WO2005072691A1 - Composition for inhibiting halitosis - Google Patents

Composition for inhibiting halitosis Download PDF

Info

Publication number
WO2005072691A1
WO2005072691A1 PCT/KR2005/000312 KR2005000312W WO2005072691A1 WO 2005072691 A1 WO2005072691 A1 WO 2005072691A1 KR 2005000312 W KR2005000312 W KR 2005000312W WO 2005072691 A1 WO2005072691 A1 WO 2005072691A1
Authority
WO
WIPO (PCT)
Prior art keywords
halitosis
composition
xanthorrhizol
inhibiting
copper
Prior art date
Application number
PCT/KR2005/000312
Other languages
English (en)
French (fr)
Inventor
Jae-Kwan Hwang
Hyung-Jin Kim
Seung-Jin Kim
Jong-Il Kim
Taek-Kyun Kang
Sang-Jin Kang
Wan-Goo Cho
Sang-Nyun Kim
Original Assignee
Lg Household & Health Care Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Household & Health Care Ltd. filed Critical Lg Household & Health Care Ltd.
Publication of WO2005072691A1 publication Critical patent/WO2005072691A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/30—Copper compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
    • B65G21/00—Supporting or protective framework or housings for endless load-carriers or traction elements of belt or chain conveyors
    • B65G21/10—Supporting or protective framework or housings for endless load-carriers or traction elements of belt or chain conveyors movable, or having interchangeable or relatively movable parts; Devices for moving framework or parts thereof
    • B65G21/14—Supporting or protective framework or housings for endless load-carriers or traction elements of belt or chain conveyors movable, or having interchangeable or relatively movable parts; Devices for moving framework or parts thereof to allow adjustment of length or configuration of load-carrier or traction element
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
    • B65G23/00—Driving gear for endless conveyors; Belt- or chain-tensioning arrangements
    • B65G23/44—Belt or chain tensioning arrangements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
    • B65G2812/00—Indexing codes relating to the kind or type of conveyors
    • B65G2812/02—Belt or chain conveyors
    • B65G2812/02128—Belt conveyors

