CN (1) CN101203228A (cg-RX-API-DMAC7.html)
AU (1) AU2006223734B2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0608546A2 (cg-RX-API-DMAC7.html)
CA (1) CA2601046A1 (cg-RX-API-DMAC7.html)
WO (1) WO2006098603A2 (cg-RX-API-DMAC7.html)

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BRPI0409179A (pt) 2003-04-04 2006-05-02 Unigen Pharmaceuticals Inc formulação de inibidores duplos de ciclooxigenase (cox) e lipoxigenase (lox) para cuidados com a pele de mamìferos
KR100720971B1 (ko) * 2004-06-11 2007-05-22 주식회사 유니젠 대나무 또는 대나무 추출물을 포함하는 안드로젠 효능성조성물
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KR102488562B1 (ko) * 2020-11-02 2023-01-12 인천대학교 산학협력단 갯끈풀 추출물을 유효성분으로 포함하는 염증 또는 아토피 피부염의 개선, 예방 또는 치료용 조성물
WO2022250313A1 (ko) * 2021-05-27 2022-12-01 주식회사 유니베라 알로에 베라 꽃 추출물, 또는 알로에 베라 꽃 추출물 및 알로에 베라 다당체를 유효성분으로 함유하는 피부 보습, 재생 촉진 및 상처 치료용 조성물
KR102543123B1 (ko) * 2021-05-27 2023-06-13 주식회사 유니베라 알로에 꽃 추출물을 유효성분으로 함유하는 피부 보습용 조성물
CN116349706B (zh) * 2021-12-27 2025-06-17 中国科学院植物研究所 水稻叶片提取物在杀虫中的应用
CN116349698B (zh) * 2021-12-27 2025-06-17 中国科学院植物研究所 水稻叶片提取物在抑制植物生长中的应用

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Also Published As

Publication number Publication date
EP1863498A2 (en) 2007-12-12
JP2008533131A (ja) 2008-08-21
KR100720973B1 (ko) 2007-05-22
WO2006098603A3 (en) 2006-11-30
BRPI0608546A2 (pt) 2010-11-16
AU2006223734B2 (en) 2012-03-29
CN101203228A (zh) 2008-06-18
KR20070039406A (ko) 2007-04-12
CA2601046A1 (en) 2006-09-21
AU2006223734A1 (en) 2006-09-21
US20080214658A1 (en) 2008-09-04

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