WO2005076757A2 - Composition stimulant la croissance des cheveux, des sourcils et des cils - Google Patents

Composition stimulant la croissance des cheveux, des sourcils et des cils Download PDF

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Publication number
WO2005076757A2
WO2005076757A2 PCT/KR2005/000198 KR2005000198W WO2005076757A2 WO 2005076757 A2 WO2005076757 A2 WO 2005076757A2 KR 2005000198 W KR2005000198 W KR 2005000198W WO 2005076757 A2 WO2005076757 A2 WO 2005076757A2
Authority
WO
WIPO (PCT)
Prior art keywords
hair
extract
growth
eyebrow
polygonum tinctorium
Prior art date
Application number
PCT/KR2005/000198
Other languages
English (en)
Other versions
WO2005076757A3 (fr
Inventor
Jong-Il Kim
Seung-Jin Kim
Hyung-Jin Kim
Sang-Nyun Kim
Sang-Jin Kang
Wan-Goo Cho
Jong-Tae Lee
Hyoung-Kook Park
Original Assignee
Lg Household & Health Care Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Household & Health Care Ltd. filed Critical Lg Household & Health Care Ltd.
Publication of WO2005076757A2 publication Critical patent/WO2005076757A2/fr
Publication of WO2005076757A3 publication Critical patent/WO2005076757A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • E—FIXED CONSTRUCTIONS
    • E02—HYDRAULIC ENGINEERING; FOUNDATIONS; SOIL SHIFTING
    • E02D—FOUNDATIONS; EXCAVATIONS; EMBANKMENTS; UNDERGROUND OR UNDERWATER STRUCTURES
    • E02D27/00—Foundations as substructures
    • E02D27/32—Foundations for special purposes
    • E02D27/42—Foundations for poles, masts or chimneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • E—FIXED CONSTRUCTIONS
    • E02—HYDRAULIC ENGINEERING; FOUNDATIONS; SOIL SHIFTING
    • E02D—FOUNDATIONS; EXCAVATIONS; EMBANKMENTS; UNDERGROUND OR UNDERWATER STRUCTURES
    • E02D5/00—Bulkheads, piles, or other structural elements specially adapted to foundation engineering
    • E02D5/22—Piles
    • E02D5/223—Details of top sections of foundation piles
    • E—FIXED CONSTRUCTIONS
    • E02—HYDRAULIC ENGINEERING; FOUNDATIONS; SOIL SHIFTING
    • E02D—FOUNDATIONS; EXCAVATIONS; EMBANKMENTS; UNDERGROUND OR UNDERWATER STRUCTURES
    • E02D5/00—Bulkheads, piles, or other structural elements specially adapted to foundation engineering
    • E02D5/22—Piles
    • E02D5/24—Prefabricated piles
    • E02D5/30—Prefabricated piles made of concrete or reinforced concrete or made of steel and concrete
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners
    • E—FIXED CONSTRUCTIONS
    • E02—HYDRAULIC ENGINEERING; FOUNDATIONS; SOIL SHIFTING
    • E02D—FOUNDATIONS; EXCAVATIONS; EMBANKMENTS; UNDERGROUND OR UNDERWATER STRUCTURES
    • E02D2600/00—Miscellaneous
    • E02D2600/20—Miscellaneous comprising details of connection between elements

