WO2006090265A3 - Procedes de preparation de levetiracetam, son intermediaire et utilisation de levetiracetam dans des compositions pharmaceutiques - Google Patents

Procedes de preparation de levetiracetam, son intermediaire et utilisation de levetiracetam dans des compositions pharmaceutiques Download PDF

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Publication number
WO2006090265A3
WO2006090265A3 PCT/IB2006/000424 IB2006000424W WO2006090265A3 WO 2006090265 A3 WO2006090265 A3 WO 2006090265A3 IB 2006000424 W IB2006000424 W IB 2006000424W WO 2006090265 A3 WO2006090265 A3 WO 2006090265A3
Authority
WO
WIPO (PCT)
Prior art keywords
levetiracetam
preparation
processes
pharmaceutical compositions
formula
Prior art date
Application number
PCT/IB2006/000424
Other languages
English (en)
Other versions
WO2006090265A2 (fr
Inventor
Surender Kumar Dhingra
Surinder Kumar Arora
Kaptan Singh
Mohan Prasad
Yatendra Kumar
Original Assignee
Ranbaxy Lab Ltd
Surender Kumar Dhingra
Surinder Kumar Arora
Kaptan Singh
Mohan Prasad
Yatendra Kumar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Surender Kumar Dhingra, Surinder Kumar Arora, Kaptan Singh, Mohan Prasad, Yatendra Kumar filed Critical Ranbaxy Lab Ltd
Publication of WO2006090265A2 publication Critical patent/WO2006090265A2/fr
Publication of WO2006090265A3 publication Critical patent/WO2006090265A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des procédés permettant de préparer (S)-2-aminobutanamide de la formule I ainsi que l'utilisation du composé de la formule I comme intermédiaire pour la préparation de lévétiracétam de formule II. L'invention concerne également un procédé de préparation de lévétiracétam et des compositions pharmaceutiques comportant le lévétiracétam.
PCT/IB2006/000424 2005-02-28 2006-02-28 Procedes de preparation de levetiracetam, son intermediaire et utilisation de levetiracetam dans des compositions pharmaceutiques WO2006090265A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN435/DEL/2005 2005-02-28
IN435DE2005 2005-02-28

Publications (2)

Publication Number Publication Date
WO2006090265A2 WO2006090265A2 (fr) 2006-08-31
WO2006090265A3 true WO2006090265A3 (fr) 2006-10-19

Family

ID=36385096

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2006/000424 WO2006090265A2 (fr) 2005-02-28 2006-02-28 Procedes de preparation de levetiracetam, son intermediaire et utilisation de levetiracetam dans des compositions pharmaceutiques

Country Status (1)

Country Link
WO (1) WO2006090265A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008077035A2 (fr) * 2006-12-18 2008-06-26 Dr. Reddy's Laboratories Ltd. Procédés de préparation de lévétiracétam
CN102558012B (zh) * 2012-03-15 2013-12-25 台州市知青化工有限公司 一种左乙拉西坦的合成方法
CN102898324A (zh) * 2012-10-19 2013-01-30 阜新龙瑞化工有限责任公司 一种(s)-2-氨基丁酰胺盐酸盐的制备方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4696943A (en) * 1984-05-15 1987-09-29 U C B Societe Anonyme (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
WO2004069796A2 (fr) * 2003-02-03 2004-08-19 Teva Pharmaceutical Industries Ltd. Procede de production de levetiracetam
EP1566376A1 (fr) * 2004-02-18 2005-08-24 Dr. Reddy's Laboratories Limited Préparation d'amides d'aminoacides

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4696943A (en) * 1984-05-15 1987-09-29 U C B Societe Anonyme (S)-alpha-ethyl-2-oxo-1-pyrrolidineacetamide
WO2004069796A2 (fr) * 2003-02-03 2004-08-19 Teva Pharmaceutical Industries Ltd. Procede de production de levetiracetam
EP1566376A1 (fr) * 2004-02-18 2005-08-24 Dr. Reddy's Laboratories Limited Préparation d'amides d'aminoacides

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KENDA, BENOIT M. ET AL: "Discovery of 4-Substituted Pyrrolidone Butanamides as New Agents with Significant Antiepileptic Activity", JOURNAL OF MEDICINAL CHEMISTRY , 47(3), 530-549 CODEN: JMCMAR; ISSN: 0022-2623, 2004, XP002383261 *
KOENIGS ERNST, MYLO BRUNO: "über einige Amide von Aminosäuren", CHEMISCHE BERICHTE, vol. 41, 1908, pages 4427 - 4443, XP009067193 *

Also Published As

Publication number Publication date
WO2006090265A2 (fr) 2006-08-31

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