WO2005046635A3 - Verfahren zur herstellung von lagerstabilen multiplen emulsionen - Google Patents

Verfahren zur herstellung von lagerstabilen multiplen emulsionen Download PDF

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Publication number
WO2005046635A3
WO2005046635A3 PCT/EP2004/012275 EP2004012275W WO2005046635A3 WO 2005046635 A3 WO2005046635 A3 WO 2005046635A3 EP 2004012275 W EP2004012275 W EP 2004012275W WO 2005046635 A3 WO2005046635 A3 WO 2005046635A3
Authority
WO
WIPO (PCT)
Prior art keywords
phase
stable
storage
producing multiple
multiple emulsions
Prior art date
Application number
PCT/EP2004/012275
Other languages
English (en)
French (fr)
Other versions
WO2005046635A2 (de
Inventor
Olaf Stange
Martina Mutter
Tanja Oswald
Mark Schmitz
Original Assignee
Bayer Technology Services Gmbh
Olaf Stange
Martina Mutter
Tanja Oswald
Mark Schmitz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Technology Services Gmbh, Olaf Stange, Martina Mutter, Tanja Oswald, Mark Schmitz filed Critical Bayer Technology Services Gmbh
Priority to US10/578,329 priority Critical patent/US7943154B2/en
Priority to BRPI0415717-6A priority patent/BRPI0415717A/pt
Priority to AU2004289048A priority patent/AU2004289048B2/en
Priority to EP04791035A priority patent/EP1682089A2/de
Priority to JP2006537212A priority patent/JP4785746B2/ja
Publication of WO2005046635A2 publication Critical patent/WO2005046635A2/de
Publication of WO2005046635A3 publication Critical patent/WO2005046635A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/113—Multiple emulsions, e.g. oil-in-water-in-oil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Colloid Chemistry (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)

Abstract

Es wird ein Verfahren zur Herstellung von lagerstabilen, multiplen Emulsionen vom Typ Wasser/Öl/Wasser (W/O/W), die ein oder mehrere Wirkstoffe enthalten, beschrieben. Das Verfahren umfasst die Schritte a) Einrühren des Wirkstoffs in eine wässrige Phase, b) Emulgieren der wässrigen Phase durch Einleiten der wässrigen Phase durch eine grobporige, poröse Membran in eine Ölphase, c) Phaseninversion der Emulsion aus b), durch Abkühlen der Mischung bei einer Kühlerate von mindestens 0,3 K/min, wobei entweder der wässrigen Phase in a) oder der Ölphase in b) oder beiden Phasen ein Emulgator zugesetzt wird.
PCT/EP2004/012275 2003-11-05 2004-10-29 Verfahren zur herstellung von lagerstabilen multiplen emulsionen WO2005046635A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
US10/578,329 US7943154B2 (en) 2003-11-05 2004-10-29 Method for producing multiple emulsions that are stable in storage
BRPI0415717-6A BRPI0415717A (pt) 2003-11-05 2004-10-29 processo para preparação de emulsões múltiplas estáveis ao armazenamento
AU2004289048A AU2004289048B2 (en) 2003-11-05 2004-10-29 Method for producing multiple emulsions that are stable in storage
EP04791035A EP1682089A2 (de) 2003-11-05 2004-10-29 Verfahren zur herstellung von lagerstabilen multiplen emulsionen
JP2006537212A JP4785746B2 (ja) 2003-11-05 2004-10-29 貯蔵安定性を有する複合エマルジョンの製造方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10351644.1 2003-11-05
DE10351644A DE10351644A1 (de) 2003-11-05 2003-11-05 Verfahren zur Herstellung von lagerstabilen multiplen Emulsionen

Publications (2)

Publication Number Publication Date
WO2005046635A2 WO2005046635A2 (de) 2005-05-26
WO2005046635A3 true WO2005046635A3 (de) 2005-11-17

Family

ID=34559347

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2004/012275 WO2005046635A2 (de) 2003-11-05 2004-10-29 Verfahren zur herstellung von lagerstabilen multiplen emulsionen

Country Status (9)

