WO2005068320A1 - Jeu de contenants de melange en cours d'utilisation - Google Patents

Jeu de contenants de melange en cours d'utilisation Download PDF

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Publication number
WO2005068320A1
WO2005068320A1 PCT/JP2004/000375 JP2004000375W WO2005068320A1 WO 2005068320 A1 WO2005068320 A1 WO 2005068320A1 JP 2004000375 W JP2004000375 W JP 2004000375W WO 2005068320 A1 WO2005068320 A1 WO 2005068320A1
Authority
WO
WIPO (PCT)
Prior art keywords
cap
plug
mouth
cap component
container
Prior art date
Application number
PCT/JP2004/000375
Other languages
English (en)
Japanese (ja)
Inventor
Keiji Hamamoto
Seiji Yoshimura
Shitomi Tamaoki
Original Assignee
Taisei Kako Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisei Kako Co., Ltd. filed Critical Taisei Kako Co., Ltd.
Priority to PCT/JP2004/000375 priority Critical patent/WO2005068320A1/fr
Priority to EP20040703265 priority patent/EP1707500A1/fr
Priority to US10/586,615 priority patent/US20070181449A1/en
Publication of WO2005068320A1 publication Critical patent/WO2005068320A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089—Containers or vials which are to be joined to each other in order to mix their contents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3205—Separate rigid or semi-rigid containers joined to each other at their external surfaces
    • B65D81/3211—Separate rigid or semi-rigid containers joined to each other at their external surfaces coaxially and provided with means facilitating admixture
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1425—Snap-fit type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/202—Separating means
    • A61J1/2031—Separating means having openings brought into alignment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2051—Connecting means having tap means, e.g. tap means activated by sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/20—Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003—Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2048—Connecting means
    • A61J1/2065—Connecting means having aligning and guiding means

Definitions

  • the present invention also relates to an in-use mixing container set capable of separately storing a freeze-dried solid drug and a solvent or a dispersion medium, and mixing and using the two in use.
  • a solid component storage portion and a liquid component storage portion which are separated from each other are provided in a single container, and the storage components are communicated with each other during use to convert the solid component into a liquid component. It is configured to be able to dissolve or disperse it in water and to spray such a chemical solution.
  • the solid component and liquid component are filled and sealed in a container under aseptic conditions at a filling factory, etc., and stored and transported while maintaining the sterile condition. Since the inside of the container is not exposed to the outside air, it can be handled and handled extremely hygienically. However, by dissolving it immediately before use, it is possible to prevent a decrease in medicinal effect.
  • the invention of the present application is intended to maintain the hermetically sealed state of the liquid agent container particularly until the two agents are connected in separate containers while the containers are connected for mixing during use. It is an object of the present invention to provide a mixing container set for use which can surely perform a mixing operation for use without zeroing out.
  • the mixing container set for use according to the present invention comprises: a first container having a first port; and a plug body detachably attached to the first port to seal an internal space of the first container from the outside air. And a second container having a second mouth, and a cap attached to the second mouth of the second container.
  • the first container and the second container are provided separately, and each opening is sealed with a stopper or a cap, so that the lyophilized preparation and its solvent etc.
  • Each of the liquid components can be aseptically filled by the same filling equipment and process as before.
  • the first container can be preferably constituted by a vial bottle
  • the second container can be constituted by a blow-molded resin bottle having, for example, a steam barrier suitable for containing a liquid component.
  • Each container can be provided with a bottomed cylindrical body at the mouth, and the inner space of this body is used to collect the contents. It can be used as a storage space.
  • the stopper that seals the mouth of the first container is preferably a rubber stopper made of butyl rubber or the like.
  • aluminum foil may be wrapped over the stopper, or a cap may be attached to the mouth of the first container so as to cover and hold the stopper. it can.
  • the cap has a first cap component that is attached to the second port in a liquid-tight manner, and a connection port that can be connected in a liquid-tight manner to the first port, and the first cap component has a liquid.
  • a second cap component that fits closely.
  • the second cap component is located axially inward of the second container from the first position, where the first and second cap components seal the internal space of the second container with outside air. May be movable relative to the first cap structure toward a second position located at the first position.
  • the communication passage for communicating between the internal space of the first container and the internal space of the second container connected to the connection port of the second cap component is as described above. It can be formed in a cap.
  • the connection port can be configured to be connected to the port of the first container when the second cap component is at the first position.
  • each of the cap components can be formed in a tubular shape, and the communication path can be mainly constituted by the internal space of these cap components.
  • a solid component such as a lyophilized preparation is contained in the first container in an aseptic state, and the solid component is stored in the second container. It is capable of accommodating a liquid component to be a solvent or a dispersion medium in an aseptic state.
  • the plug is removed from the mouth of the first container, and the first mouth opened upward.
  • the connection port of the second cap component of the second container turned upside down is connected. At this time, the second cap component is still in the first position, and the second port remains sealed, so that the liquid component in the second container does not spill.
  • the second container having the connection port connected to the first port is pushed toward the first container, the second container is pushed by the first container to move the second cap component from the first position to the second container.
  • the communication path is formed in the cap, and the second communication path is formed through the communication path.
  • the liquid component in the container can be transferred into the first container without spilling.
  • sufficiently mixing dissolving or dispersing
  • the mixed liquid agent passes through the communication passage from the first container which is turned upside down. All of them are transferred to the second container.
