WO2005044343A1 - Dispositif de distribution dosee de liquide - Google Patents

Dispositif de distribution dosee de liquide Download PDF

Info

Publication number
WO2005044343A1
WO2005044343A1 PCT/AT2004/000383 AT2004000383W WO2005044343A1 WO 2005044343 A1 WO2005044343 A1 WO 2005044343A1 AT 2004000383 W AT2004000383 W AT 2004000383W WO 2005044343 A1 WO2005044343 A1 WO 2005044343A1
Authority
WO
WIPO (PCT)
Prior art keywords
pressure medium
liquid
housing
chamber
infusion
Prior art date
Application number
PCT/AT2004/000383
Other languages
German (de)
English (en)
Inventor
Bernhard GALLNBÖCK
Original Assignee
Pro-Med Medizinische Produktions- Und Handels-Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pro-Med Medizinische Produktions- Und Handels-Ag filed Critical Pro-Med Medizinische Produktions- Und Handels-Ag
Publication of WO2005044343A1 publication Critical patent/WO2005044343A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/148—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags
    • A61M5/1483—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons flexible, e.g. independent bags using flexible bags externally pressurised by fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M2005/14204—Pressure infusion, e.g. using pumps with gas-producing electrochemical cell
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M2005/14513—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons with secondary fluid driving or regulating the infusion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/142—Pressure infusion, e.g. using pumps
    • A61M5/145—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons
    • A61M5/14586—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of a flexible diaphragm
    • A61M5/14593—Pressure infusion, e.g. using pumps using pressurised reservoirs, e.g. pressurised by means of pistons pressurised by means of a flexible diaphragm the diaphragm being actuated by fluid pressure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16804—Flow controllers
    • A61M5/16827—Flow controllers controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
    • A61M5/16877—Adjusting flow; Devices for setting a flow rate

