WO2005058287A3 - Transdermal delivery system of hormones without penetration enhancers - Google Patents

Transdermal delivery system of hormones without penetration enhancers Download PDF

Info

Publication number
WO2005058287A3
WO2005058287A3 PCT/IB2004/052752 IB2004052752W WO2005058287A3 WO 2005058287 A3 WO2005058287 A3 WO 2005058287A3 IB 2004052752 W IB2004052752 W IB 2004052752W WO 2005058287 A3 WO2005058287 A3 WO 2005058287A3
Authority
WO
WIPO (PCT)
Prior art keywords
hormones
patch
penetration enhancers
delivery system
transdermal delivery
Prior art date
Application number
PCT/IB2004/052752
Other languages
English (en)
French (fr)
Other versions
WO2005058287A2 (en
Inventor
Stefan Bracht
Michael Dittgen
Petra Huber
Thomas Langguth
Dirk Schenk
Original Assignee
Schering Ag
Stefan Bracht
Michael Dittgen
Petra Huber
Thomas Langguth
Dirk Schenk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34702342&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2005058287(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to NZ548091A priority Critical patent/NZ548091A/en
Priority to CA2549916A priority patent/CA2549916C/en
Priority to BRPI0417530A priority patent/BRPI0417530B8/pt
Priority to AU2004298930A priority patent/AU2004298930B2/en
Priority to KR1020067013923A priority patent/KR101168449B1/ko
Priority to EA200601089A priority patent/EA011160B1/ru
Priority to CN2004800413210A priority patent/CN1913878B/zh
Application filed by Schering Ag, Stefan Bracht, Michael Dittgen, Petra Huber, Thomas Langguth, Dirk Schenk filed Critical Schering Ag
Priority to JP2006543709A priority patent/JP4965263B2/ja
Priority to MXPA06006682A priority patent/MXPA06006682A/es
Publication of WO2005058287A2 publication Critical patent/WO2005058287A2/en
Publication of WO2005058287A3 publication Critical patent/WO2005058287A3/en
Priority to IL176112A priority patent/IL176112A/en
Priority to NO20062594A priority patent/NO341989B1/no
Priority to ZA2006/05713A priority patent/ZA200605713B/en
Priority to CU20100143A priority patent/CU23868B1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7076—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising ingredients of undetermined constitution or reaction products thereof, e.g. rosin or other plant resins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
PCT/IB2004/052752 2003-12-12 2004-12-10 Transdermal delivery system of hormones without penetration enhancers WO2005058287A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
MXPA06006682A MXPA06006682A (es) 2003-12-12 2004-12-10 Hormonas de administracion transdermica que no necesitan potenciadores de penetracion.
CN2004800413210A CN1913878B (zh) 2003-12-12 2004-12-10 无需渗透促进剂的激素透皮传递
BRPI0417530A BRPI0417530B8 (pt) 2003-12-12 2004-12-10 composição para a liberação transdérmica de hormônios sem a necessidade de melhoradores de penetração, sistema terapêutico transdérmico, e kit
AU2004298930A AU2004298930B2 (en) 2003-12-12 2004-12-10 Transdermal delivery system of hormones without penetration enhancers
JP2006543709A JP4965263B2 (ja) 2003-12-12 2004-12-10 浸透増強剤を必要としないホルモンの経皮送達
EA200601089A EA011160B1 (ru) 2003-12-12 2004-12-10 Композиция для трансдермальной доставки гормонов без необходимости использования агентов, усиливающих проникновение, и ее применения
CA2549916A CA2549916C (en) 2003-12-12 2004-12-10 Transdermal delivery system of hormones without penetration enhancers
NZ548091A NZ548091A (en) 2003-12-12 2004-12-10 Transdermal delivery system of hormones without penetration enhancers
KR1020067013923A KR101168449B1 (ko) 2003-12-12 2004-12-10 침투 증진인자가 필요없는 호르몬의 경피 전달계
IL176112A IL176112A (en) 2003-12-12 2006-06-05 Skin-containing preparation through the stomach containing gastodone and carrier, a medical system for the administration through the skin containing gastodon and a kit
NO20062594A NO341989B1 (no) 2003-12-12 2006-06-06 Transdermal administrasjon av hormoner uten behov for penetrasjonsenhancere.
ZA2006/05713A ZA200605713B (en) 2003-12-12 2006-07-11 Transdermal delivery system of hormones without penetration enhancers
CU20100143A CU23868B1 (es) 2003-12-12 2010-07-05 Hormonas de administración transdérmica que no necesitan potenciadores de penetración

