WO2006090579A1 - Procédé de fabrication d’une structure alvéolaire avec des trous isolés - Google Patents

Procédé de fabrication d’une structure alvéolaire avec des trous isolés Download PDF

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Publication number
WO2006090579A1
WO2006090579A1 PCT/JP2006/302074 JP2006302074W WO2006090579A1 WO 2006090579 A1 WO2006090579 A1 WO 2006090579A1 JP 2006302074 W JP2006302074 W JP 2006302074W WO 2006090579 A1 WO2006090579 A1 WO 2006090579A1
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Prior art keywords
hole
film
solvent
manufacturing
main body
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PCT/JP2006/302074
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English (en)
Japanese (ja)
Inventor
Masatsugu Shimomura
Masaru Tanaka
Hiroshi Yabu
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National University Corporation Hokkaido University
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Priority to JP2007504656A priority Critical patent/JP5050205B2/ja
Publication of WO2006090579A1 publication Critical patent/WO2006090579A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C41/00—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor
    • B29C41/02—Shaping by coating a mould, core or other substrate, i.e. by depositing material and stripping-off the shaped article; Apparatus therefor for making articles of definite length, i.e. discrete articles
    • B29C41/12—Spreading-out the material on a substrate, e.g. on the surface of a liquid

Definitions

  • the present invention relates to a method for manufacturing a her cam structure, and more specifically, a her cam structure having excellent heat resistance and chemical resistance and having isolated pores. It relates to a method for manufacturing.
  • Hercam structures are expected to be applied in the fields of optics, electronics, and biotechnology.
  • field of optics and electronics for example, application to high-performance composite materials, catalysts, nonlinear optical materials, memory elements and the like is expected.
  • Biotechnology In one field, in a porous film having a Herkam structure, the Herkam pattern provides a cell adhesion surface, and the porous structure provides access to the cell support base and a nutrient supply route. Is shown.
  • Patent Document 1 Japanese Patent Laid-Open No. 2003-80538
  • Patent Document 2 Japanese Laid-Open Patent Publication No. 2003-128832 (published May 8, 2003)
  • the method using this self-organization phenomenon is a highly accurate honeycomb structure that does not require complicated manufacturing equipment and is long to manufacture and requires time as in the manufacturing method using the mold technology described above.
  • the body can be manufactured.
  • the present invention has been made in view of the above-mentioned problems, and the object thereof is to isolate the holes formed when manufacturing a her cam structure by self-organization using droplets as saddles. It is to provide technology that can be in a state.
  • the present inventors have performed a proper post-treatment after producing a her cam structure having a droplet as a bowl and having a hole, whereby the her cam It has been found that it is possible to form a hole isolated from each other by fusing a part of the structure body at a fine level and closing a communication portion of a plurality of holes, thereby completing the present invention.
  • a method for manufacturing a her cam structure according to the present invention is a method for manufacturing a honeycomb structure having a plurality of holes arranged in a honeycomb shape in order to solve the above-described problems.
  • the film-like body obtained in the hole forming step includes a hole isolation step of isolating individual holes by partially deforming or removing the structure around the holes. It is said.
  • the body material in the hole isolation step, is melted by heating the film body, or the film body is exposed to a solvent or a solution capable of dissolving the body material.
  • the surrounding structure may be partially changed, or the surrounding structure of the hole may be partially removed by the adhesion and peeling of the adhesive to the surface of the film-like body.
  • an adhesive tape can be used as an adhesive.
  • the material solution can contain a catalyst that promotes the polymerization reaction of the monomer material.
  • the first solvent is a hydrophobic organic solvent and the second solvent is water
  • the hole forming step it is preferable to form droplets on the surface of the liquid film by blowing a gas containing the vapor of the second solvent onto the liquid film.
  • the liquid film is formed by casting the material solution onto the surface of the support in the liquid film forming step.
  • the present invention also includes a her cam structure manufactured by the above manufacturing method.