Definitions

  • the invention relates to a device for the metered delivery of liquid, in particular infusion liquid, with a housing which receives liquid in a liquid chamber connected to an outlet and has a pressure medium chamber, via which a flexible wall of the liquid chamber can be acted upon with a pressure medium.
  • the liquid chamber, the pressure medium chamber and a pressure gas generator are accommodated in a common housing.
  • the gas pressure generator consists of a reaction chamber that contains an organic acid, usually citric acid in the required concentration, and a carbonate preparation, usually sodium carbonate with binders, separated from the container by a membrane, which is pressed into a tablet.
  • a reaction gas usually carbon dioxide, which is passed through a hydrophobic, gas-permeable membrane and via a line into the pressure medium chamber , from where the infusion liquid is pressurized via the flexible wall of the liquid chamber.
  • the infusion rate can take place via the gas pressure and / or via a control valve in the infusion line leading from the device to the patient.
  • Such devices for the metered delivery of an infusion liquid have the advantage that you can supply a patient with an infusion liquid over a longer period of time with an almost constant pressure, the patient during the Administration of the infusion remains mobile since he can wear the device on the body.
  • a disadvantage of this known device is that only one drug can be administered as an infusion with one device.
  • the invention is therefore based on the object of providing the simplest possible device for dispensing a liquid, in particular an infusion liquid, which allows simultaneous administration of two liquids, in particular infusion liquids, with a relatively small space requirement.
  • the invention solves this problem in that the housing has at least two liquid chambers with separate outlets which can be acted upon by a flexible wall with pressure medium via a common pressure medium chamber.
  • a space-saving device for dispensing at least two liquids at the same time is created in a simple manner by the housing having at least two liquid chambers which can be pressurized via a flexible wall and which can be pressurized via a common pressure medium chamber in order to achieve the pressure in to be able to administer the liquid chambers of filled or diluted medicinal products or, for example, pesticides or fertilizers for plants or the like in a simple manner at the same time.
  • liquids Before the liquids are dispensed in a metered manner, only the liquid chambers need to be filled or, if appropriate, medication has already been added to the pre-filled liquid chambers, after which the pressure medium chamber is filled with a pressure medium and the liquids from the flexible wall pressure medium acting on the liquids can be discharged via the respective outlet at the desired pressure.
  • the device according to the invention is particularly advantageously suitable for infusing a wide variety of medicament solutions which either consist of medicaments which are incompatible with one another or which require different carrier solutions.
  • foams or the like can also be used as pressure medium, although it is particularly advisable when using gases as pressure medium if the pressure medium chamber is sealed off from the liquid chambers by means of a gas-tight membrane and can be connected to a gas pressure source.
  • the gas pressure source could, however, just as well be inserted into a corresponding recess formed by the pressure medium chamber, as a result of which a particularly compact device according to the invention can be created.
  • the gas pressure generators known from WO 95/23641 A1 are particularly recommended, which are preferably connected to the pressure medium chamber via a control and / or pressure reducing valve, in order to ensure the most constant, adjustable pressure over the entire administration period of the infusion liquid and that To be able to interrupt gas supply to the pressure medium chamber at any time if necessary.
  • a conventional pressure relief valve can be provided as the pressure reducing valve.
  • the gas pressure source is removable with the control or the housing preferably assigned to the housing. Pressure reducing valve is connected.
  • liquid chambers In order to be able to administer different volumes of the at least two liquids with different flow rates simultaneously or in succession, it is advantageous to assign a flow controller to the outlets of the liquid chambers, via which flow controller the liquids preferably open into a common infusion tube. If medicinal products should be able to be introduced easily and quickly into a respective liquid chamber, it is advantageous if the liquid chambers each have an infusion opening for medicinal products. This makes it possible to infuse a wide variety of amounts of medication into the liquid chambers, for example, highly concentrated initial doses or low-concentration maintenance doses.
  • the housing is preferably made of plastic as required, whereby it has proven to be particularly advantageous to form the two housings as pouches, each having a liquid chamber that can be acted upon by a membrane with pressure medium via a common pressure medium chamber, resulting in a compact, easy-to-use device according to the invention and / or if the housing consists of two interconnected housing parts, the flexible walls delimiting the pressure medium chamber being arranged in the region of the parting plane of the two housing parts.
  • FIG. 1 shows a device according to the invention in a sectional side view
  • FIG. 2 shows the device from FIG. 1 with a partially filled pressure medium chamber
  • FIG. 3 shows the device from FIGS. 1 and 2 in plan view.
  • the housing 1 consists of two interconnected housing parts 6, 7, the membranes 4 delimiting the pressure medium chamber 3 being arranged in the region of the division plane T of the two housing parts 6, 7.
  • Each of the two interconnected housing parts 6, 7 receives a membrane 4, which seals the pressure medium chamber 3 in a gas-tight manner with respect to the liquid chambers 2.
  • the pressure medium chamber 3 is connected via a line 8 to a gas pressure source 9 which can be removed from the housing.
  • a control valve 10 and a pressure reducing valve 11 are arranged, with which the gas supply from the gas pressure source 9 to the pressure medium chamber 3 can be controlled and regulated and the gas pressure can be limited to a presettable maximum value.
  • the liquids pressurized in the liquid chambers 2 are discharged from the device via an outlet 12, with the outlets 12 of the liquid chambers 2 each being assigned a flow controller 13, via which flow controller 13 the liquids open into a common infusion tube.
  • separate infusion sets with defined flow rates can also be used for the infusion, which if necessary are brought together to form an infusion tube in front of a venous catheter.
  • the gas pressure source 9 consists of a container 15 with a hydrophobic, gas-permeable membrane 16, which absorbs an organic acid 17, in particular citric acid, in the required concentration and with a tablet separated from the acid 17 via a film 18 or the like 19 pressed carbonate preparation, in particular from sodium carbonate with binders.
  • a medicament is added to the liquid chambers pre-filled with carrier solutions via an infusion opening 20 and the desired flow rates are set by means of the flow regulator 13. Then the gas pressure source 11 is connected to the housing and activated in that the tablet 19 is brought into contact with the acid 17 by destroying the film 18, after which the pressure medium, in particular carbon dioxide, is produced as a result of the chemical reaction taking place.
  • the gas-permeable membrane 16 ensures that only gases get into the pressure medium chamber 3 and liquids are retained in the container 15.
  • the gas is introduced from the container 15 via the control valve 10 into the pressure medium chamber 3, where the membranes 4 apply the desired pressure from the device via the outlets 12 to the infusion liquids contained in the liquid chambers 2 and drive it out of the housing 1.

