WO2005079969A1 - Procede et dispositif pour produire des multi-microcapsules stables au stockage comportant des composants fonctionnels synergiquement actifs a liberation controlee - Google Patents

Procede et dispositif pour produire des multi-microcapsules stables au stockage comportant des composants fonctionnels synergiquement actifs a liberation controlee Download PDF

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Publication number
WO2005079969A1
WO2005079969A1 PCT/EP2004/001860 EP2004001860W WO2005079969A1 WO 2005079969 A1 WO2005079969 A1 WO 2005079969A1 EP 2004001860 W EP2004001860 W EP 2004001860W WO 2005079969 A1 WO2005079969 A1 WO 2005079969A1
Authority
WO
WIPO (PCT)
Prior art keywords
substance
components
capsule
spray
main
Prior art date
Application number
PCT/EP2004/001860
Other languages
German (de)
English (en)
Inventor
Erich Windhab
Original Assignee
Eidgenössische Technische Hochschule Zürich (Eth)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eidgenössische Technische Hochschule Zürich (Eth) filed Critical Eidgenössische Technische Hochschule Zürich (Eth)
Priority to PCT/EP2004/001860 priority Critical patent/WO2005079969A1/fr
Priority to EP04714281A priority patent/EP1722885A1/fr
Publication of WO2005079969A1 publication Critical patent/WO2005079969A1/fr
Priority to US11/510,869 priority patent/US20070122488A1/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/20—After-treatment of capsule walls, e.g. hardening
    • B01J13/22—Coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/04—Making microcapsules or microballoons by physical processes, e.g. drying, spraying

Definitions

  • the invention has for its object to provide a method by means of which it should be possible to encapsulate functional substances / substance components with respect to a pharmacological / medical and / or nutritional effect in such a way that on the one hand they show no interactions under storage conditions and on the other hand, when applied in accordance with the ambient conditions, a defined adjustable release of the encapsulated substances / substance components with regard to the time of release and release rate, as well as a synergistic interaction.
  • the invention has for its object to provide a suitable device for performing the method according to the invention.
  • a further significant advantage results from the spatial proximity of the substances / substance components fixed in a microcapsule, since this leads to their release from the microcapsule for contact and, as a result of the appropriate substance / substance component combination, for targeted synergistic interactions.
  • Another advantage is the setting according to the invention of the time of release and the rate of release of encapsulated functional substances / substance components by a suitable choice coordinated with the environmental conditions during use, which is based on these functional Capsule materials forming shell layers, as well as their layer thickness and microstructure.
  • iron remedies taken to remedy iron deficiency symptoms under the general conditions in the stomach of humans low pH values
  • oxidation effects when interacting with e.g. B. oxidized phytic acids from plant foods or dairy products so impaired in terms of their absorbability in the small intestine and thus limited in bioavailability.
  • the concept according to the invention provides such optimization options due to the encapsulation methodology according to the invention of several functional substance / substance components in a multi-capsule.
  • HKMP main capsule matrix phase
  • the FSi are preferably used in solid, crystalline or partially crystalline form. In pre-encapsulation steps, the FSi is first embedded in a subcapsule matrix phase (SKMPi).
  • these SKMPi are chosen opposite to the FSi in terms of their hydrophilicity / hydrophobicity.
  • the molecular structure of the SKMPi is preferably largely amorphous (glass-like), crystalline / semi-crystalline or gel-like using the SKMP-specific manufacturing process.
  • additional boundary surface layers are created by means of surface-active substances as diffusion barriers between FSi and SKMPi and between SKMPi and HKMP.
  • Such an interface layer can also surround the main capsule as a surface layer (GFH).
  • Wet grinding is preferably carried out in a ball mill with grinding bodies which are matched in size to the grinding fineness to be achieved and preferably consist of ceramic material.
  • grinding bodies which are matched in size to the grinding fineness to be achieved and preferably consist of ceramic material.
  • roller or hammer mills can also be used.
  • Step 4 MAIN CAPSULE PRODUCTION -
  • the mixed suspension of i subcapsule types in fluid HKMP which is defined in terms of the quantitative ratio and concentration of the various SKi and is produced from steps 3, is again sprayed into a cold room in a further process step preferred according to the invention and is then hardened or solidified according to mechanisms. Description solidified in step 3 and thus formed the main capsules. These are removed in powder form at the end of step 4.
  • the main capsules obtained are stored at temperatures which are below the melting and / or glass transition temperatures the layer-forming substance components or substance component mixtures.
  • FS1 an antioxidant
  • FS2 a nutritionally or pharmacologically / medically relevant compound
  • the cladding layers enable the thermal, mechanical, pH and enzymatic stability properties to be set.
  • the corresponding can also be dismantled Wrapping layer may be desired in order to finally ensure the release of the FSi at the destination.
  • the centrifugal forces acting in such currents favor the separation of the sprayed subcapsules / main capsules on the spray tower walls in the lower conical tower areas (11, 32).
  • the completed multi-microcapsules (main capsules) are usually the second cold spray tower removed by means of a rotary valve (33) or an alternative discharge device.
  • subcapsules after the first cold spray tower can also represent a preferred end product and can be removed as such.
  • each cold spray tower can have one or more such coating spray devices.
  • the respectively associated coating spray nozzles are then preferably arranged according to the invention in zones lying one above the other in order to produce defined coatings lying one above the other.
  • a supply takes place here in the cold spray towers according to the invention instead of the cold gas injection (nozzles 20, 22) of hot gas / drying gas.
  • the nitrogen tank (19) is also replaced by an air heater.
  • HKMP main capsule - matrix phase
  • NMH network-forming macromolecules in the main capsule matrix phase
  • NMSi network-forming macromolecules in the subcapsule matrix phase