Definitions

  • the present invention relates to a composition for inhibiting halitosis.
  • Halitosis is generated by producing malodor-causing substances, which are
  • Main components causing halitosis are Volatile Sulfide
  • VSC Hydrogen Sulf ⁇ de(H 2 S), Methyl Mercaptan(CH 3 SH),
  • volatile amine compounds such as triethylamine, aldehydes, fatty acids, ammonia, and the like.
  • compositions for enhancing oral health including
  • xanthorrhizol extracted and isolated from Curcuma xanthorrhiza were disclosed (see, KR 2000-0000256, 2000-0000342, 2000-0006939 and 2000-0073295), which used antibacterial activity of Xanthorrhizol on oral microorganisms.
  • KR 2000-0000256, 2000-0000342, 2000-0006939 and 2000-0073295 used antibacterial activity of Xanthorrhizol on oral microorganisms.
  • compositions for enhancing oral health including copper compounds such as copper gluconate which can eliminate halitosis-causing substances were disclosed in PCT/US 92/10662, JP8198709A2, JP7165544A2, WO02/41862, and so on. However, those
  • compositions for enhancing oral health were focused to simple halitosis-inhibiting system where primary causes of halitosis or halitosis-generating substances were
  • the present invention is designed to solve the problems of the prior art, and
  • an object of the invention is to provide a composition for inhibiting halitosis which not only can eliminate both halitosis-generating causes and halitosis-generating
  • the copper compound is at least one selected from copper gluconate, copper
  • composition for inhibiting halitosis according to the present invention
  • Curcuma Xanthorrhiza belongs to the ginger family, known as turmeric produced in Jaba, one of the traditional medicinal plants in Indonesia, and it is known to have various physiological activities such as triglyceride decreasing action, antitumor action, serum cholesterol decreasing action, and so on.
  • Curcuma Xanthorrhiza belongs to the ginger family, known as turmeric produced in Jaba, one of the traditional medicinal plants in Indonesia, and it is known to have various physiological activities such as triglyceride decreasing action, antitumor action, serum cholesterol decreasing action, and so on.
  • xanthorrhizol may be extracted from the Curcuma xanthorrhiza (see, KR 2000-0073295). Since xanthorrhizol has excellent antibacterial activity against
  • bacteria in oral cavity such as Streptococcus mutans, Streptococcus sobrinus,
  • Porphyromonas gingivalis and so on, it is known that it can be used effectively for prevention and treatment of caries and periodontal disease in a form of oral cleanser etc.
  • the copper compound at least one selected from copper gluconate, copper acetate, copper sulfate, sodium copper chlorophyllin, and the like may be used.
  • Aforementioned compounds are edible and safe enough for human ingestion to have
  • the inventors of the present invention revealed that when a mixture of xanthorrhizol and copper compound was added to a composition for inhibiting halitosis,
  • composition had strong effects in inhibiting halitosis by synergy between them, and then completed the present invention.
  • composition for inhibiting halitosis of the present invention 0.01 - 5 wt% of xanthorrhizol and 0.0001 - 1 wt% of copper compound are contained on the
  • composition for inhibiting halitosis of the present invention may be formulated in any form of toothpaste, mouthwash, mouthspray, edible film or other oral
  • the toothpaste composition of the present invention contains xanthorrhizol and
  • copper compound and may further contains abrasive, humectant, binder, frothing agent,
  • sweetening agent preservative, pH adjuster, flavoring agent, and so on.
  • an abrasive calcium carbonate, calcium hydrogen phosphate, precipitated silica, hydrous alumina, silica gel, insoluble sodium metaphosphate,
  • zirconium silicate, or the like may be employed alone or in combination of two or more.
  • the content of the abrasive in the composition may be 20 - 70wt%, preferably 35 -
  • a humectant glycerine, sorbitol solution, polyethylene glycol, or the like
  • humectantin the composition may be 20 - 60wt%, preferably 20 - 50wt%.
  • a binder carrageenan, xanthan gum, sodium carboxymetnyl cellulose, carboxyvinyl polymer, sodium alginate, or the like is suitable for the composition of the present invention.
  • the content of the binder is 0.1 - 3.0wt%, preferably 0.5 - 2.0wt%.
  • anionic surfactant such as sodium alkyl sulfate, sodium lauroyl sarcosinate, and so on, nonionic surfactant such as sorbitan fatty acid ester,
  • polyoxyethylene hydrogenated castor oil polyoxyethylene polyoxypropylene copolymer, and so on, or the like may be employed in the composition.
  • a frothing agent the
  • anionic surfactant and the nonionic surfactant may be used alone or in combination of
  • sweetening agent sodium saccharin, aspartame, acesulfame, stevioside, glycyrrhizinic acid, or the like may be employed alone or in combination of two or more.
  • the sweetening agent may be contained in the composition in an amount of
  • the preservative may be used in the composition in an amount of 0.05 ⁇ 0.25wt%.
  • phosphoric acid sodium phosphate, citric acid, sodium citrate, succinic acid, sodium succinate, tartaric acid, sodium tartarate, or the like may
  • the pH adjuster may be used in the composition in an amount of 0.02 - 1.5wt%.
  • odoriferous substances commonly used in a toothpasteand food flavoring agents for example, peppermint oils, menthol, spearmint oils, carvon, anice oils, anitol, Eucalyptus oils, Clove oils, eugenol, Winter green oils, methyl salicylate, cinnamon oils, cinnamic aldehyde and other aromatic components may be contained alone or in combination of two or more.
  • the content of the flavoring agent is 0.1 - 2.0wt%, preferably 0.5 ⁇ 1.5wt%.
  • composition for inhibiting halitosis of the present invention may mix effective amounts of xanthorrhizol and copper compound with suitable amount of the common components aforementioned.
  • Toothpaste compositions were prepared in accordance with the components andcontents as listed in Table 1.
  • Mouthwash compositions were prepared in accordance with the components and contents as listed in Table 3.
  • Edible film compositions were prepared in accordance with the components and contents as listed in Table 7.
  • Comparative Examples 4-1 - 4-3 on halitosis inhibition were measured. Chosen 30 subjects, male or female, not having dental caries were fed with the same meal, and then their initial levels of halitosis were measured using Halimeter. Subsequently, each of the above edible film compositions was adhered to the tongue, and then their levels of halitosis were measured again using Halimeter after the film was completely dissolved by saliva. The Halimeter was performed as above mentioned. The values of halitosis were averaged to obtain inhibitory rates on halitosis of the edible film. The results are shown in Table 8.
  • composition for inhibiting halitosis according to the above, the composition for inhibiting halitosis according to the
  • composition for inhibiting halitosis may be formulated in forms of gum, oral mouth rinses, ointment and patch as well as toothpaste, mouthwash,

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Emergency Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
PCT/KR2005/000312 2004-02-02 2005-02-02 Composition for inhibiting halitosis WO2005072691A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2004-0006698 2004-02-02
KR1020040006698A KR101071433B1 (ko) 2004-02-02 2004-02-02 구취억제용 조성물

Publications (1)

Publication Number Publication Date
WO2005072691A1 true WO2005072691A1 (en) 2005-08-11

Family

ID=34825063

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2005/000312 WO2005072691A1 (en) 2004-02-02 2005-02-02 Composition for inhibiting halitosis

Country Status (2)