Landscapes

  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Fluid Mechanics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention concerne un dispositif de distribution dosée de liquide, en particulier de liquide de perfusion. Ce dispositif comprend un logement (1) pourvu d'une chambre à liquide (2) reliée à une évacuation (20) et contenant le liquide, ainsi que d'une chambre à agent de pression (3) qui exerce une action sur une paroi souple de la chambre à liquide (2), par l'intermédiaire d'un agent de pression (5). L'objectif de cette invention est de créer une pompe de perfusion compacte destinée à distribuer plusieurs liquides de perfusion, à l'aide de moyens particulièrement simples. A cet effet, le logement (1) comporte au moins deux chambres à liquide (2) qui comprennent des évacuations distinctes (12) et qui peuvent être soumises à l'action d'une chambre à agent de pression (3) commune, respectivement par l'intermédiaire d'une paroi souple, au moyen dudit agent de pression (5).
PCT/AT2004/000383 2003-11-05 2004-11-02 Dispositif de distribution dosee de liquide WO2005044343A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ATA1766/2003 2003-11-05
AT17662003A AT412945B (de) 2003-11-05 2003-11-05 Vorrichtung zur dosierten abgabe von flüssigkeit

Publications (1)

Publication Number Publication Date
WO2005044343A1 true WO2005044343A1 (fr) 2005-05-19

Family

ID=34140237

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AT2004/000383 WO2005044343A1 (fr) 2003-11-05 2004-11-02 Dispositif de distribution dosee de liquide

Country Status (2)

Country Link
AT (1) AT412945B (fr)
WO (1) WO2005044343A1 (fr)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1895988A2 (fr) * 2005-05-25 2008-03-12 Palyon Medical Corporation Pompe implantable multi-reservoir a capacites de debit variables
US7708730B2 (en) 2006-01-30 2010-05-04 Palyon Medical (Bvi) Limited Template system for multi-reservoir implantable pump
WO2010145908A1 (fr) * 2009-05-20 2010-12-23 Sanofi-Aventis Deutschland Gmbh Dispositif d'administration de médicament
US8114055B2 (en) 2005-05-10 2012-02-14 Palyon Medical (Bvi) Limited Implantable pump with infinitely variable resistor
US8177750B2 (en) 2005-05-10 2012-05-15 Palyon Medical (Bvi) Limited Variable flow infusion pump system
US8211060B2 (en) 2005-05-10 2012-07-03 Palyon Medical (Bvi) Limited Reduced size implantable pump
US8568360B2 (en) 2011-12-28 2013-10-29 Palyon Medical (Bvi) Limited Programmable implantable pump design
US8591456B2 (en) 2011-12-28 2013-11-26 Palyon Medical (Bvi) Limited Multiple reservoir programmable pump
EP2674623A1 (fr) * 2012-06-11 2013-12-18 VARTA Microbattery GmbH Dispositif et procédé destinés à la sortie dosée d'un fluide
ITRM20130076A1 (it) * 2013-02-12 2014-08-13 Gianfranco Cappello Pompa ad infusione per infondere ad un paziente soluzioni acquose e non acquose, in particolare non omogenee.
US8915893B2 (en) 2005-05-10 2014-12-23 Palyon Medical (Bvi) Limited Variable flow infusion pump system
IT201700057784A1 (it) * 2017-05-26 2018-11-26 Angiodroid S R L Metodo per la preparazione e l'erogazione di una dose di un mezzo di contrasto gassoso per l'esecuzione di angiografie, e dispositivo che attua tale metodo
EP3593832A1 (fr) * 2018-07-11 2020-01-15 Debiotech S.A. Système d'administration de médicaments
CN112384268A (zh) * 2018-07-11 2021-02-19 生物技术公司 药物输送系统
US12042626B2 (en) 2018-02-16 2024-07-23 Debiotech S.A. Status indicator of a drug delivery system

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT503144B1 (de) * 2006-02-08 2008-02-15 Pro Med Medizinische Produktio Vorrichtung zur dosierten abgabe von flüssigkeit

Citations (3)

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Publication number Priority date Publication date Assignee Title
US5578005A (en) * 1993-08-06 1996-11-26 River Medical, Inc. Apparatus and methods for multiple fluid infusion
US5743878A (en) * 1991-06-25 1998-04-28 Medication Delivery Devices, Inc. Infusion pump, treatment fluid bag therefor, and method for the use thereof
US5785688A (en) * 1996-05-07 1998-07-28 Ceramatec, Inc. Fluid delivery apparatus and method

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5743878A (en) * 1991-06-25 1998-04-28 Medication Delivery Devices, Inc. Infusion pump, treatment fluid bag therefor, and method for the use thereof
US5578005A (en) * 1993-08-06 1996-11-26 River Medical, Inc. Apparatus and methods for multiple fluid infusion
US5785688A (en) * 1996-05-07 1998-07-28 Ceramatec, Inc. Fluid delivery apparatus and method

