WO2005016949A3 - Derives d'acide sialique - Google Patents
Derives d'acide sialique Download PDFInfo
- Publication number
- WO2005016949A3 WO2005016949A3 PCT/GB2004/003484 GB2004003484W WO2005016949A3 WO 2005016949 A3 WO2005016949 A3 WO 2005016949A3 GB 2004003484 W GB2004003484 W GB 2004003484W WO 2005016949 A3 WO2005016949 A3 WO 2005016949A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sialic acid
- acid derivatives
- passivated
- instance
- polysialic acids
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH] (Somatotropin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/44—Antibodies bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
- C07K17/12—Cellulose or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
Abstract
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03254989.1 | 2003-08-12 | ||
EP03254989 | 2003-08-12 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005016949A2 WO2005016949A2 (fr) | 2005-02-24 |
WO2005016949A3 true WO2005016949A3 (fr) | 2005-03-31 |
Family
ID=34178604
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2004/003511 WO2005016974A1 (fr) | 2003-08-12 | 2004-08-12 | Derive d'acide sialique destine a la derivatisation et a la conjugaison proteinique |
PCT/GB2004/003484 WO2005016949A2 (fr) | 2003-08-12 | 2004-08-12 | Derives d'acide sialique |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2004/003511 WO2005016974A1 (fr) | 2003-08-12 | 2004-08-12 | Derive d'acide sialique destine a la derivatisation et a la conjugaison proteinique |
Country Status (7)
Country | Link |
---|---|
US (4) | US7807824B2 (fr) |
EP (1) | EP1654290B1 (fr) |
JP (1) | JP4566194B2 (fr) |
KR (1) | KR101113726B1 (fr) |
ES (1) | ES2735809T3 (fr) |
RU (1) | RU2333223C2 (fr) |
WO (2) | WO2005016974A1 (fr) |
Families Citing this family (52)
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US7807824B2 (en) * | 2003-08-12 | 2010-10-05 | Lipoxen Technologies Limited | Sialic acid derivatives for protein derivatisation and conjugation |
CN101039964B (zh) * | 2004-08-12 | 2012-11-14 | 利普生技术有限公司 | 带电多糖的分级 |
US7645860B2 (en) | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
KR101400105B1 (ko) * | 2006-07-25 | 2014-06-19 | 리폭센 테크놀로지즈 리미티드 | N-말단 폴리시알화 |
GB0615067D0 (en) * | 2006-07-28 | 2006-09-06 | Ttp Communications Ltd | Reconfigurable signal processing scheme |
CA2670618C (fr) | 2006-12-15 | 2016-10-04 | Baxter International Inc. | Conjugue du facteur viia et de l'acide (poly)sialique presentant une demi-vie in vivo prolongee |
PL2115010T3 (pl) * | 2007-02-28 | 2012-07-31 | Lipoxen Tech Limited | Zmniejszanie zawartości endotoksyny w kwasach polisialowych |
WO2008113192A1 (fr) * | 2007-03-16 | 2008-09-25 | Bien-Air Holding S.A. | Piece a main a usage dentaire ou chirurgical |
JP4966434B2 (ja) * | 2008-10-15 | 2012-07-04 | バクスター・インターナショナル・インコーポレイテッド | 結合抗体の存在下における組換え血液凝固因子のpeg化 |
US8716448B2 (en) | 2009-02-03 | 2014-05-06 | Amunix Operating Inc. | Coagulation factor VII compositions and methods of making and using same |
TW201042257A (en) * | 2009-05-26 | 2010-12-01 | Baxter Int | Detection of antibody that binds to water soluble polymer-modified polypeptides |
KR101912335B1 (ko) * | 2009-07-27 | 2018-10-26 | 리폭센 테크놀로지즈 리미티드 | 비혈액 응고 단백질의 글리코폴리시알화 |
ES2597954T3 (es) | 2009-07-27 | 2017-01-24 | Baxalta GmbH | Conjugados de proteína de la coagulación sanguínea |
NZ623810A (en) | 2009-07-27 | 2015-10-30 | Lipoxen Technologies Ltd | Glycopolysialylation of non-blood coagulation proteins |
RU2522846C2 (ru) * | 2009-11-30 | 2014-07-20 | Российская Федерация, От Имени Которой Выступает Министерство Промышленности И Торговли Российской Федерации | Лекарственный препарат и способ улучшения реологических свойств мокроты и ингаляционное применение такого препарата |
