WO2006004297A1 - Implant metallique osseoinducteur pour corps vivant et procede de production - Google Patents

Implant metallique osseoinducteur pour corps vivant et procede de production Download PDF

Info

Publication number
WO2006004297A1
WO2006004297A1 PCT/KR2005/000947 KR2005000947W WO2006004297A1 WO 2006004297 A1 WO2006004297 A1 WO 2006004297A1 KR 2005000947 W KR2005000947 W KR 2005000947W WO 2006004297 A1 WO2006004297 A1 WO 2006004297A1
Authority
WO
WIPO (PCT)
Prior art keywords
living body
osseo
metal implant
layer
implant
Prior art date
Application number
PCT/KR2005/000947
Other languages
English (en)
Inventor
Eung-Sun Byon
Yong-Soo Jeong
Jong-Kuk Kim
Young-Taeg Sul
Beom-Seok Chang
Li-La Cho
Original Assignee
Korea Institute Of Machinery And Materials
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Institute Of Machinery And Materials filed Critical Korea Institute Of Machinery And Materials
Priority to BRPI0510301-0A priority Critical patent/BRPI0510301A/pt
Priority to US11/578,178 priority patent/US8920869B2/en
Priority to EP05789726A priority patent/EP1740128A4/fr
Publication of WO2006004297A1 publication Critical patent/WO2006004297A1/fr
Priority to US14/579,591 priority patent/US20150209480A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22C—FOUNDRY MOULDING
    • B22C9/00—Moulds or cores; Moulding processes
    • B22C9/08—Features with respect to supply of molten metal, e.g. ingates, circular gates, skim gates
    • B22C9/082—Sprues, pouring cups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/06—Titanium or titanium alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/082—Inorganic materials
    • A61L31/088—Other specific inorganic materials not covered by A61L31/084 or A61L31/086
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B08—CLEANING
    • B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B7/00—Cleaning by methods not provided for in a single other subclass or a single group in this subclass
    • B08B7/0035—Cleaning by methods not provided for in a single other subclass or a single group in this subclass by radiant energy, e.g. UV, laser, light beam or the like
    • C—CHEMISTRY; METALLURGY
    • C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
    • C23C—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; SURFACE TREATMENT OF METALLIC MATERIAL BY DIFFUSION INTO THE SURFACE, BY CHEMICAL CONVERSION OR SUBSTITUTION; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL
    • C23C8/00—Solid state diffusion of only non-metal elements into metallic material surfaces; Chemical surface treatment of metallic material by reaction of the surface with a reactive gas, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals
    • C23C8/06—Solid state diffusion of only non-metal elements into metallic material surfaces; Chemical surface treatment of metallic material by reaction of the surface with a reactive gas, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using gases
    • C23C8/08—Solid state diffusion of only non-metal elements into metallic material surfaces; Chemical surface treatment of metallic material by reaction of the surface with a reactive gas, leaving reaction products of surface material in the coating, e.g. conversion coatings, passivation of metals using gases only one element being applied
    • C23C8/10—Oxidising
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
    • C25D11/02—Anodisation
    • C25D11/26—Anodisation of refractory metals or alloys based thereon
    • C—CHEMISTRY; METALLURGY
    • C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
    • C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
    • C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
    • C25D11/02—Anodisation
    • C25D11/34—Anodisation of metals or alloys not provided for in groups C25D11/04 - C25D11/32
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/30925—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth etched
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A61F2002/30929—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth having at least two superposed coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/3097—Designing or manufacturing processes using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00017—Iron- or Fe-based alloys, e.g. stainless steel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00023—Titanium or titanium-based alloys, e.g. Ti-Ni alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00029—Cobalt-based alloys, e.g. Co-Cr alloys or Vitallium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00011—Metals or alloys
    • A61F2310/00035—Other metals or alloys
    • A61F2310/00089—Zirconium or Zr-based alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00598—Coating or prosthesis-covering structure made of compounds based on metal oxides or hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00598—Coating or prosthesis-covering structure made of compounds based on metal oxides or hydroxides
    • A61F2310/00616—Coating made of titanium oxide or hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00598—Coating or prosthesis-covering structure made of compounds based on metal oxides or hydroxides
    • A61F2310/00622—Coating made of chromium oxide or hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00598—Coating or prosthesis-covering structure made of compounds based on metal oxides or hydroxides
    • A61F2310/00628—Coating made of cobalt oxide or hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00598—Coating or prosthesis-covering structure made of compounds based on metal oxides or hydroxides
    • A61F2310/00634—Coating made of zirconium oxide or hydroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00389—The prosthesis being coated or covered with a particular material
    • A61F2310/00592—Coating or prosthesis-covering structure made of ceramics or of ceramic-like compounds
    • A61F2310/00796—Coating or prosthesis-covering structure made of a phosphorus-containing compound, e.g. hydroxy(l)apatite