  • the first container and the cap are removed from the mouth of the second container, and a discharge device such as an eye drop nozzle or a pump sprayer is attached to the second mouth, so that the second container is used as a discharge container for the mixed liquid agent. It can be used.
  • a discharge device such as an eye drop nozzle or a pump sprayer
  • the first cap component is irremovably engaged with the second port when the second cap component is at the first position, and the second cap component is When the component is at the second position, the engagement with the second port may be released.
  • the first cap component cannot be removed from the second mouth unless the second cap component is moved from the first position to the second position by the above-described time-consuming mixing operation. It is possible to prevent the cap from being inadvertently removed from the second container, and to ensure the reliability of the mixing operation.
  • the first cap component includes a locking portion that is detachably engaged with the second port so as to prevent axial movement with respect to the second port, and the second cap component includes the locking portion.
  • a lock portion for forcibly pressing the locking portion so that the locking portion engages with the second opening when in the first position; and releasing the engagement when in the second position.
  • a release portion that engages with the locking portion so as to move the locking portion in the direction.
  • the first cap component includes an inner cylindrical portion protruding outward in the axial direction of the second opening, and a plug fixed to a tip of the inner cylindrical portion, and the outer diameter of the plug is An opening portion is provided between the plug and the inner cylinder portion, wherein the connection port portion is fitted into the first port portion; The inner cylinder portion is fitted inside the connection port portion, and when the second cap component is at the first position, the plug is fitted inside the connection port portion in a liquid-tight manner at the tip end of the connection port portion to form the connection portion.
  • the plug can be detached from the connection port to form the communication passage.
  • the plug is formed separately from the inner cylindrical portion, and the plug is mounted and fixed to the inner cylindrical portion from the front end in the axial direction, and the outer peripheral edge of the plug is connected to the distal end of the connection port of the second cap component.
  • the second cap component can be prevented from being detached from the first cap component by the plug, and the structure can be simplified and the assemblability can be improved.
  • the plug and the inner cylindrical portion are integrally formed, and the plug and the inner cylindrical portion are integrally connected via a plurality of connection ribs spaced apart in the circumferential direction.
  • the opening may also be used. According to this, it is possible to further reduce the number of components, and to further reduce costs.
  • the stopper that comes into contact with the second cap component is detachably provided so as to restrict the movement of the second cap component from the first position to the second position. May be. According to this, it is possible to prevent the second cap component from accidentally moving to the second position, opening the mouth of the second container, and exposing the liquid component to the atmosphere.
  • the stopper may be detachably attached to the outer periphery of the body of the second container, or may be detachably attached to the outer periphery of the first cap assembly.
  • the connection port of the second cap component is fitted inside the first port, and the second cap component is located radially outward of the connection port and at the front end in the axial direction.
  • a locking portion extending toward the first opening, a flange portion protruding radially outward is provided at the first opening portion, and the locking piece has a connection opening portion at the first opening portion.
  • Franc when inlaid It may be one that axially engages with the base end side peripheral edge of the joint portion. According to this, when the connection port is connected to the port of the first container, the first port is held by the locking piece provided on the outer periphery of the connection port, and thus after the mixing operation is completed. When the first container is separated from the second container, the cap together with the first container can be separated from the second container. Therefore, the operation in the post-process after mixing can be simplified, and the time from mixing to use can be shortened.
  • the first cap member includes a first cylindrical portion mounted on the outer peripheral side of the second mouth portion, and a second cylindrical portion connected to the first cylindrical portion.
  • a second cylinder portion having an inner diameter smaller than an inner diameter of the second mouth portion, and the second cap member having a plug fitted in a base end portion of the second cylinder portion.
  • the plug closes the communication passage by the plug when the second cap structure is in the first position, and forms the communication passage when the second cap structure is in the second position.
  • the first cap component further includes a third cylinder portion continuously provided on the distal end side of the second cylinder portion, and a connection port of the second cap component is internally fitted in the first port.
  • the second cap component further includes a flange portion formed radially outward from a base end of the connection port, and the flange portion is fitted inside the third cylindrical portion, An engagement projection is provided on the inner peripheral surface of the cylindrical portion so as to axially engage the flange so as to prevent the second cap component from moving from the first position to the second position.
  • the third cylindrical portion can be elastically deformed radially outward so that the engagement between the engagement convex portion and the flange portion is released.
  • the following in-use mixing method can be easily performed.
  • (1) the solid component is sealed and stored in the first container, and the solvent or the dispersion medium of the solid component is stored in the second container independent of the first container.
  • the liquid container to be used is sealed in the container, and the first container is opened when the container is used for (2), while the sealed container state of the second container is maintained, and the second container is inserted into the mouth of the opened first container.
  • a communication passage for communicating the internal space of the first container and the internal space of the second container is opened inside the connection portion, and the first component is connected through the communication passage.
  • the second component are mixed, and the mixed solution is contained in a second container.
  • the first container is removed from the second container, and the liquid in the second container is placed in the second container.
  • the mixed liquid in the second container can be discharged, and before the mixing, the second container used as a liquid component container is discharged in the second container. It is characterized in that it is used as a vessel. According to this, at the time of storage or transportation before mixing at the time of use, there are two containers that make up the set, so the packing material does not become too large as compared with the case where the spray container is separately provided, This will make it easier to handle and reduce costs.
  • the second container used as the storage container for the liquid components before mixing at the time of use is diverted as the discharge device of the liquid mixture after the mixing at the time of use, cost reduction by reducing the number of components and waste amount Therefore, it is possible to reduce environmental impact and improve environmental performance.
