WO2006008038A1 - Methyliden-d-xylopyranosyl- und oxo-d-xylopyranosyl-substituierte phenyle, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung - Google Patents
Methyliden-d-xylopyranosyl- und oxo-d-xylopyranosyl-substituierte phenyle, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung Download PDFInfo
- Publication number
- WO2006008038A1 WO2006008038A1 PCT/EP2005/007582 EP2005007582W WO2006008038A1 WO 2006008038 A1 WO2006008038 A1 WO 2006008038A1 EP 2005007582 W EP2005007582 W EP 2005007582W WO 2006008038 A1 WO2006008038 A1 WO 2006008038A1
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- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- group
- cycloalkyl
- methylidene
- cycloalkenyl
- Prior art date
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- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title claims abstract description 37
- 239000003814 drug Chemical class 0.000 title claims abstract description 21
- 150000001875 compounds Chemical class 0.000 title claims description 101
- 238000000034 method Methods 0.000 title claims description 16
- 238000004519 manufacturing process Methods 0.000 title claims description 13
- 102000000070 Sodium-Glucose Transport Proteins Human genes 0.000 claims abstract description 12
- 108010080361 Sodium-Glucose Transport Proteins Proteins 0.000 claims abstract description 12
- 102100037202 Sodium/myo-inositol cotransporter 2 Human genes 0.000 claims abstract description 12
- 101710090560 Sodium/myo-inositol cotransporter 2 Proteins 0.000 claims abstract description 12
- 230000002401 inhibitory effect Effects 0.000 claims abstract description 9
- 208000030159 metabolic disease Diseases 0.000 claims abstract description 8
- -1 pyrrolidin-1-ylcarbonyl Chemical group 0.000 claims description 136
- 125000000217 alkyl group Chemical group 0.000 claims description 108
- 229910052739 hydrogen Inorganic materials 0.000 claims description 67
- 239000001257 hydrogen Substances 0.000 claims description 64
- 239000000460 chlorine Substances 0.000 claims description 59
- 229910052801 chlorine Inorganic materials 0.000 claims description 59
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 57
- 229910052731 fluorine Inorganic materials 0.000 claims description 51
- 229910052760 oxygen Inorganic materials 0.000 claims description 50
- 239000011737 fluorine Substances 0.000 claims description 49
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 46
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 42
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 40
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 38
- 125000001424 substituent group Chemical group 0.000 claims description 36
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 35
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 35
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 35
- 150000003839 salts Chemical class 0.000 claims description 35
- 125000003545 alkoxy group Chemical group 0.000 claims description 31
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 29
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 28
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 26
- 229910052794 bromium Inorganic materials 0.000 claims description 26
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 25
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 24
- 125000003118 aryl group Chemical group 0.000 claims description 24
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 24
- 229910052717 sulfur Inorganic materials 0.000 claims description 24
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 23
- 239000000203 mixture Substances 0.000 claims description 22
- 238000011282 treatment Methods 0.000 claims description 22
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 20
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 20
- 125000003342 alkenyl group Chemical group 0.000 claims description 20
- 238000002360 preparation method Methods 0.000 claims description 20
- 210000004027 cell Anatomy 0.000 claims description 19
- 125000001072 heteroaryl group Chemical group 0.000 claims description 19
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 18
- 125000000623 heterocyclic group Chemical group 0.000 claims description 18
- 125000001841 imino group Chemical group [H]N=* 0.000 claims description 18
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 16
- 239000001301 oxygen Substances 0.000 claims description 16
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 14
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 14
- 125000000304 alkynyl group Chemical group 0.000 claims description 13
- 125000004432 carbon atom Chemical group C* 0.000 claims description 13
- 125000001153 fluoro group Chemical group F* 0.000 claims description 13
- 238000011321 prophylaxis Methods 0.000 claims description 13
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 12
- 229910052796 boron Inorganic materials 0.000 claims description 12
- 201000010099 disease Diseases 0.000 claims description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 11
- 230000008569 process Effects 0.000 claims description 10
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 9
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 9
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 8
- 125000000000 cycloalkoxy group Chemical group 0.000 claims description 8
- 208000002249 Diabetes Complications Diseases 0.000 claims description 7
- 125000005129 aryl carbonyl group Chemical group 0.000 claims description 7
- 239000003085 diluting agent Substances 0.000 claims description 7
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 7
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims description 7
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 7
- 206010012655 Diabetic complications Diseases 0.000 claims description 6
- 125000003282 alkyl amino group Chemical group 0.000 claims description 6
- 239000000969 carrier Substances 0.000 claims description 6
- 206010012601 diabetes mellitus Diseases 0.000 claims description 6
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 claims description 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 6
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 6
- 125000005740 oxycarbonyl group Chemical group [*:1]OC([*:2])=O 0.000 claims description 6
- 230000036961 partial effect Effects 0.000 claims description 6
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims description 6
- 125000003830 C1- C4 alkylcarbonylamino group Chemical group 0.000 claims description 5
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 5
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 5
- 125000004414 alkyl thio group Chemical group 0.000 claims description 5
- 125000005135 aryl sulfinyl group Chemical group 0.000 claims description 5
- 125000004104 aryloxy group Chemical group 0.000 claims description 5
- 229910052799 carbon Inorganic materials 0.000 claims description 5
- 125000004076 pyridyl group Chemical group 0.000 claims description 5
- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims description 5
- 125000006698 (C1-C3) dialkylamino group Chemical group 0.000 claims description 4
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 claims description 4
- 125000005163 aryl sulfanyl group Chemical group 0.000 claims description 4
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims description 4
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 4
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 4
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims description 4
- 239000002934 diuretic Substances 0.000 claims description 4
- 125000002541 furyl group Chemical group 0.000 claims description 4
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 claims description 4
- 125000001041 indolyl group Chemical group 0.000 claims description 4
- 230000005764 inhibitory process Effects 0.000 claims description 4
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims description 4
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 claims description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 4
- 239000008194 pharmaceutical composition Substances 0.000 claims description 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 4
- 125000000168 pyrrolyl group Chemical group 0.000 claims description 4
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims description 4
- 125000001544 thienyl group Chemical group 0.000 claims description 4
- 125000004769 (C1-C4) alkylsulfonyl group Chemical group 0.000 claims description 3
- 201000001320 Atherosclerosis Diseases 0.000 claims description 3
- 206010007558 Cardiac failure chronic Diseases 0.000 claims description 3
- 206010020772 Hypertension Diseases 0.000 claims description 3
- 208000008589 Obesity Diseases 0.000 claims description 3
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims description 3
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims description 3
- 125000002947 alkylene group Chemical group 0.000 claims description 3
- 239000002220 antihypertensive agent Substances 0.000 claims description 3
- 229940030600 antihypertensive agent Drugs 0.000 claims description 3
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims description 3
- 125000002837 carbocyclic group Chemical group 0.000 claims description 3
- 125000005149 cycloalkylsulfinyl group Chemical group 0.000 claims description 3
- 125000005144 cycloalkylsulfonyl group Chemical group 0.000 claims description 3
- 125000006576 di-(C1-C3-alkyl)-aminocarbonyl group Chemical group 0.000 claims description 3
- 229940030606 diuretics Drugs 0.000 claims description 3
- 125000005553 heteroaryloxy group Chemical group 0.000 claims description 3
- 125000002883 imidazolyl group Chemical group 0.000 claims description 3
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 3
- 150000007522 mineralic acids Chemical class 0.000 claims description 3
- 125000001624 naphthyl group Chemical group 0.000 claims description 3
- 235000020824 obesity Nutrition 0.000 claims description 3
- 150000007524 organic acids Chemical class 0.000 claims description 3
- 235000005985 organic acids Nutrition 0.000 claims description 3
- 125000004434 sulfur atom Chemical group 0.000 claims description 3
- 125000004760 (C1-C4) alkylsulfonylamino group Chemical group 0.000 claims description 2
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- 206010060378 Hyperinsulinaemia Diseases 0.000 claims description 2
- 201000001431 Hyperuricemia Diseases 0.000 claims description 2
- 208000013016 Hypoglycemia Diseases 0.000 claims description 2
- 206010022489 Insulin Resistance Diseases 0.000 claims description 2
- 208000007976 Ketosis Diseases 0.000 claims description 2
- 208000001145 Metabolic Syndrome Diseases 0.000 claims description 2
- 206010027417 Metabolic acidosis Diseases 0.000 claims description 2
- 206010030113 Oedema Diseases 0.000 claims description 2
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- 125000004658 aryl carbonyl amino group Chemical group 0.000 claims description 2
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- 230000007850 degeneration Effects 0.000 claims description 2
- LTVOKYUPTHZZQH-UHFFFAOYSA-N difluoromethane Chemical group F[C]F LTVOKYUPTHZZQH-UHFFFAOYSA-N 0.000 claims description 2
- 125000005224 heteroarylcarbonylamino group Chemical group 0.000 claims description 2
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims description 2
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- 201000008980 hyperinsulinism Diseases 0.000 claims description 2
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- 150000002431 hydrogen Chemical class 0.000 claims 11
- 150000003254 radicals Chemical class 0.000 claims 6
- 125000004465 cycloalkenyloxy group Chemical group 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 claims 1
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 230000004153 glucose metabolism Effects 0.000 claims 1
- HVZWVEKIQMJYIK-UHFFFAOYSA-N nitryl chloride Chemical compound [O-][N+](Cl)=O HVZWVEKIQMJYIK-UHFFFAOYSA-N 0.000 claims 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 33
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 31
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 27
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/04—Carbocyclic radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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Definitions
- the present invention relates to D-xylopyranosyl-substituted phenyls of the general formula I.