JP5914363B2 (ja) | 2010-02-16 | 2016-05-11 | ノヴォ ノルディスク アー/エス | 低減されたvwf結合を有する因子viii分子 |
MX346271B (es) | 2010-07-30 | 2016-07-08 | Baxalta Inc | Catalizadores nucleofílicos para enlace de oxima. |
BR112013015898A2 (pt) | 2010-12-22 | 2018-06-26 | Baxter International Inc. | derivado de ácido graxo solúvel em água, e, métodos para preparar um derivado de ácido graxo e uma proteína terapêutica conjugada. |
EP3412314A1 (fr) | 2011-05-27 | 2018-12-12 | Baxalta GmbH | Protéines thérapeutiques conjuguées au poly(acide sialique) et leurs procédés de préparation |
WO2012170969A2 (fr) | 2011-06-10 | 2012-12-13 | Biogen Idec Ma Inc. | Composés pro-coagulants et leurs procédés d'utilisation |
TWI596110B (zh) | 2011-09-23 | 2017-08-21 | 諾佛 儂迪克股份有限公司 | 新穎升糖素類似物 |
NZ626945A (en) | 2012-01-12 | 2016-10-28 | Biogen Ma Inc | Chimeric factor viii polypeptides and uses thereof |
CN111548418A (zh) | 2012-02-15 | 2020-08-18 | 比奥贝拉蒂治疗公司 | 因子viii组合物及其制备和使用方法 |
KR20190094480A (ko) | 2012-02-15 | 2019-08-13 | 바이오버라티브 테라퓨틱스 인크. | 재조합 인자 viii 단백질 |
AU2013204754C1 (en) | 2012-05-16 | 2018-10-11 | Takeda Pharmaceutical Company Limited | Nucleophilic Catalysts for Oxime Linkage |
AU2013270683A1 (en) | 2012-06-08 | 2014-12-11 | Biogen Ma Inc. | Chimeric clotting factors |
EP2858659B1 (fr) | 2012-06-08 | 2019-12-25 | Bioverativ Therapeutics Inc. | Composés pro-coagulants |
PT2882450T (pt) | 2012-07-11 | 2020-02-19 | Bioverativ Therapeutics Inc | Complexo de fator viii com xten e a proteína fator de von willebrand, e utilizações do mesmo |
WO2014170496A1 (fr) | 2013-04-18 | 2014-10-23 | Novo Nordisk A/S | Co-agonistes stables du récepteur du glucagon/glp -1 à action retardée et à usage médical |
TW202003554A (zh) | 2013-08-14 | 2020-01-16 | 美商百歐維拉提夫治療公司 | 因子viii-xten融合物及其用途 |
EP3903599A1 (fr) | 2013-09-25 | 2021-11-03 | Bioverativ Therapeutics Inc. | Procédés d'inactivation de virus sur colonne |
WO2015070014A1 (fr) | 2013-11-08 | 2015-05-14 | Biogen Idec Ma Inc. | Composé de fusion procoagulant |
SI3091997T1 (sl) | 2014-01-10 | 2022-10-28 | Bioverativ Therapeutics Inc. | Himerni proteini faktorja VIII in njihova uporaba |
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MA40835A (fr) | 2014-10-23 | 2017-08-29 | Biogen Ma Inc | Anticorps anti-gpiib/iiia et leurs utilisations |
MA40861A (fr) | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | Anticorps anti-glycoprotéines iib/iiia |
JP6909203B2 (ja) | 2015-08-03 | 2021-07-28 | バイオベラティブ セラピューティクス インコーポレイテッド | 第ix因子融合タンパク質及びそれらの製造方法及び使用方法 |
AU2016362606A1 (en) | 2015-12-03 | 2018-06-28 | Takeda Pharmaceutical Company Limited | Factor VIII with extended half-life and reduced ligand-binding properties |
MA45473A (fr) | 2016-04-04 | 2019-02-13 | Shire Human Genetic Therapies | Inhibiteur de c1 estérase conjugué et ses utilisations |
CZ308106B6 (cs) * | 2016-06-27 | 2020-01-08 | Contipro A.S. | Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití |
CN109890413B (zh) | 2016-09-02 | 2024-04-16 | 赛诺菲巴斯德股份有限公司 | 脑膜炎奈瑟氏菌疫苗 |
WO2018175752A1 (fr) * | 2017-03-22 | 2018-09-27 | Genentech, Inc. | Compositions d'anticorps optimisées pour le traitement de troubles oculaires |
US20190083636A1 (en) | 2017-04-25 | 2019-03-21 | Lipoxen Technologies Limited | Methods of treating diseases related to net formation with parenteral administration of polysialylated dnase i |
WO2018197545A1 (fr) | 2017-04-25 | 2018-11-01 | Lipoxen Technologies Limited | Procédés de traitement de myélomes multiples exprimant des niveaux élevés de récepteur d'epo à l'aide de psa-epo |
MX2020009975A (es) | 2018-03-28 | 2020-10-12 | Bristol Myers Squibb Co | Proteinas de fusion interleucina-2/receptor alfa de interleucina-2 y metodos de uso. |
PE20210632A1 (es) | 2018-07-03 | 2021-03-23 | Bristol Myers Squibb Co | Formulaciones de fgf-21 |