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un procédé et un dispositif pour générer des systèmes de capsules à plusieurs composants (c.-à-d. des multi-microcapsules) dans lesquels deux ou plus de deux substances fonctionnelles ou composants de substance fonctionnelle sont encapsulé(e)s de manière spatialement séparée, de façon que, lors du stockage, les composants encapsulés ne puissent pas interagir, mais lorsque lesdites multi-microcapsules sont administrées, les substances ou composants de substance encapsulé(e)s soient libéré(e)s de manière ciblée, simultanément ou successivement, en fonction de leur domaine d'application, la vitesse de libération et l'interaction synergique des substances ou composants de substance étant éventuellement contrôlées. Le procédé selon l'invention ainsi que le dispositif correspondant permettent de concevoir des multi-microcapsules dans lesquelles plusieurs substances fonctionnelles ou composants de substance fonctionnelle sont enveloppé(e)s au moyen d'une ou de plusieurs couches de matière présentant des propriétés de stabilité mécanique, thermique et physico-chimique ou biochimique définies, qui, en fonction des conditions d'utilisation, contrôlent le site de libération des substances fonctionnelles ou des composants de substance fonctionnelle encapsulé(e)s, leur cinétique de libération, ainsi que les interactions synergiques.
PCT/EP2004/001860 2004-02-25 2004-02-25 Procede et dispositif pour produire des multi-microcapsules stables au stockage comportant des composants fonctionnels synergiquement actifs a liberation controlee WO2005079969A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PCT/EP2004/001860 WO2005079969A1 (fr) 2004-02-25 2004-02-25 Procede et dispositif pour produire des multi-microcapsules stables au stockage comportant des composants fonctionnels synergiquement actifs a liberation controlee
EP04714281A EP1722885A1 (fr) 2004-02-25 2004-02-25 Procede et dispositif pour produire des multi-microcapsules stables au stockage comportant des composants fonctionnels synergiquement actifs a liberation controlee
US11/510,869 US20070122488A1 (en) 2004-02-25 2006-08-24 Multi-functional microcapsules and method and device for manufacturing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2004/001860 WO2005079969A1 (fr) 2004-02-25 2004-02-25 Procede et dispositif pour produire des multi-microcapsules stables au stockage comportant des composants fonctionnels synergiquement actifs a liberation controlee