Definitions

  • the present invention relates to a composition for stimulating hair, eyebrow and eyelash growth, and more particularly to a composition for stimulating hair, eyebrow and eyelash growth comprising an extract of Polygonum tinctorium or a plant belonging to the same genus as Polygonum tinctorium, as an active ingredient.
  • Minoxidil is one of two hair growth agents which have been approved by the U.S. Food and Drug Administration (FDA). Minoxidil was originally developed as a drug for the treatment of hypertension with the aim of reducing blood pressure. Since hair growth was observed during use, minoxidil has been used as a hair growth agent. Although the hair growth mechanisms of minoxidil are not fully understood, it is believed that minoxidil expands blood vessels and increases blood flow therethrough to facilitate supply of nutrients to hair roots, resulting in stimulation of hair growth.
  • FDA U.S. Food and Drug Administration
  • minoxidil enhances the expression of vascular endothelial growth factor (NEGF), which is a growth factor associated with vasodilatation in the dermal papilla as a main cell constituting hair roots (Br. J. of DermatoL, 1998, 138: 407-411).
  • NEGF vascular endothelial growth factor
  • minoxidil promotes activation of dermal papilla cells in the hair roots during incubation in vitro (Skin Pharmacol., 1996, 9: 3-8), and promotion the growth of hair follicles in the tissue culture of follicles (J. Invest. DermatoL, 1989, 92: 315-320).
  • finasteride a main ingredient of Propecia sold by Merck inhibits the conversion of the male hormone testosterone to dihydrotestosterone, which is a more potent male hormone than testosterone.
  • 1 mg tablet of finasteride as a therapeutic agent against hair loss in men was approved by the U.S. FDA in December, 1997, and is currently present on the market. The tablet turned out to have significant clinical effects, but there has been reports that finasteride inhibits sexual functions of men as a side effect (J. Am. Acad. DermatoL, 1998; 39; 578-589). Since finasteride shows no satisfactory clinical effects, like minoxidil, and may cause the danger of side effects, studies to develop an agent with superior hair growth effects are actively being undertaken.
  • the present inventors have screened a variety of natural products in order to locate substances with hair growth effects, and as a result, have found that extracts of Polygonum tinctorium belonging to the family Polygonaceae and plants belonging to the same genus as Polygonum tinctorium have superior efficacy on the stimulation of hair, eyebrow and eyelash growth.
  • Polygonum tinctorium belonging to the family Polygonaceae is a 60-90 cm-tall annual grass.
  • the leaves of the natural plant are used in the present invention.
  • Polygonum tinctorium sap has been used to treat insect's bites and festering, and has been used originally as a natural dye.
  • Representative plants belonging to the same genus as Polygonum tinctorium include Periscaria tinctoria H.
  • the present invention has been made in view of the above problems, and the present invention provides a composition for stimulating hair, eyebrow and eyelash growth which comprises an extract of Polygonum tinctorium belonging to the family Polygonaceae or a plant belonging to the same genus as Polygonum tinctorium.
  • the present inventors have earnestly and intensively conducted research to develop novel ingredients capable of stimulating hair, eyebrow and eyelash growth from a variety of natural products, and as a result, have found that extracts of Polygonum tinctorium belonging to the family Polygonaceae and plants belonging to the same genus as Polygonum tinctorium show stimulatory effects on hair, eyebrow and eyelash growth.
  • a composition for stimulating hair, eyebrow and eyelash growth which comprises, as an active ingredient, an extract of Polygonum tinctorium belonging to the family Polygonaceae or a plant belonging to the same genus as Polygonum tinctorium.
  • the present invention provides a composition for stimulating hair, eyebrow and eyelash growth comprising a primary extract of Polygonum tinctorium leaves as an active ingredient, which is prepared by extracting dried Polygonum tinctorium leaves with at least one solvent selected from methanol (MeOH), ethanol (EtOH), propanol, methyl ethyl ketone, propylene glycol, acetonitrile, and acetone.