  • another method for manufacturing a her cam structure that is useful in the present invention is a method for manufacturing a honeycomb structure having a plurality of holes arranged in a two-cam configuration, and having adjacent holes. Manufactured by self-organizing at least part of the main body material, which has at least part of the communicating part that communicates with the hole! In contrast to the pre-cam structure precursor, the structure around the hole is partially deformed or removed. Further, the present invention is characterized in that it includes a hole isolation process for isolating individual holes in the communication portion.
  • the body material in the hole isolation step, is melted by heating the film body, or the film body is exposed to a solvent or solution that can dissolve the body material.
  • the surrounding structure may be partially changed, or the surrounding structure of the hole may be partially removed by the adhesion and peeling of the adhesive to the surface of the film-like body.
  • an adhesive tape can be used as an adhesive.
  • At least a polymer material or a monomer material that is polymerized by a polymerization reaction can be used as the main body material.
  • the obtained cam-cam structure is used as a finished body. Instead, it is treated as an intermediate, and post-treatment such as heating, exposure to a solution, and physical processing is applied to the intermediate.
  • post-treatment such as heating, exposure to a solution, and physical processing is applied to the intermediate.
  • honeycomb structures having various structures according to various purposes and applications, and it is possible to expand the field of use of honeycomb structures and further improve their practicality. Monkey.
  • FIG. 1 (a) is a view showing a scanning line electron microscope (SEM) photograph of the Hercam film obtained in Example 1.
  • Fig. 1 (b) is a view showing an SEM photograph of the honeycomb film obtained in Example 2.
  • FIG. 2 is a view showing an SEM photograph of the honeycomb film obtained in Example 3.
  • FIG. 3 (a) is a view showing an optical micrograph of the intermediate knob-cam film obtained in Example 4. is there.
  • FIG. 3 (b) is a view showing an SEM photograph of the knob-cam film (finished product) obtained in Example 4.
  • FIG. 4 is a view showing an SEM photograph of the honeycomb film obtained in Example 5.
  • the structure having the holes is heated or exposed to a solvent or the like.
  • the structure body around the hole can be fused up and down, so that an isolated partition wall can be formed around the hole, and an isolated hole can be formed. it can.
  • the manufacturing method of the her cam structure according to the present invention is divided into steps, a step of preparing a solution of a material (main body material) that becomes a main body of the her cam structure (material solution preparation step), A step of forming a liquid film on the support using the obtained solution (liquid film forming step), a step of forming pores by self-organizing the main body material by evaporating the solvent from the obtained liquid film (Hole formation process) and a process of isolating the formed holes (hole isolation process).
  • the production method will be specifically described based on the above-mentioned division of each process.
  • a material solution is prepared by dissolving or dispersing at least a main body material serving as a main body of the Hercam structure in an arbitrary solvent (referred to as a first solvent for convenience).
  • the main body material used in the present invention is not particularly limited as long as it is a material capable of forming fine pores by a subsequent hole forming step! Specifically, for example, examples described later As shown in Fig. 5, various polymer materials (polymer or rosin) can be mentioned.
  • polymer material examples include aliphatic polyesters such as polylactic acid, polyhydroxybutyric acid, polystrength prolatatone, polyethylene adipate, polybutylene adipate; polymethylmetatalylate, polytetrahydrofurol.
  • Polyacrylic acid esters such as furylmetatalylate; Aliphatic polycarbonates such as polybutylene carbonate and polyethylene carbonate; Polyimides, polyamideimides, polyetherimides, polyesterimides, and other polymers Although riimides etc. can be mentioned, it is not specifically limited.
  • these polymer materials an appropriate material can be selected according to the use of the Hercam structure. Moreover, only one kind of these polymer materials may be used, or a polymer blend obtained by combining two or more kinds may be used! /.
  • the main body material may be a monomer material that is polymerized by a polymerization reaction rather than a polymer material itself.
  • the specific monomer material is not particularly limited.
  • the monomer compound used for the polymerization of the above-described polymer material can be appropriately selected and used.
  • a polymer material may be combined with a monomer material, an oligomer material, or other crosslinking agent.
  • a monomer structure or oligomer material is subjected to a cross-linking reaction, thereby making it possible to produce a herm structure having a three-dimensional structure at the molecular level.