Definitions

  • the present invention relates to Osseo-inductive metal implants for a living body and the producing method thereof.
  • the layer of metal oxide and the layer of bio-active material injected are to be formed for the purpose of implanting in the human body.
  • a method implanting hydroxyapatite onto the surface by settling down the implants in the mixed electrolyte solution of calcium ion and phosphate ion, and contacting anode and cathode alternatively JP-A 1998-503108), a method anodizing the surface of implants by spark discharge in an electrolyte including calcium ions(EP 0232791), a method forming a coating film having each phase of titanite and alkali titanite on the surface by baking after settling down base titanium in a alkali solution and calcium ions respectively(JP-A 1998-179718), a method settling down in alkali solution by heat treating after ion implanting calcium on a base titanium surface(JP-A 1998-243997) and the like are disclosed.
  • the purpose of present invention is providing Osseo-inductive metal implants, composed of including the layer of metal oxide and the layer of bio-active material for a living body and the producing method thereof, so as to have high bone bonding force and quick recovery time by implanting various types of bio-active material on the surface of metal implant to be operated to various patients in the fields of dentistry, orthopedic surgery, ENT, mandibulofacial surgery, plastic surgery and the like to strengthen the function of Osseo integration.
  • the present invention relates to Osseo-inductive metal implants for a living body is characterized in a layer of a metal oxide and a layer of a bio-active material formed in this order on the metal implants surface.
  • the said metal implants according to the present invention may be applied without any limitation.
  • titanium of commercial purity or some titanium alloys comprising any one or more of Al, V, Na, Mg, P, Nb, Zr, Sn, Pt and Ta of 0.1 to 15% by weight added thereto.
  • Said titanium of commercial purity is called that with purity of 98% to 99% including impurities of nitrogen, carbon, hydrogen, oxygen, iron, aluminum and the like of 1 to 2% by weight.
  • cobalt-chromium alloy, stainless steel (314, 316, 316L 22-13-5 Stainless Steel) and zirconium alloy and the like may be applied.
  • a cobalt-chromium alloy means the one comprising any one or more of Mo, W, Ni, Mn, C, Si and Fe of 0.1 to 45% by weight added to cobalt-chromium.
  • a stainless steel means the one comprising Ni of 10 to 16%, Cr of 10 to 18% , Mo of 2 to 3% by weight and any one or more of C, Si, Mn, P and S of 0.01 to 2% by weight added to Fe of purity of 60 to 73%, or the one comprising Cr of 20 to 24%, Ni of 11 to 14%, Mn of 4 to 6%, Mo of 1 to 3%, Nb of 0.1 to 0.3%, N of 0.2 to 0.4%, V of 0.1 to 0.3% by weight and any one or more of C, Si, P and S of 0.01 to 1.2% by weight added to Fe of 52 to 61% of purity.
  • a zirconium alloy means the one comprising any one or more of Hf of 0.005 to 10%, Nb of 0 to 4%, Sn of 0 to 3%, Mo of 0 to 2%, Fe of 0.1 to 1%, Cr of 0 to 1%, Ni of 0 to 0.1%, Cu of 0 to 0.1% by weight added to Zr of 90 to 98.5% of purity.
  • a metal oxide layer of metal implants according to the present invention is preferred to be 3nm to 20 ⁇ m thick.
  • the thickness of less than 3nm is not desirable due to less than that of automatically oxidized film.
  • the oxide layer is very brittle leading to cracking, peeling and the like during long period of implants in the living body, which is not desirable as the cause of biomedical foreign body reaction.
  • any one or more methods of auto ⁇ matically forming by reacting with oxygen in the air after mechanical processing, forming by anode reaction in an electrolyte, and forming by heat treating in the air or in the atmosphere of plasma may be possible.
  • the thickness thereof is 3 to 20nm.
  • the layer has a double structure composed of a barrier type porous oxidized coated film which thickness is 50nm to 20 ⁇ m.
  • Said bio-active material according to the present invention means a material suitable to biocompatibility as adding on the surface of the metal implant surface by surface engineering.
  • the term of biocompatibility in the field of bio-active material means a function maintaining without any side effects or toxicity while the material or system functions in a living body.
  • the biocompatibility is classified into two as follows: i) bioinert property: a property attaching to the living tissue by a mor ⁇ phological fixation only, without any toxicity or side effects and without combining with tissue cells in a living body, and ii) bioactive property: a property capable of bioactive fixation without any negative reaction to the living tissue.
  • a living-active material according to the present invention means a bioactive material.
  • the present invention relates to the implants with a characteristic inducing a biochemical bonding eventually by adding a bioactive material leading to increase reactivity with the tissue, and producing thereof.
  • the bio-active material forming an implanted layer of a bio-active material has to be determined suitably considering the condition of the patient, operated portion, bone density.
  • a bio-active material capable of inducing a high bioactivity and bone bonding any alloy composed of any one of Li, Na, K, Rb, Cs, Fr, Mg, Ca, Sr, Ba, Ra, Sc, Y, Lu, Ti, Zr, Hf, Nb, Ta, Cr, Mo, W, Mn, Re, Fe, Ru, Os, Co, Rh, Ir, Ni, Pd, Pt, Cu, Ag, Au, Zn, Ga, In, Ti, Sn, Bi and an alloy of combination thereof may be applied.
  • the eventual purpose of the present invention is to induce a biochemical bonding not by the previous mechanical bonding but by the surface control of a bio- active material for the bone tissue and the implant-surface, it is very critical to choose said bio-active material.
