Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
  • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
  • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
  • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• • A—HUMAN NECESSITIES
  • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
  • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
  • A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K33/00—Medicinal preparations containing inorganic active ingredients
  • A61K33/40—Peroxides
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
  • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K9/00—Medicinal preparations characterised by special physical form
  • A61K9/08—Solutions
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
  • A61P17/00—Drugs for dermatological disorders
  • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Definitions

• Ozone-dissolved glycerin solution solidified ozone-dissolved glycerin, ozone-dissolved mixed solution, method for producing ozone-dissolved glycerin solution, method for producing ozone-dissolved mixed solution, and method for storing ozone-dissolved glycerin solution
• the present invention relates to an ozone-dissolved glycerin solution, an ozone-dissolved glycerin solid, an ozone-dissolved mixed solution, a method for producing an ozone-dissolved glycerin solution, a method for producing an ozone-dissolved mixed solution, and a method for storing an ozone-dissolved glycerin solution.
• ozone has a strong iridescent effect and is useful for sterilization.
• As a general method for producing gaseous ozone there is a method of discharging a part of air to ozone.
• ozone water in which ozone is dissolved in water is also used.
• the method of producing ozone water includes dissolving ozone produced by discharging air into water by some method, and oxygen generated by directly electrolyzing water using an electrode having an ozone generation catalytic function such as platinum. Some parts are ozone-ridden and immediately dissolved in water
• Patent Document 1 Japanese Patent Application Laid-Open No. 10-139645
• the ozone concentration immediately after the production of the ozone-enclosed viscous body is low, the ozone concentration decreases when the storage period is prolonged, and the sterilization effect cannot be maintained.
• it may be oxidized by ozone to produce harmful oxides (peroxides).
• An object of the present invention is to maintain an ozone concentration sufficient for exhibiting a bactericidal effect and a wound healing effect for a long period of time, and to produce ozone-dissolved glycerol that does not generate harmful oxidants.
• the present invention provides a method for producing an ozone-dissolved glycerin solution, a method for producing an ozone-dissolved mixed solution, a method for producing an ozone-dissolved mixed solution, and a method for storing an ozone-dissolved glycerin solution.
• the invention described in claim 1 is an ozone-dissolved glycerin solution, wherein at least 400 ppm of ozone is dissolved in a 75 wt% or more non-oxidized glycerin solution. It is characterized by
• ozone is dissolved at a high concentration in the non-oxidizing glycerin at a high concentration, so that an ozone concentration sufficient to exhibit a bactericidal effect is obtained. It can be kept for a long time.
• the invention described in claim 2 is an ozone-dissolved mixed solution, wherein an ozone-dissolved glycerin solution having an ozone power of OO ppm or more dissolved in a non-oxidized glycerin solution of 75 wt% or more is treated with water.
• Ozone is dissolved in at least 80 ppm by mixing with any one of petroleum, petrolatum, and polyethylene glycol.
• the high concentration of glycerin is irritating to the skin, and therefore, when used in a lotion or a serum, it is necessary to reduce the concentration of glycerin.
• the irritation of glycerin can be suppressed by mixing the ozone-dissolved glycerin solution with one of water, vaseline, and polyethylene glycol.
• ozone Since Oppm or more is dissolved, sufficient sterilization ability can be exhibited.
• the invention described in claim 3 is a method for producing an ozone-dissolved glycerin solution.
• a gas containing ozone is brought into gas-liquid contact with a glycerin solution of 75% by weight or more to dissolve ozone of 400 ppm or more.
• ozone is dissolved in high-concentration glycerin at a high concentration by bringing a gas containing ozone into gas-liquid contact with a glycerin solution of 75 wt% or more.
• An ozone-dissolved glycerin solution can be produced.
• the invention described in claim 4 is a method for producing an ozone-dissolved mixed solution, wherein a gas containing ozone is brought into gas-liquid contact with a glycerin solution of 75 wt% or more to dissolve 400 ppm or more of ozone. It is characterized in that ozone is dissolved by 80 ppm or more by mixing and stirring with any one of water, petrolatum and polyethylene glycol.
• the invention described in claim 5 is a method for storing an ozone-dissolved glycerin solution.
• the ozone-dissolved glycerin solution in which ozone is dissolved in the non-oxidizing glycerin solution is stored refrigerated or frozen.
• refrigerated storage is to store at 5 ° C or more and 10 ° C or less, and frozen storage is
• the glycerin concentration of the ozone-dissolved glycerin solution and The ozone concentration is arbitrary.
• the ozone-dissolved glycerin solution in which ozone is dissolved in the non-oxidizing glycerin solution is stored at room temperature by refrigeration or freezing. Can also maintain the ozone concentration at a high concentration for a long time.