  • the first container can be constituted by a bottle (for example, a conventionally known vial bottle) made of a material having excellent gas barrier properties such as glass.
  • a bottle for example, a conventionally known vial bottle
  • the solid component can be contained in the bottle in an aseptic state, and in particular, the unstable freeze-dried preparation can be stably stored in the glass container.
  • a lid member is further provided on the first mouth (for example, see Japanese Patent Application Laid-Open No. 9-278510). It is possible to wear a ring with the disclosed opening mechanism).
  • the lid member includes a locking member formed by arranging a plurality of locking tongues on a peripheral edge of a disk-shaped top plate in a circumferential direction, and a cover member mounted on an outer peripheral side of the plurality of locking tongues.
  • Each of the locking tongues extends downward from the periphery of the top plate portion, and is elastically deformable so that the lower end thereof expands and contracts in the radial direction. be able to.
  • the upper end of the locking member and the lower end of the holder member can be integrally formed via a breakable connection portion.
  • the holder member is pushed downward with respect to the locking member.
  • the connecting portion By breaking the connecting portion, the holder member is attached to the outer periphery of the plurality of locking tongues, and the plurality of locking tongues are deformed inward in the radial direction by the one member of the holder.
  • the first At the outer periphery of the mouth.
  • locking portions (such as concave portions or convex portions) that lock each other when the holder member is mounted on the outer circumference of the locking tongue piece are provided on the inner peripheral surface of the holder member and the outer peripheral surface of the locking tongue piece.
  • a locking portion for locking to the outer peripheral edge near the upper end of the locking member may be provided on the inner periphery near the lower end of the holder member. According to this, it is possible to remove the locking member from the lower part while pulling out the holder member.
  • This lid member can be suitably used for holding a stopper made of, for example, butyl rubber attached to the mouth of a glass vial, and for improving the reliability of airtightness. In addition to the time mixing container set, it can be appropriately used.
  • FIG. 1 is a longitudinal sectional view showing a mixing container set for use according to a first embodiment of the present invention.
  • (a) shows a solution bottle and a resin bottle also serving as a spray container
  • (b) shows a resin bottle. Shows a vial bottle.
  • FIG. 2 is a front view of a resin bottle of the mixing container set for the same use.
  • FIG. 3 is a process chart showing a mixing process in use of the mixing container set in use.
  • FIG. 4 is a longitudinal sectional view showing a mixing container set for use according to a second embodiment of the present invention.
  • (a) shows a discharge nozzle as a discharge device
  • (b) shows a vial bottle.
  • (C) shows a resin bottle which is also used as a solution container and an otolaryngological medicine container.
  • FIG. 5 is a process chart showing a mixing process in use of the mixing container set in use.
  • FIG. 6 is a vertical cross-sectional view illustrating a mixing container set for use according to a third embodiment of the present invention.
  • a shows a discharge nozzle which is a discharge device
  • b shows a vial bottle
  • c shows a resin bottle which also serves as a dissolving liquid container and an ophthalmic solution discharging container.
  • FIG. 7 is a process chart showing a mixing process in use of the mixing container set in use.
  • FIG. 8 is a longitudinal sectional view showing a mixing container set for use according to a fourth embodiment of the present invention.
  • FIG. 8 (a) shows a dissolving liquid container and a resin potter which also serves as a spray container
  • FIG. Shows a vial bottle.
  • FIG. 9 is a front view of the resin bottle of the mixing container set for the same use.
  • FIG. 10 is a process chart showing a mixing process in use of the mixing container set in use.
  • FIGS. 1 to 3 show a mixing container set for use according to a first embodiment of the present invention.
  • the mixing container set for use comprises a vial 1 for containing a solid component comprising a lyophilized preparation. (A first container) and a resin bottle 2 (a second container) for containing a liquid component which is a solvent or a dispersion medium of a solid component.
  • the liquid component itself may contain an active ingredient.
  • This set can be suitably used, for example, as a dissolving-type nasal spray pump container for use, and can be used for other appropriate uses.
  • the vial 1 is made of glass, and integrally has a cylindrical mouth 4 (first mouth) at the upper end of a cylindrical body 3 having a bottom.
  • a rubber stopper 5 made of butyl rubber or the like is fitted in the mouth 4 in a liquid-tight manner, and a lid member 6 (for preventing the stopper 5 from being accidentally detached and improving airtightness). Rubber stopper).
  • a flange 7 is provided at the upper end of the mouth 4 to protrude outward in the radial direction.
  • the lid member 6 is attached to the mouth 4 by being locked to the flange 7.
  • the flange portion 7 may be provided at a halfway portion of the mouth portion 4 in the axial direction.
  • the flange portion 7 is provided at an intermediate portion in the axial direction, the upper surface structure of the vial 1 becomes two-stage, and a gap is formed between the flange portion 7 and the flange portion 9 of the plug 5. This By inserting a fingertip into the gap, the plug 5 can be easily removed.
  • the plug 5 is integrally provided with a hermetic plug 8 that fits into the mouth 4 and a flange 9 that contacts the upper surface of the mouth 4.
  • the outer diameter of the flange 9 is substantially the same as the outer diameter of the flange 7 of the mouth 4.
  • a concave portion 10 extending upward from the lower end portion is formed on a side portion of the sealing portion 8, and in a half-plugged state in which the upper end of the concave portion 10 is located higher than the upper end of the mouth portion 4, An air passage is formed between the plug 5 and the mouth 4 by the concave portion 10.