  • a composition for stimulating hair, eyebrow and eyelash growth comprising a secondary extract of Polygonum tinctorium, which is prepared by further extracting the primary extract with at least one solvent selected from dichloromethane, chloroform (CHC1 ), hexane, and ether.
  • composition of the present invention may be formulated into liquids, sprays, gels, pastes, emulsions, creams, conditioners, and shampoos.
  • Example 1 Hair tonics
  • Example 1-1 Preparation of hair tonics containing extract of Polygonum tinctorium leaves
  • Example 1-2 Preparation of hair tonics containing extract of Isatis tinctoria leaves
  • the ingredients were mixed in compliance with the compositions indicated in Table 2 below, stirred, and completely dissolved to prepare three hair tonics.
  • the effects of Formulation 1 on hair growth were evaluated through an animal experiment in Experimental Example 2 that follows. [27] Table 2
  • Example 1-3 Preparation of hair creams containing extract of Polygonum tinctorium leaves
  • the oil-phase ingredients and aqueous-phase ingredients were mixed in compliance with the compositions indicated in Table 3 below and completely dissolved in separate containers by heating to 80°C.
  • the dissolved oil-phase ingredients and aqueous-phase ingredients at 80°C were combined and emulsified. After completion of the emul- sif ⁇ cation, the respective mixtures were allowed to cool to room temperature.
  • To the mixtures were added a perfume and a colorant, followed by mixing, to prepare three hair creams. Water was added in such an amount that the total weight of the oil-phase and aqueous-phase ingredients was adjusted to 100% by weight.
  • Example 1-4 Preparation of hair creams containing extract of Isatis tinctoria leaves
  • the oil-phase ingredients and aqueous-phase ingredients were mixed in compliance with the compositions indicated in Table 4 below and completely dissolved in separate containers by heating to 80°C.
  • the dissolved oil-phase ingredients and aqueous-phase ingredients at 80°C were combined and emulsified. After completion of the emul- sif ⁇ cation, the respective mixtures were allowed to cool to room temperature.
  • To the mixtures were added a perfume and a colorant, followed by mixing, to prepare three hair creams. Water was added in such an amount that the total weight of the oil-phase and aqueous-phase ingredients was adjusted to 100% by weight.
  • Example 1-5 Preparation of shampoos containing extract of Polygonum tinctorium leaves
  • Example 1-6 Preparation of shampoos containing extract of Isatis tinctoria leaves
  • Example 1-7 Preparation of hair conditioners containing extract of Polygonum tinctorium leaves
  • the oil-phase ingredients and aqueous-phase ingredients were mixed in compliance with the compositions indicated in Table 7 below and completely dissolved in separate containers by heating to 80°C.
  • the dissolved oil-phase ingredients and aqueous-phase ingredients at 80°C were combined and emulsified. After completion of the emul- sif ⁇ cation, the respective mixtures were allowed to cool to room temperature.
  • To the mixtures were added a perfume and a colorant, followed by mixing, to prepare three hair conditioners. Water was added in such an amount that the total weight of the oil- phase and aqueous-phase ingredients was adjusted to 100% by weight.
  • Example 1-8 Preparation of hair conditioners containing extract of Isatis tinctoria leaves
  • the oil-phase ingredients and aqueous-phase ingredients were mixed in compliance with the compositions indicated in Table 8 below and completely dissolved in separate containers by heating to 80°C.
  • the dissolved oil-phase ingredients and aqueous-phase ingredients at 80°C were combined and emulsified. After completion of the emul- sif ⁇ cation, the respective mixtures were allowed to cool to room temperature.
  • To the mixtures were added a perfume and a colorant, followed by mixing, to prepare three hair conditioners. Water was added in such an amount that the total weight of the oil- phase and aqueous-phase ingredients was adjusted to 100% by weight.