• the invention described in claim 6 is an ozone-dissolved glycerin solidified product, wherein ozone is dissolved in a non-oxidizing glycerin solution, and the ozone-dissolved glycerin solution is cooled and solidified. It is characterized by having.
• the solidified ozone-dissolved glycerin is an ozone-dissolved glycerin solution in a cooled and solidified state, and glycerin may be crystallized and solidified, or may be supercooled and become viscous in the entire solution. May be high and solidified. Further, glycerin may be solidified alone, or may be solidified together with other components constituting the solution.
• the glycerin concentration and ozone concentration of the ozone-dissolved glycerin solution are arbitrary.
• ozone is dissolved in the non-oxidized glycerin solution, and the ozone-dissolved glycerin solution is cooled and solidified. It is possible to maintain a high concentration of ozone for a longer period of time, because ozone is not easily released. The invention's effect
• high concentration ozone is dissolved in high concentration glycerin solution.
• the dissolved concentration of ozone in the ozone-dissolved glycerin solution can be maintained for a long time at a concentration sufficient for use as a disinfectant or the like.
• the ozone-dissolved glycerin solution is mixed with any of water, vaseline, and polyethylene glycol, the ozone-dissolving power is not lost, and a harmful odonide (peroxydani) is included. No ozone-dissolved mixed solution can be produced.
• the ozone concentration can be maintained at a high level for a long period of time as compared with the case of storing it at room temperature. Further, by cooling and solidifying the ozone-dissolved glycerin solution, ozone is released from the liquid state, and the ozone concentration can be maintained at a high level for a longer period of time.
• Ozone dissolved glycer of the present invention A phosphorus solution can be produced by bringing a high-concentration glycerin solution and a high-ozone-concentration gas into gas-liquid contact.
• a gas having a high ozone concentration can be produced by, for example, an ozone generator that generates ozone by silently discharging oxygen gas.
• oxygen gas When oxygen gas is used, a medical oxygen cylinder may be used, or oxygen gas produced by an oxygen generator may be used. With air, nitrogen oxides are produced.
• a gas with a high ozone concentration is generated using air and the ozone concentration is measured by the potassium iodide titration method, the apparent consumption of potassium iodide increases, but this is due to nitrogen oxide. Since nitrogen oxides are harmful substances, the method using air is not suitable for actual use.
• a glycerin solution having a glycerin concentration of 75% by weight or more can be used as the high-concentration glycerin solution.
• a glycerin concentration of 84 to 87% by weight of the Japanese Pharmacopoeia is preferred. It is more preferred to use concentrated glycerin of at least%. Further, it is more preferable to use purified glycerin having a concentration of 98.5 wt% or more. This is because if the glycerin concentration is high, ozone can be dissolved at a higher concentration.
• a high-concentration glycerin solution As a method of bringing a high-concentration glycerin solution into contact with a gas having a high ozone concentration and a gas, for example, a high-concentration (for example, 98 wt% or more) glycerin solution is put into a tank, and the tank is filled with a diffuser tube. There is a method of discharging a gas having a high ozone concentration as fine bubbles.
• an ozone-dissolved glycerin solution having an ozone concentration of about 3000 ppm can be produced by aerating a gas having an ozone concentration of 80 gZkL (about 37,000 ppm) in concentrated glycerin for about 7 days.
• the final concentration of ozone is determined depending on the glycerin concentration.
• the final concentration of ozone is approximately 400 ppm at a glycerin concentration of 75 wt%, and the final concentration of ozone is approximately 500 ppm at a glycerin concentration of 85 wt%.
• the final concentration of ozone is about 100 ppm, and at 98 wt% of glycerin, the final concentration of ozone is about 3000 ppm.
• the finally obtained ozone-dissolved glycerin solution preferably has a glycerin concentration of 75 wt% or more and an ozone concentration of 400 ppm or more, more preferably a glycerin concentration of 80 wt% or more and an ozone concentration of 500 ppm or more. More preferably, the ozone concentration is 10 OOppm or more when the glycerin concentration is 90 wt% or more.The ozone concentration is 30 when the glycerin concentration is 98 wt% or more. Most preferably, it is at least OO ppm.
• the ozone-dissolved glycerin solution produced in this way has a high initial concentration of ozone, has a long half-life of ozone concentration as described later, and maintains the ozone concentration required as a disinfectant for a long period of time. You can do it.