- a further subject of this invention relates to medicaments containing a compound of the formula I according to the invention and to the use of a compound according to the invention for the preparation of a medicament for the treatment of metabolic diseases.
- processes for the preparation of a medicament and of a compound according to the invention are the subject of this invention.
- the object of the present invention is to disclose novel pyranosyl-substituted phenyls, in particular those which have an activity with respect to sodium-dependent glucose cotransporters SGLT, in particular SGLT2.
- a further object of the present invention is to show pyranosyl-substituted phenylene which, in vitro and / or in vivo, has an increased inhibitory effect on the sodium-dependent glucose cotransporter SGLT2 and / or has improved pharmacological or pharmacokinetic properties in comparison with known structurally similar compounds ,
- a first subject of the present invention are D-xylopyranosyl-substituted
- R 1 is hydrogen, fluorine, chlorine, bromine, C 1-6 -alkyl, C 2-6 -alkynyl, C 2-6 -alkenyl, C 3-7 -cycloalkyl, C 1-6 -cycloalkyl-C 1-4 -alkyl, C 5 .
- alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl radicals are partially or completely fluorinated or mono- or disubstituted by identical or different substituents selected from chlorine, hydroxy, C 1-3 alkoxy and C 1-3 alkyl substituted can be, and
- cycloalkyl and cycloalkenyl radicals one or two methylene groups can be replaced independently of one another by O, S, CO, SO or SO 2 , and
- N-heterocycloalkyl radicals a methylene group may be replaced by CO or SO 2 , and
- R 2 is hydrogen, fluorine, chlorine, bromine, hydroxyl, C 1-4 -alkyl, C 1-4 -alkoxy, cyano or nitro, where alkyl radicals may be mono- or polysubstituted by fluorine, or
- R 1 and R 2 may be joined together such that R 1 and R 2 together form a C. 3
- R 1 and R 2 together form a C. 3
- 5- alkylene or C 3-5 alkenylene bridge which is partially or completely fluorinated or mono- or disubstituted by identical or different substituents selected from chlorine, hydroxy, Ci. 3- alkoxy and C 1-3 -alkyl and in which one or two methylene groups can be replaced independently of one another by O, S 1 CO, SO, SO 2 or NR N ,
- R 3 is hydrogen, fluorine, chlorine, bromine, C ⁇ -Alky !, C 2-6 alkynyl, C 2-6 alkenyl, C 3-7 -cycloalkyl, C ⁇ -cycloalkyl-C L s-alkyl, C 5-7 cycloalkenyl, C 5 . 7 -cycloalkenyl-C 1-3 -alkyl, aryl, heteroaryl, C 1-4 -alkylcarbonyl, arylcarbonyl, heteroarylcarbonyl, aminocarbonyl, Ci.
- alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl radicals are partially or completely fluorinated or mono- or disubstituted by identical or different substituents selected from chlorine, hydroxy, C 1-3 alkoxy and C 1-3 alkyl substituted can be, and
- cycloalkyl and cycloalkenyl radicals one or two methylene groups can be replaced independently of one another by O, S, CO, SO or SO 2 , and
- N-heterocycloalkyl radicals a methylene group may be replaced by CO or SO 2 , and
- R 4 is hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, d. 3 alkyl, C 1-3 alkoxy or by 1 to 3 fluorine atoms substituted methyl or methoxy, or
- R 3 and R 4 may be linked together such that R 3 and R 4 together form a C 3-5 alkylene or C 3-5 alkenylene bridge which partially or completely fluorinated or on or may be substituted in duplicate with the same or different substituents selected from chlorine, hydroxy, C 1-3 alkoxy and C 1-3 alkyl, and in the one or two methylene groups independently of one another by O, S, CO, SO, SO 2 or NR N can be replaced
- R 5 is hydrogen, fluorine, chlorine, bromine, iodine, cyano, nitro, C 1-3 -alkyl, C 1-3 -alkoxy or by
- R N independently of one another are H or C 1-4 -alkyl
- L are independently selected from the group consisting of fluorine, chlorine,
- R 7c independently of one another have a meaning selected from the group hydrogen, (Ci -18 alkyl) carbonyl, (C 1-18 -alkyl) oxycarbonyl, arylcarbonyl and aryl- (C 1-3 -alkyl) - carbonyl own,
- alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups may be partly or completely fluorinated or mono- or disubstituted by identical or different substituents selected from chlorine, cyano, hydroxy, Ci -3 alkoxy and C 1-3 alkyl may be substituted, and
- the above-mentioned unsubstituted methylidene group or the above-mentioned monosubstituted methylidene groups may be easily substituted with fluorine, chlorine, C 1-3 alkyl, cyano or nitro, and
- cycloalkyl, cycloalkenyl, cycloalkylidene and cycloalkenylidene radicals one or two methylene groups may independently be replaced by O, S, CO, SO, SO 2 or NR N , or
- X represents a group according to the sub-formula
- R x is hydrogen, fluorine, chlorine, cyano, trifluoromethyl or C 1-3 -alkyl
- B is a single bond, -O- or -NR N -,
- R B is hydrogen, C 1-6 alkyl, C 3-6 alkenyl, C 3-6 alkynyl, C 1-6 cycloalkyl, C 5-7
- Cycloalkenyl Cs ⁇ -cycloalkyl-C L s -alkyl-, Cs ⁇ -cycloalkenyl-C L s -alkyl-, aryl, heteroaryl, aryl-C 1-4 -alkyl- or heteroaryl-C 1-3 -alkyl-,
- alkyl, cycloalkyl and cycloalkenyl groups -3 alkyl may be substituted partly or totally fluorinated or mono- or disubstituted by identical or different substituents selected from chlorine, cyano, hydroxyl, C 1-3 alkoxy, and Ci or
- Z is oxygen, methylene, dimethylmethylene, difluoromethylene or carbonyl
- aryl groups mentioned in the definition of the abovementioned radicals are to be understood as meaning phenyl or naphthyl groups which may be independently of one another monosubstituted or disubstituted by identical or different radicals L;
- a pyrrolyl, furanyl, thienyl, pyridyl, indolyl, benzofuranyl, benzothiophenyl, quinolinyl or isoquinolinyl group is to be understood,
- N-heterocycloalkyl radical mentioned in the definition of the abovementioned radicals is to be understood as meaning a saturated carbocyclic ring which has an imino group in the ring, which represents another optionally substituted imino group or an O or S atom may have in the ring, and
- alkyl groups may be straight-chain or branched
- the compounds of the general formula I according to the invention and their physiologically tolerable salts have valuable pharmacological properties, in particular an inhibiting action on sodium-dependent glucose cotransporters SGLT, in particular SGLT2. Furthermore, compounds of the invention may have an inhibitory effect on the sodium-dependent glucose cotransporter SGLT1. Compared to a possible inhibitory effect on SGLT1, the compounds of the invention preferably selectively inhibit SGLT2.
- the present invention also relates to the physiologically tolerable salts of the compounds according to the invention with inorganic or organic acids.
- Another object of this invention are pharmaceutical compositions containing at least one compound of the invention or a physiologically acceptable salt according to the invention in addition to optionally one or more inert carriers and / or diluents.
- Another object of this invention is the use of at least one compound of the invention or a physiologically acceptable salt of such a compound for the manufacture of a medicament for the treatment or prophylaxis of Diseases or conditions is suitable, which can be influenced by inhibition of the sodium-dependent glucose cotransporter SGLT, in particular SGLT2.
- Another object of this invention is the use of at least one compound of the invention for the manufacture of a medicament for the treatment of metabolic diseases. suitable is.
- Another object of this invention is the use of at least one compound of the invention for the manufacture of a medicament for inhibiting the sodium-dependent glucose cotransporter SGLT, in particular SGLT2.
- a process for the preparation of a medicament according to the invention is the subject of this invention, characterized in that a compound according to the invention is incorporated into one or more inert carriers and / or diluents by a non-chemical route.
- the present invention also provides a process for the preparation of the compounds of general formula I according to the invention, characterized in that
- R 1 is H, Ci -4 -alkyl, (C 1-18 alkyl) carbonyl, Arylcarbonyl or aryl- (C 1-3 alkyl) -carbonyl, in which the alkyl or aryl groups may be mono- or polysubstituted by halogen; R 8a , R 8b ,
- R 8c independently of one another have meanings given previously and below for the radicals R 7a , R 7b , R 7c , a benzyl group or an R a R b R c Si group or a ketal or acetal group, in particular an alkylidene or Aryialkyliden- ketal or acetal group, wherein each two adjacent radicals R 8a , R 8b , R 8c , R 8d is a cyclic ketal or acetal group or a 1, 2-di (Ci -3 alkoxy) -1, 2-di may form (Ci -3 alkyl) -ethylene bridge, wherein the above-mentioned ethylene bridge together with two oxygen atoms and the associated two carbon atoms of the pyranose ring form a substituted dioxane ring, particularly a 2,3-
- R a , R b , R c independently of one another are C 1-4 -alkyl, aryl or aryl-C 1-3 -alkyl, in which the aryl or alkyl groups may be mono- or polysubstituted by halogen;
- aryl groups mentioned in the definition of the abovementioned radicals are phenyl or naphthyl groups, preferably phenyl groups;
- R 7a , R 7b and R 7c are hydrogen
- a protective moiety used in the reactions described above according to process a) or b) is split off again and / or
- a compound of general formula I thus obtained is selectively derivatized or substituted on a hydroxy group and / or
- a compound of the general formula I thus obtained is converted into its salts, in particular for the pharmaceutical application into its physiologically tolerated salts.