  • a catalyst can be added as necessary to promote a polymerization reaction or a cross-linking reaction.
  • a known appropriate substance can be selected and used according to the specific type of the monomer material or the like and the type of polymerization or crosslinking reaction.
  • the first solvent is not particularly limited as long as it can dissolve or disperse various substances used as the main body material.
  • various polymer materials or monomer materials used as raw materials thereof
  • these polymer materials can be dissolved or dispersed.
  • Various organic solvents can be suitably used.
  • halogen-based organic solvents such as black mouth form and methylene chloride; aromatic hydrocarbons such as benzene, toluene and xylene; esters such as ethyl acetate and butyl acetate; methyl isobutyl ketone and the like Water-insoluble ketones; ethers such as jetyl ether; and the like. It is also possible to use a solvent such as carbon dioxide. These solvents may be used alone or as a mixed solvent in which two or more kinds are combined as necessary.
  • the first solvent used is preferably a solvent having as low an affinity as possible with water.
  • it is preferably a water-insoluble (hydrophobic) solvent.
  • the method for preparing the material solution is not particularly limited, and a preferable preparation method may be appropriately selected and used depending on the type of the main body material to be used.
  • a polymer material it may be difficult to smoothly dissolve in a solvent because of its large molecular weight compared to a low-molecular compound or substance. Therefore, various treatments such as heating and application of ultrasonic waves may be performed during dissolution or dispersion. It is also possible to use a polymer polymerization solvent solution obtained by the polymerization reaction as it is as a material solution.
  • the above-mentioned material solution may contain known additives in a range that does not affect the formation of the hard cam structure and control of the shape.
  • an amphiphilic compound having an affinity for both the first solvent and the second solvent as the main body material in addition to the main material.
  • the surface tension between the second solvent droplet and the liquid solvent first solvent can be reduced in the pore formation process, so that the droplets aggregate and fuse into one lump. It can be effectively prevented.
  • the hard cam structure can be manufactured even better.
  • the amphiphilic compound is not particularly limited. However, when a hydrophobic organic solvent is used as the first solvent and water is used as the second solvent, an amphiphilic polymer is used. Can be.
  • the amphiphilic polymer include an amphiphilic polymer having polyacrylamide as a main chain skeleton, a dodecyl group as a hydrophobic side chain, and a carboxyl group as a hydrophilic side chain, and a polyethylene glycol Z polypropylene glycol block copolymer. Is mentioned.
  • the hydrophobic side chain is a non-polar linear group such as a methylene group or a phenylene group, except for a linking group such as an ester group or an amide group.
  • the hydrophilic side chain preferably has a structure having a hydrophilic part such as a polar group, an ionic dissociation group, or an oxyethylene group at the terminal via a linking part such as a methylene group.
  • the ratio of the hydrophobic side chain to the hydrophilic side chain depends on the size, nonpolarity, polarity strength, and hydrophobic organic solvent hydrophobicity.
  • the unit ratio is in the range of 3Zl to lZ3. It is desirable that Also, in the case of a copolymer, a block copolymer in which a hydrophobic side chain and a hydrophilic side chain form a block as long as the solubility in a hydrophobic solvent is not affected, as compared with an alternating polymer of hydrophilic side chains of hydrophobic side chains. It is preferable that
  • the Hercam structure that is useful in the present invention can be used as a cell culture substrate in the biotechnology field, for example. Therefore, it is preferable to use a non-toxic amphiphilic compound for such applications.
  • Non-toxic amphiphilic compounds such as polyethylene glycol z polypropylene glycol block copolymer, acrylamide polymer as the main chain skeleton, dodecyl group as hydrophobic side chain and ratato group as hydrophilic side chain, or Amphiphilic polymers that also have a carboxyl group, or ion complexes of heparin dextran sulfate, ionic polymers such as nucleic acids (DNA and RNA) and long chain alkyl ammonium salts, gelatin, collagen, It is desirable to use an amphiphilic polymer having a water-soluble protein such as albumin as a hydrophilic group.