Country Link
KR (1) KR101071433B1 (ko)
WO (1) WO2005072691A1 (ko)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140271495A1 (en) * 2013-03-15 2014-09-18 Chun Lim Abbott Topical Copper Ion Treatments and Methods of Treatment Using Topical Copper Ion Treatments in the Oral-Respiratory-Otic Areas of the Body
US10398733B2 (en) 2013-03-15 2019-09-03 Cda Research Group, Inc. Topical copper ion treatments and methods of treatment using topical copper ion treatments in the dermatological areas of the body
US10813948B2 (en) 2013-03-15 2020-10-27 Cda Research Group, Inc. Methods of treatment using topical copper ion formulations
US11000545B2 (en) 2013-03-15 2021-05-11 Cda Research Group, Inc. Copper ion compositions and methods of treatment for conditions caused by coronavirus and influenza
US11193184B2 (en) 2019-02-22 2021-12-07 Cda Research Group, Inc. System for use in producing a metal ion suspension and process of using same
US11318089B2 (en) 2013-03-15 2022-05-03 Cda Research Group, Inc. Topical copper ion treatments and methods of making topical copper ion treatments for use in various anatomical areas of the body

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5211940A (en) * 1991-06-21 1993-05-18 Lion Corporation Transparent liquid oral composition
KR20000065613A (ko) * 1999-04-07 2000-11-15 김선봉 감태 추출물을 포함하는 악취제거 및 충치 예방용 조성물

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5211940A (en) * 1991-06-21 1993-05-18 Lion Corporation Transparent liquid oral composition
KR20000065613A (ko) * 1999-04-07 2000-11-15 김선봉 감태 추출물을 포함하는 악취제거 및 충치 예방용 조성물

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HWANG J.K. ET AL: "Antibacterial activity of xanthorrhizol from Curcuma xanthorrhiza against oral pathogens", FITOTERAPIA, vol. 71, no. 3, 2000, pages 321 - 323 *
YOUNG A. ET AL: "Effects of metal salts on the oral production of volatile sulfur-containing compounds (VSC)", JOURNAL OF CLINICAL PERIODONTOLOGY, vol. 28, no. 2, 2001, pages 776 - 781 *

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11007143B2 (en) * 2013-03-15 2021-05-18 Cda Research Group, Inc. Topical copper ion treatments and methods of treatment using topical copper ion treatments in the oral-respiratory-otic areas of the body
AU2014235706B2 (en) * 2013-03-15 2018-11-01 Cda Research Group, Inc. Topical copper ion treatments
US20140271495A1 (en) * 2013-03-15 2014-09-18 Chun Lim Abbott Topical Copper Ion Treatments and Methods of Treatment Using Topical Copper Ion Treatments in the Oral-Respiratory-Otic Areas of the Body
EP3003247A4 (en) * 2013-03-15 2017-01-04 CDA Research Group, Inc. Topical copper ion treatments
US11083750B2 (en) 2013-03-15 2021-08-10 Cda Research Group, Inc. Methods of treatment using topical copper ion formulations
US10398733B2 (en) 2013-03-15 2019-09-03 Cda Research Group, Inc. Topical copper ion treatments and methods of treatment using topical copper ion treatments in the dermatological areas of the body
US10813948B2 (en) 2013-03-15 2020-10-27 Cda Research Group, Inc. Methods of treatment using topical copper ion formulations
US11857514B2 (en) 2013-03-15 2024-01-02 Cda Research Group, Inc. Topical copper ion treatments and methods of treatment using topical copper ion treatments in the dermatological areas of the body
CN105407858A (zh) * 2013-03-15 2016-03-16 Cda研究集团股份有限公司 局部铜离子治疗物
US20160008272A1 (en) * 2013-03-15 2016-01-14 Cda Research Group, Inc. Topical Copper Ion Treatments and Methods of Treatment Using Topical Copper Ion Treatments in the Oral-Respiratory-Otic Areas of the Body
US11000545B2 (en) 2013-03-15 2021-05-11 Cda Research Group, Inc. Copper ion compositions and methods of treatment for conditions caused by coronavirus and influenza
US11253544B2 (en) 2013-03-15 2022-02-22 Cda Research Group, Inc. Methods of treatment using topical copper ion formulations
US11298316B2 (en) 2013-03-15 2022-04-12 Cda Research Group, Inc. Topical copper ion treatments and methods of treatment using topical copper ion treatments in the oral-respiratory-otic areas of the body
US11318089B2 (en) 2013-03-15 2022-05-03 Cda Research Group, Inc. Topical copper ion treatments and methods of making topical copper ion treatments for use in various anatomical areas of the body
US11717535B2 (en) 2013-03-15 2023-08-08 Cda Research Group, Inc. Copper ion compositions and methods of treatment for conditions caused by coronavirus and influenza
US11459638B2 (en) 2019-02-22 2022-10-04 Cda Research Group, Inc. System for use in producing a metal ion suspension and process of using same
US11193184B2 (en) 2019-02-22 2021-12-07 Cda Research Group, Inc. System for use in producing a metal ion suspension and process of using same

Also Published As

Publication number Publication date
KR101071433B1 (ko) 2011-10-10
KR20050078531A (ko) 2005-08-05

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