- R 1 to R 5 , R x , R B , B, X, Z, L, R N , R 7a , R 7b , R 7c have the meanings given above and below ,
- radicals, substituents or groups in a compound may have the same or different meanings.
- the radical R 3 is preferably in the meta or para position to the -Z bridge, so that compounds according to the following formulas 1.1 and 1.2, in particular of the formula 1.2, are preferred:
- aryl used above and below for example in the groups X, R B , R 1 and R 3 , preferably denotes phenyl.
- the aryl group in particular the phenyl group, may be monosubstituted or disubstituted by identical or different radicals L.
- heteroaryl used above and below, for example in the groups X, R B , R 1 and R 3 , preferably denotes pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, oxadiazolyl, thiazolyl or thiadiazolyl , In accordance with the general definition and unless stated otherwise, the heteroaryl group may be monosubstituted or disubstituted by identical or different radicals L.
- R 1 is preferably hydrogen, fluorine, chlorine, bromine, C 1-6 -alkyl, C 2-6 -alkynyl, C 2-6 -alkenyl, C 3 . 7 -cycloalkyl, C 5 . 7 cycloalkenyl, C 1-4 alkylcarbonyl, aminocarbonyl, C 1-4 - alkylaminocarbonyl, di- (C 1-3 alkyl) aminocarbonyl, C 1-4 alkoxycarbonyl, C 1-4 alkylamino, di (C .
- alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups may be partly or completely fluorinated or mono- or disubstituted by identical or different substituents selected from chlorine, hydroxy, Ci -3 alkoxy and Ci may be substituted, -3 -alkyl , and
- cycloalkyl and cycloalkenyl radicals one or two methylene groups can be replaced independently of one another by O, S, CO, SO or SO 2 , and
- N-heterocycloalkyl radicals a methylene group may be replaced by CO or SO 2 .
- group R 1 is a cycloalkyl or cycloalkenyl radical in which one or two methylene groups are independently of each other substituted by O, S, CO, SO or SO 2 , preferred meanings of the radical R 1 are selected from the group consisting of tetrahydrofuranyl , Tetrahydrofuranonyl, tetrahydrothienyl, tetrahydropyranyl, tetrahydropyranonyl, dioxanyl and trioxanyl.
- group R 1 is an N-heterocycloalkyl radical in which a methylene group is replaced by CO or SO 2
- preferred meanings of the radical R 1 are selected from the group consisting of pyrrolidinone, piperidinone, piperazinone and morpholinone.
- R 1 particularly preferably denotes hydrogen, fluorine, chlorine, bromine, C 1-6 -alkyl, C 2-6 -alkynyl, C 2-6 -alkenyl, C 3 . 7 -cycloalkyl, C 5-7 -cycloalkenyl, C 1-6 -alkyloxy, C 3-7 -cycloalkyloxy or cyano, where in cycloalkyl and cycloalkenyl groups one or two methylene units are independently of one another replaced by O or CO and alkyl, alkenyl and alkynyl radicals may be partially or completely fluorinated.
- R 1 examples of the most preferred R 1 are hydrogen, fluorine, chlorine, bromine, methyl, ethyl, isopropyl, trifluoromethyl, methoxy, cyclopentyloxy and cyano.
- the radical R 3 is preferably fluorine, chlorine, bromine, C 1-6 -alkyl, C 2-6 -alkynyl, C 2-6 -alkenyl, C 3-7 -cycloalkyl, Cs ⁇ -cycloalkyl-methyl, C 5- 7 cycloalkenyl, Cs ⁇ cycloalkenyl-methyl, aryl, heteroaryl, CI_ 4 alkylcarbonyl, aminocarbonyl, C 1-4 alkylaminocarbonyl, DKC L s-alkyl) - aminocarbonyl, C 1-4 alkoxycarbonyl, di- (Ci - 3- alkyl) amino, pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl, C 1-4 -alkylcarbonylamino, C 1-6 -alkoxy, C 3-7 -cycloalkyloxy, C 5 , 7 - cycloalkenyl oxy, aryl
- alkyl, alkenyl, alkynyl, cycloalkyl and cycloalkenyl groups may be partly or completely fluorinated or mono- or disubstituted by identical or different substituents selected from chlorine, hydroxy, Ci -3 -alkoxy and C 1-3 alkyl substituted can, and
- cycloalkyl and cycloalkenyl radicals one or two methylene groups can be replaced independently of one another by O, S, CO, SO or SO 2 , and
- N-heterocycloalkyl radicals a methylene group may be replaced by CO or SO 2 ,
- aryl and heteroaryl are as defined above and aryl and heteroaryl groups may be independently of one another mono- or disubstituted by identical or different radicals L substituted.
- group R 3 is a cycloalkyl or cycloalkenyl radical in which one or two methylene groups are replaced independently of one another by O, S, CO, SO or SO 2 , preferred meanings of the group R 3 are selected from the group consisting of tetrahydrofuranyl , Tetrahydrofuranonyl, tetrahydrothienyl, tetrahydropyranyl, tetrahydropyranonyl, dioxanyl and trioxanyl.
- group R 3 is an N-heterocycloalkyl radical in which one methylene group has been replaced by CO or SO 2
- preferred meanings of the radical R 3 are selected from the group consisting of pyrrolidinone, piperidinone, piperazinone and morpholinone.
- R 3 are C 1-6 alkyl, C 2-6 alkynyl, C 1-4 alkyloxy, C 3-7 cycloalkyl, C 3-7 cycloalkyloxy and hydroxy wherein in the cycloalkyl groups one or two methylene units independently replaced by O or CO and alkyl radicals may be partially or completely fluorinated.
- R 3 are methyl, ethyl, ethynyl, isopropyl, methoxy, ethoxy, isopropyloxy, difluoromethoxy, cyclopentyloxy, tetrahydrofuran-3-yloxy and hydroxy.
- a selection of the most preferred representatives of R 3 is methyl, ethyl, ethynyl, isopropyl, methoxy, ethoxy, difluoromethoxy, cyclopentyloxy and hydroxy.
- the group X is preferably oxygen, methylidene, fluoromethylidene, d -6 alkyl methylidene, C 2-6 alkynyl-methylidene, C 2 - 6 alkenyl methylidene, C 3-7 or C 3-7 -CyClOaIKyI- methylidene cycloalkylidene,
- alkyl, alkenyl and alkynyl radicals can be partially or fully fluorinated and independently of one another mono- or disubstituted by substituents selected from chlorine, hydroxyl, C 1-3 -alkoxy and C 1-3 -alkyl, and
- the above-mentioned unsubstituted methylidene group or the above-mentioned monosubstituted methylidene groups may be easily substituted with fluorine, chlorine, C 1-3 -alkyl or cyano, and
- X is preferably a group according to the partial formula T.
- R x is hydrogen, fluorine, cyano, trifluoromethyl or C 1-3 -alkyl
- B is a single bond, -O- or -NR N -,
- R B is C 1-6 alkyl, C 3-7 cycloalkyl, C 5-7 cycloalkenyl, C 3-7 cycloalkyl C 1-3 alkyl, C 5-7
- Cycloalkenyl-Ci -3 alkyl, aryl, heteroaryl, arylC 1-3 alkyl- or heteroaryl-C means 1-3 alkyl, wherein alkyl, cycloalkyl and cycloalkenyl radicals may be partially or completely fluorinated or mono- or disubstituted by identical or different substituents selected from cyano, hydroxy, C 1-3 alkoxy and C 1-3 alkyl, or
- Very particularly preferred radicals of the group X are oxygen, methylidene, fluoromethylidene, difluoromethylidene, C 1-6 -alkylmethylidene and C 3-7 -cycloalkylidene.
- Examples of the most preferred X are oxygen, methylidene, fluoromethylidene, difluoromethylidene, ethylidene, isobutylidene and cyclopentylidene
- X is preferably oxygen
- X 2 represents preferably methylidene, fluoromethylidene, Ci- ⁇ -alkyl-methylidene, C - 6 alkynyl-methylidene, C 2-6 alkenyl-methylidene, C 3-7 -cycloalkyl or C-methylidene ⁇ cycloalkylidene,
- alkyl, alkenyl and alkynyl radicals can be partially or fully fluorinated and independently of one another mono- or disubstituted by substituents selected from chlorine, hydroxyl, C 1-3 -alkoxy and C 1-3 -alkyl, and
- a methylene group may be replaced by O, S or NR N or an ethylene group may be replaced by -NR N -CO-, -CO-NR N -, -O-CO- or -CO-O-.