  • liquid film refers to a state in which the above-mentioned material solution is stably formed by spreading in the form of a film on the surface of the support in the solution state.
  • the material of the support does not affect the liquid film.
  • the support is not altered or corroded by the first solvent, the main body material, or other additives contained in the liquid film.
  • the support is made of a material.
  • inorganic materials such as glass, metal and silicon wafers; organic materials excellent in organic solvent resistance such as polypropylene, polyethylene, polyetherketone and polyfluorinated styrene; water, liquid paraffin , Liquids such as liquid polyether, and the like can be used.
  • aluminum or glass is used.
  • the specific shape of the support is not particularly limited as long as the liquid film can be stably held on the surface thereof.
  • a flat substrate substrate
  • a curved substrate may be used according to the shape of the huck cam structure.
  • a rotating body such as a rotating drum or a rotating belt can be used.
  • the surface of the support may have a smoothness capable of holding a liquid film, but it should be peelable on the premise that the support is peeled off after the hole forming step described later. In order to improve it, a known surface treatment is applied!
  • the specific method for laminating the liquid film on the support is not particularly limited, and is a casting method in which a material solution is cast onto the support surface; a bar coater, a roll coater, a knife coater, etc. Examples thereof include a coating method using a known coating member; an extrusion coating method using various known dies; a dip method in which a support is immersed in a material solution; and the like.
  • the liquid film is formed by the casting method, but of course, the present invention is not limited to this, and an appropriate method is selected in consideration of the material solution, the type of support, the manufacturing scale, etc. Can be used.
  • the conditions in the liquid film lamination method are not particularly limited, and the state of the liquid film formed on the support changes before it enters the hole forming step. Set the appropriate conditions according to the lamination method within the range that does not change the quality of the components!
  • the first solvent is volatilized from the formed liquid film, and the self-organization of the body material accompanying the formation of droplets of the second solvent that does not mix with the first solvent results in the above-mentioned
  • a plurality of holes are formed in a harcome shape with a droplet as a bowl.
  • the solvent used as the second solvent is not specifically limited.
  • a known solvent that does not mix with the first solvent may be selected and used according to the type of the first solvent.
  • water it is preferable to use water as the second solvent, but of course, it is not limited to this, and a hydrophilic organic solvent such as various lower alcohols is used in combination with water. Can also be used.
  • a gas containing water vapor is blown onto the liquid film to form droplets on the surface of the liquid film, and from the liquid film to hydrophobicity.
  • the body material is self-assembled by evaporating the organic solvent.
  • the liquid film formed on the support is deprived of latent heat when the hydrophobic organic solvent evaporates. Therefore, on the liquid film surface (that is, evaporative cooling) whose temperature has decreased, the water vapor contained in the gas condenses into minute water droplets (droplets) and adheres to the liquid film surface.
  • the surface tension between the water droplet and the hydrophobic organic solvent is reduced by the action of the hydrophilic portion of the amphiphilic compound contained in the liquid film. Aggregating and fusing into a single mass is effectively avoided.
  • water droplets are transferred and accumulated by evaporation of the solvent and the flow of the material solution in the liquid film based on the compensation from the surroundings, and are further closely packed by the transverse capillary force.
  • the main body material contained in the liquid film is self-organized using the filled water droplets as a bowl shape, and a hermetic pattern structure is formed.
  • the gas containing water vapor for example, an inert gas such as air, nitrogen gas, or argon gas can be suitably used. Gases other than inert gas can be used depending on the type of liquid film components (main body material, first solvent, etc.) and the type of support.
  • This blowing gas may be a single gas or a mixed gas such as air.
  • the humidity in other words, the vapor pressure of the second solvent
  • the flow rate in order to form a good Hercam structure.
  • These humidity and flow rate control methods are not particularly limited, and may be controlled using known techniques related to gas flow and spraying.
  • specific ranges of humidity and flow rate are not particularly limited, and appropriate conditions may be set in consideration of the material solution, the type of support, the manufacturing scale, and the like. For example, in the examples described later, the humidity is 70% and the spraying flow rate is 2 to 3 liters Z.