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/510,869 Continuation US20070122488A1 (en) 2004-02-25 2006-08-24 Multi-functional microcapsules and method and device for manufacturing same
AU2006222667A Division AU2006222667A1 (en) 2004-02-25 2006-09-25 Storage-Stable Multimicrocapsules Having Adjustably Synergistic Functional Ingredients and Method and Device for Making the Same

Publications (1)

Publication Number Publication Date
WO2005079969A1 true WO2005079969A1 (fr) 2005-09-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/001860 WO2005079969A1 (fr) 2004-02-25 2004-02-25 Procede et dispositif pour produire des multi-microcapsules stables au stockage comportant des composants fonctionnels synergiquement actifs a liberation controlee

Country Status (2)

Country Link
EP (1) EP1722885A1 (fr)
WO (1) WO2005079969A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1869982A2 (fr) * 2006-06-03 2007-12-26 Messer Group GmbH Procédé et dispositif de fabrication d'une matière en forme de poudre et riche en graisses
CN114127217A (zh) * 2019-03-25 2022-03-01 斯皮拉技术有限公司 多组分体系和多组分体系的制造方法
US11401485B2 (en) 2017-05-24 2022-08-02 Henkel Ag & Co. Kgaa Microcapsule system for polysensory olfactory effects I

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695466A (en) * 1983-01-17 1987-09-22 Morishita Jintan Co., Ltd. Multiple soft capsules and production thereof
DE19750679A1 (de) * 1997-11-15 1999-05-27 Inst Lebensmittelwissenschaft Verfahren zum Erzeugen von wasserhaltigen, gefrorenen bzw. erstarrten, lagerstabilen, rieselfähigen Pulvermikrokapseln und daraus bestehenden wasserhaltigen, gefrorenen bzw. erstarrten, lagerstabilen, rieselfähigen Pulvermikrokapselsystemen und Einrichtung zum Durchführen des Verfahrens
DE10104841A1 (de) * 2001-02-01 2002-09-12 Henkel Kgaa Kapseln-in-Kapsel-System und Verfahren zu seiner Herstellung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695466A (en) * 1983-01-17 1987-09-22 Morishita Jintan Co., Ltd. Multiple soft capsules and production thereof
DE19750679A1 (de) * 1997-11-15 1999-05-27 Inst Lebensmittelwissenschaft Verfahren zum Erzeugen von wasserhaltigen, gefrorenen bzw. erstarrten, lagerstabilen, rieselfähigen Pulvermikrokapseln und daraus bestehenden wasserhaltigen, gefrorenen bzw. erstarrten, lagerstabilen, rieselfähigen Pulvermikrokapselsystemen und Einrichtung zum Durchführen des Verfahrens
DE10104841A1 (de) * 2001-02-01 2002-09-12 Henkel Kgaa Kapseln-in-Kapsel-System und Verfahren zu seiner Herstellung

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1869982A2 (fr) * 2006-06-03 2007-12-26 Messer Group GmbH Procédé et dispositif de fabrication d'une matière en forme de poudre et riche en graisses
EP1869982A3 (fr) * 2006-06-03 2008-08-27 Messer Group GmbH Procédé et dispositif de fabrication d'une matière en forme de poudre et riche en graisses
US11401485B2 (en) 2017-05-24 2022-08-02 Henkel Ag & Co. Kgaa Microcapsule system for polysensory olfactory effects I
CN114127217A (zh) * 2019-03-25 2022-03-01 斯皮拉技术有限公司 多组分体系和多组分体系的制造方法

Also Published As

Publication number Publication date
EP1722885A1 (fr) 2006-11-22

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