  • Example 2 Eyebrow growth agents [47] Example 2-1. Preparation of eyebrow growth tonics containing extract of Polygonum tinctorium leaves
  • Example 2-2 Preparation of eyebrow growth tonics containing extract of Isatis tinctoria leaves
  • the oil-phase ingredients and aqueous-phase ingredients were mixed in compliance with the compositions indicated in Table 11 below and completely dissolved in separate containers by heating to 80°C.
  • the dissolved oil-phase ingredients and aqueous-phase ingredients at 80°C were combined and emulsified. After completion of the emulsification, the respective mixtures were allowed to cool to room temperature.
  • a perfume and a colorant followed by mixing, to prepare three eyebrow growth creams. Water was added in such an amount that the total weight of the oil-phase and aqueous-phase ingredients was adjusted to 100% by weight.
  • Example 2-4 Preparation of eyebrow growth creams containing extract of Isatis tinctoria leaves
  • the oil-phase ingredients and aqueous-phase ingredients were mixed in compliance with the compositions indicated in Table 12 below and completely dissolved in separate containers by heating to 80°C.
  • the dissolved oil-phase ingredients and aqueous-phase ingredients at 80°C were combined and emulsified. After completion of the emulsification, the respective mixtures were allowed to cool to room temperature.
  • a perfume and a colorant followed by mixing, to prepare three eyebrow growth creams. Water was added in such an amount that the total weight of the oil-phase and aqueous-phase ingredients was adjusted to 100% by weight.
  • Example 2-5 Preparation of eyebrow growth essences containing extract of Polygonum tinctorium leaves [60] The ingredients were mixed in compliance with the compositions indicated in Table 13 below, stirred, and completely dissolved to prepare three eyebrow growth essences. [61] Table 13 Unit: wt% (w/w)
  • Example 2-6 Preparation of eyebrow growth essences containing extract of Isatis tinctoria leaves [63] The ingredients were mixed in compliance with the compositions indicated in Table 14 below, stirred, and completely dissolved to prepare three eyebrow growth essences.
  • mice (C57BL/6, female) were used. First, hairs around the back of the mice were shaved using an electric razor. Then, the weight of the mice was measured and all the mice were divided into several groups of 8 mice each in such a manner that the weight distribution in each group was constant.
  • mice After the mice were acclimated to their environments for 1 day, Polygonum tinctorium leaf extract (1%) and Rogaine (containing 5% minoxidil) were applied in an amount of 100 D (0.1% w/v) once daily for 20 days on the shaved back area of each mouse.
  • the level of hair growth in each mouse was determined by calculating a rate (effective area) of the area where new hairs grew in the shaved area, as observed by visual examination.
  • the Polygonum tinctorium leaf extract (1%, Formulation 1 shown in each table) shows noticeable stimulatory effects on hair growth, compared to a control group applied by a vehicle alone. Further, the Polygonum tinctorium leaf extract shows superior efficacy to Rogaine (containing 5% minoxidil). The appearance of the back of the mice in the control and all test groups was compared over the experimental period of 30 days, and as a result, no specific skin irritation was observed.
  • Effective area (%) (area where new hair grew)/(total area where hair are shaved) x 100
  • composition of the present invention could be formulated into liquids, sprays, gels, pastes, emulsions, creams, conditioners, shampoos, and the like.
  • hair tonics, hair creams, hair conditioners, and hair shampoos were prepared herein.
  • tonics, creams and essences for eyebrow growth were provided herein.
  • the test groups exhibit superior stimulatory effects on hair, eyebrow and eyelash growth, compared to the control group.
  • the present invention provides a composition for stimulating hair, eyebrow and eyelash growth comprising an extract of Polygonum tinctorium or a plant belonging to the same genus as Polygonum tinctorium, as an active ingredient.
  • the composition of the present invention exhibits excellent stimulatory effects on hair, eyebrow and eyelash growth.