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US52871803P 2003-12-12 2003-12-12
US60/528,718 2003-12-12
EP03078881 2003-12-12
EP03078881.4 2003-12-12

Publications (2)

Publication Number Publication Date
WO2005058287A2 WO2005058287A2 (en) 2005-06-30
WO2005058287A3 true WO2005058287A3 (en) 2006-03-02

Family

ID=34702342

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2004/052752 WO2005058287A2 (en) 2003-12-12 2004-12-10 Transdermal delivery system of hormones without penetration enhancers

Country Status (15)

Country Link
JP (1) JP4965263B2 (und)
KR (1) KR101168449B1 (und)
CN (1) CN1913878B (und)
AU (1) AU2004298930B2 (und)
BR (1) BRPI0417530B8 (und)
CA (1) CA2549916C (und)
CU (1) CU23868B1 (und)
EA (1) EA011160B1 (und)
EC (1) ECSP066694A (und)
IL (1) IL176112A (und)
MX (1) MXPA06006682A (und)
NO (1) NO341989B1 (und)
NZ (1) NZ548091A (und)
WO (1) WO2005058287A2 (und)
ZA (1) ZA200605713B (und)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL219030B1 (pl) 2003-02-21 2015-03-31 Schering Ag Transdermalny system terapeutyczny w postaci plastra odporny na działanie promieniowania UV
US8962013B2 (en) 2005-05-02 2015-02-24 Bayer Intellectual Property Gmbh Multi-layered transdermal system with triazine UV absorber
DE102005050729A1 (de) * 2005-10-19 2007-04-26 Schering Ag Verfahren zur präventiven bedarfsweisen hormonalen Kontrazeption
FR2900048B1 (fr) * 2006-04-21 2012-11-16 Oreal Compositions comprenant un derive diphenyl-methane hydroxyle
PL2613772T3 (pl) 2010-09-06 2017-06-30 Bayer Intellectual Property Gmbh Plastry transdermalne z niską dawką o wysokim uwalnianiu leku
DE102010040299A1 (de) * 2010-09-06 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Transdermale therapeutische Systeme mit kristallisationsinhibierender Schutzfolie (Release Liner)
AU2015203180B2 (en) * 2010-09-06 2016-06-30 Bayer Intellectual Property Gmbh Transdermal therapeutic systems with crystallization-inhibiting protective film (release liner)
NZ627242A (en) * 2012-01-27 2016-08-26 Agile Therapeutics Inc Transdermal hormone delivery
US20180125860A1 (en) * 2015-05-18 2018-05-10 Agile Therapeutics, Inc. Contraceptive Compositions and Methods for Improved Efficacy and Modulation of Side Effects

