WO2005000262A1 - Composition cosmetique utilisant un medicament a base d'herbes - Google Patents

Composition cosmetique utilisant un medicament a base d'herbes Download PDF

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Publication number
WO2005000262A1
WO2005000262A1 PCT/KR2004/001570 KR2004001570W WO2005000262A1 WO 2005000262 A1 WO2005000262 A1 WO 2005000262A1 KR 2004001570 W KR2004001570 W KR 2004001570W WO 2005000262 A1 WO2005000262 A1 WO 2005000262A1
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WIPO (PCT)
Prior art keywords
weight
range
cosmetic composition
effect
skin
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Application number
PCT/KR2004/001570
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English (en)
Inventor
Joon Shik Shin
Duk Kyun Ahn
Young Ock Kim
Original Assignee
Joon Shik Shin
Duk Kyun Ahn
Young Ock Kim
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Filing date
Publication date
Application filed by Joon Shik Shin, Duk Kyun Ahn, Young Ock Kim filed Critical Joon Shik Shin
Priority claimed from KR1020040048735A external-priority patent/KR100585444B1/ko
Publication of WO2005000262A1 publication Critical patent/WO2005000262A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention relates to a cosmetic composition comprising herb medicines effective in anti-aging of skin and treating acne.
  • the present invention relates to the cosmetic composition comprising the mixture prepared by mixing each extract of Glycyrrhizae Radix, Lonicera japonica, Polygonum multiflorum, Taraxacum platycarpum, Aloe ferox, chestnut inner shell, Angelica dahurica, Scutellaria baicalensis, Poria cocos, Saururus chinensis, rice bran, Coptis chinensis and Ostrea gigas' at a constant mixed ratio.
  • the cosmetic composition of the present invention is good for skin and health care, and in particular, can be effectively used for improving skin resilience, hydration, diminishing pores, anti-wrinkle and treating acne.
  • the term "protection of the face” means to make senescence retarded, and therefore, protection of the. facial skin is to maintain natural beauty of health such as ruddy complexion, gloss, resilience, whitening and hydration.
  • a novel effective ingredient for cosmetics or a technique for removing facial wrinkles has been drawing much attention in line with people's desire to keep and maintain younger physical appearances during senescence as human's life span lengthens due to development in science.
  • the skin is one of most complex organs which comprises an epidermal layer, a dermal layer, a boundary layer between them and subcutaneous adipose tissue layer. A wrinkle is formed as a result of many comprehensive changes occurred at these layers.
  • the process of forming a wrinkle begins with gradually spreading a papillary layer's winding, a boundary region located between the epidermal layer and the dermal layer, and losing adhesive power to a scleroprotein fiber, which results in making skin surface drooped by degrees. Then, a change in the epidermal tissue occurs, and in particular, skin flexibility becomes decreased due to denaturation of fibrous tissue, and subcutaneous fats gradually crowd into the lower part and are newly distributed.
  • a basic principle of cosmetics for anti-wrinkle is to increase thickness of the epidermal layer by improving hydration state of a stratum corneum and quality of a natural cutaneous sebaceous layer.
  • a fibroblast in the dermal layer is stimulated to increase the production of collagen, elastine (scleroprotein), proteoglycan and glycoprotein.
  • elastine sebaceous protein
  • proteoglycan and glycoprotein.
  • the effect to be obtained at the epidermis can be achieved by using an emulsion of good quality comprising a moisturizing ingredient.
  • An acne called comedo in Chinese medical science breaks out when heat accumulates in blood vessels of stomach and colon due to dyspepsia, constipation or irregular diets, sebaceous glands' function increases as a result of imbalanced endocrine system during growth, and bacteria proliferate at the increased sebaceous glands.
  • An acne remedy in Chinese medical science is based on a theory of 'Clear- up of heat and toxic material' by liberating the heat accumulated at the internal organs, making clear the blood, and restoring the cause of internal disproportion.
  • the acne may be treated with an anti-histamine agent, a tranquillizer or a steroid agent.
  • Chinese medical science regards that a respiratory system including lung and colon manages skin functions, and thus, skin diseases are caused by weakening cutaneous immunity due to functional disorder of the respiratory system or malfunction of an autonomic nerve system.