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Structural Engineering (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Civil Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Paleontology (AREA)
  • Mining & Mineral Resources (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Cosmetics (AREA)

Abstract

L'invention concerne une composition destinée à stimuler la croissance des cheveux, des sourcils et des cils. Cette composition contient un extrait de Polygonum tinctorium ou d'une plante appartenant au même genre que le Polygonum tinctorium. La composition selon l'invention présente des propriétés supérieures de stimulation de la croissance des cheveux, des sourcils et des cils.
PCT/KR2005/000198 2004-01-27 2005-01-25 Composition stimulant la croissance des cheveux, des sourcils et des cils WO2005076757A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020040004914A KR20050077310A (ko) 2004-01-27 2004-01-27 인디고 추출물을 이용한 모발, 눈썹 및 속눈썹 성장촉진제
KR10-2004-0004914 2004-01-27

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WO2005076757A2 true WO2005076757A2 (fr) 2005-08-25
WO2005076757A3 WO2005076757A3 (fr) 2005-10-06

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090263339A1 (en) * 2005-05-27 2009-10-22 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenky Agent for external application to the skin
US10232006B2 (en) 2015-04-09 2019-03-19 Galderma S.A. Pharmaceutical composition comprising refined indigo naturalis extract and the use thereof
US10251926B2 (en) 2015-04-09 2019-04-09 Galderma S.A. Extract from indigo naturalis and a process for preparing the same
FR3072576A1 (fr) * 2017-10-19 2019-04-26 Laboratoires M&L Utilisation cosmetique d'un extrait d'une plante indigofere
US10668120B2 (en) 2015-04-09 2020-06-02 Galderma Sa Antibacterial indigo naturalis or indigo-producing plant extract and use thereof

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6803849B2 (ja) 2015-04-09 2020-12-23 ガルデルマ・ソシエテ・アノニム インジゴナチュラリス又はインジゴ産生植物の抽出物を用いたアトピー性皮膚炎の処置
KR102561068B1 (ko) * 2022-12-23 2023-07-28 주식회사 마카네이쳐 인디루빈을 함유한 샴푸바 및 그 제조방법

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1088775A (zh) * 1992-12-31 1994-07-06 新疆自治区药物研究所 奥斯曼眼部化妆品及其制备方法
CN1279059A (zh) * 1999-12-30 2001-01-10 李�瑞 秀发再生液及其制备方法
JP2002275037A (ja) * 2001-03-19 2002-09-25 Hoyu Co Ltd 育毛・養毛剤
US6524625B2 (en) * 1998-06-30 2003-02-25 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyuto Physiologically active extract obtained from indigo plant polygonum tinctorium
EP1317915A1 (fr) * 2000-09-11 2003-06-11 Shiseido Company, Ltd. Agents nourrissant les cheveux et procede de selection de ces agents

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1088775A (zh) * 1992-12-31 1994-07-06 新疆自治区药物研究所 奥斯曼眼部化妆品及其制备方法
US6524625B2 (en) * 1998-06-30 2003-02-25 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyuto Physiologically active extract obtained from indigo plant polygonum tinctorium
CN1279059A (zh) * 1999-12-30 2001-01-10 李�瑞 秀发再生液及其制备方法
EP1317915A1 (fr) * 2000-09-11 2003-06-11 Shiseido Company, Ltd. Agents nourrissant les cheveux et procede de selection de ces agents
JP2002275037A (ja) * 2001-03-19 2002-09-25 Hoyu Co Ltd 育毛・養毛剤

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090263339A1 (en) * 2005-05-27 2009-10-22 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenky Agent for external application to the skin
US10232006B2 (en) 2015-04-09 2019-03-19 Galderma S.A. Pharmaceutical composition comprising refined indigo naturalis extract and the use thereof
US10251926B2 (en) 2015-04-09 2019-04-09 Galderma S.A. Extract from indigo naturalis and a process for preparing the same
US20190160128A1 (en) 2015-04-09 2019-05-30 Galderma S.A. Pharmaceutical composition comprising refined indigo naturalis extracts and the use thereof
US10555985B2 (en) 2015-04-09 2020-02-11 Galderma S.A. Pharmaceutical composition comprising refined Indigo naturalis extracts and the use thereof
US10668120B2 (en) 2015-04-09 2020-06-02 Galderma Sa Antibacterial indigo naturalis or indigo-producing plant extract and use thereof
US10695391B2 (en) 2015-04-09 2020-06-30 Galderma S.A. Extract from Indigo Naturalis and a process for preparing the same
US11116811B2 (en) 2015-04-09 2021-09-14 Galderma S.A. Pharmaceutical composition comprising refined indigo naturalis extracts and the use thereof
FR3072576A1 (fr) * 2017-10-19 2019-04-26 Laboratoires M&L Utilisation cosmetique d'un extrait d'une plante indigofere

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WO2005076757A3 (fr) 2005-10-06
KR20050077310A (ko) 2005-08-02

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