  • the thickness of layer for said bio-active material is preferably lnm to 3 ⁇ m. In the case of less than lnm thick, it is not desirable as the quantity of the bio-active material required for inducing a biochemical bonding with a living body according to the present invention. In the case of over 3 m thick, it is not desirable because a con ⁇ siderable amount of the surface erosion occurs as it takes a longer time for injecting the bio-active material, and eventually, the previously injected material is eliminated.
  • the method of producing Osseo-inductive metal implants for a living body according to the present invention comprises the following steps:
  • any one of Ti of the commercial purity, cobalt-chromium alloy, stainless steel and zirconium alloy is to be mechanically processed in a desired form, wherein any method well known in the art for mechanical processing may be applied.
  • step (1) the methods how to form the layer of the metal oxide on the surface of the metal implant mechanical processed as said are as follows:
  • the thickness of the oxide is different depending on the method of mechanical processing, the used coolant, the surface roughness, the method of sterilization. However, it is desirable to maintain the thickness within the range of 3 to 20nm.
  • the thickness of the metal oxide layer is increased when increasing electric voltage step by step and making anodic reaction in any one electrolyte or mixed solution thereof out of sulfuric acid , oxalate, phosphoric acid, chrome chloride, acetic acid of 2 to 25% each by weight.
  • the type of the formed metal oxide layer is es ⁇ sentially that of barrier, wherein as comparatively thin and compact layer of the barrier on the boundary surface between the metal and metal oxide, and the coated film of the dielectric are destroyed in accordance with the voltage increase leading to form a double structure composed of irregular and thick porous anodic oxidized film.
  • the temperature is over 300°C, it is not desirable because there may be danger such as thermal strain and crack during shrinking. If the pressure is less than IMPa, it is not also desirable because penetrating depth is insignificant by which sterilization on the porous surface is not sufficiently carried out.
  • a uniform and compact layer of the metal oxide is formed when a mechanical processed metal implant is heated in the air or in the plasma atmosphere at 150 to 1300°C. If less than 150°C, it is not desirable because the speed of oxide film forming is very slow. If more than 1300°C, it is not also desirable because it approaches the melting temperature leading to heat distortion.
  • the metal oxide layer may be formed by a method combined two or more of said (a) to (c).
  • step (2) cleaning to eliminate polluted material and impurities absorbed on the surface of the metal oxide are carried out by two steps of normal wet and dry cleaning.
  • the wet cleaning is performed by degreasing, water cleaning, pickling and the like.
  • plasma cleaning is carried out by mounting the metal implant to the cathode portion of a vacuum chamber mounted to a jig after said wet cleaning.
  • said plasma cleaning is carried out by using plasma composed of any ion of argon, nitrogen, oxygen or more mixed ions.
  • the plasma cleaning condition it is appropriate to perform within 1 minute to 1 hour applying 50 to 3000V of DC voltage under pressure of 0.1 to 13.3Pa. In such case, it may be also possible to apply the DC voltage in a pulse form. If the pressure is less than 0.1Pa, it is not desirable as the forming of plasma is difficult, if the pressure is over 13.3Pa, as the cleaning effect is weak due to short average free stroke of the ion, if the voltage is less than 50V, as the impact energy level of the ion is not high, and if over 3000V, as a poor surface is provided by ion damages on the surface respectively.
  • the surface of metal oxide layer is modified by implanting ionized bio-active material into the surface of the metal oxide, wherein the layer of the metal oxide as the peripheral surface layer is a nuclear element during symphysis, thus, the surface deformation of the metal oxide layer may greatly effect on the biocompatibility and symphysis as cells react directly with the peripheral metal oxide layer for the implant.
  • the ionized bio-active material used at step (3) is obtainable in a vacuum chamber.
  • Vacuum Arc Filtered Vacuum Arc
  • MEVVA Metal Vapor Vacuum Arc
  • Ion plating CVD: Chemical Vapor Deposition
  • PACVD Plasma Assisted Chemical Vapor Deposition
  • Sputtering Laser ablation and a combination thereof
  • a vacuum chamber any one of Vacuum Arc, Filtered Vacuum Arc, MEVVA: Metal Vapor Vacuum Arc, Ion plating, CVD: Chemical Vapor Deposition, PACVD: Plasma Assisted Chemical Vapor Deposition, Sputtering, Laser ablation and a combination thereof may be used.
  • step (3) as a method of implanting said ionized bio-active material into the surface of the metal oxide by applying electrical energy, any one of Beamline Ion Im ⁇ plantation, PSILPlasma Source Ion Implantation, MePIII&D:Metal Plasma Immersion Ion Implantation, Deposition and a combination thereof may be used.
  • IKeV IxIO 13 to 1x10 ions/cm as for an ionized implanted amount. If the ionized implanted energy is less than IKeV, it is not desirable as etching occurs in advance rather than the ionized implant, on the other hand, if over IMeV, it is also not desirable as a biochemical bonding at the boundary has difficulty due to too deep implanting depth. Also, if the ionized implant amount is less than 1x10 ions/cm it is not desirable as the metal or the metal oxide layer loses their characteristics due to excessive implanted material.