  • the lid member 6 includes a locking member 13 in which a plurality of locking tongue pieces 12 are arranged in a circumferential direction on a peripheral edge of the disc-shaped top plate portion 11, and a plurality of locking members 13 of the locking member 13. And a cylindrical holder member 14 attached to the outer peripheral side of the tongue piece 12.
  • the locking member 13 and the holder member 14 can be integrally formed through a thin connecting portion which can be easily broken at the time of manufacturing, and can be formed at the time of cabbing after filling the vial 1 with the lyophilized preparation. By pushing the holder member 14 in, the connecting portion is broken, so that both can be separated.
  • the lid member 6 is preferably made of a resin that can be incinerated and disposed of.
  • eight locking tongues 12 are equally arranged in the circumferential direction so as to surround the mouth portion 4, and a slit is formed between two adjacent locking tongues 12.
  • Each locking tongue piece 12 is configured to be elongated in the vertical direction, extends downward from the periphery of the top plate part 11, and is elastically deformable so that the lower end side expands and contracts in the radial direction. In the non-deformed state, the lower end is formed to expand radially outward from the upper end.
  • a locking projection 15 is provided on the inner peripheral surface of the locking tongue to be able to lock in the axial direction on the flange 7 of the mouth 4.
  • the lower end of the locking tongue piece 12 is provided with a protruding portion 16 protruding radially outward.
  • the holder member 14 is formed of a cylinder having an inner diameter substantially matching the outer diameter of the top plate portion 11, and a flange portion 17 protruding radially outward is provided at the upper end of the holder member 14. I have.
  • the shaft length of the holder member 14 is substantially equal to the shaft length of the locking member 13. Have been made equal.
  • the stopper 5 is half-plugged into the mouth portion 4 of the vial bottle 1 to evaporate the liquid component of the drug solution in the freeze-drying device, and the vapor is discharged to the outside of the bottle via the ventilation passage formed by the recess 10. .
  • the stopper 5 is completely plugged into the mouth 4, and the freeze-dried preparation is hermetically sealed in the internal space of the vial 1.
  • the locking member 13 of the lid member 6 is covered with the plug 5 and the mouth portion 4 and the holder member 14 is pushed strongly downward, so that the connecting portion 15 is broken and the holder member 1 4 is attached to the outer peripheral side of the locking member 13, and the locking tongue 1 2 is elastically deformed radially inward by the holder member 14, and the locking tongue 1 2 of the locking tongue 1 2 5.
  • the plug body 5 can be reliably held by the lid member 6 unless the holder member 14 is detached from the locking member 13.
  • the bottle 2 has a cylindrical mouth 22 formed integrally with an upper end of a bottomed cylindrical body 21.
  • a cylindrical base 23 with a bottom is attached to the lower part of the bottle 2.
  • Bottoming Norre 2 together with the body portion 2 1 of the axial center is bulged formed radially outward, t bottle is formed so as to gradually decreases in diameter in accordance with the transition from the axial center to the bottom side
  • the mouth 22 at the upper end of the cylinder 2 has a cylindrical shape that opens upward, and has a threaded portion 22 a for screwing a pump spray device described later on its outer peripheral surface.
  • a flange 22b is formed on the lower side (base end side) of the screw portion 22a and protrudes radially outward.
  • a cap 30 mainly composed of a cylindrical first cap component 31 and a cylindrical second cap component 32 is attached to the mouth 22 of the bottle 2.
  • the mouth 22 is hermetically and liquid-tightly sealed by the cap 30, while the cap 30 is connected to the vial 1 during use.
  • the two-agent mixing work can be easily performed by using the
  • the first cap component 31 includes a ring-shaped base 31 a that comes into contact with the upper surface of the bottom opening 22, a bottle base 22 extending axially inward from the base 31 a, and a bottle base 22. It has a 3 lb cylindrical seal tube that fits in a liquid tight manner inside the
  • the first cap component 31 includes a plurality of locking pieces 31 c (locking portions) extending inward (downward) in the axial direction from the outer peripheral edge of the base 31 a.
  • the plurality of locking pieces 31c are substantially equally spaced apart from each other in the circumferential direction, and are configured to be deformable so that the lower end side of each locking piece 31c expands radially outward.
  • An engagement projection 40 is provided on the inner surface near the lower end of each locking piece 3 1 c to engage with the lower surface of the flange 22 b of the bottle mouth 22.
  • 3 1 c is capable of engaging and disengaging with the bottle mouth 22 so as to prevent axial movement with respect to the bottle mouth 22.
  • a guide locking portion 31d is provided in a folded shape on the outer peripheral surface of the lower end portion of each locking piece 31c.
  • the first cap component 31 includes a cylindrical inner cylindrical portion 31 e extending axially outward (upward) from the inner peripheral edge of the base portion 31 a, and a cylindrical inner cylindrical portion 31 e. It has a mouth 31 f provided integrally with the distal end portion, and a plug 31 g fixed to the distal end of the inner cylindrical portion 31 e by fitting to the rod 31 f.
  • the plug 31g is separately molded, and the other components are integrally molded by injection molding or the like.
  • the outer diameter of the plug 3 1 g is smaller than the inner diameter of the mouth 4 of the vial 1.
  • An opening 41 is formed between the plug 3 1 g and the rod 31 f and the inner cylinder 31 e so that the liquid component in the bottle 2 can freely flow to the outer peripheral side of the plug 31 g. To be able to flow into.