WO2020099513A1 (fr) | 2018-11-13 | 2020-05-22 | Lipoxen Technologies Limited | Glyco-polysialylation de blinatumomab |
JP2022519586A (ja) * | 2019-02-04 | 2022-03-24 | ゼネティック バイオサイエンシーズ インコーポレイテッド | 糖ポリシアル酸化治療用タンパク質を使用する方法 |
EP3986918A1 (fr) | 2019-06-18 | 2022-04-27 | Bayer Aktiengesellschaft | Analogues d'adrénomédulline pour stabilisation à long terme et leur utilisation |
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EP0273388A2 (fr) * | 1986-12-29 | 1988-07-06 | Mect Corporation | Dérivés de l'acide sialique ayant un groupe carbonyl réactif |
EP0454898A1 (fr) * | 1990-03-30 | 1991-11-06 | Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) | Protéine modifiée avec glycosaminoglycanes, son procédé de production et compositions pharmaceutiques le contenant |
WO1998015566A1 (fr) * | 1996-10-08 | 1998-04-16 | Macquarie Research Ltd. | Derives de glycane |
EP1035137A1 (fr) * | 1999-03-12 | 2000-09-13 | Pasteur Merieux Serums Et Vaccins | Procédé d'amination réductrice des polysaccharides |
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WO2001087922A2 (fr) | 2000-05-16 | 2001-11-22 | Lipoxen Technologies Limited | Derivatisation de proteines |
US7807824B2 (en) * | 2003-08-12 | 2010-10-05 | Lipoxen Technologies Limited | Sialic acid derivatives for protein derivatisation and conjugation |
WO2005016973A1 (fr) * | 2003-08-12 | 2005-02-24 | Lipoxen Technologies Limited | Derives d'acide polysialique |
KR101400105B1 (ko) * | 2006-07-25 | 2014-06-19 | 리폭센 테크놀로지즈 리미티드 | N-말단 폴리시알화 |
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2004
- 2004-08-12 US US10/568,043 patent/US7807824B2/en active Active
- 2004-08-12 KR KR1020067002900A patent/KR101113726B1/ko active IP Right Grant
- 2004-08-12 RU RU2006107546/04A patent/RU2333223C2/ru active
- 2004-08-12 ES ES04768074T patent/ES2735809T3/es active Active
- 2004-08-12 WO PCT/GB2004/003511 patent/WO2005016974A1/fr active Application Filing
- 2004-08-12 EP EP04768074.9A patent/EP1654290B1/fr not_active Expired - Fee Related
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2010
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0273388A2 (fr) * | 1986-12-29 | 1988-07-06 | Mect Corporation | Dérivés de l'acide sialique ayant un groupe carbonyl réactif |
EP0454898A1 (fr) * | 1990-03-30 | 1991-11-06 | Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) | Protéine modifiée avec glycosaminoglycanes, son procédé de production et compositions pharmaceutiques le contenant |
WO1998015566A1 (fr) * | 1996-10-08 | 1998-04-16 | Macquarie Research Ltd. | Derives de glycane |
EP1035137A1 (fr) * | 1999-03-12 | 2000-09-13 | Pasteur Merieux Serums Et Vaccins | Procédé d'amination réductrice des polysaccharides |
Non-Patent Citations (1)
Title |
---|
WINZLER R. J.: "Effect of periodate oxidation and borohydride reduction on the biology of the major glycoprotein of human erythrocytes", CELL. ANTIGENS, LECT. SUM. CONF. 1972, MEETING DATE 1971, vol. 1972, 1972, pages 145 - 152, XP008042203 * |
Also Published As
Publication number | Publication date |
---|---|
US9452224B2 (en) | 2016-09-27 |
RU2333223C2 (ru) | 2008-09-10 |
KR101113726B1 (ko) | 2012-02-27 |
WO2005016949A2 (fr) | 2005-02-24 |
US20140220046A1 (en) | 2014-08-07 |
US20170007706A1 (en) | 2017-01-12 |
EP1654290A1 (fr) | 2006-05-10 |
US8653255B2 (en) | 2014-02-18 |
US20110082077A1 (en) | 2011-04-07 |
US7807824B2 (en) | 2010-10-05 |
EP1654290B1 (fr) | 2019-03-13 |
RU2006107546A (ru) | 2007-09-20 |
KR20060096981A (ko) | 2006-09-13 |
US20070191597A1 (en) | 2007-08-16 |
US10406209B2 (en) | 2019-09-10 |
JP2007501889A (ja) | 2007-02-01 |
ES2735809T3 (es) | 2019-12-20 |
JP4566194B2 (ja) | 2010-10-20 |
WO2005016974A1 (fr) | 2005-02-24 |
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