  • the method of producing Osseo-inductive metal implants for a living body may comprise additional step of post treatment further after the implant treatment of the ionized bio-active material for said step (3), wherein there are a heat treating method such as heating in the air, in a vacuum, a hydrothermal treating method, dipping method in any one or more mixed solution of hydroxy apatite, calcium, phosphoric acid, or any one or more combined treating method out of heating at 25 to 300°C under state of deepening in said solution or ultrasonic vibration.
  • the post treatment may also be omitted.
  • the Osseo-inductive metal implants produced by said method according to the present invention may be applied usefully in the fields of dentistry, orthopedic surgery,
  • Fig.l is a photo comparing reactivity to a living body of a metal implants for an example (Fig. Ia) and a comparative example (Fig. Ib).
  • Fig.2 is a perspective view showing the section of a metal implant for an example(Fig. 2a) and an electron micrograph showing the section of metal implant for a comparative example(Fig. 2b)
  • Fig.3 is a graph showing an Auger depth profile for the boundary of a metal implant for an example.
  • Fig.4 is scanning electron microscopic photos observed after metal implants of an example (Fig. 4a) and a comparative example (Fig. 4b) were immersed in pseudo body fluid at 36.5°C for 28 days.
  • Fig.5 is a FR-IR graph measured after metal implants of an example (b) and a comparative example (a) were immersed in a pseudo body fluid for 28 days at 36.5°C.
  • Fig.6 is reactive test results for the symphysises of an example (Fig. ⁇ a) and a comparative example (Fig. 6b).
  • Step 1 Forming of the metal oxide layer on the surface of a titanium implant
  • Step 3 Ionization of a bio-active material and formation of layer of bio-active material implanted
  • Ca was ionized by the vacuum arc method. That is, pulse electric current of 200A was applied to the calcium cathode of 6mm diameter. Then, the pulse interval was 300 ⁇ s, and the frequency was 3Hz.
  • the metal implant made by the comparative example has a clear boundary between the base metal and the coating layer. It is not desirable to provoke the inflammation of bone tissues near the implant and the like due to de- laminating from the boundary or fine defect of inner part of the coating layer.
  • the metal implant according to the present invention is characterized in that it has no boundary by forming a bio-active implant layer integrated with a base metal, the delaminating does not occur comparing with the prior arts of coating.
  • the bio-active material on the surface is integrated with a base material, it is found that it has an excellent advantage of reactivity with a living body at the same time.
  • each implant made by each example and comparative example was settled down in body blood plasma and SBF, simulated body fluid which inorganic concentration is similar to the plasma for specified period of time, and each apatite formability thereof was measured. The results are shown in Fig. 4 and Fig. 5.
  • the apatite as a material composed of Ca and P is known as the precursor of hydroxyapatite, a major component of the bone.
  • FIG. 4 is scanning microscopic photos observed after the example(Fig. 4a) and the comparative example(Fig. 4b) were settled down in SBF at 36.5°C for 28 days.
  • the comparative example it is found that particles of small bulb shape were formed on the surface, meanwhile, in the case of the example, leaf like particles were formed on the surface, which size or density was considerably increased comparing over the comparative example. Furthermore, it can be seen that particles contacted mutually to be interconnected.
  • FT-IR analysis was carried out, which result is shown in Fig. 5.
  • the phase of the particles formed on the surface is composed of apatite. It can be verified that the formation of the apatite was promoted by the implanted calcium ion.
  • Test example 4 promotes the formation of apatite, it can be found that it not only reacted faster and excellent os ⁇ teogenesis when being inserted into the human body but also the healing time could be reduced.
  • each implant was implanted to a healthy white rabbit from New Zealand. Each implant was carried out in each left and right shank located below about 10mm from each knee joint. After three weeks elapsed since each implant was performed, the specimens were collected from the rabbit. Then, after fixing and de ⁇ hydration thereof, Observations based on the tectology which results are shown in Fig. ⁇ a(example) and Fig. 6b(comparative example) were made.
  • the implant made by example was more excellent than that made by the comparative example not only in newly formed bone near the cortical bone but also in the speed of new bone formation for the edosteal new bone formation of subcotex and the amount of new bone fo rmation.
  • the metal which bio-active material is implanted in particular, titanium/titanium alloy and cobalt-chromium alloy, stainless steel(314, 316, 316L, and 22-13-5 Stainless Steel) and zirconium alloy implants are a total sum of Osseo-inductive metal implant for bio-active material and control technology for surface components , wherein reactivity with a living body is excellent and compact film without any boundary is formed leading to generate a biochemical layer without any degradation and peeling, as the synotosis of the implant and the biomass due to such biochemical combination and the healing time becomes faster, it may be applied usefully as a medical device for implanting bio masses for dentistry, orthopedic surgery, mandibulofacial surgery, surgical operation and veterinary surgical operation and the like.