• the amount of ozone released from the ozone-dissolved glycerin solution is extremely small. Therefore, ozone can be gradually released over a long period of time at the use site and the arrival site of the ozone-dissolved glycerin solution. Further, since the amount of released ozone is extremely small, this ozone-dissolved glycerin solution does not have an ozone smell at all even though a high concentration of ozone is dissolved.
• the ozone-dissolved glycerin solution is refrigerated at 5 ° C to 10 ° C or frozen at 5 ° C or less to further reduce the amount of ozone released. Therefore, the ozone concentration can be maintained at a high level for a longer period of time than when stored at room temperature.
• the ozone-dissolved glycerin solution is cooled to be a solidified ozone-dissolved glycerin solution, it is possible to maintain the ozone concentration at which ozone is released more easily than in the liquid state, for a longer period of time.
• the solidified ozone-dissolved glycerin is an ozone-dissolved glycerin solution in a cooled and solidified state, and the glycerin may be crystallized and solidified, or may become a supercooled state and the viscosity of the entire solution may increase. You may.
• glycerin may be solidified alone or may be solidified together with other components constituting the solution.
• ozone-dissolved glycerin solutions having a glycerin concentration of 75 wt% or more and an ozone concentration of 400 ppm or more can be stored in a refrigerator or frozen for a longer period of time. , Can be maintained at a high concentration. The same applies to the case where it is cooled to obtain a solid ozone-dissolved glycerin.
• the ozone-dissolved glycerin solution can be used as it is depending on the application. However, when used in a lotion or a serum, the high concentration of glycerin is irritating to the skin. Preferably, the concentration is 20 wt% or less. For this reason, it is preferable to dilute the ozone-dissolved glycerin solution by mixing it with an appropriate diluent.
• a diluent those which are not easily rancid by ozone are suitable, and water, petrolatum, polyethylene glycol and the like are suitable.
• water it is preferable to use pure water or ultrapure water. If water contains impurities, it can be oxidized by ozone and produce oxides (peroxides) that irritate the skin and reduce its efficacy.
• purified petrolatum which contains few impurities and is hardly rancid. Impurities are also oxidized to ozone, which also produces oxides (peroxides) that irritate the skin and reduce drug efficacy.
• purified petrolatum Proto (registered trademark) manufactured by Maruishi Pharmaceutical Co., Ltd., Sun White (registered trademark) manufactured by Nikko Guatemala Co., Ltd., or the like can be used.
• Macrogol ointment When using polyethylene glycol, it is desirable to use Macrogol ointment specified by the Japanese Pharmacopoeia.
• the macrogol ointment is a mixture of liquid macrogol 400 and solid macrogol 4000 at a ratio of approximately 1: 1.
• the mixing ratio may be appropriately changed in order to adjust the viscosity according to the power application. Further, a polymer agent may be added to adjust the viscosity.
• Macrogol is hygroscopic and can be preserved by mixing with glycerin. It is highly wet and can be used as an ointment.
• the ozone-dissolved mixed solution obtained by diluting the ozone-dissolved glycerin solution with these diluents preferably has an ozone concentration of 80 ppm or more. If the ozone concentration is 80 ppm or more, the sterilizing ability can be exhibited. Further, when the ozone concentration is 100 ppm or more, the sterilizing ability can be more exhibited. Further, when the ozone concentration is 500 ppm or more, a wound healing effect can be obtained, and when the ozone concentration is 100 ppm or more, an excellent wound healing effect can be exhibited as described later.
• the above ozone-dissolved mixed solution is also stored in a refrigerator at 5 ° C or more and 10 ° C or less or frozen and stored at 5 ° C or less to further reduce the amount of ozone released from the ozone-dissolved mixed solution.
• the ozone concentration can be maintained at a higher level for a longer period of time than when stored at room temperature.
• the ozone-dissolved mixed solution can also be cooled to obtain an ozone-dissolved glycerin solidified product, similarly to the ozone-dissolved glycerin solution.
• solidified ozone-dissolved glycerin In the case of solidified ozone-dissolved glycerin,
• the ozone concentration at which ozone is released more easily than in the liquid state can be maintained at a high concentration for a longer period.
• Concentrated glycerin and ozone were brought into gas-liquid contact to produce an ozone-dissolved glycerin solution.
• the concentrated glycerin means glycerin having a concentration of 98 wt% or more of the Japanese Pharmacopoeia product.
• a Teflon (registered trademark) tank having a capacity of 50 L was used as the contact tank.
• An air diffuser was installed at the bottom of the tank so that ozone could be supplied as fine bubbles into the tank.
• the ozone generator used was a silent discharge ozone generator with an ozone generation capacity of 100 g / h using oxygen with a concentration of 90% or more as a raw material.