  • the blowing gas is desirably subjected to dust removal treatment such as passing through a filter before being blown onto the liquid film.
  • dust removal treatment such as passing through a filter before being blown onto the liquid film.
  • dust in the atmosphere affects the hard cam structure formed as condensation nuclei of water vapor, it is necessary to install dust removal equipment at the manufacturing site. preferable.
  • the hole isolation step individual holes are isolated by partially deforming or removing the structure around the holes from the film-like body obtained in the hole forming step.
  • the nozzle-cam structure obtained in the hole forming step is used as an intermediate, and a process for isolating the holes from the intermediate is performed. Specifically, when the holes are in communication, the communication portion is closed, and if the trunk or pillar of the honeycomb structure has a certain thickness or width, the periphery of the communication portion is removed.
  • the method for closing the hole communication portion is not particularly limited, but a typical method is to heat the intermediate body (film-like body) of the Hercam structure obtained in the hole forming step. Then, the structure around the hole may be partially changed by thermally fusing the periphery of the hole or by partially dissolving the film-like body by exposure to various solutions or solvents.
  • the method for heating the film-like body is not particularly limited, and the type of the main body material to be the film-like body, that is, the honeycomb structure, the macro shape of the honeycomb structure (in the case of a film form, A suitable heating method may be selected according to various conditions such as film thickness, width, length, and the like. In the Example mentioned later, the film-form film-form body is heated using the hot stage.
  • the heating temperature for heating the film-like body is not particularly limited, and an appropriate temperature may be set according to the melting point or glass transition temperature (Tg) of the main body material.
  • Tg melting point or glass transition temperature
  • heating around Tg can soften and melt the periphery of the hole to effectively close the communication hole (see, for example, the heating temperatures of Examples 2 and 4).
  • the degree of softening and melting around the hole can be controlled by changing the heating temperature, the hole is not completely isolated, or the wall thickness of the isolated hole is changed. Can be used.
  • the state of the honeycomb structure itself can also be controlled by controlling the heating temperature rather than simply isolating the communication holes.
  • the type of the solution or solvent to be used is not particularly limited as long as it can dissolve the main body material.
  • a good solvent for the main body material an acidic solution, an alkaline solution, or the like can be used.
  • the main body material is various polymers, for example, Black mouth form, which is a good solvent for the child material, is used (see Example 3).
  • the degree of dissolution around the pores can be controlled by changing the exposure conditions or changing the type of solvent used, as in the case of the above heating (for example, In Example 3, it is possible to change the thickness of the stem of the Her-cam structure, the height of the pillar, etc.), so that the hole is not completely isolated or the wall of the isolated hole is The thickness can be changed. Therefore, in the present invention, the state of the Herckum structure itself can be controlled also by controlling the exposure conditions to the solution and the solvent.
  • the exposure conditions include, but are not particularly limited to, the exposure time of the film-like body to the solution or solvent, the exposure temperature, the concentration of the solution or solvent, and the like.
  • a method for partially removing the structure around the hole is not particularly limited.
  • the surface of the film-like body An operation for adhering and peeling the pressure-sensitive adhesive can be mentioned (see Example 5).
  • the adhesive body and its degree of adhesion may be selected appropriately depending on the strength of the main body material and the shape of the cam structure (the size of the trunk and pillars).
  • an adhesive tape is used as the pressure-sensitive adhesive body.
  • the manufacturing method according to the present invention need not include all of the material solution preparation step, the liquid film formation step, the hole formation step, and the hole isolation step, but may include at least the hole isolation step.
  • the material solution an already prepared solution can be used. Therefore, the material solution can be omitted, and only the hole isolation step may be performed on the already manufactured Hercum structure. .
  • a step of separating the formed two-cam structure from the support force may be included.
  • the her cam structure which is useful in the present invention is manufactured by the above manufacturing method and may have a plurality of holes arranged in a her cam shape.
  • the hole is isolated.
  • the independent holes are regularly arranged in a Harcam shape.