Abstract

Cette invention porte sur un implant métallique osséoinducteur destiné à un corps vivant et sur son procédé de fabrication. Pour produire cet implant métallique osséoinducteur, on forme, sur la surface de l'implant métallique, la couche d'oxyde métallique et la couche de matériau bioactif injecté.
PCT/KR2005/000947 2004-04-26 2005-03-31 Implant metallique osseoinducteur pour corps vivant et procede de production WO2006004297A1 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
BRPI0510301-0A BRPI0510301A (pt) 2004-04-26 2005-03-31 implantes de metal de indução de osso para um corpo vivo e processo de produção dos mesmos
US11/578,178 US8920869B2 (en) 2004-04-26 2005-03-31 Osseoinductive metal implants for a living body and producing method thereof
EP05789726A EP1740128A4 (fr) 2004-04-26 2005-03-31 Implant metallique osseoinducteur pour corps vivant et procede de production
US14/579,591 US20150209480A1 (en) 2004-04-26 2014-12-22 Osseo-inductive metal implants for a living body and the producing method thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2004-0028550 2004-04-26
KR20040028550 2004-04-26

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/578,178 A-371-Of-International US8920869B2 (en) 2004-04-26 2005-03-31 Osseoinductive metal implants for a living body and producing method thereof
US14/579,591 Division US20150209480A1 (en) 2004-04-26 2014-12-22 Osseo-inductive metal implants for a living body and the producing method thereof

Publications (1)

Publication Number Publication Date
WO2006004297A1 true WO2006004297A1 (fr) 2006-01-12

Family

ID=35783068

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2005/000947 WO2006004297A1 (fr) 2004-04-26 2005-03-31 Implant metallique osseoinducteur pour corps vivant et procede de production

Country Status (5)

Country Link
US (2) US8920869B2 (fr)
EP (1) EP1740128A4 (fr)
KR (1) KR100714244B1 (fr)
BR (1) BRPI0510301A (fr)
WO (1) WO2006004297A1 (fr)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007090433A2 (fr) * 2006-02-09 2007-08-16 Plus Orthopedics Ag Oxydes purifies avec de nouvelles morphologies formees a partir d'alliages de ti
EP1972298A1 (fr) * 2007-03-20 2008-09-24 Heraeus Kulzer GmbH Revêtement biocompatible ayant la couleur des dents d'implants dentaires
EP2014319A1 (fr) * 2007-07-09 2009-01-14 Astra Tech AB Implant de tissu osseux comprenant des ions de strontium
WO2009007371A1 (fr) 2007-07-09 2009-01-15 Astra Tech Ab Implant de tissu osseux comprenant des ions de lithium
WO2009007373A1 (fr) * 2007-07-09 2009-01-15 Astra Tech Ab Nanosurface
WO2009053670A3 (fr) * 2007-10-25 2010-02-25 Plasma Coatings Limited Procédé de formation d'un revêtement bioactif
WO2010025721A3 (fr) * 2008-09-05 2010-11-11 Verein Zur Förderung Von Innovationen Durch Forschung, Entwicklung Und Technologietransfer E. V. (Verein Innovent E.V.) Implant dégradable et procédé pour sa production et son utilisation
WO2010025720A3 (fr) * 2008-09-05 2010-11-11 Verein Zur Förderung Von Innovationen Durch Forschung, Entwicklung Und Technologietransfer E. V. (Verein Innovent E.V.) Implant et procédé pour sa production et son utilisation
WO2011054153A1 (fr) * 2009-11-06 2011-05-12 詹振强 Obtention d'ions d'argent
CN102895706A (zh) * 2012-11-12 2013-01-30 重庆大学 一种生物医用耐蚀多孔复合材料及其制备方法
CN102965626A (zh) * 2012-12-17 2013-03-13 中国南方航空工业(集团)有限公司 粉末冶金多孔材料的镀镍方法
WO2013144185A1 (fr) * 2012-03-30 2013-10-03 Dentsply Ih Ab Dispositif médical présentant une surface comprenant de l'oxyde de gallium
CN105726146A (zh) * 2016-04-05 2016-07-06 苏州雅微医疗科技有限公司 牙周病用种植体及其制备方法
CN106048549A (zh) * 2016-05-25 2016-10-26 伍旭 一种能杀菌的合金制作方法
CN108324995A (zh) * 2018-02-11 2018-07-27 福建工程学院 超声粒子嵌入技术表面修饰三维多孔生物支架的制备方法
CN110152056A (zh) * 2019-05-27 2019-08-23 吉林大学 一种在钛合金表面快速引入功能离子的方法
CN114481015A (zh) * 2021-12-20 2022-05-13 安徽理工大学 一种富含CaTiO3的纳米晶β型钛合金的制备方法、制得的钛合金
EP2614842B1 (fr) 2009-02-19 2022-09-07 Neoss Limited Procédé de traitement de surface pour dispositif médical implantable