- a substituted cycloalkylidene group is preferably selected from the group consisting of dihydrofuranylidene, dihydropyranylidene, dihydrothiophenylidene, pyrrolidinylidene, piperidinylidene, dihydrofuranonylidene,
- radicals of the group X according to this second embodiment are methylidene, fluoromethylidene, difluoromethylidene, C 1-6 -alkyl-methylidene, C 3-7 -cycloalkyl-methylidene and C 3 . 7- Cycloalkyliden, in particular methylidene, fluoromethylidene, difluoromethylidene and C 1-4 alkyl methylidene.
- radicals X are methylidene, fluoromethylidene and difluoromethylidene.
- X preferably denotes a group according to the partial formula T.
- R x is hydrogen, fluorine, cyano, trifluoromethyl or C 1-4 -alkyl
- B is a single bond, -O- or -NR N -,
- R B Ci- 6 alkyl, C 3 - 7 cycloalkyl, C 5-7 cycloalkenyl, Cs-C ⁇ cycloalkyl T -alkyl, C 5-7 -
- alkyl, cycloalkyl and cycloalkenyl radicals partially or completely fluorinated or selected once or twice with identical or different substituents alkyl may be substituted from cyano, hydroxy, Ci -3 alkoxy and d-3, or
- X has a meaning according to the above sub-formula T, in which
- R x is hydrogen or C 1-3 -alkyl
- B is a single bond, -O- or -NR N -,
- alkyl and cycloalkyl radicals to be partially or completely fluorinated or simply with cyano, hydroxy, Ci -3 alkoxy or substituted C 1-3 alkyl, or
- R B is methyl, ethyl, isopropyl or phenyl
- R B is methyl, ethyl, isopropyl or phenyl and R N is H or methyl.
- R 1 or R 3 cycloalkyl, cycloalkenyl, cycloalkylidene or cycloalkenylidene rings present in which two methylene groups are replaced by O or S or replaced by CO, SO or SO 2 or optionally NR N are, then these methylene groups are preferably not directly connected. However, when two methylene groups are replaced by O and CO, they may be directly linked together to form an -O-CO- or -CO-O- group.
- X, R 1 or R 3 is a cycloalkyl, cycloalkenyl, cycloalkylidene or cycloalkenylidene group having one or two methylene groups replaced according to the invention
- the relevant group X, R 1 or R 3 is preferably a cycloalkyl -, Cycloalkenyl-, Cycloalkyliden- or Cycloalkenyliden- group in which a methylene group replaced by O, S, CO, SO or SO 2 or an ethylene group is replaced by -O-CO- or -CO-O-.
- radical R 2 are hydrogen, fluorine, chlorine, bromine, methyl, hydroxyl, methoxy, ethoxy, trifluoromethoxy, cyano, nitro and methyl substituted by 1 to 3 fluorine atoms.
- R 2 are hydrogen, fluorine, hydroxyl, methoxy, ethoxy and methyl, in particular hydrogen and methyl.
- R 1 and R 2 may be linked together in such a way that R 1 and R 2 together preferably form a C 3-4 bridge, in which one or two methylene units can be replaced independently of one another by O, NR N or CO.
- the interconnected radicals R 1 and R 2 together with the phenyl ring to which they are attached form a bicyclic ring system selected from dihydroindane, dihydroindole, dihydrobenzofuran, tetrahydroquinoline, tetrahydroquinolinone, tetrahydroisoquinoline, tetrahydroisoquinolinone and tetrahydronaphthalene.
- radical R 4 are hydrogen and fluorine, in particular hydrogen.
- R 3 and R 4 may be linked together in such a way that R 1 and R 2 together preferably form a C 3 ⁇ bridge, in the one or two
- Methylene units can be replaced independently of one another by O, NR N or CO.
- the interconnected radicals R 3 and R 4 together with the phenyl ring to which they are attached form a bicyclic ring system selected from dihydroindane, dihydroindole, dihydrobenzofuran, tetrahydroquinoline, tetrahydroquinolinone, tetrahydroisoquinoline, tetrahydroisoquinolinone and tetrahydronaphthalene.
- radical R 5 are hydrogen and fluorine, in particular hydrogen.
- radical Z are oxygen and methylene, in particular methylene.
- R 7a, R 7b, R 7c independently of one another preferably are hydrogen, (C 1-8 alkyl) oxycarbonyl, (Ci -18 alkyl) carbonyl, benzoyl, particularly hydrogen or (C ⁇ ⁇ -Alky oxycarbonyl-, (C 1 -C 4) alkylcarbonyl, particularly preferably hydrogen, methoxycarbonyl, ethoxycarbonyl, methylcarbonyl or ethylcarbonyl.
- R 7a , R 7b and R 7c are hydrogen.
- R 7a, R 7b, and R have the compounds of the formula I 1 7c a meaning according to the invention other than hydrogen, for example C 1-8 alkylcarbonyl, sich- are preferred as intermediates in the synthesis of compounds of formula I in which R 7a , R 7b and R 7c are hydrogen.
- the substituents L are independently of one another preferably selected from the group consisting of fluorine, chlorine, bromine, C 1-3 -alkyl, difluoromethyl, trifluoromethyl, C 1-3 -alkoxy, difluoromethoxy, trifluoromethoxy and cyano, more preferably selected from the group consisting of Fluorine, chlorine, methyl, trifluoromethyl, methoxy and difluoromethoxy.
- Particularly preferred compounds of general formula I are selected from the group of formulas 1.2a to l.2d, in particular of formula 1.2c:
- R 1 to R 5 , X, Z, R 7a , R 7b , R 7c are as previously defined.
- R 1 is hydrogen, fluorine, chlorine, bromine, C 1-6 -alkyl, C 2-6 -alkynyl, C 2 . 6 alkenyl, C 3-7 -
- R 3 is C 1-6 alkyl, C 2-6 alkynyl, C 1-4 alkyloxy, C 3-7 cycloalkyl, C 3-7 cycloalkyloxy or
- alkyl radicals can be partially or completely fluorinated, particularly preferably methyl, ethyl, ethynyl, isopropyl, methoxy, ethoxy, isopropyloxy, difluoromethoxy,
- X (1) is oxygen
- alkyl, alkenyl and alkynyl radicals are partially or completely fluorinated and independently of one another with one or two
- Fluorine, chlorine, C 1-3 alkyl or cyano may be substituted, and wherein in a cycloalkylidene group a methylene group may be replaced by O, S or NR N or an ethylene group may be replaced by -NR N -CO-, -CO-NR N -, -O-CO- or -CO-O-;
- X particularly preferably denotes methylidene, fluoromethylidene, difluoromethylidene, or C 3 . 7- cycloalkylidene; or
- R x is hydrogen, fluorine, cyano, trifluoromethyl or C 1-3 -alkyl
- B is a single bond, -O- or -NR N -,
- R B is C 1-6 alkyl, Cs-r-cycloalkyl, C ⁇ cycloalkenyl, C 3-7 cycloalkyl-Ci -3 - alkyl, C ⁇ cycloalkenyl-C L a-alkyl, aryl , Heteroaryl, arylC ⁇ s-alkyl or heteroaryl-Ci.
- 3- alkyl means
- alkyl, cycloalkyl and cycloalkenyl groups may be partly or completely fluorinated or mono- or disubstituted by identical or different substituents selected from cyano, hydroxy, Ci -3 alkoxy, and d. 3 alkyl, or
- X is the partial formula T given above, in which R x is hydrogen or C 1-3 -alkyl,
- B is a single bond, -O- or -NR N -,
- R B is C 1-6 -alkyl-, C 3-7 -cycloalkyl- or aryl- L -alkyl-, or in case B meaning single bond or -NR N - can also be aryl,
- alkyl and cycloalkyl radicals may be partially or completely fluorinated or may be monosubstituted by cyano, hydroxy, C 1-3 -alkoxy or C 1-4 -alkyl, or
- R B and B with each other to form a heterocyclic ring selected from pyrrolidine, morpholine, piperidine, piperazine and piperazine, wherein the heterocyclic ring on the
- R 2 is hydrogen, fluorine, chlorine, bromine, methyl, hydroxy, methoxy, ethoxy,
- Methyl in particular hydrogen or methyl
- R 4 is hydrogen or fluorine, in particular hydrogen
- R 5 is hydrogen or fluorine, in particular hydrogen
- Z is oxygen or methylene, in particular methylene
- R 7a, R 7b, R 7c are independently hydrogen, (C 1-8 alkyl) oxycarbonyl, (Ci.i 8 alkyl) carbonyl or benzoyl, particularly hydrogen or (Ci -6 alkyl) oxycarbonyl, (C 1-8 - alkyl) carbonyl, particularly preferably hydrogen, methoxycarbonyl, ethoxycarbonyl, methylcarbonyl or ethylcarbonyl, very particularly preferably hydrogen, and
- R N independently of one another are H or C 1-4 -alkyl
- L independently of one another fluorine, chlorine, bromine, d -3- alkyl, difluoromethyl
- Trifluoromethyl C 1-3 alkoxy, difluoromethoxy, trifluoromethoxy and cyano
- those compounds are also preferred in which the phenyl group which bears the substituent R 3 has at least one further substituent R 4 and / or R 5 which is different from hydrogen. According to this variant, those compounds are also preferred which have a substituent R 4 meaning fluorine.
- the phenyl radical bearing the substituent R 3 is preferably at most twice fluorinated.