  • the specific shape of the hard cam structure that is useful in the present invention that is, the hard cam structure
  • the typical shape (primary shape) of the her cam structure according to the present invention is as follows.
  • a flat-shaped her cam film may be a her cam film.
  • These Hercam film Z films may have a quadratic secondary shape such as a square or a rectangle, a circular or elliptical secondary shape, or a more complicated secondary film. You may have the following shape. These secondary shapes are appropriately set according to the use of the honeycomb structure, and can be easily manufactured by performing secondary processing such as punching or cutting the manufactured honeycomb film Z film. (See Examples).
  • the Hercom structure that is useful in the present invention may be a honeycomb structure film having an array structure of stretched pores by stretching.
  • the stretching method is not particularly limited.
  • the stretching can be performed by pinching two or more ends of the her cam structure with tweezers or hands and pulling in the extending direction.
  • stretching can be carried out using a micro-manipulator.
  • a pair of rolling rollers or the like may be used.
  • the state of the hole formed in the hard cam structure that is useful in the present invention is not particularly limited, and may be a through hole or a non-through hole. Further, depending on the application in which all the holes do not need to be isolated, the holes may be partially or periodically communicated. Such a state can be achieved by controlling various conditions of the manufacturing method.
  • the application field of the honeycomb structure obtained by the present invention is not particularly limited, and can be used in a wide variety of known fields in which the honeycomb structure can be used.
  • large-area 'flexible display devices, surface light emitters such as EL panels, display devices, and electronic devices such as memory elements; nonlinear optical materials such as photonic crystals and optical waveguides, and light energy conversion Examples include optical (and electronic) fields such as devices; chemical fields such as various catalysts and microreactors; biotechnology fields such as DNA chips, microarrays, macroarrays, protein chips, and cell culture substrates.
  • a nodular-cam-like porous body having periodic and isolated pores is expected to be applied to a photonic crystal element.
  • matrix materials such as electrodes
  • the structure can be stably maintained in heat or a solvent.
  • the influence of substrate turnover on cell growth and separation has recently been elucidated, but it is also resistant to various solvents, so it can be used as a stable pattern base material.
  • the use as a cell culture substrate is promising.
  • the periodic shape of the cams with holes isolated from each other is very promising as a microreactor.
  • an aluminum substrate 5 cm square, 0.1 mm thick, manufactured by Niraco
  • 5 ml of the material solution was cast to form a liquid film.
  • High-humidity air (humidity 70%) was blown onto this liquid film in an environment of temperature 25 ° C and humidity 30% (for 31itterZ).
  • a hard cam structure intermediate no-cam film
  • the intermediate knife-cam film formed on the aluminum substrate was punched into a circular shape having a diameter of 1 cm using a punching blade.
  • 0s, 5s, and 40s in Fig. 1 (a) indicate the heating time at 100 ° C (0 seconds, 5 seconds, and 40 seconds).
  • the Top view shows the front (0 °) force observed on the substrate, and the Ti It view shows the substrate observed by tilting 45 °.
  • Example 2 of hole isolation process by thermal melting>
  • Example 1 Under the same conditions as in Example 1, an intermediate no-cam film was prepared by an independent process, and the intermediate no-cam film was heated at 100 ° C. for 50 seconds, thereby completing the half-cam. A structure (Hercam film) was produced.
  • Figure 1 (b) shows the result of observation of the resulting hard cam film by SEM. The observation conditions are the same as in Example 1.
  • a material solution was prepared using polymethylmetatalylate (PMMA, Aldrich) and CAP polymer as the main material, and black mouth form as the first solvent.
  • PMMA polymethylmetatalylate
  • CAP polymer CAP polymer
  • black mouth form black mouth form
  • 7 ml of the material solution was cast to form a liquid film.
  • High-humidity air humidity 70%
  • a Hercam structure intermediate nonicuminolem having a continuous hole was obtained as an intermediate.
  • Example 4 Example 3 of hole isolation process by heat melting>
  • Polybutadiene (trade name: RB820, JSR) and CAP polymer were used as the main body material, and a material solution was prepared using black mouth form as the first solvent. Polybutadiene and CAP polymer were dissolved in black mouth form so that the weight ratio was 10: 1, and a material solution was prepared so that the final concentration of the main body material was 1.5 mg / ml.