Country Link
US (1) US7943154B2 (de)
EP (1) EP1682089A2 (de)
JP (1) JP4785746B2 (de)
CN (1) CN100496462C (de)
AU (1) AU2004289048B2 (de)
BR (1) BRPI0415717A (de)
DE (1) DE10351644A1 (de)
RU (1) RU2367411C2 (de)
WO (1) WO2005046635A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2039352A1 (de) * 2007-09-18 2009-03-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) Lipid-Nanokapseln mit wässrigem Kern zur Einkapselung hydrophiler und/oder lipophiler Moleküle
CN107029802A (zh) * 2016-11-04 2017-08-11 河西学院 一种制备磁性多孔材料的方法
CN108166311A (zh) * 2017-10-24 2018-06-15 苏州丰倍生物科技有限公司 一种植物型纸张防黏剂及其制备方法
CN108126545A (zh) * 2018-01-25 2018-06-08 吉林冠界生物技术有限公司 一种疫苗乳化设备及其使用方法
CA3098981A1 (en) 2018-05-23 2019-11-28 Unilever Plc Nanoemulsions and a method for making the same
CN110101661B (zh) * 2019-05-21 2022-01-21 肇庆大华农生物药品有限公司 一种可快速产生抗体的油乳剂灭活疫苗配方及其制备方法
CN113429942B (zh) * 2021-07-14 2022-02-15 广东工业大学 一种适用于水溶性无机盐的相变复合材料及其制备方法
CN114469734B (zh) * 2021-10-13 2023-08-04 成都科建生物医药有限公司 一种蒽环类药物脂质体的制备装置与制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020051748A1 (en) * 1998-12-22 2002-05-02 William C. Snow Stabilized water-in-oil-in-water antigen delivery system

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60199833A (ja) * 1984-03-26 1985-10-09 Meiji Milk Prod Co Ltd 医薬品、化粧品等用ｗ／ｏ／ｗ型複合エマルジヨンの製造法
JP2558107B2 (ja) * 1986-12-18 1996-11-27 第一製薬株式会社 外用剤
DE8808248U1 (de) 1988-06-28 1989-08-24 Wilcke, Hans, 5484 Bad Breisig, De
US5316773A (en) 1990-07-19 1994-05-31 Otsuka Pharmaceutical Co., Ltd. Particulate preparation containing a flourracil derivative and hydroxypropylmethyl-cellulose
EP0546174B1 (de) * 1991-06-29 1997-10-29 Miyazaki-Ken Monozerstreute einfache und doppelte emulsionen und herstellungsverfahren
JP3011530B2 (ja) 1992-04-06 2000-02-21 森永乳業株式会社 スプレッドとその製造法
FR2733151B1 (fr) * 1995-04-20 1997-05-23 Seppic Sa Composition therapeutique comprenant un antigene ou un generateur in vivo d'un compose comprenant une sequence d'acides amines
DE19630176C2 (de) * 1996-07-26 2000-11-02 Babor Gmbh & Co Dr Kosmetische und pharmazeutische Mittel, gebildet durch eine nach dem Phaseninversionsverfahren erzeugte W/O/W-Emulsion
JPH10137576A (ja) * 1996-11-12 1998-05-26 Pola Chem Ind Inc Ｗ／ｏ／ｗエマルションの製造方法
US20060003012A9 (en) * 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
JP4124323B2 (ja) * 2002-03-29 2008-07-23 株式会社Ａｄｅｋａ 可塑性乳化油脂組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020051748A1 (en) * 1998-12-22 2002-05-02 William C. Snow Stabilized water-in-oil-in-water antigen delivery system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
HIDEAKI OKOCHI, MASAHIRO NAKANO, ADVANCED DRUG DELIVERY REVIEWS, vol. 45, 2000, pages 5 - 26, XP002341117 *

Also Published As

Publication number Publication date
RU2367411C2 (ru) 2009-09-20
CN1901883A (zh) 2007-01-24
DE10351644A1 (de) 2005-06-09
JP2007509666A (ja) 2007-04-19
EP1682089A2 (de) 2006-07-26
AU2004289048A1 (en) 2005-05-26
JP4785746B2 (ja) 2011-10-05
WO2005046635A2 (de) 2005-05-26
BRPI0415717A (pt) 2006-12-19
CN100496462C (zh) 2009-06-10
RU2006119296A (ru) 2007-12-27
AU2004289048B2 (en) 2010-03-04
US7943154B2 (en) 2011-05-17
US20070253986A1 (en) 2007-11-01

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