- Particularly preferred compounds of general formula I are selected from the group:
- halogen denotes an atom selected from the group consisting of F, Cl, Br and I, in particular F, Cl and Br.
- n- alkyl where n may have a value of 1 to 18, means a saturated, branched or unbranched hydrocarbon group having 1 to n carbon atoms.
- examples of such groups include methyl, ethyl, n-propyl, iso-propyl, butyl, iso-butyl, sec-butyl, tert-butyl, n-pentyl, iso-pentyl, neo-pentyl, tert-pentyl, n-hexyl, iso-hexyl, etc.
- methylidene means a radical linked via a double bond
- C 1-n- alkyl-methylidene means a methylidene group in which one hydrogen atom is substituted by a C 1 -n- alkyl group.
- C 2-n alkynyl wherein n has a value of 3 to 6, denotes a branched or unbranched hydrocarbon group having 2 to n C atoms and a C ⁇ C triple bond.
- groups include ethynyl, 1-propynyl, 2-propynyl, 1-butynyl, 2-butynyl, 3-butynyl, 1-pentynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-hexynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 4-methyl-2-pentynyl, etc.
- alkynyl groups are attached to the remainder of the molecule via the C atom in position 1. Therefore, terms such as 1-propynyl, 2-propynyl, 1-butynyl, etc. are synonymous with the names 1-propyn-1-yl, 2-propyn-1-yl, 1-butyn-1-yl, etc. in anologic application also applies to C 2 . n alkenyl groups.
- C 1-n -alkoxy or d -n- alkyloxy refers to a C 1 -n- alkyl-O-group in which C 1-n -alkyl is as defined above.
- groups include methoxy, ethoxy, n-propoxy, iso -propoxy, n-butoxy, iso-butoxy, sec-butoxy, tert-butoxy, n-pentoxy, iso-pentoxy, neo-pentoxy, tert-pentoxy, n- Hexoxy, iso-hexoxy etc.
- groups include methylcarbonyl, ethylcarbonyl, n-propylcarbonyl, iso -propylcarbonyl, n-butylcarbonyl, iso-butylcarbonyl, sec-butylcarbonyl, tert -butylcarbonyl, n-pentylcarbonyl, iso-pentylcarbonyl, neo-pentylcarbonyl, tert-pentylcarbonyl, n- Hexylcarbonyl, iso-hexylcarbonyl, etc.
- C 3-n -cycloalkyl denotes a saturated mono-, bi-, tri- or spirocarbocyclic group having 3 to n C atoms.
- groups include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl, cyclododecyl, decalin, bicyclo [3.2.1.] Octyl, spiro [4.5] decyl, norpinyl, norbornyl, norcaryl, adamantyl, etc.
- the term C 3-7 cycloalkyl saturated monocyclic groups Preferably the term C 3-7 cycloalkyl saturated monocyclic groups.
- C 3-7 -cycloalkylidene means a Cs- ⁇ -cycloalkane radical which is connected via a double bond to the remainder of the relevant molecule.
- Examples of C 3-7 cycloalkylidene radicals are cyclopropylidene, cyclobutylidene, cyclopentylidene, cyclohexylidene, cycloheptylidene.
- C ⁇ cycloalkyloxy denotes a C ⁇ n-cycloalkyl-O group, wherein C n 3 - cycloalkyl is as defined above.
- Examples of such groups include cyclopropyloxy, cyclobutyloxy, cyclopentyloxy, cyclohexyloxy, cycloheptyloxy, etc.
- Tn- (C 1 -alkyl) silyl includes silyl groups having the same or two or three different alkyl groups.
- di- (C1. 3 alkyl) amino comprises amino groups which have identical or two different alkyl groups.
- N-heterocycloalkyl denotes a saturated carbocyclic ring which has an imino group in the ring and which may additionally have a further optionally substituted imino group or an O or S atom in the ring.
- An imino group is understood to mean the group -NH-. Examples of such N-heterocycloalkyl groups are pyrrolidine, piperidine, piperazine, N-alkylpiperazine and morpholine.
- alkyl radicals substituted, for example fluorinated may be, this includes not only alkyl radicals in the groups which are directly alkyl, but also in other, alkyl radicals
- X, R 1 and R 3 in the meaning alkoxy, wherein alkyl radicals may be partially or completely fluorinated, also difluoromethoxy and trifluoromethoxy.
- the compounds according to the invention can be obtained using synthesis methods known in principle.
- the compounds are preferably obtained according to the preparation process according to the invention explained in more detail below.
- D-xylose derivatives described below can be made available from D-glucose by replacement or appropriate derivatization of the 6-hydroxy group and subsequent substitution with the desired residue.
- the following schemes are representative of some synthetic access routes to the claimed compounds.
- the individual reactions are largely standard transformations in organic chemistry and easily understood by the skilled person.
- the group of the sub-formula which is substituted according to the invention will be described
- the PG radicals symbolize protective groups which may, for example, have a meaning of the radicals R 8a , R 8b and R 8c .
- Scheme 1 shows a possible synthetic route to compounds of the formula I according to the invention in which X is O or methylidene.
- X is O or methylidene.
- the 6-OH group is eliminated to form the methylidene analogue XI.
- This transformation can be carried out in one stage with reagents such as the Burgess reagent (Et 3 NSO 2 NCOOMe).
- a two-stage synthetic route proceeds via the intermediate transformation of the OH group into a leaving group A, preferably Chloride, bromide, iodide or sulfonate such as tosylate, mesylate or trifluoromethylsulfonate, followed by elimination of leaving group A with organic or inorganic bases, especially DBU, hydroxides or alcoholates such as methylate, ethylate or tert-butylate (see Example 1).
- the OH group can also be used either directly according to a Mitsunobu variant (see Synthesis 1981, 1-28 and Org.
- the work-up of the primary or secondary zonides formed in the ozonolysis can be either reductive, such as borohydrides, dialkyl sulfides or triarylphosphines, or oxidative, such as with hydrogen peroxide.
- the D-glucose derivative X at the 6-OH group is oxidized to aldehyde XIII.
- oxidizing agents are DMSO and oxalyl chloride, as described, for example, according to Swern, Dess-Martin periodinan, manganese dioxide, chromium (VI) reagents such as PCC or potassium dichromate, tetramethylpiperidine oxide (TEMPO) or perrhutenates.
- the radical R can be introduced by addition of a corresponding organometallic compound such as a lithium, magnesium, cerium, zinc, chromium or indium compound, which can carry the corresponding radical R once or several times, and then provides the alcohol XIV (see M.
- the target compound XV can be obtained therefrom by dehydration according to the procedure already described for the transformation from X to XI. Depending on whether the addition of the radical R was stereoselective, only a double bond isomer or a mixture of the two is obtained.
- the aldehyde XIII if necessary under the action of a base such as triethylamine, generates the olefin XVI which carries a transition-metal-activatable group LG such as for example a tosylate, triflate, nonaflate, chlorine, bromine or iodine.
- a base such as triethylamine
- Transition metals such as palladium, nickel, rhodium, copper or iron allow the replacement of the activated function LG in XVI with radicals R, in the coupling reaction, for example, on silicon (eg Hiyama coupling), boron (eg Suzuki coupling), tin (eg Stille coupling), zinc or zirconium (eg Negishi coupling), magnesium (eg Kumada coupling or Kochi coupling), lithium (eg Kumada coupling), aluminum, indium, chromium (eg Nozaki-Hiyama-Kishi reaction ) or copper (eg Sonogashira coupling) can be bound (see L.
- XVI can also be obtained by a Heck reaction or a variant thereof by means of a nickel, palladium or Rhodium catalyst can be attached.
- the introduction of the radical R takes place stereoselectively under retention and gives the product XVII with the E or Z configuration as a function of the double bond configuration in the starting material XVI (see Chem. Rev. 2000, 100 (8), 3009-3066).
- Oxidation eg with TEMPO / NaOCl or K 2 Cr 2 O 7
- Scheme 3 depicts the preparation of di-substituted methylidene pyridine derivatives in which R is as defined above and R 'is C 1-3 alkyl or cyano.
- R 1 and R may also be linked together and together form a C 3-7 cycloalkylidene or C 5-7 cycloalkenylidene moiety, where in the cycloalkylidene and cycloalkenylidene radicals one or two methylene groups are independently O, S, CO, SO, SO 2 or NR N can be replaced.
- the carboxylic acid XVIII is prepared by oxidation with, for example, sodium chlorite.
- the carboxylic acid is also accessible from the glucose derivative X by oxidation with tetramethylpiperidine oxide (TEMPO) and hypochlorite or with potassium dichromate.
- TEMPO tetramethylpiperidine oxide
- the carboxylic acid can be converted into the corresponding Weinreb amide (residual CO-NMe-OMe), to which the radical R is an R-metal compound, the metal being, for example, lithium or magnesium can be monoadded to ketone XIX.
- the carboxylic acid chloride from the carboxylic acid to which, in turn, an R metal compound can be added analogously, in the presence of a catalyst such as palladium, copper, nickel or iron.
- the carboxylic acid XVIII can also be reacted directly with organolithium compounds carrying R directly to the ketone XIX.
- a second radical R 1 is added via addition of a corresponding organometallic compound to the alcohol XX.
- the organometallic compound in this case may be, for example, a lithium, Grignard, chromium or cerium compound.