  • the skin diseases may categorized into two groups that one is excess syndrome caused by morbidly accelerating the viscera's function dealing with the skin and the other is deficiency syndrome caused by falling the function.
  • the key point of Chinese medical science is to mitigate the difference of the visceral functions that induces the excess and deficiency syndrome. While the excess syndrome showing rash and severe itching is the case of having high fever in a body and is mostly found in Soyangin or heat Taeeumin, the deficiency syndrome taken ill when exposed to cold atmosphere can be easily seen in Soeumin or cold Taeeumin who has a weak and cold constitution susceptible to weakening the physical function. The excess syndrome is treated by liberating internal thermal toxicity and the deficiency syndrome is treated by supplementing the viscera's deficient function using herb medicines that are effective in immunopotentiation.
  • the present inventors have endeavored to develop cosmetic ingredients effective in anti-aging of skin (anti-wrinkle, hydration, resilience and so on), diminishing pores and treating acne by protecting a stratum corneum.
  • a cosmetic composition comprising the mixture prepared by mixing each extract of Glycyrrhizae Radix, Lonicera japonica, Polygonum multiflorum, Taraxacum platycarpum, Aloe ferox, chestnut inner shell, Angelica dahurica, Scutellaria baicalensis, Poria cocos, Saururus chinensis, rice bran, Coptis chinensis and Ostrea gigas at a constant mixed ratio.
  • the cosmetic composition of the present invention is good for skin and health care, and in particular, can be effectively used for improving skin resilience, hydration, diminishing pores, anti-wrinkle and treating acne.
  • an object of the present invention is to provide a cosmetic composition effective in anti-aging and treating acne which comprises extracts of
  • Glycyrrhizae Radix Lonicera japonica, Polygonum multiflorum, Taraxacum platycarpum,
  • Fig. 1 shows the result of comparing the therapeutic effect on acne of the cosmetic composition of the present invention before and after the use.
  • Fig. 2 shows the result of comparing the anti-wrinkle effect of the cosmetic composition of the present invention before (A) and after (B) the use.
  • Fig. 3 shows the result of comparing the skin hydration effect of the cosmetic composition of the present invention before and after the use.
  • Fig. 4 shows the result of comparing the effect of diminishing pores of the cosmetic composition of the present invention before (A) and after (B) the use.
  • Fig. 1 shows the result of comparing the therapeutic effect on acne of the cosmetic composition of the present invention before and after the use.
  • Fig. 2 shows the result of comparing the anti-wrinkle effect of the cosmetic composition of the present invention before (A) and after (B) the use.
  • Fig. 3 shows the result of comparing the skin hydration effect of the cosmetic composition of the present invention before and after the use.
  • Fig. 4 shows the result of comparing the effect
  • Fig. 5 shows the result of comparing the protective effect on a stratum corneum of the cosmetic composition of the present invention before and after the use.
  • Fig. 6 shows the result of comparing the inhibitory effect on pigment deposition of the cosmetic composition of the present invention before and after the use.
  • Fig. 7 shows the result of comparing the anti-aging effect of the cosmetic composition of the present invention before and after the use.
  • Fig. 8 shows the result of comparing the effect of reducing the ratio of redness at a target site of the cosmetic composition of the present invention before and after the use.
  • the present invention provides a cosmetic composition effective in anti- aging and treating acne which is prepared by mixing each extract of Glycyrrhizae Radix, Lonicera japonica, Polygonum multiflorum, Taraxacum platycarpum, Aloe ferox, chestnut inner shell, Angelica dahurica, Scutellaria baicalensis, Poria cocos, Saururus chinensis, rice bran, Coptis chinensis and Ostrea gigas at a constant mixed ratio.
  • the present invention relates to a cosmetic composition
  • a cosmetic composition comprising the mixed extract of Glycyrrhizae Radix, Lonicera japonica, Polygonum multiflorum, Taraxacum platycarpum, Aloe ferox, chestnut inner shell, Angelica dahurica, Scutellaria baicalensis, Poria cocos, Saururus chinensis, rice bran, Coptis chinensis and Ostrea gigas which is effective in improving resilience, hydration, diminishing pores, anti- wrinkle, treating acne and alleviating skin irritation.