  • the second cap component 32 is fitted into the first cap component 31 in a liquid-tight manner, and has a cylindrical connection port that can be connected to the mouth 4 of the vial 1 in a liquid-tight manner.
  • the second cap component 32 is located at a first position (see FIG. 1) in which the first and second cap components 31 and 32 seal the internal space of the bottle 2 from outside air.
  • the second cap member 32 is movable relative to the first cap member toward a second position located inward in the axial direction of the bottle 2.
  • a communication passage is formed in the cap 30 for communicating between the internal space of the vial 1 and the internal space of the potter 2 connected to the connection port 3 2a of the second cap assembly 32. It is supposed to be.
  • the second cap member 32 includes a flange 32 extending radially outward from the base end of the connection port 32a, and a diameter of the connection port 32a.
  • a plurality of locking pieces 32 c in the circumferential direction extending outward from the flange portion 32 b and extending from the flange portion 32 b toward the front end (outward) in the circumferential direction, and the axial direction from the flange portion 32 b.
  • a cylindrical release portion 32d extending toward the base end (inward), and a cylindrical body extending from the outer peripheral edge of the flange portion 32b toward the base end in the axial direction. 3 2 e.
  • a locking projection 42 is provided on the inner surface near the front end of the locking piece 32c so that when the connection port 32a is fitted inside the vial 4 of the vial 1, it is connected.
  • the locking projections 42 axially engage the peripheral edge of the flange portion 7 of the vial 1 in the axial direction, so that the mouth portion 4 of the vial 1 is chucked by the second cap component 32. I am getting it.
  • a locking piece 3 1 of the first cap component 31 is provided on the inner peripheral surface of the main body 3 2 e of the second cap component 32 when the second cap component 32 is in the first position.
  • a locking portion 32 f forcibly pressing the locking piece 32 c from the outer surface side is formed so as to bulge out so that c engages with the flange portion 22 b of the bottom portion 22.
  • the 1 cap component can be irremovably engaged with the bottle mouth 22.
  • the release portion 32 d is axially separated from the guide locking portion 31 d of the first cap component 31, and The distal end of the release portion 32d and the guide locking portion 31d are arranged to face each other in the axial direction.
  • the distal end of the release portion 32d engages with the guide locking portion 31d to lock the first cap member 31.
  • the locking piece 3 1c is moved in a direction (ie, radially outward) in which the engagement between the piece 3 1c and the flange portion 2 2b of the bottle mouth 22 is released, and the first cap component 3 The engagement with the bottom opening 22 of 1 is released.
  • the mutual contact surfaces of the disengagement part 32 d and the guide locking part 31 d are formed in a tapered shape. It is.
  • connection port 32a The distal end of the connection port 32a is tapered so that the second cap component 32 is in the first position.
  • the outer peripheral edge of the plug 31g is engaged with the distal end surface of the connection port 32a, and the plug 31 also makes the distal opening of the connection port 32a liquid-tight and airtight. It is sealed so that the communication passage is closed.
  • connection port 3 2a When the connection port 3 2a is fitted into the port 4 of the vial 1 and the second cap structure 32 is moved to the second position, the plug 3 1 g force is applied to the shaft from the connection port 3 2a.
  • the vial 1 is spaced apart in the direction and enters the vial 4 of the vial 1, thereby forming the communication passage.
  • the main body 3 of the second cap component 32 is attached to the bottle body 21 so as to restrict the second cap component 32 from moving from the first position to the second position.
  • the stopper 4 that comes into contact with the lower end surface of e is detachably mounted.
  • the movement is regulated by interposing a stopper 44 between the step 21 a provided on the bottle body 21 and the lower end of the second cap assembly 32. .
  • an outer cap 45 is further screwed onto the cap 30 to prevent the outer cap 45 from contaminating the plug 31 g in particular.
  • the cap 30 can be wrapped with aluminum foil or the like.
  • Step (a) shows the delivery form of the product, that is, the state during transportation and storage.
  • step (b) the lid member 6 and the stopper 5 are removed from the mouth 4 of the vial 1, and the outer cap 45 of the bottle 2 is removed.
  • steps (c) to (d) the bottle 2 is turned upside down and the connection port 32 a is pushed into the mouth 4 of the vial 1 to connect the two containers 1 and 2.
  • the stopper 44 prevents the movement of the second cap assembly 32 to the second position, the end of the connection port 3 2a is opened before the connection is completed, causing liquid leakage. This Not even.
  • the second cap component 32 is relatively positioned with respect to the first cap component 31.
  • the plug 31g is detached from the connection port 32a, and a communication passage is formed in the cap 30 for communicating the internal space of the vial 1 with the internal space of the bottle 2.
  • the liquid component in the bottle 2 flows into the vial 1 via the communication path.
  • the release portion 32 d of the second cap component 32 engages with the guide locking portion 31 d of the locking piece 31 c of the first cap component 31, and Engagement of the locking piece 31c with the bottle mouth 22 is released by expanding the locking piece 31c radially outward.
  • step (g) After sufficiently mixing the solid component and the liquid component, as shown in step (g), the whole is turned upside down and the bottle 2 is positioned on the lower side and the vial 1 is positioned on the upper side. All flows into bottle 2. Then, when the vial 1 is separated from the bottle 2 as shown in step (h), the engagement between the cap 30 and the bottle opening 22 has already been released as described above, Cap 30 is removed from bottle 2. Then, as shown in step (i), by attaching a separately prepared discharge device 50 such as a pump spray device to the bottle opening 22, the bottle used as the container for the liquid component before mixing is provided. 2 can be used as a discharge container.