  • a glass petri dish having an outer diameter of 9 cm and covered with a cover glass (18 mm X 18 mm, MATSUNAMI) was used as a support.
  • a cover glass (18 mm X 18 mm, MATSUNAMI)
  • 5 ml of the material solution was cast to form a liquid film.
  • the liquid film was sprayed with nitrogen through an air-washing bottle containing 200 ml of deionized water in an environment of a temperature of 23 ° C. and a humidity of 53% (21itterZ).
  • a hard cam structure intermediate hard cam film having a continuous hole is obtained as an intermediate. It was.
  • the obtained intermediate knot-cam film was cut out together with the cover glass, and observed with an optical microscope (trade name: BH-2, OLYMPUS). The result is shown in Fig. 3 (a). Also, the intermediate hard-cam film cut out from each cover glass is heated at 100 ° C for 1 minute with a heater (trade name: RH6000, manufactured by Japan High-Tech) to melt the intermediate hard-cam film. V. A finished Hercam structure (Harcam film) was manufactured.
  • the resulting Hercam film was observed by SEM.
  • the observation conditions were a magnification of 100 to L000, a voltage of 10 to 25 kv, and a substrate tilted by 0 ° to 75 °.
  • the result is shown in Fig. 3 (b).
  • the upper two SEM images in Fig. 3 (b) show the state of the substrate before heating, and the left side is an observation of the front (0 °) of the substrate. The right side is observed with the substrate tilted 70 °.
  • the two lower SEM images in Fig. 3 (b) show the state of the substrate after heating, and are observed with the substrate tilted 70 ° on both the left and right sides.
  • the lower left SEM image in FIG. 3B is a non-penetrating membrane
  • the lower right SEM image is a penetrating membrane.
  • a material solution was prepared using polytetrahydrofurfuryl metatalylate (Aldrich) and CAP polymer as the main material, and black mouth form as the first solvent. Polytetrahydrofurfuryl metatalylate and CAP polymer were dissolved in chloroform so as to have a weight ratio of 10: 1, and a material solution was prepared so that the final concentration of the main body material was 4 mgZml.
  • a glass petri dish having an outer diameter of 9 cm was used as a support.
  • 5 ml of the above material solution was cast to form a liquid film.
  • High-humidity air humidity 70%
  • a honeycomb structure intermediate honeycomb film having a continuous hole was obtained as an intermediate.
  • An adhesive tape (Cellotape (registered trademark), -Chiban Co., Ltd.) was applied to the surface of the intermediate knob-cam film, and then the tape was peeled off. The operation was repeated once and twice. As a result, the structure around the hole is formed in the intermediate film-cam film. A partially removed Hercam structure (No., two cam film) was produced.
  • the dimple structure was produced on the surface of the glass petri dish by repeating the operation of pasting and peeling with an adhesive tape three times.
  • the shape of the Her-cam structure is obtained by performing post-processing on the No-cam structure obtained by self-organizing the main body material using a droplet as a bowl shape. Is controlling. For this reason, it is possible to obtain a microporous membrane with a Hercam structure having various structures according to various purposes and applications, and it is possible to expand the field of use of the Hercam structure. Therefore, the present invention can be used in the fields of a microreactor, a photonic crystal, a cell culture substrate, etc. using a Hercom structure having isolated holes.

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  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Laminated Bodies (AREA)
  • Moulding By Coating Moulds (AREA)

Abstract

L’invention concerne une solution de matériau comprenant un solvant organique hydrophobe et un matériau polymérique dissout ou dispersé dans celui-ci que l’on applique à un substrat pour élaborer un film liquide de la solution de matériau. On souffle une vapeur d’eau contenant un gaz à la surface du film liquide pour ainsi constituer des trous dans une disposition alvéolaire tout en utilisant les gouttelettes d’eau résultantes comme gabarit. L’objet en film résultant est chauffé ou exposé à un bon solvant pour que le matériau polymérique se déforme partiellement ou bien pour enlever la structure entourant les trous et ainsi isoler les trous individuels. Cette technique permet de produire une structure alvéolaire avec des trous isolés grâce à une auto-organisation utilisant les gouttelettes comme gabarit.