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100742565B1 (ko) * 2005-01-14 2007-07-25 주식회사 엔아이비 고강도 저탄성 티타늄 합금 및 이를 이용한 생체적합성의생체 재료
KR101157309B1 (ko) * 2009-07-03 2012-06-15 주식회사 제노스 생체적합성 금속이 코팅된 고분자 임플란트 및 그 제조방법
SE0950972A1 (sv) * 2009-12-17 2011-06-18 Tigran Technologies Ab Publ Poröst block av titan eller titanlegering
EP2399620B1 (fr) * 2010-06-28 2016-08-10 Biotronik AG Implant et son procédé de fabrication
KR101252767B1 (ko) * 2010-07-08 2013-04-11 (주)에스이피 플라즈마를 이용한 임플란트 유닛의 표면처리방법 및 그 방법으로 제조된 임플란트 유닛 및 임플란트 유닛의 플라즈마 표면처리장치
KR101233279B1 (ko) 2010-08-06 2013-02-14 설영택 임플란트용 표면금속 산화물, 이를 이용한 임플란트 또는 장치 및 그의 제조방법
EP2662051A1 (fr) * 2012-05-11 2013-11-13 Dentsply IH AB Dispositif médical comportant une surface comprenant des nanoparticules
KR101494758B1 (ko) * 2013-08-12 2015-02-23 주식회사 비앤메디 표면처리 및 은나노 코팅을 이용한 의료용 티타늄 차폐막의 제조 방법
DE102014010032B4 (de) * 2014-07-08 2017-03-02 Technische Universität Braunschweig Titanlegierung
EP3034033A1 (fr) 2014-12-16 2016-06-22 Nobel Biocare Services AG Implant dentaire
RU2604085C1 (ru) * 2015-10-08 2016-12-10 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Саратовский государственный технический университет имени Гагарина Ю.А." (СГТУ имени Гагарина Ю.А.) Способ формирования наноструктурированного биоинертного покрытия на титановых имплантатах
CN110565144A (zh) * 2018-11-01 2019-12-13 赵全明 一种兼具抗菌和促成骨的多孔生物陶瓷涂层及其制备方法和应用
CN111876707B (zh) * 2020-08-04 2021-11-19 安徽理工大学 一种具有促骨再生及抗菌双功能钛合金的改性方法及改性后的钛合金
TWI736433B (zh) * 2020-09-26 2021-08-11 羅政立 晶體取向結構鈦合金牙科植體及其製造方法
CN115607731A (zh) * 2022-10-17 2023-01-17 四川大学 一种聚醚酮酮复合材料、制备方法和用途

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5603338A (en) 1994-11-30 1997-02-18 Innovative Implants, Inc. Implant surface preparation utilizing acid treatment
JPH10243997A (ja) * 1997-03-03 1998-09-14 Nippon Electric Glass Co Ltd 生体インプラント材料の製造方法
WO2002096475A1 (fr) * 2001-05-29 2002-12-05 Mediteam Dental Ab Oxyde modifie
WO2004010887A1 (fr) * 2002-07-25 2004-02-05 Nobel Biocare Ab (Publ) Moyen d'utilisation d'une matiere osteoinductive ou bioactive pour induire la croissance osseuse et/ou pour ameliorer la stabilite des implants dans l'os de la machoire, implant utilise a cet effet

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5214095A (en) * 1975-07-23 1977-02-02 Sumitomo Chemical Co Implant in bone
DD246028A1 (de) 1986-02-12 1987-05-27 Karl Marx Stadt Tech Hochschul Keramisiertes metallimplantat
DE4009337A1 (de) * 1990-03-23 1991-09-26 Repenning Detlev Verfahren zur herstellung von osteointegrierenden oberflaechen auf skelettimplantaten sowie skelettimplantat
JPH055703A (ja) 1991-06-27 1993-01-14 Mitsubishi Heavy Ind Ltd 吸光度検出装置
JPH0557012A (ja) 1991-09-04 1993-03-09 Advance Co Ltd 複合インプラント
JPH0780014A (ja) * 1993-09-14 1995-03-28 Nikon Corp 骨内インプラント
US5558718A (en) * 1994-04-08 1996-09-24 The Regents, University Of California Pulsed source ion implantation apparatus and method
DE19504386C2 (de) 1995-02-10 1997-08-28 Univ Dresden Tech Verfahren zur Herstellung einer gradierten Beschichtung aus Calciumphosphatphasen und Metalloxidphasen auf metallischen Implantaten
JPH08257109A (ja) * 1995-03-28 1996-10-08 Nikon Corp 骨内インプラント及びその製造方法
IT1288038B1 (it) * 1996-04-30 1998-09-10 Flametal S P A Procedimento per la preparazione di rivestimenti di idrossiapatite
JPH10179718A (ja) 1996-12-25 1998-07-07 Nippon Electric Glass Co Ltd 生体インプラント材料及びその製造方法
JP3201302B2 (ja) * 1997-02-10 2001-08-20 松下電器産業株式会社 基板のプラズマクリーニング装置
JP3289140B2 (ja) 1999-06-17 2002-06-04 独立行政法人産業技術総合研究所 高生体親和性インプラント及びその作製法
KR20010018331A (ko) * 1999-08-18 2001-03-05 정태섭 알칼리 처리에 의한 생체용 임플란트의 생체활성 부여
JP4109494B2 (ja) 2002-05-14 2008-07-02 株式会社アドバンス インプラントの製造方法
AU2003272451A1 (en) 2002-09-16 2004-04-30 Lynntech Coatings, Ltd. Anodically treated biocompatible implants
KR100487119B1 (ko) 2002-11-26 2005-05-03 설영택 마그네슘 티타네이트 산화막 임플란트 및 그 제조방법