  • a separately prepared discharge device 50 such as a pump spray device
  • the pump spray device 50 includes a cylindrical cap member screwed into the mouth 22, a suction device for sucking up liquid stored in the internal space of the bottle 2 from the bottom side of the internal space, A suction pipe, and a pump section for generating a suction force for sucking the liquid through the suction pipe and the suction pipe, and suction! / Spray section for spraying the raised liquid to the outside.
  • the suction pipe, the pump section, and the spray section are connected in the axial direction, and the pump section is attached and held by a cap member.
  • the suction pipe is located at the center of the axis of the bottle, and extends axially over substantially the entire length of the bottle.
  • the rubber stopper is made of butyl rubber
  • the vial bottle is made of glass
  • the plug is made of low-density polyethylene
  • the vial lid is made of polypropylene
  • the bottle is made of high-density polyethylene
  • the other components are polypropylene or It is recommended to be made of high density polyethylene.
  • FIG. 4 and FIG. 5 show a mixing container set for use according to a second embodiment of the present invention, which can be suitably used particularly as a dissolution container for use in otolaryngology.
  • a mixing container set for use according to a second embodiment of the present invention which can be suitably used particularly as a dissolution container for use in otolaryngology.
  • the same components as those in the first embodiment are denoted by the same reference numerals, detailed description thereof will be omitted, and different configurations and operational effects will be described.
  • the rubber stopper 5 of the vial As the rubber stopper 5 of the vial 1, a conventionally known rubber stopper is used. After the rubber stopper 5 is fitted to the mouth 4, the entire vial 1 is aluminum-wrapped.
  • the first cap component 31 is not provided with the locking piece, and is configured to be screwed to the outer periphery of the bottle mouth 22.
  • the plug 31 g and the other components are integrally formed, and the plug 31 g and the inner cylindrical portion 31 e are provided with a plurality of connection ribs 31 h that are spaced apart in the circumferential direction. And a plurality of connecting ribs 31 h are formed as openings 41.
  • the plug 3 1 g is fitted only on the inner peripheral side of the connection port 32 a, and the distal end surface of the connection port 32 a so as to prevent the second cap component 32 from coming off. Is not engaged.
  • the main body 32 e of the second cap component 32 is externally fitted to the first cap component, and an undercut portion 46 is provided at the fitting portion, whereby the second cap component 32 is provided. This prevents accidental detachment of the second cap component 31 from the second cap component 31.
  • the release part 32 d, the guide locking part 31 d, and the lock part 32 f in the first embodiment are not provided in the second embodiment either. Even if it is moved to the position, the engagement (screw engagement) between the first cap component and the bottle mouth 22 is not automatically released. Therefore, in order to remove the cap 30 from the bottle mouth 22 in the process after mixing the two liquids, the vial 1 and the bottle 2 are relatively rotated. At this time, in order to prevent the second cap component 32 from idling relative to the first cap component 31, the second cap component 32 is located at the second position. The two cap component 32 and the first cap component 31 are engaged with each other in the rotational operation direction.
  • the engaging portion is an appropriate portion, for example, the lower end portion of the main body 3 2 e of the second cap component 32. It is preferable to provide in! /.
  • the discharge device 50 of the present embodiment uses a discharge nozzle.
  • the time-of-use mixing step in this embodiment is also substantially the same as that in the first embodiment, and therefore, detailed description will be omitted with reference to FIG.
  • FIGS. 6 and 7 show a mixing container set for use according to a third embodiment of the present invention, which differs from the second embodiment only in the shape of the bottles and is otherwise the same. And the detailed description is omitted.
  • this embodiment can be suitably used especially as an eye drop container.
  • FIG. 8 to 10 show a mixing container set for use according to a fourth embodiment of the present invention, which can be suitably used particularly as a dissolving nasal drop container for use. Since the vial 1 and its stopper structure, and the bottle 2 are the same as those in the first embodiment, the same reference numerals are given and the detailed description is omitted, and different configurations and operational effects will be described.
  • a cap 50 mainly composed of a cylindrical first cap component 51 and a cylindrical second cap component 52 is attached to the mouth 22 of the bottle 2 of the present embodiment.
  • the mouth 22 is hermetically and liquid-tightly sealed with the cap 50, while the cap 50 is closed during use. It is used as a connection adapter with the vianole bottle 1 so that the two-agent mixing operation can be performed easily and reliably.
  • the first cap component 51 has a cylindrical first cylindrical portion 5 la screwed on the outer peripheral side of the bottle mouth portion 22, and a cylindrical second cylindrical portion 5 1 a connected to the first cylindrical portion 51 a.
  • the main part is constituted by a holder part 51 d substantially in the shape of a force which is provided in series.
  • a screw portion to be screwed with the screw portion 22a on the outer periphery of the bottle mouth is provided on the inner peripheral surface of the first cylindrical portion 51a.
  • the inner and outer diameters of the second cylindrical part 5 1 b are the bottle mouth
  • the inner diameter of the second cylindrical portion 51 b is smaller than the inner diameter of the second cylindrical portion 22.
  • the base end of the second cylindrical portion 51 b protrudes into the bottom opening 22.
  • the first tubular portion 51a and the second tubular portion 51b are integrally connected via a flange portion 51e, and the lower surface of the flange portion 51e is It faces the upper surface of the mouth.
  • a rubber packing 53 is provided between the flange 51 e and the bottom opening 22. It is interposed.
