WO2006056182A1 - Nouveaux principes actifs pour assurer le traitement, le diagnostic et la prophylaxie de la degenerescence maculaire - Google Patents

Nouveaux principes actifs pour assurer le traitement, le diagnostic et la prophylaxie de la degenerescence maculaire Download PDF

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Publication number
WO2006056182A1
WO2006056182A1 PCT/DE2005/002106 DE2005002106W WO2006056182A1 WO 2006056182 A1 WO2006056182 A1 WO 2006056182A1 DE 2005002106 W DE2005002106 W DE 2005002106W WO 2006056182 A1 WO2006056182 A1 WO 2006056182A1
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WO
WIPO (PCT)
Prior art keywords
alkyl
carbon atoms
radical
group
empirical formula
Prior art date
Application number
PCT/DE2005/002106
Other languages
German (de)
English (en)
Inventor
Thomas Schrader
Frank-Gerrit KLÄRNER
Michael Fokkens
Reza Zadmard
Jolanta Polkowska
Frank Bastkowski
Christian Jasper
Original Assignee
Philipps-Universität Marburg
Universität Duisburg-Essen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Philipps-Universität Marburg, Universität Duisburg-Essen filed Critical Philipps-Universität Marburg
Publication of WO2006056182A1 publication Critical patent/WO2006056182A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4021—Esters of aromatic acids (P-C aromatic linkage)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056—Esters of arylalkanephosphonic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4084—Esters with hydroxyaryl compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne de nouveaux principes actifs, qui interagissent avec le cation lipophile A2E (N-rétinyl-N-étinylidène-éthanolamine) de la rétine et s'utilisent pour assurer le traitement, le diagnostic et la prophylaxie de la dégénérescence maculaire sèche liée à l'âge. Les principes actifs selon l'invention sont des dérivés de calixarène substitués par phosphate ou phosphonate et ce qu'il est convenu d'appeler des clips. Les clips sont des combinaisons cycliques condensées, dans lesquelles des combinaisons cycliques aromatiques sont interconnectées par l'intermédiaire de groupes bicyclo-[2.2.1]-hept-2-ène, de sorte que l'ensemble de la molécule décrive un 'U' et forme une cavité.
PCT/DE2005/002106 2004-11-24 2005-11-23 Nouveaux principes actifs pour assurer le traitement, le diagnostic et la prophylaxie de la degenerescence maculaire WO2006056182A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102004056822A DE102004056822A1 (de) 2004-11-24 2004-11-24 Neue Wirkstoffe zu Therapie, Diagnostik und Prophylaxe der Makula-Degeneration
DE102004056822.7 2004-11-24

Publications (1)

Publication Number Publication Date
WO2006056182A1 true WO2006056182A1 (fr) 2006-06-01

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ID=35788629

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2005/002106 WO2006056182A1 (fr) 2004-11-24 2005-11-23 Nouveaux principes actifs pour assurer le traitement, le diagnostic et la prophylaxie de la degenerescence maculaire

Country Status (2)

Country Link
DE (1) DE102004056822A1 (fr)
WO (1) WO2006056182A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008148168A1 (fr) * 2007-06-07 2008-12-11 The University Of Western Australia Procédés de préparation de dérivés de calixarènes
WO2010102248A3 (fr) * 2009-03-05 2010-11-04 The Regents Of The University Of California Pince moléculaire pour le traitement d'amyloses
CN101987894B (zh) * 2009-07-30 2012-11-07 沁阳市双屿防腐设备有限公司 热塑性塑料制备无卤阻燃纳米复合材料的方法
US10918657B2 (en) 2013-11-08 2021-02-16 The Regents Of The University Of California Treatment of spinal cord injury or traumatic brain injury by inhibition of synuclein protein aggregation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994003164A1 (fr) * 1992-08-06 1994-02-17 Genelabs Technologies, Inc. Inhibition et traitement de l'infection par un virus a enveloppe avec des composes de calix(n) arene
US5409959A (en) * 1991-01-29 1995-04-25 Genelabs Incorporated Antithrombotic treatment with calix(n)arene compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5409959A (en) * 1991-01-29 1995-04-25 Genelabs Incorporated Antithrombotic treatment with calix(n)arene compounds
WO1994003164A1 (fr) * 1992-08-06 1994-02-17 Genelabs Technologies, Inc. Inhibition et traitement de l'infection par un virus a enveloppe avec des composes de calix(n) arene

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
CHRISTIAN JASPER;THOMAS SCHRADER;JENS PANITZKY; FRANK-GERRIT KLÄRNER: "Selective Complexation of N-Alkylpyridinium Salts: Recognition of NAD+ in Water", ANGEW. CHEM. INT. ED, vol. 41, no. 8, 2002, pages 1355 - 1358, XP002368744 *
DARIUSZ WITT, JOANNA DZIEMIDOWICZ, JANUSZ RACHON: "Calix[4]arene Phosphonates - Recognition of Amino Alcohols in Water", HETEROATOM CHEMISTRY, vol. 15, no. 2, 23 March 2004 (2004-03-23), pages 155 - 161, XP008060328 *
FRANK-GERRIT KLÄRNER; BJÖRN KAHLERT: "Molecular Tweezers and Clips as Synthetic Receptors. Molecular Recognition and Dynamics in Receptor-Subtrate Complexes", ACC. CHEM. RES., vol. 36, 2003, pages 919 - 932, XP002368745 *
ZADMARD, REZA; JUNKERS, MATTHIAS; SCHRADER, THOMAS; GRAWE, THOMAS; KRAFT, ARNO: "Capsule-like Assemblies in Polar Solvents", JOURNAL OF ORGANIC CHEMISTRY, vol. 68, no. 17, 2003, pages 6511 - 6521, XP002368699 *
ZADMARD, REZA; SCHRADER, THOMAS; GRAWE, THOMAS; KRAFT, ARNO: "Self-Assembly of Molecular Capsules in Polar Solvents", ORGANIC LETTERS, vol. 4, no. 10, 2002, pages 1687 - 1690, XP002368700 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008148168A1 (fr) * 2007-06-07 2008-12-11 The University Of Western Australia Procédés de préparation de dérivés de calixarènes
US8252954B2 (en) 2007-06-07 2012-08-28 The Curators Of The University Of Missouri Processes for the preparation of calixarene derivatives
WO2010102248A3 (fr) * 2009-03-05 2010-11-04 The Regents Of The University Of California Pince moléculaire pour le traitement d'amyloses
US8791092B2 (en) 2009-03-05 2014-07-29 The Regents Of The University Of California Molecular tweezers for the treatment of amyloid-related diseases
CN101987894B (zh) * 2009-07-30 2012-11-07 沁阳市双屿防腐设备有限公司 热塑性塑料制备无卤阻燃纳米复合材料的方法
US10918657B2 (en) 2013-11-08 2021-02-16 The Regents Of The University Of California Treatment of spinal cord injury or traumatic brain injury by inhibition of synuclein protein aggregation

Also Published As

Publication number Publication date
DE102004056822A1 (de) 2006-06-08

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