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5603338A (en) 1994-11-30 1997-02-18 Innovative Implants, Inc. Implant surface preparation utilizing acid treatment
US5876453A (en) 1994-11-30 1999-03-02 Implant Innovations, Inc. Implant surface preparation
JPH10243997A (ja) * 1997-03-03 1998-09-14 Nippon Electric Glass Co Ltd 生体インプラント材料の製造方法
WO2002096475A1 (fr) * 2001-05-29 2002-12-05 Mediteam Dental Ab Oxyde modifie
WO2004010887A1 (fr) * 2002-07-25 2004-02-05 Nobel Biocare Ab (Publ) Moyen d'utilisation d'une matiere osteoinductive ou bioactive pour induire la croissance osseuse et/ou pour ameliorer la stabilite des implants dans l'os de la machoire, implant utilise a cet effet

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
FUJIBAYASHI S. ET AL: "Osteoinduction of porous bioactive titanium metal", BIOMATERIALS, vol. 25, no. 3, February 2004 (2004-02-01), pages 443 - 450, XP004469637 *
LACEFIELD W.R.: "Materials characteristics of uncoated/ceramic-coated implant materials", ADV. DENT. RES., vol. 13, 1999, pages 21 - 26, XP008117498 *
See also references of EP1740128A4 *
SUL PHD THESIS, 2002

Cited By (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007090433A2 (fr) * 2006-02-09 2007-08-16 Plus Orthopedics Ag Oxydes purifies avec de nouvelles morphologies formees a partir d'alliages de ti
WO2007090433A3 (fr) * 2006-02-09 2007-11-01 Plus Orthopedics Ag Oxydes purifies avec de nouvelles morphologies formees a partir d'alliages de ti
EP1972298A1 (fr) * 2007-03-20 2008-09-24 Heraeus Kulzer GmbH Revêtement biocompatible ayant la couleur des dents d'implants dentaires
CN101686861A (zh) * 2007-07-09 2010-03-31 艾斯特勒科技公司 包含锂离子的骨组织植入物
JP2010533012A (ja) * 2007-07-09 2010-10-21 アストラ・テック・アクチエボラーグ ストロンチウムイオンを含む骨組織インプラント
WO2009007372A2 (fr) * 2007-07-09 2009-01-15 Astra Tech Ab Implant de tissu osseux comprenant des ions de strontium
WO2009007373A1 (fr) * 2007-07-09 2009-01-15 Astra Tech Ab Nanosurface
EP2022447A1 (fr) * 2007-07-09 2009-02-11 Astra Tech AB Nanosurface
WO2009007372A3 (fr) * 2007-07-09 2009-03-05 Astra Tech Ab Implant de tissu osseux comprenant des ions de strontium
US8632836B2 (en) 2007-07-09 2014-01-21 Astra Tech Ab Nanosurface
US8597676B2 (en) 2007-07-09 2013-12-03 Astra Tech Ab Bone tissue implant comprising lithium ions
CN101686862A (zh) * 2007-07-09 2010-03-31 艾斯特勒科技公司 纳米表面
WO2009007371A1 (fr) 2007-07-09 2009-01-15 Astra Tech Ab Implant de tissu osseux comprenant des ions de lithium
JP2010533011A (ja) * 2007-07-09 2010-10-21 アストラ・テック・アクチエボラーグ リチウムイオンを含む骨組織インプラント
US9642708B2 (en) 2007-07-09 2017-05-09 Astra Tech Ab Nanosurface
US9744263B2 (en) 2007-07-09 2017-08-29 Astra Tech Ab Bone tissue implant comprising strontium ions
US9889227B2 (en) 2007-07-09 2018-02-13 Astra Tech Ab Bone tissue implant comprising strontium ions
AU2008274302B2 (en) * 2007-07-09 2011-12-01 Astra Tech Ab A bone tissue implant comprising strontium ions
AU2008274301B2 (en) * 2007-07-09 2012-04-26 Astra Tech Ab A bone tissue implant comprising lithium ions
US20130013081A1 (en) * 2007-07-09 2013-01-10 Astra Tech Ab Nanosurface
EP2014319A1 (fr) * 2007-07-09 2009-01-14 Astra Tech AB Implant de tissu osseux comprenant des ions de strontium
US8852418B2 (en) 2007-10-25 2014-10-07 Plasma Coatings Limited Method of forming a bioactive coating
WO2009053670A3 (fr) * 2007-10-25 2010-02-25 Plasma Coatings Limited Procédé de formation d'un revêtement bioactif
WO2010025721A3 (fr) * 2008-09-05 2010-11-11 Verein Zur Förderung Von Innovationen Durch Forschung, Entwicklung Und Technologietransfer E. V. (Verein Innovent E.V.) Implant dégradable et procédé pour sa production et son utilisation
WO2010025720A3 (fr) * 2008-09-05 2010-11-11 Verein Zur Förderung Von Innovationen Durch Forschung, Entwicklung Und Technologietransfer E. V. (Verein Innovent E.V.) Implant et procédé pour sa production et son utilisation
EP2614842B1 (fr) 2009-02-19 2022-09-07 Neoss Limited Procédé de traitement de surface pour dispositif médical implantable
WO2011054153A1 (fr) * 2009-11-06 2011-05-12 詹振强 Obtention d'ions d'argent
US9420798B2 (en) 2009-11-06 2016-08-23 Raymond Chin Preparation of silver ion
WO2013143857A1 (fr) * 2012-03-30 2013-10-03 Dentsply Ih Ab Dispositif médical présentant une surface comprenant un métal antimicrobien
WO2013144185A1 (fr) * 2012-03-30 2013-10-03 Dentsply Ih Ab Dispositif médical présentant une surface comprenant de l'oxyde de gallium
RU2651463C1 (ru) * 2012-03-30 2018-04-19 Дентспли Их Аб Медицинское устройство с поверхностью, содержащей металл противомикробного действия
CN102895706A (zh) * 2012-11-12 2013-01-30 重庆大学 一种生物医用耐蚀多孔复合材料及其制备方法
CN102895706B (zh) * 2012-11-12 2015-07-08 重庆大学 一种生物医用耐蚀多孔复合材料及其制备方法
CN102965626A (zh) * 2012-12-17 2013-03-13 中国南方航空工业(集团)有限公司 粉末冶金多孔材料的镀镍方法
CN105726146A (zh) * 2016-04-05 2016-07-06 苏州雅微医疗科技有限公司 牙周病用种植体及其制备方法
CN106048549A (zh) * 2016-05-25 2016-10-26 伍旭 一种能杀菌的合金制作方法
CN108324995A (zh) * 2018-02-11 2018-07-27 福建工程学院 超声粒子嵌入技术表面修饰三维多孔生物支架的制备方法
CN110152056A (zh) * 2019-05-27 2019-08-23 吉林大学 一种在钛合金表面快速引入功能离子的方法
CN114481015A (zh) * 2021-12-20 2022-05-13 安徽理工大学 一种富含CaTiO3的纳米晶β型钛合金的制备方法、制得的钛合金
CN114481015B (zh) * 2021-12-20 2023-10-03 安徽理工大学 一种富含CaTiO3的纳米晶β型钛合金的制备方法、制得的钛合金