  • the third tubular portion 51c is configured to be able to fit into the mouth 4 of the vial 1, and when the third tubular portion 51c is fitted to the mouth 4, the mouth 4
  • An engagement projection 54 is provided on the inner peripheral surface of the third cylindrical portion 51 c to be axially engaged with the base end of the flange 7.
  • the third cylindrical portion 51 c has slits 55 as shown in FIGS. 8 and 9. Is formed, so that a predetermined circumferential portion of the third cylindrical portion 51c can be elastically deformed radially outward.
  • the holder 51 d is shaped to fit the shape of the shoulder and the body of the vial 1, and when the third cylindrical portion 51 c is fitted to the mouth 4, the holder 51 d is formed.
  • the inner peripheral surface of the vial can hold the outer peripheral surface on the upper side of the vial 1.
  • the second cap component 52 is provided with a cylindrical connection port 52 a that is fitted inside the vial 4 of the vial 1 in a liquid-tight and air-tight manner, and is connected to the connection port 52 a.
  • a cylindrical joint portion 52b fitted inside the second cylinder portion 51b so as to be slidable in the axial direction; and a cylindrical joint portion 52b fitted inside the axial base end portion of the second cylinder portion 51b.
  • It is mainly composed of a bottom cylindrical plug 52c and a flange 52d formed radially outward from the axial base end of the connection port 52a. Of these components, only the plug 52c is separately formed, and the other components are integrally formed.
  • the distal end of the plug 52c and the proximal end of the joint 52b are in contact with each other.
  • the plug 52c can be integrally formed with the joint part 52b.
  • the flange portion 52d and the connection port portion 52a can be appropriately combined as a separate member configuration.
  • the second cap component 52 is placed in a first position (see FIG. 8) in which the interior space of the bottle 2 is sealed from the outside air by the first and second cap components 51, 52. Is also relatively movable with respect to the first cap member 51 toward a second position (see FIG. 10 (d)) located axially inward of the bottle 2.
  • a communication passage for communicating between the internal space of the vial 1 and the internal space of the bottle 2 connected to the connection port 52 a of the second cap assembly 52 is provided. It is formed within 0.
  • the peripheral wall of the plug 52 c is provided with an opening 56 penetrating inside and outside thereof.
  • the opening 56 of the plug 52 c is formed. Is exposed below the base end of the second tubular portion 51b, so that the communication passage is opened.
  • the opening portion 56 of the plug 52c is housed above the lower end portion of the second cylindrical portion 51b, and The plug 52c can close the communication path.
  • the flange portion 52 d of the second cap component 52 is fitted inside the third cylindrical portion 51 c of the first cap component 51.
  • the flange portion 52 d is axially engaged with the engagement convex portion 54 so that the second cap component 52 has a second position. Movement to the position is prevented.
  • the predetermined portion in the circumferential direction of the third cylindrical portion 51c can be elastically deformed radially outward. Therefore, when the vial 1 connected to the connection port 52a is strongly pushed, the flange portion 5c The third cylindrical portion 51c is forcibly pushed outward in the radial direction by 2d, and the engagement between the flange portion 52d and the engaging convex portion 54 is released. Can be relatively moved.
  • a cover cap 45 is attached to the tip of the holder 51 d to prevent the inner surfaces of the first cap component 51 and the second cap component 52 from being contaminated. ing.
  • Step (a) shows the delivery form of the product, that is, the state during transportation and storage.
  • step (b) the lid member 6 and the stopper 5 are removed from the mouth 4 of the vial 1, and the cover cap 45 of the bottle 2 is removed.
  • step (c) the bottle 2 is turned upside down, and the connection port 52a is placed in a vial. Push into the mouth 4 of the vial 1 and connect both containers 1 and 2.
  • steps (d) to (e) the second cap component 52 moves axially relative to the first cap component 51.
  • the opening portion 56 of the plug 52c is exposed to the inner space of the bottle, and a communication passage for communicating the inner space of the vial 1 and the inner space of the bottle 2 is formed in the cap 50, The liquid component in the bottle 2 flows into the vial 1 via the communication path.
  • step (f) After sufficient mixing of the solid component and the liquid component, the whole liquid is turned upside down as shown in step (f) to position the bottle 2 on the lower side and the vial 1 on the upper side. All flows into bottle 2. Then, as shown in step (g), by holding the holder part 51 d and rotating the entire first cap assembly 51, the cap 50 is removed from the bottom opening 22 into the vial bottle 1. Remove with.
  • the operations from the step (d) to the step (g) can be performed by holding the holder 51d, and a series of operations can be simplified and quickly performed.
  • step (h) by attaching a separately prepared discharge device 50 such as a pump spray device to the bottle opening 22, the bottle 2 used as a container for the liquid component before mixing was prepared.
  • a separately prepared discharge device 50 such as a pump spray device
  • the liquid component when connecting the first container and the second container to mix the solid component and the liquid component at the time of use, the liquid component is not reduced to zero and the mixing ratio is determined at a predetermined mixing ratio. Indeed, it is possible to produce a mixed solution and to handle it in a sanitary manner.
  • the mixed liquid is stored in the second container, and a discharge device is attached to this container, which can be used as a discharge container such as a spray container. Mixing at the time of use can be accurately performed while reducing the amount of water.