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992007590A1 (en) * 1990-10-29 1992-05-14 Alza Corporation Transdermal contraceptive formulations, methods and devices
EP0573133A1 (de) * 1988-10-27 1993-12-08 Schering Aktiengesellschaft Mittel zur transdermalen Applikation das Gestoden enthält
US5512292A (en) * 1990-10-29 1996-04-30 Alza Corporation Transdermal contraceptive formulations methods and devices
US5858394A (en) * 1993-08-26 1999-01-12 Schering Aktiengesellschaft Agent for transdermal administration that contains gestodene esters
US5904931A (en) * 1994-02-18 1999-05-18 Schering Aktiengesellschaft Transdermal therapeutic systems that contain sex steroids and dimethyl isosorbide
DE19906152A1 (de) * 1999-02-10 2000-08-17 Jenapharm Gmbh Wirkstoffhaltige Laminate für Transdermalsysteme
WO2002034200A2 (de) * 2000-10-27 2002-05-02 Lts Lohmann Therapie-Systeme Ag Transdermale therapeutische systeme mit lichtempfindlichen wirkstoffen
WO2002045701A2 (en) * 2000-12-05 2002-06-13 Noven Pharmaceuticals, Inc. Crystallization inhibition of drugs in transdermal drug delivery systems

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0787488A4 (en) * 1994-11-18 1998-06-03 Hisamitsu Pharmaceutical Co TRANSDERMAL ABSORBABLE PLASTER
WO1996040355A1 (en) * 1995-06-07 1996-12-19 Cygnus, Inc. Transdermal patch and method for administering 17-deacetyl norgestimate alone or in combination with an estrogen
JP4346696B2 (ja) * 1996-05-28 2009-10-21 久光製薬株式会社 経皮治療用装置
JP4167750B2 (ja) * 1997-04-16 2008-10-22 久光製薬株式会社 経皮吸収用基剤及び該基剤を含有する経皮吸収製剤
JP4399044B2 (ja) * 1998-10-14 2010-01-13 久光製薬株式会社 吸収促進剤及び該吸収促進剤を有してなる経皮吸収製剤
KR20010112479A (ko) * 1999-07-01 2001-12-20 나까도미 히로다카 경피흡수 첩부제

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0573133A1 (de) * 1988-10-27 1993-12-08 Schering Aktiengesellschaft Mittel zur transdermalen Applikation das Gestoden enthält
WO1992007590A1 (en) * 1990-10-29 1992-05-14 Alza Corporation Transdermal contraceptive formulations, methods and devices
US5512292A (en) * 1990-10-29 1996-04-30 Alza Corporation Transdermal contraceptive formulations methods and devices
US5858394A (en) * 1993-08-26 1999-01-12 Schering Aktiengesellschaft Agent for transdermal administration that contains gestodene esters
US5904931A (en) * 1994-02-18 1999-05-18 Schering Aktiengesellschaft Transdermal therapeutic systems that contain sex steroids and dimethyl isosorbide
DE19906152A1 (de) * 1999-02-10 2000-08-17 Jenapharm Gmbh Wirkstoffhaltige Laminate für Transdermalsysteme
WO2002034200A2 (de) * 2000-10-27 2002-05-02 Lts Lohmann Therapie-Systeme Ag Transdermale therapeutische systeme mit lichtempfindlichen wirkstoffen
WO2002045701A2 (en) * 2000-12-05 2002-06-13 Noven Pharmaceuticals, Inc. Crystallization inhibition of drugs in transdermal drug delivery systems

Also Published As

Publication number Publication date
AU2004298930B2 (en) 2009-11-26
MXPA06006682A (es) 2006-08-11
AU2004298930A1 (en) 2005-06-30
NO20062594L (no) 2006-07-10
NZ548091A (en) 2009-12-24
EA200601089A1 (ru) 2006-12-29
KR20060128910A (ko) 2006-12-14
JP2007513938A (ja) 2007-05-31
CU20100143A7 (es) 2011-10-31
ECSP066694A (es) 2006-10-31
ZA200605713B (en) 2008-01-08
BRPI0417530B8 (pt) 2021-05-25
CN1913878B (zh) 2010-05-26
NO341989B1 (no) 2018-03-12
CN1913878A (zh) 2007-02-14
IL176112A0 (en) 2006-10-05
BRPI0417530A (pt) 2007-03-13
KR101168449B1 (ko) 2012-07-25
CA2549916C (en) 2013-09-17
JP4965263B2 (ja) 2012-07-04
EA011160B1 (ru) 2009-02-27
WO2005058287A2 (en) 2005-06-30
CA2549916A1 (en) 2005-06-30
CU23868B1 (es) 2013-03-27
BRPI0417530B1 (pt) 2018-01-23
IL176112A (en) 2011-02-28