- the second organometallic reaction can also be an intramolecular addition of the radical R to the ketone, the corresponding cycloalkanols or cycloalkenols being obtained.
- the last reaction step of the sequence is again a dehydration, which can be carried out as described above.
- Scheme 4 shows a further alternative to the preparation of compounds of type XV starting from lactone XII, which is obtainable analogously to Scheme 1.
- the lactone XII is reacted with a mixture of the desired radical R, which is present as dihalide, for example dibromide or diiodide, zinc and titanium tetrachloride (see J. Org. Chem. 1987, 52 (19), 4410-4412).
- R which is present as dihalide
- R for example dibromide or diiodide
- titanium tetrachloride see J. Org. Chem. 1987, 52 (19), 4410-4412.
- the fluoro- and difluoromethylidene Compound by reacting the lactone XII with FCHBr 2 or F 2 CBr 2 , (Me 2 N) 3 P and Zn produce (see J. Chem. Soc, Chem. Commun. 1989, 19, 1437-1439).
- Synthesis route to XXIII leads, for example, via the nitrile XXII, which can be obtained from the lactone XII by reaction with triphenylphosphanylideneacetonitrile or a derivative thereof (see Tetrahedron Asymmetry 2000, 11 (2), 417-421).
- Addition of the corresponding R B -B radicals as anions or neutral compounds such as R B -O7R B -OH, R B -NR N 7R B -NR N H or R B 7R B -H then give after hydrolysis of the imine intermediate the Target compounds XXIII.
- Hydrolysis of the nitrile compound XXII to the corresponding carboxylic acid and additions thereto or activated derivatives thereof, such as carboxylic acid chloride or anhydride, may also result in product XXIII.
- R 8a , R 8b and R 8c are as defined above and represent, for example, independently of one another acetyl, pivaloyl, benzoyl, tert-butoxycarbonyl, benzyloxycarbonyl, trialkylsilyl, benzyl or substituted benzyl,
- Suitable reducing agents for the reaction are, for example, silanes, such as triethyl, tripropyl, triisopropyl or diphenylsilane, sodium borohydride, sodium cyanoborohydride, zinc borohydride, borane, lithium aluminum hydride, diisobutylaluminum hydride or samarium iodide.
- the reductions preferably take place in the presence of a suitable acid such as hydrochloric acid, toluenesulfonic acid, trifluoroacetic acid, acetic acid, boron trifluoride etherate, trimethylsilyl triflate, titanium tetrachloride, tin tetrachloride, scandium triflate or zinc iodide.
- a suitable acid such as hydrochloric acid, toluenesulfonic acid, trifluoroacetic acid, acetic acid, boron trifluoride etherate, trimethylsilyl triflate, titanium tetrachloride, tin tetrachloride, scandium triflate or zinc iodide.
- reaction in a solvent such as methylene chloride, chloroform, acetonitrile, toluene, hexane, diethyl ether, tetrahydrofuran, dioxane, ethanol, water or mixtures thereof at temperatures between -60 0 C and 12O 0 C are performed.
- a particularly suitable reagent combination consists for example of triethylsilane and boron trifluoride etherate, which is conveniently used in acetonitrile or dichloromethane at temperatures of -60 0 C and 60 0 C used.
- hydrogen may be used in the presence of a transition metal catalyst such as palladium on carbon or Raney nickel in solvents such as tetrahydrofuran, ethyl acetate, methanol, ethanol, water or acetic acid for the transformation shown.
- a transition metal catalyst such as palladium on carbon or Raney nickel
- solvents such as tetrahydrofuran, ethyl acetate, methanol, ethanol, water or acetic acid for the transformation shown.
- R 8a to R 8c one of the protective groups defined above, such as an acyl, arylmethyl,
- the cleavage of an acyl, acetal or ketal protecting group used is carried out, for example, hydrolytically in an aqueous solvent, for example in water, isopropanol / water, acetic acid / water, tetrahydrofuran / water or dioxane / water, in the presence of an acid such as trifluoroacetic acid, Hydrochloric acid or sulfuric acid or aprotic, for example in the presence of iodotrimethylsilane, at temperatures between 0 and 120 ° C., preferably at temperatures between 10 and 100 ° C.
- an aqueous solvent for example in water, isopropanol / water, acetic acid / water, tetrahydrofuran / water or dioxane / water
- an acid such as trifluoroacetic acid, Hydrochloric acid or sulfuric acid or aprotic, for example in the presence of iodotrimethylsilane, at temperatures
- the cleavage of an acyl radical can also be carried out in the presence of an alkali metal base such as lithium hydroxide, sodium hydroxide or potassium hydroxide.
- the cleavage of a Trifluoracetylrestes is preferably carried out by treatment with an acid such as hydrochloric acid, optionally in the presence of a solvent such as acetic acid at temperatures between 50 and 120 0 C or by treatment with sodium hydroxide, optionally in the presence of a solvent such as tetrahydrofuran or methanol at temperatures between 0 and 50 ° C.
- Trimethylsilylrestes example, in water, an aqueous
- Solvents such as diethyl ether, tetrahydrofuran or dichloromethane,
- fluoride reagents e.g. Tetrabutylammonium fluoride.
- cleavage of a benzyl, methoxybenzyl or benzyloxycarbonyl radical is advantageously carried out by hydrogenolysis, e.g. with hydrogen in the presence of a catalyst such as palladium / carbon in a suitable solvent such as methanol, ethanol,
- cleavage of a 2,4-dimethoxybenzyl radical is preferably carried out in trifluoroacetic acid in the presence of anisole.
- tert-butyl or tert-Butyloxycarbonylrestes is preferably carried out by treatment with an acid such as trifluoroacetic acid or hydrochloric acid or by treatment with iodotrimethylsilane optionally with the use of a solvent such as methylene chloride, dioxane, methanol or diethyl ether.
- an acid such as trifluoroacetic acid or hydrochloric acid
- iodotrimethylsilane optionally with the use of a solvent such as methylene chloride, dioxane, methanol or diethyl ether.
- optionally present reactive groups such as ethynyl, hydroxy, amino, alkylamino or imino groups can be protected during the reaction by conventional protective groups, which after the reaction again such u.a. be split off above.
- the trimethylsilyl or triisopropyl group can be considered as a protective group for an ethynyl group.
- the 2-hydroxisoprop-2-yl group can also be used as a protective group.
- Suitable protecting groups for an amino, alkylamino or imino group are, for example, the formyl, acetyl, trifluoroacetyl, ethoxycarbonyl, tert-butoxycarbonyl, benzyloxycarbonyl, benzyl, methoxybenzyl or 2,4-dimethoxybenzyl groups.
- the compounds of general formula I thus obtained can be selectively derivatized on a hydroxy group or the hydroxy group itself can be substituted (see Examples VII, VIII 1 1, 2, 4, 5, 6).
- the compounds of general formula I obtained can be separated into their enantiomers and / or diastereomers.
- cis / trans mixtures can be separated into their cis and trans isomers, and compounds having at least one optically active carbon atom can be resolved into their enantiomers.
- the cis- / trans mixtures obtained can be purified by chromatography into their cis and trans isomers, the compounds of general formula I which are obtained in racemates, by methods known per se (see Allinger NL and Eliel EL in " Topics in Stereochemistry ", Vol. 6, Wiley Interscience, 1971) in their optical antipodes and compounds of general formula I having at least 2 asymmetric carbon atoms due to their physicochemical differences according to known methods, eg by chromatography and / or fractional crystallization, into their diastereomers, which, if they are obtained in racemic form, can then be separated into the enantiomers as mentioned above.
- the separation of enantiomers is preferably carried out by column separation on chiral phases or by recrystallization from an optically active solvent or by reacting with a, with the racemic compound salts or derivatives such as esters or amides forming optically active substance, in particular acids and their activated derivatives or alcohols, and Separating the diastereomeric salt mixture or derivative obtained in this way, for example due to different solubilities, where from the pure diastereomeric salts or derivatives, the free antipodes can be released by the action of suitable agents.
- optically active acids are, for example, the D and L forms of tartaric acid or dibenzoyltartaric acid, di-O-toluenoic acid, malic acid, mandelic acid, camphorsulfonic acid, glutamic acid, aspartic acid or quinic acid.
- optically active alcohols are (+) - or (-) - menthol and, for example, (+) - or (-) - menthyloxycarbonyl as the optically active acyl radical in amides.
- the compounds of the formula I obtained can be converted into their salts, in particular for the pharmaceutical application, into their physiologically acceptable salts with inorganic or organic acids.
- suitable acids are hydrochloric acid, hydrobromic acid, sulfuric acid, methanesulfonic acid, phosphoric acid, fumaric acid, succinic acid, lactic acid, citric acid, tartaric acid or maleic acid.
- the compounds obtained can be converted into mixtures, for example in 1: 1 or 1: 2 mixtures with amino acids, in particular with alpha-amino acids such as proline or phenylalanine, which may have particularly favorable properties such as high crystallinity.
- the compounds of the general formula I according to the invention and their physiologically tolerated salts have valuable pharmacological properties, in particular an inhibiting action on sodium-dependent glucose cotransporters SGLT, preferably SGLT2.