• the generated gas containing ozone was released from the air diffuser tube into the tank for 7 days to obtain an ozone-dissolved glycerin solution having an ozone concentration of 3000 ppm final.
• the obtained ozone-dissolved glycerin solution was stored at room temperature, refrigerated (about 5 ° C), and frozen (about -20 ° C)! , And the half-life of the ozone concentration was measured. The measurement of ozone concentration was carried out using the method for determining the amount of lithium iodide.
• the ozone concentration was reduced by half in about 6 months. During refrigeration, the ozone concentration was reduced by half in about 16 months. After three years of refrigeration, the rate of change in ozone concentration was 98%, indicating almost no change. This is thought to be because the glycerin in the ozone-dissolved glycerin solution crystallized due to freezing, or the viscosity of the entire solution became higher, and ozone was not released than in the liquid state.
• ozone-dissolved glycerin solution (hereinafter referred to as ozondiel) produced from concentrated glycerin by the above-described method, an ozone-dissolved mixed solution obtained by mixing macrogol ointment (hereinafter referred to as ozone ointment), and a strong electrolytic acid jell And electrolyzed acidic functional water.
• VMC ozone ointment
• VMC ozone giel
• MIZ strong electrolytic acid gir
• OXILIZE R registered (registered) (Trademark), manufactured by Miura Electronics Co., Ltd.).
• ozone ointment and the ozone diel those in which the dissolved concentration of ozone was adjusted to 100 ppm were used.
• the strong electrolytic acid jell is a soft type with pH 2.14, redox potential 463 mV, effective chlorine concentration Oppm, and the electrolytic acidic functional water is adjusted to pH 2.14, redox potential 11 57 mV, effective chlorine concentration 37.33 ppm. Was used.
• the diameter of the wound site of the rat was measured on days 1, 3, 5, and 7, and immediately thereafter, the rat was sacrificed and a sample was collected. The measurement of the diameter was performed at four places for one small part, and the average value was used as the measurement result.
• the collected sample was embedded in paraffin to prepare a section, which was then subjected to HE staining, and the epithelium of the sample was analyzed. And the formation of granulation tissue were observed. In addition, Azan staining was performed to examine the degree of proliferation of collagen fibers during the wound healing process.
• the reduction rate of the diameter of the wound site was 98.1% for the electrolyzed acidic functional water, 93.5% for the strongly electrolyzed acidic jewel, 98.0% for the ozone jewel, and 94.3% for the ozone ointment. No difference was observed.
• the rate of reduction of the diameter of the wound site was 82.5% for the electrolyzed acidic functional water, 82.5% for the strongly electrolyzed acidic jewel, 80.5% for the ozone jewel, and 86.5% for the ozone ointment. No difference was observed.
• the reduction rate of the diameter of the wound site was 70.5% for the electrolyzed acidic functional water, 66.5% for the strongly electrolyzed acidic jewel, 63.5% for the ozone jewel, and 63.0% for the ozone ointment. No difference was observed.
• the reduction rate of the diameter of the wound site was 57.5% for the electrolyzed acidic functional water, 51.0% for the strongly electrolyzed acidic jewel, 44.0% for the ozone jewel, and 41.5% for the ozone ointment. Significant differences were found between the electrolytic acidic functional water and ozone ointment, between the electrolytic acidic functional water and ozone ointment, and between the strong acidic acidic water and ozone ointment.
• the regeneration of granulation tissue was observed in the electrolytic acidic functional water, and the absorption of the fibrin layer was promoted.
• the strong electrolytic acid jewel granulation tissue formation with inflammatory cell infiltration was observed in the subepithelium, and although a little, the regeneration of basal cells and the formation of fibers toward the center of the wound were observed. Admitted.
• ozone jewels granulation tissue formation with inflammatory cell infiltration and regeneration of epithelium from the wound margin were observed.
• ozone ointment inflammatory cell infiltration in granulation tissue was slightly abolished, and relatively good epithelial regeneration was observed.
• ozone ointment exhibited almost the same visual course of treatment as ozone diels and strong electrolytic acid diels.
• degree of epithelial regeneration histologically, ozone ointment was the best, followed by ozone die, strong electrolytic acidic die, and electrolytic acidic functional water in this order.
• Ozone ointment has the advantage that it can be easily applied to wounds like strong electrolytic acid jewels and ozone jewels, suggesting that it can be applied as a therapeutic agent to wounds.
• the ozone ointment to which the present invention has been applied has an advantage that it can be easily applied to the wound area, and therefore can be applied as a therapeutic agent to the wound area.

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• 2004
  • 2004-02-20 JP JP2004044088A patent/JP4677192B2/ja not_active Expired - Lifetime
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