PCT/JP2006/302074 2005-02-25 2006-02-07 Procédé de fabrication d’une structure alvéolaire avec des trous isolés WO2006090579A1 (fr)

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EP1967342A1 (fr) 2007-03-08 2008-09-10 Ricoh Company, Ltd. Panneau d'affichage, procédé de fabrication d'un panneau d'affichage et unité d'affichage
JP2008248075A (ja) * 2007-03-30 2008-10-16 Fujifilm Corp 多孔質膜及びその製造方法
JP2008296481A (ja) * 2007-05-31 2008-12-11 Mitsui Chemicals Inc ３次元構造が形成された樹脂フィルムの製造方法
JP2010229373A (ja) * 2009-03-30 2010-10-14 Fujifilm Corp 多孔体の製造方法
WO2010150794A1 (fr) * 2009-06-23 2010-12-29 Canon Kabushiki Kaisha Procédé de production d'un film polymère poreux et film polymère poreux produit par le procédé
JP2013503761A (ja) * 2009-09-08 2013-02-04 エスケー イノベーション シーオー．， エルティーディー． 表面モフォロジーが調節された光学フィルム及びその製造方法
CN111397834A (zh) * 2020-04-24 2020-07-10 中国空气动力研究与发展中心超高速空气动力研究所 一种大口径高超声速风洞蜂窝器的加工方法
JP7199815B2 (ja) 2017-02-28 2023-01-06 公立大学法人大阪 電気化学デバイスおよびその製造方法

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JP2002347107A (ja) * 2001-05-22 2002-12-04 Inst Of Physical & Chemical Res 延伸フィルムおよびそれを用いた細胞培養基材
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JP2002347107A (ja) * 2001-05-22 2002-12-04 Inst Of Physical & Chemical Res 延伸フィルムおよびそれを用いた細胞培養基材
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Publication number Priority date Publication date Assignee Title
EP1967342A1 (fr) 2007-03-08 2008-09-10 Ricoh Company, Ltd. Panneau d'affichage, procédé de fabrication d'un panneau d'affichage et unité d'affichage
US8241731B2 (en) 2007-03-08 2012-08-14 Ricoh Company, Ltd. Display panel, method of manufacturing a display panel, and display unit
JP2008248075A (ja) * 2007-03-30 2008-10-16 Fujifilm Corp 多孔質膜及びその製造方法
JP2008296481A (ja) * 2007-05-31 2008-12-11 Mitsui Chemicals Inc ３次元構造が形成された樹脂フィルムの製造方法
JP2010229373A (ja) * 2009-03-30 2010-10-14 Fujifilm Corp 多孔体の製造方法
US8518490B2 (en) 2009-03-30 2013-08-27 Fujifilm Corporation Porous material production method
WO2010150794A1 (fr) * 2009-06-23 2010-12-29 Canon Kabushiki Kaisha Procédé de production d'un film polymère poreux et film polymère poreux produit par le procédé
JP2011006520A (ja) * 2009-06-23 2011-01-13 Canon Inc 多孔質高分子膜の製造方法及びその製造方法で製造した多孔質高分子膜
US8916619B2 (en) 2009-06-23 2014-12-23 Canon Kabushiki Kaisha Method of producing porous polymer film and porous polymer film produced by the method
JP2013503761A (ja) * 2009-09-08 2013-02-04 エスケー イノベーション シーオー．， エルティーディー． 表面モフォロジーが調節された光学フィルム及びその製造方法
JP7199815B2 (ja) 2017-02-28 2023-01-06 公立大学法人大阪 電気化学デバイスおよびその製造方法
CN111397834A (zh) * 2020-04-24 2020-07-10 中国空气动力研究与发展中心超高速空气动力研究所 一种大口径高超声速风洞蜂窝器的加工方法

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