- the biological properties of the new compounds can be tested as follows: The ability of the substances to inhibit SGLT-2 activity can be demonstrated in an experimental setup in which a CH0-K1 cell line (ATCC No. CCL 61) or alternatively a HEK293 cell line (ATCC No. CRL-1573), stable with an expression vector pZeoSV (Invitrogen, EMBL accession number L36849) which contains the cDNA for the coding sequence of the human sodium glucose cotransporter 2 (Genbank Acc No. No. NM_003041) (CHO-hSGLT2 or HEK-hSGLT2). These cell lines transport sodium-dependent 14 C-labeled alpha-methyl-glucopyranoside ( 14 C-AMG, Amersham) into the cell interior.
- pZeoSV Invitrogen, EMBL accession number L36849
- the SGLT-2 assay is performed as follows:
- CHO-hSGLT2 cells are transfected into Ham 's F12 medium (BioWhittaker) with 10% fetal calf serum and 250 ⁇ g / ml Zeocin (Invitrogen), HEK293-hSGLT2 cells in DMEM medium with 10% fetal calf serum and 250 ⁇ g / ml Zeocin (Invitrogen) cultured.
- the cells are detached from the culture flasks by washing twice with PBS and subsequent treatment with trypsin / EDTA. After addition of cell culture medium, the cells are centrifuged off, resuspended in culture medium and counted in a Casy cell counter.
- an analogous test is set up in which the cDNA for hSGLTI (Genbank Acc No. NM000343) is expressed instead of the hSGLT2 cDNA in CHO-K1 or HEK293 cells.
- the measurement of the cellular membrane potential can also be used for the biological testing of substances.
- the cell models described above can be used.
- 10,000 cells per well of a poly-D-lysine coated 384-well black plate with clear bottom are seeded in culture medium and incubated for 16 hours at 37 ° C, 5% CO 2 .
- the cells are then washed twice with glucose-free HBSS buffer (12.67 mol / l CaCl 2 , 4.93 mmol / l MgCl 2 , 4.07 mmol / l MgSO 4 , 4.41 mmol / l KH 2 PO 4 , pH 7 , 4) and overlaid with 20 ⁇ l of HBSS.
- glucose-free HBSS buffer (12.67 mol / l CaCl 2 , 4.93 mmol / l MgCl 2 , 4.07 mmol / l MgSO 4 , 4.41 mmol / l KH 2 PO 4 , pH 7 , 4) and overlaid with 20 ⁇ l of HBSS.
- 20 .mu.l loading buffer Membrane Potential Assay Kit Explorer R8126, Molecular Devices GmbH, Ismaning
- 20 .mu.l of the substance to be tested in a suitable concentration is for a further 30 min. incubated at
- the measurement takes place in the Fluorescent Imaging Plate Reader (Molecular Devices GmbH, Ismaning) at 485 nm excitation wavelength and is started by adding 20 ⁇ l stimulation buffer (140 mM NaCl and 120 mM glucose). The depolarization of the cell caused by the glucose-induced Na + influx can be measured and quantified as a change in fluorescence.
- the compounds of the general formula I according to the invention can have, for example, EC50 values below 1000 nM, in particular below 200 nM, particularly preferably below 50 nM.
- the compounds of general formula I according to the invention and their corresponding pharmaceutically acceptable salts are in principle suitable for treating and / or preventing all those conditions or diseases caused by inhibition of SGLT activity ,
- the SGLT-2 activity can be influenced.
- compounds of the invention are in particular for the prophylaxis or treatment of diseases, in particular metabolic diseases, or conditions such as diabetes mellitus type 1 and / or type 2, diabetic complications (such as retinopathy, nephropathy or neuropathy, diabetic foot, ulcer, macroangiopathy), metabolic acidosis or Ketosis, reactive hypoglycemia, hyperinsulinemia, glucose metabolism disorder, insulin resistance, metabolic syndrome, dyslipidaemias of various genesis, atherosclerosis and related diseases, obesity, hypertension, chronic heart failure, edema, hyperuricemia.
- these substances are suitable to prevent beta cell degeneration such as apoptosis or necrosis of pancreatic beta cells.
- the substances are further suited to improve or restore the functionality of pancreatic cells, in addition to increase the number and size of pancreatic beta cells.
- the compounds of the invention are also useful as diuretics or antihypertensives and for the prophylaxis and treatment of the acute Kidney failure suitable.
- the compounds according to the invention are particularly suitable for the prophylaxis or treatment of diabetes, in particular diabetes mellitus type 1 and type 2, and / or diabetic complications.
- the dosage required to achieve a corresponding effect in treatment or prophylaxis usually depends on the compound to be administered, on the patient, on the nature and severity of the disease or condition and on the nature and frequency of administration, and is at the discretion of the physician to be treated , Appropriately, the dosage with intravenous administration in the range of 1 to 100 mg, preferably 1 to 30 mg, and oral administration in the range of 1 to 1000 mg, preferably 1 to 100 mg, each 1 to 4 x daily, are.
- the compounds of formula I according to the invention optionally in combination with other active substances, together with one or more inert conventional carriers and / or diluents, e.g.
- lactose cane sugar, microcrystalline cellulose, magnesium stearate, polyvinylpyrrolidone, citric acid, tartaric acid, water, water / ethanol, water / glycerine, water / sorbitol, water / polyethylene glycol, propylene glycol, cetylstearyl alcohol, carboxymethylcellulose or fatty substances such as hard fat or their suitable mixtures , incorporated into common pharmaceutical preparations such as tablets, dragees, capsules, powders, solutions, suspensions or suppositories.
- the compounds of the invention may also be used in combination with others
- Active ingredients in particular for the treatment and / or prophylaxis of the aforementioned diseases and conditions can be used.
- Suitable further active substances for such combinations are, in particular, those which, for example, enhance the therapeutic activity of an SGLT inhibitor according to the invention with regard to one of the indicated indications and / or which allow a reduction in the dosage of a SGLT inhibitor according to the invention.
- Therapeutics suitable for such a combination include, for example, antidiabetics such as metformin, sulfonylureas (eg glibenclamide, tolbutamide, glimepiride), nateglinides, repaglinides, thiazolidinediones (eg rosiglitazones, pioglitazones), PPAR-gamma agonists (eg Gl 262570) and Antagonists, PPAR-gamma / alpha modulators (eg KRP 297), alpha-glucosidic inhibitors (eg acarbose, voglibose), DPPIV inhibitors (eg LAF237, MK-431), alpha2-antagonists, insulin and insulin analogues, GLP-1 and GLP -1 analogs (eg exendin) 4) or amylin.
- antidiabetics such as metformin, sulfonylureas (e
- active ingredients suitable as combination partners are inhibitors of protein tyrosine phosphatase 1, substances that influence deregulated glucose production in the liver, such as inhibitors of glucose-6-phosphatase, or fructose-1, 6-bisphosphatase, glycogen phosphorylase, glucagon receptor antagonists and inhibitors phosphoenolpyruvate carboxykinase, glycogen synthase kinase or pyruvate dehydrokinase, lipid lowering agents such as HMG-CoA reductase inhibitors (eg simvastatin, atorvastatin), fibrates (eg bezafibrate, fenofibrate), nicotinic acid and its derivatives, PPAR-alpha agonists, PPAR-delta agonists, ACAT inhibitors (eg Avasimibe) or cholesterol resorption inhibitors such as.
- HMG-CoA reductase inhibitors eg simvastatin, atorvastatin
- Ezetimibe bile acid sequestrants such as colestyramine, ileal bile acid transport inhibitors, HDL enhancing compounds such as inhibitors of CETP or regulators of ABC1 or drugs for the treatment of obesity such as sibutramine or tetrahydrolipstatin, dexfenfluramine, axokines, antagonists of the cannabinoidi receptor, MCH-1 receptor antagonists, MC4 receptor agonists, NPY5 or NPY2 antagonists or ⁇ 3 agonists such as SB-418790 or AD-9677 as well as agonists of the 5HT2c receptor.
- bile acid sequestrants such as colestyramine, ileal bile acid transport inhibitors, HDL enhancing compounds such as inhibitors of CETP or regulators of ABC1 or drugs for the treatment of obesity such as sibutramine or tetrahydrolipstatin, dexfenfluramine, axokines, antagonists of the cannabinoidi receptor
- angiotensin II receptor antagonists examples include candesartan cilexetil, potassium losartan, eprosartan mesylate, valsartan, telmisartan, irbesartan, EXP-3174, L-158809, EXP-3312, olmesartan, medoxomil, tasosartan, KT-3-671, GA-0113, RU-64276, EMD-90423, BR-9701, etc.
- Angiotensin II receptor antagonists are preferably used for the treatment or prophylaxis of hypertension and diabetic complications, often in combination with a diuretic such as hydrochlorothiazide.
- uric acid synthesis inhibitors or uricosuric agents for the treatment or prophylaxis of gout, a combination with uric acid synthesis inhibitors or uricosuric agents is suitable.
- a combination with GABA receptor antagonists, Na-channel blockers, topiramate, protein kinase C inhibitors, advanced glycation endproduct inhibitors or aldose reductase inhibitors can be used.
- the dose for the previously mentioned combination partners is expediently 1/5 of the usually recommended lowest dosage up to 1/1 of the normally recommended dosage.
- another object of this invention relates to the use of a compound of the invention or a physiologically acceptable salt of such a compound in combination with at least one of the previously described as combination partners active ingredients for the preparation of a medicament, which is suitable for the treatment or prophylaxis of diseases or conditions by Inhibition of the sodium-dependent glucose cotransporter SGLT can be influenced.