Cited By (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8591478B2 (en) 2005-05-10 2013-11-26 Palyon Medical (Bvi) Limited Reduced size implantable pump
US8114055B2 (en) 2005-05-10 2012-02-14 Palyon Medical (Bvi) Limited Implantable pump with infinitely variable resistor
US8211060B2 (en) 2005-05-10 2012-07-03 Palyon Medical (Bvi) Limited Reduced size implantable pump
US8915893B2 (en) 2005-05-10 2014-12-23 Palyon Medical (Bvi) Limited Variable flow infusion pump system
US8177750B2 (en) 2005-05-10 2012-05-15 Palyon Medical (Bvi) Limited Variable flow infusion pump system
US8034030B2 (en) 2005-05-25 2011-10-11 Palyon Medical (Bvi) Limited Multi-reservoir implantable pump with variable flow rate capabilities
US8034029B2 (en) 2005-05-25 2011-10-11 Palyon Medical (Bvi) Limited Multi-reservoir implantable pump with patient controlled actuation
EP1895988A4 (fr) * 2005-05-25 2013-03-20 Palyon Medical Bvi Ltd Pompe implantable multi-reservoir a capacites de debit variables
EP1895988A2 (fr) * 2005-05-25 2008-03-12 Palyon Medical Corporation Pompe implantable multi-reservoir a capacites de debit variables
US7708730B2 (en) 2006-01-30 2010-05-04 Palyon Medical (Bvi) Limited Template system for multi-reservoir implantable pump
US7914510B2 (en) 2006-01-30 2011-03-29 Palyon Medical (Bvi) Limited Template system for multi-reservoir implantable pump
WO2010145908A1 (fr) * 2009-05-20 2010-12-23 Sanofi-Aventis Deutschland Gmbh Dispositif d'administration de médicament
JP2012527272A (ja) * 2009-05-20 2012-11-08 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング 薬物送達デバイス
US8568360B2 (en) 2011-12-28 2013-10-29 Palyon Medical (Bvi) Limited Programmable implantable pump design
US8591456B2 (en) 2011-12-28 2013-11-26 Palyon Medical (Bvi) Limited Multiple reservoir programmable pump
US8961466B2 (en) 2011-12-28 2015-02-24 Palyon Medical (Bvi) Limited Programmable implantable pump design
US8808231B2 (en) 2011-12-28 2014-08-19 Palyon Medical (Bvi) Limited Multiple reservoir programmable pump
EP2674623A1 (fr) * 2012-06-11 2013-12-18 VARTA Microbattery GmbH Dispositif et procédé destinés à la sortie dosée d'un fluide
ITRM20130076A1 (it) * 2013-02-12 2014-08-13 Gianfranco Cappello Pompa ad infusione per infondere ad un paziente soluzioni acquose e non acquose, in particolare non omogenee.
IT201700057784A1 (it) * 2017-05-26 2018-11-26 Angiodroid S R L Metodo per la preparazione e l'erogazione di una dose di un mezzo di contrasto gassoso per l'esecuzione di angiografie, e dispositivo che attua tale metodo
WO2018215984A1 (fr) * 2017-05-26 2018-11-29 Angiodroid S.R.L. Procédé de préparation et d'alimentation d'une dose d'un agent de contraste gazeux pour angiographie et dispositif mettant en œuvre un tel procédé
CN110891631A (zh) * 2017-05-26 2020-03-17 安焦德罗伊德有限责任公司 用于准备和供给用于血管造影术的一定剂量气态造影剂的方法以及实现该方法的装置
US11369734B2 (en) * 2017-05-26 2022-06-28 Angiodroid S.R.L. Method for the preparation and supply of a dose of a gaseous contrast agent for angiography, and device that actualizes such a method
IL270868B1 (en) * 2017-05-26 2023-11-01 Angiodroid S R L A method for preparing and delivering a dose of gaseous contrast agent for angiography and a device that performs such a method
IL270868B2 (en) * 2017-05-26 2024-03-01 Angiodroid S R L A method for preparing and delivering a dose of gaseous contrast agent for angiography and a device that performs such a method
US12042626B2 (en) 2018-02-16 2024-07-23 Debiotech S.A. Status indicator of a drug delivery system
EP3593832A1 (fr) * 2018-07-11 2020-01-15 Debiotech S.A. Système d'administration de médicaments
CN112384268A (zh) * 2018-07-11 2021-02-19 生物技术公司 药物输送系统
CN112384268B (zh) * 2018-07-11 2023-03-10 生物技术公司 药物输送系统
US12070571B2 (en) 2018-07-11 2024-08-27 Debiotech S.A. Drug delivery system

Also Published As

Publication number Publication date
AT412945B (de) 2005-09-26
ATA17662003A (de) 2005-02-15

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