  • the cosmetic composition of the present invention can maximize the effect of improving skin condition with minimizing side effects and be effectively used as a safe material for preparing cosmetics.
  • Constituents of the cosmetic composition of the present invention are described in detail, as follows. Glycyrrhizae Radix having the decholesterol effect can prevent sclerosis of arteries, detoxify a poisonous material, and strengthen liver function.
  • the cosmetic composition of the present invention comprises the Glycyrrhizae Radix in the range of 5 to 15 weight %. If it is used less than 5 weight%, the effect of diminishing pores becomes insignificant, while if it is used more than 15 weight%, it would result in edema.
  • the cosmetic composition of the present invention comprises the Lonicera japonica in the range of 4 to 15 weight% to exert synergic effect with other herb medicines. If it is used less than 4 weight%, there is a problem of unduly exfoliating a stratum corneum. In contest, if it is used more than 15 weight%, it gives out strong fragrance. Polygonum multiflorum shows activities of developing stamina, strengthening hematopoietic function, stimulating fatigue recovery and tranquilizing.
  • the cosmetic composition comprises the Polygonum multiflorum in the range of 5 to 15 weight%. If it is used less than 5 weight%, the effects of anti- wrinkle and improving cutaneous resilience are insignificant, and if it is used more than 15 weight%, it may cause a diarrhea.
  • Taraxacum platycarpum commonly known as a dandelion for its pharmaceutical name, makes pus easily oozed out and is effective in treating gastroenteropathy, asthma, bronchitis, chronic hepatitis and edema.
  • the cosmetic composition of the present invention comprises the Taraxacum platycarpum in the range of 4 to 15 weight%.
  • the cosmetic composition of the present invention comprises the Aloe ferox in the range of 3 to 10 weight %. If it is used less than 3 weight%, the effects of hydration and diminishing pores become insignificant, while if it is used more than 10 weight%, it becomes too viscous to be used as a cosmetic ingredient.
  • Chestnut inner shell is effective in whitening, oily skin, detoxification, astringency, resilience, contraction of pores (in particular, sweat pores) and anti- wrinkle.
  • the cosmetic composition of the present invention comprises the chestnut inner shell in the range of 3 to 15 weight%. If it is used less than 3 weight%, the effects of anti-wrinkle and diminishing pores become insignificant, while if it is used more than 15 weight%, the mixture becomes insoluble.
  • Angelica dahurica has been widely used for treating a cold, a headache, a dental pain, hemostasis, women's disease such as bloody flux, hemagogue and piles or nervous disease.
  • the cosmetic composition of the present invention comprises the Angelica dahurica in the range of 8 to 20 weight %.
  • the cosmetic composition comprises the Scutellaria baicalensis in the range of 2 to 5 weight %. If it is used less than 2 weight%, it would not improve skin conditions, while if it is used more than 5 weight%, there is a problem of coloring. Poria cocos is good for robustness, excretion and tranquility, and can be effectively used for treating kidney troubles, cystitis and urethritis.
  • the cosmetic composition of the present invention comprises the Poria cocos in the range of 8 to 15 weight %.
  • the cosmetic composition of the present invention comprises the Saururus chinensis in the range of 2 to 18 weight%. If it is used less than 2 weight%, it would not improve skin conditions, while if it is used more than 18 weight%, there is a problem of occurring a rash. It has been known that rice bran has anti-oxidative activity.
  • the cosmetic composition of the present invention comprises the rice bran in the range of 1 to 3 weight%. If it is used less than 1 weight%, the whitening effect becomes insignificant, while if it is used more than 3 weight%, the mixture becomes coarse, and therefore, it is difficult to spread it on the skin.
  • the rice bran it is possible to use Phellodendron amurense for obtaining the same whitening effect.
  • the cosmetic composition is yellowish when prepared by using the Phellodendron amurense, it is preferable to use the rice bran considering its commercial value.