- This is preferably a metabolic disorder, in particular one of the previously mentioned diseases or conditions, especially diabetes or diabetic complications.
- both agents are administered to the patient together; in a staggered use both active ingredients are administered to the patient in a period of less than or equal to 12, in particular less than or equal to 6 hours in succession.
- a further subject of this invention relates to a pharmaceutical composition
- a pharmaceutical composition comprising a compound according to the invention or a physiologically acceptable salt of such a compound and at least one of the active ingredients previously described as combination partners in addition to optionally one or more inert carriers and / or diluents.
- a pharmaceutical composition according to the invention comprises a combination of a compound of the formula I according to the invention or a physiologically tolerated salt of such a compound and at least one angiotensin II receptor antagonist in addition to optionally one or more inert carriers and / or diluents.
- the compound of the invention, or a physiologically acceptable salt, and the further active ingredient to be combined therewith can be present together in one dosage form, for example a tablet or capsule, or separately in two identical or different dosage forms, for example as so-called kit-of-parts.
- kit-of-parts H atoms of hydroxyl groups are not explicitly shown in each case. The following examples are intended to illustrate the present invention without limiting it:
- active compound 1 denotes one or more compounds according to the invention, including salts thereof
- active substance also encompasses the other active substances.
- 1 tablet contains:
- Active ingredient, lactose and starch are mixed and uniformly moistened with an aqueous solution of polyvinylpyrrolidone. After screening of the moist mass (2.0 mm mesh size) and drying in a rack oven at 50 0 C is again sieved (1.5 mm mesh) and the lubricant mixed. The ready-to-use mixture is processed into tablets. Tablet weight: 220 mg
- Diameter 10 mm, biplan with facet on both sides and one-sided part notch.
- 1 tablet contains:
- the active substance mixed with milk sugar, corn starch and silica is moistened with a 20% strength aqueous solution of polyvinylpyrrolidone and beaten through a sieve with a mesh size of 1.5 mm.
- the dried at 45 0 C granules are rubbed again through the same sieve and mixed with the specified amount of magnesium stearate. From the mixture tablets are pressed.
- 1 capsule contains:
- Corn starch drink about 180.0 mg
- the active ingredient is mixed with the excipients, passed through a sieve of 0.75 mm mesh size and mixed homogeneously in a suitable device.
- the final mixture is filled into size 1 hard gelatin capsules.
- Capsule shell hard gelatin capsule size 1.
- Composition 1 suppository contains: active ingredient 150.0 mg
- Polyethylene glycol 1500 550.0 mg
- the active ingredient is distributed homogeneously therein and the melt is poured into pre-cooled molds.
- Active ingredient 10.0 mg 0.01 n hydrochloric acid s.q.
- the active ingredient is dissolved in the required amount of 0.01 N HCl, isotonic with saline, sterile filtered and filled into 2 ml ampoules.
- Active ingredient 50.0 mg 0.01 n hydrochloric acid s.q.
- the active ingredient is dissolved in the required amount 0.01 N HCl, made isotonic with sodium chloride, sterile filtered and filled into 10 ml ampoules.
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Abstract
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Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002572819A CA2572819A1 (en) | 2004-07-17 | 2005-07-13 | Methylidene-d-xylopyranosyl-substituted and oxo-d-xylopyranosyl-substituted phenyls, medicaments containing these compounds, their use and method for the production thereof |
EP05771787A EP1771460A1 (de) | 2004-07-17 | 2005-07-13 | Methyliden-d-xylopyranosyl- und oxo-d-xylopyranosyl-substituierte phenyle, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
JP2007521855A JP2008506734A (ja) | 2004-07-17 | 2005-07-13 | メチリデン−d−キシロピラノシル置換及びオキソ−d−キシロピラノシル置換フェニル、これらの化合物を含む薬剤、それらの使用及びそれらの製造方法 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004034690.9 | 2004-07-17 | ||
DE102004034690A DE102004034690A1 (de) | 2004-07-17 | 2004-07-17 | Methyliden-D-xylopyranosyl-und Oxo-D-xylopyranosyl-substituierte Phenyle, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006008038A1 true WO2006008038A1 (de) | 2006-01-26 |
WO2006008038A8 WO2006008038A8 (de) | 2006-05-18 |
Family
ID=34993232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2005/007582 WO2006008038A1 (de) | 2004-07-17 | 2005-07-13 | Methyliden-d-xylopyranosyl- und oxo-d-xylopyranosyl-substituierte phenyle, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
Country Status (6)
Country | Link |
---|---|
US (1) | US20060019948A1 (de) |
EP (1) | EP1771460A1 (de) |
JP (1) | JP2008506734A (de) |
CA (1) | CA2572819A1 (de) |
DE (1) | DE102004034690A1 (de) |
WO (1) | WO2006008038A1 (de) |
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002083066A2 (en) * | 2001-04-11 | 2002-10-24 | Bristol-Myers Squibb Company | Amino acid complexes of c-aryl glucosides for treatment of diabetes and method |
WO2003099836A1 (en) * | 2002-05-20 | 2003-12-04 | Bristol-Myers Squibb Company | C-aryl glucoside sglt2 inhibitors and method |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7393836B2 (en) * | 2004-07-06 | 2008-07-01 | Boehringer Ingelheim International Gmbh | D-xylopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture |
-
2004
- 2004-07-17 DE DE102004034690A patent/DE102004034690A1/de not_active Withdrawn
-
2005
- 2005-07-13 WO PCT/EP2005/007582 patent/WO2006008038A1/de not_active Application Discontinuation
- 2005-07-13 EP EP05771787A patent/EP1771460A1/de not_active Withdrawn
- 2005-07-13 CA CA002572819A patent/CA2572819A1/en not_active Abandoned
- 2005-07-13 JP JP2007521855A patent/JP2008506734A/ja active Pending
- 2005-07-15 US US11/182,986 patent/US20060019948A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002083066A2 (en) * | 2001-04-11 | 2002-10-24 | Bristol-Myers Squibb Company | Amino acid complexes of c-aryl glucosides for treatment of diabetes and method |
WO2003099836A1 (en) * | 2002-05-20 | 2003-12-04 | Bristol-Myers Squibb Company | C-aryl glucoside sglt2 inhibitors and method |
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WO2008013280A1 (fr) | 2006-07-27 | 2008-01-31 | Chugai Seiyaku Kabushiki Kaisha | Dérivé de spirocétal substitué et utilisation de celui-ci comme médicament dans le traitement du diabète |
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US9834573B2 (en) | 2010-06-12 | 2017-12-05 | Theracos Sub, Llc | Crystalline form of benzylbenzene SGLT2 inhibitor |
US8987323B2 (en) | 2010-06-12 | 2015-03-24 | Theracos, Inc. | Crystalline form of benzylbenzene SGLT2 inhibitor |
US10596120B2 (en) | 2011-03-07 | 2020-03-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions |
US11564886B2 (en) | 2011-03-07 | 2023-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions |
US20180185291A1 (en) | 2011-03-07 | 2018-07-05 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions |
WO2013038429A2 (en) | 2011-09-13 | 2013-03-21 | Panacea Biotec Ltd. | Novel sglt inhibitors |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
US9192617B2 (en) | 2012-03-20 | 2015-11-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
US9725478B2 (en) | 2012-04-10 | 2017-08-08 | Theracos Sub, Llc | Process for the preparation of benzylbenzene SGLT2 inhibitors |
US9193751B2 (en) | 2012-04-10 | 2015-11-24 | Theracos, Inc. | Process for the preparation of benzylbenzene SGLT2 inhibitors |
US9573959B2 (en) | 2013-03-14 | 2017-02-21 | Msd International Gmbh | Methods for preparing SGLT2 inhibitors |
EP3466431A1 (de) | 2013-03-14 | 2019-04-10 | MSD International GmbH | Kristalline formen und verfahren zur herstellung von sglt2 hemmstoffen |
US9949998B2 (en) | 2013-04-05 | 2018-04-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
US9949997B2 (en) | 2013-04-05 | 2018-04-24 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
US11090323B2 (en) | 2013-04-05 | 2021-08-17 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
US10258637B2 (en) | 2013-04-05 | 2019-04-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
US11813275B2 (en) | 2013-04-05 | 2023-11-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
US11833166B2 (en) | 2013-04-05 | 2023-12-05 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
US11918596B2 (en) | 2013-04-05 | 2024-03-05 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
US11666590B2 (en) | 2013-04-18 | 2023-06-06 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
US10093616B2 (en) | 2013-10-12 | 2018-10-09 | Theracos Sub, Llc | Preparation of hydroxy-benzylbenzene derivatives |
US9464043B2 (en) | 2013-10-12 | 2016-10-11 | Theracos Sub, Llc | Preparation of hydroxy-benzylbenzene derivatives |
Also Published As
Publication number | Publication date |
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US20060019948A1 (en) | 2006-01-26 |
EP1771460A1 (de) | 2007-04-11 |
JP2008506734A (ja) | 2008-03-06 |
WO2006008038A8 (de) | 2006-05-18 |
DE102004034690A1 (de) | 2006-02-02 |
CA2572819A1 (en) | 2006-01-26 |
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