Similar Documents

Publication Publication Date Title
MY152750A (en) Transdermal delivery system of hormones without penetration enhancers
WO2001078701A3 (en) Method and compositions for preventing hormone induced adverse effects
HU9802326A3 (en) Transdermal medicament for administering 17-deacetyl norgestimate alone or in combination with an estrogen
IE83582B1 (en) Subsaturated transdermal drug delivery device exhibiting enhanced drug flux
JP2005263814A (ja) テストステロンを投与するための皮膚パッチおよび方法。
RS20060348A (en) Extended use combination comprising estrogens and progestins
JP2009512658A5 (und)
WO1992020377A1 (en) Skin permeation enhancer compositions using glycerol monolinoleate
CU20100143A7 (es) Hormonas de administración transdérmica que no necesitan potenciadores de penetración
TW200514560A (en) Pharmaceutical formulation for contraception and hormone-replacement therapy
CA2391430A1 (en) Improved transdermal contraceptive delivery system and process
UA77150C2 (en) Use of mesoprogestins j867, j912, or j1042 for female contraception, pharmaceutical composition and kit (variants)
MXPA05003364A (es) Parche transdermico de 17(-estradiol/levonorgestrel para hormonoterapia restitutiva.
AU5105699A (en) Formulations for the transdermal administration of fenoldopam
TH115856B (th) การนำส่งฮอร์โมนผ่านผิวหนังโดยไม่ต้องการสารเพิ่มการแทรกซึม
CU20060121A7 (es) Hormonas de administración transdérmica que no necesitan potenciadores de penetración
UY28668A1 (es) Hormonas de administración transdérmica que no necesitan potenciadores de penetración
TH76877B (th) การนำส่งฮอร์โมนผ่านผิวหนังโดยไม่ต้องการสารเพิ่มการแทรกซึม
TH115856A (th) การนำส่งฮอร์โมนผ่านผิวหนังโดยไม่ต้องการสารเพิ่มการแทรกซึม

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG US UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IS IT LT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 176112

Country of ref document: IL

WWE Wipo information: entry into national phase

Ref document number: 3279/DELNP/2006

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2549916

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2006543709

Country of ref document: JP

Ref document number: 12006501154

Country of ref document: PH

WWE Wipo information: entry into national phase

Ref document number: PA/a/2006/006682

Country of ref document: MX

WWE Wipo information: entry into national phase

Ref document number: 2004298930

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: CR2006-008465

Country of ref document: CR

WWE Wipo information: entry into national phase

Ref document number: 548091

Country of ref document: NZ

WWE Wipo information: entry into national phase

Ref document number: 06064000

Country of ref document: CO

WWE Wipo information: entry into national phase

Ref document number: 200601089

Country of ref document: EA

ENP Entry into the national phase

Ref document number: 2004298930

Country of ref document: AU

Date of ref document: 20041210

Kind code of ref document: A

WWP Wipo information: published in national office

Ref document number: 2004298930

Country of ref document: AU

WWE Wipo information: entry into national phase

Ref document number: 2006/05713

Country of ref document: ZA

Ref document number: 1020067013923

Country of ref document: KR

Ref document number: 200605713

Country of ref document: ZA

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
WWE Wipo information: entry into national phase

Ref document number: 200480041321.0

Country of ref document: CN

WWP Wipo information: published in national office

Ref document number: 1020067013923

Country of ref document: KR

122 Ep: pct application non-entry in european phase
ENP Entry into the national phase

Ref document number: PI0417530

Country of ref document: BR

WWE Wipo information: entry into national phase

Ref document number: D2010143

Country of ref document: CU