Also Published As

Publication number Publication date
KR20060045135A (ko) 2006-05-16
EP1740128A1 (fr) 2007-01-10
US20090017087A1 (en) 2009-01-15
US20150209480A1 (en) 2015-07-30
US8920869B2 (en) 2014-12-30
KR100714244B1 (ko) 2007-05-02
EP1740128A4 (fr) 2011-08-24
BRPI0510301A (pt) 2007-10-02

Similar Documents

Publication Publication Date Title
US8920869B2 (en) Osseoinductive metal implants for a living body and producing method thereof
İzmir et al. Anodization of titanium alloys for orthopedic applications
Xue et al. In vivo evaluation of plasma sprayed hydroxyapatite coatings having different crystallinity
Liu et al. Surface modification of titanium, titanium alloys, and related materials for biomedical applications
US8382823B2 (en) Biodegradable stent and method for manufacturing the same
Shabalovskaya et al. Critical overview of Nitinol surfaces and their modifications for medical applications
EP2187982B1 (fr) Implant de tissu osseux comprenant des ions de strontium
Izman et al. Surface modification techniques for biomedical grade of titanium alloys: oxidation, carburization and ion implantation processes
WO2003086495A1 (fr) Dispositifs medicaux prothetiques presentant une biocompatibilite amelioree
De Aza et al. In vitro bioactivity of laser ablation pseudowollastonite coating
JP4635177B2 (ja) 生体親和性インプラント材及びその製造方法
JP2019511346A (ja) 組織接着性向上用コーティング
JP2014534882A (ja) リン酸カルシウム層を有する金属材料及びその製造方法
KR20070063114A (ko) 금속 임플란트 및 그 제조방법
Mousa et al. Surface modification of magnesium and its alloys using anodization for orthopedic implant application
CN104434539A (zh) 可植入人或动物体内的装置的表层的制备方法
KR100953959B1 (ko) 양극산화법에 의한 임플란트재료 및 그 제조방법
US20070083269A1 (en) Method of producing endosseous implants or medical prostheses by means of ion implantation and endosseous implant or medical prosthesis thus obtained
JPH0731627A (ja) インプラントとその製造方法
KR100865345B1 (ko) 나노튜브에 의해 치아회분말이 코팅되도록 한 치과용임플란트 제조방법
WO2007069532A1 (fr) Implant compatible aux os et son procede de fabrication
Lee et al. Corrosion and biocompatibility behavior of the micro-arc oxidized AZ31B alloy in simulated body fluid
Park et al. The bioactivity of enhanced Ti-32Nb-5Zr alloy with anodic oxidation and cyclic calcification
KR100453289B1 (ko) 임프란트 표면 처리용 전해질 용액 및 상기 전해질 용액을이용한 임프란트 표면 처리 방법
Gao et al. Corrosion and bone response of magnesium implants after surface modification by heat-self-assembled monolayer

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SM SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
REEP Request for entry into the european phase

Ref document number: 2005789726

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2005789726

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: DE

WWW Wipo information: withdrawn in national office

Ref document number: DE

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
WWP Wipo information: published in national office

Ref document number: 2005789726

Country of ref document: EP

ENP Entry into the national phase

Ref document number: PI0510301

Country of ref document: BR

WWE Wipo information: entry into national phase

Ref document number: 11578178

Country of ref document: US