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Package Specialized In Special Use (AREA)

Abstract

L'invention concerne un jeu de contenants de mélange en cours d'utilisation permettant une opération de mélange sécurisée en cours d'utilisation sans fuite goutte à goutte d'agents chimiques par maintien de l'état d'étanchéité des goulots de contenants pour liquides en particulier jusqu'à ce que les contenants soient accouplés entre eux pour permettre le mélange en cours d'utilisation tout en stockant deux agents chimiques dans les contenants, respectivement, un bouchon en caoutchouc (5) étant ajusté détachable sur la partie goulot (4) d'un flacon (1) et une capsule (30) étant ajustée sur la partie goulot (22) du contenant pour liquides (2). La capsule (30) comprend une première structure (31) ajustée de manière étanche aux liquides sur la partie goulot (22) et une seconde structure (32) ajustée de manière étanche aux liquides sur la première structure (31) et présentant une partie port d'accouplement (32a) pouvant être accouplée de manière étanche aux liquides à la partie goulot (4). La seconde structure (32) peut être déplacée d'une première position dans laquelle l'espace intérieur du contenant pour liquides (2) est étanche par rapport à l'air extérieur vers une seconde position sur le côté intérieur axial de la première position, et lorsque la seconde structure est placée sur la seconde position, le flacon (1) accouplé à la partie port d'accouplement (32a) peut communiquer avec l'espace intérieur du contenant pour liquides (2).
PCT/JP2004/000375 2004-01-19 2004-01-19 Jeu de contenants de melange en cours d'utilisation WO2005068320A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PCT/JP2004/000375 WO2005068320A1 (fr) 2004-01-19 2004-01-19 Jeu de contenants de melange en cours d'utilisation
EP20040703265 EP1707500A1 (fr) 2004-01-19 2004-01-19 Jeu de contenants de melange en cours d'utilisation
US10/586,615 US20070181449A1 (en) 2004-01-19 2004-01-19 Guidance route search device, navigation device, and method of searching guidance route

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2004/000375 WO2005068320A1 (fr) 2004-01-19 2004-01-19 Jeu de contenants de melange en cours d'utilisation

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WO2005068320A1 true WO2005068320A1 (fr) 2005-07-28

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FR2967655B1 (fr) * 2010-11-24 2014-03-14 Biocorp Rech Et Dev Dispositif de bouchage d'un recipient, recipient equipe d'un tel dispositif et procede de fermeture d'un lot de tels recipients
ES2678545T3 (es) 2011-09-29 2018-08-13 Ge Healthcare As Envase
WO2013087817A1 (fr) * 2011-12-15 2013-06-20 Ge Healthcare As Emballage
WO2016162814A1 (fr) 2015-04-10 2016-10-13 Dompe' Farmaceutici S.P.A. Procédé de fabrication d'un dispositif de distribution pour gouttes ophtalmiques
MA41906A (fr) * 2015-04-10 2018-02-13 Dompe Farm Spa Dispositif de distribution de gouttes oculaires
ITUA20162072A1 (it) 2016-06-30 2017-12-30 Platinum Corp Srl Dropper a volume controllato
TWI629223B (zh) * 2017-01-24 2018-07-11 禪與徠特有限公司 一種具有夾持功能暨可調和飲品之容器
EP3750574B1 (fr) * 2019-06-13 2024-01-03 Trenta2 S.r.l. Système de transfert de liquide et composants associés
EP4245687A1 (fr) * 2022-03-17 2023-09-20 Bnova SA Ensemble capuchon pour un récipient de recharge
US11905086B2 (en) 2022-03-17 2024-02-20 Bnova Sa Cap assembly for a refill container

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Publication number Priority date Publication date Assignee Title
JPH0634316Y2 (ja) * 1988-07-01 1994-09-07 株式会社吉野工業所 二液混合容器
JPH08280807A (ja) * 1995-04-18 1996-10-29 Taisei Kako Kk 用時溶解スプレー容器及び該容器を用いた用時溶解スプレー
JP2558588B2 (ja) * 1993-01-07 1996-11-27 前田産業株式会社 デュアルチャンバーボトル
JP2865276B2 (ja) * 1995-07-11 1999-03-08 ベクトン・ディキンソン・アンド・カンパニー バイアルのコネクタ組立体
WO2000002795A1 (fr) * 1998-07-10 2000-01-20 Pentapharm Ag Systeme de raccord double pour flacons
FR2789369A1 (fr) * 1999-02-10 2000-08-11 Biodome Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif
US20010003996A1 (en) * 1998-04-20 2001-06-21 Hubert Jansen Transfer set for vials and medical containers

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0634316Y2 (ja) * 1988-07-01 1994-09-07 株式会社吉野工業所 二液混合容器
JP2558588B2 (ja) * 1993-01-07 1996-11-27 前田産業株式会社 デュアルチャンバーボトル
JPH08280807A (ja) * 1995-04-18 1996-10-29 Taisei Kako Kk 用時溶解スプレー容器及び該容器を用いた用時溶解スプレー
JP2865276B2 (ja) * 1995-07-11 1999-03-08 ベクトン・ディキンソン・アンド・カンパニー バイアルのコネクタ組立体
US20010003996A1 (en) * 1998-04-20 2001-06-21 Hubert Jansen Transfer set for vials and medical containers
WO2000002795A1 (fr) * 1998-07-10 2000-01-20 Pentapharm Ag Systeme de raccord double pour flacons
FR2789369A1 (fr) * 1999-02-10 2000-08-11 Biodome Dispositif de connexion entre un recipient et un contenant et ensemble pret a l'emploi comprenant un tel dispositif

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US20070181449A1 (en) 2007-08-09

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