  • Coptis chinensis inhibits bacterial growth and proliferation by inhibiting DNA replication and shows strong anti-inflammatory and immunopotentiating effects.
  • the cosmetic composition of the present invention comprises the Coptis chinensis in the range of 1 to 3 weight%. If it is used less than 1 weight%, the effect of improving skin is too poor, while if it is used more than 3 weight%, there will be a coloring problem. Ostrea gigas has immunopotentiating effect and sedative activity.
  • the cosmetic composition of the present invention comprises the Ostrea gigas in the range of 3 to 15 weight%. If it is used less than 3 weight%, the effect of improving skin becomes too poor, while if it is used more than 15 weight%, there is a problem that the skin becomes hardened.
  • the above-mentioned herb medicines are extracted with a solvent selected from the group consisting of water, 30% aqueous ethanol solution, 80% aqueous 1,3-butyleneglycol solution and 40% aqueous propyleneglycol solution, respectively, and then, each extract is mixed at a predetermined mixed ratio as described above, to obtain a mixed extract.
  • the mixed extract can be prepared by mixing the herb medicines at a predetermined mixed ratio as described above, and extracting them with the solvent selected from the group consisting of water, 30% aqueous ethanol solution, 80% aqueous 1,3-butyleneglycol solution and 40% aqueous propyleneglycol solution.
  • the mixed extract is extracted by heat at 95 to 100 °C for 2.5 to 3.5 in a distiller equipped with a cooling condenser, and the resulting extract is subjected to filtration.
  • a residue thus obtained is subjected to solvent extraction one more time according to the same method as described above, and the resulting extract is subjected to filtration again.
  • a filtrate thus obtained is concentrated under reduced pressure and freeze-dried to prepare the mixed extract of herb medicines. It has been confirmed that the mixed extract shows the effects of anti-wrinkle, hydration, diminishing pores, preventing a stratum corneum, inhibiting pigment deposition, treating acne, inhibiting red degree, alleviating skin irritation and so on, and therefore, can be effectively used for improving skin conditions.
  • the mixed extract of the present invention to basic cosmetics (astringent, lotion, cream, essence, cleansing foam, cleansing water, pack) or make-up cosmetics (foundation, make-up base, powder) in the range of 0.001 to 10.0 weight% based on a dry weight of cosmetic ingredients.
  • basic cosmetics astringent, lotion, cream, essence, cleansing foam, cleansing water, pack
  • make-up cosmetics foundation, make-up base, powder
  • Examples 1 and 2 An extract was prepared by extracting herb medicines having constitutions and contents as shown in Table 1 with water, and re-extracted by heating at 100 ° C for 3 hrs in a distiller equipped with a cooling condenser. The extract was filtered to obtain a residue, and then, the residue was subjected to the same extraction one more time as described above. The resulting extract was filtered with a filter paper, concentrated under reduced pressure, and freeze-dried. [Table 1]
  • Constitutions of item D were gradually added to distilled water (B) and agitated until the mixture became soft.
  • Constitutions of item F were added to the mixture.
  • Polyethylene glycol was dissolved in octyl dodecanol of item D, and then, constitutions of item E were mixed thereto.
  • the evenly dispersed extract of Example 1 (A) was added to the mixture and mixed until the mixture became homogeneous. Finally, constitutions of item C were added to the resulting mixture.
  • Test Example 1 Therapeutic effect on acne
  • the cream prepared in Preparation Example 1 was applied to a patient's forehead, check and nose. Five days after that, the therapeutic effect on acne of the experimental group was compared with that of the control group without the treatment of the cream.
  • the therapeutic effect on acne was measured by applying a magnetic surface of a skin measuring instrument (IDIPS) to the forehead, check and nose of the patient, and the result was shown in Fig. 1, where y axis represents a relative value of the experimental group with regard to a perfect value of the therapeutic effect on acne as 5 points. The perfect value was 5 points and the lowest point was zero.
  • IDIPS skin measuring instrument
  • Test Example 2 Anti-wrinkle effect 60 subjects at the age of 30 or older having facial wrinkles were selected and subdivided into 3 groups consisting of 20 subjects. Each group was allowed to use the cream of Preparation Example 1. Before the use, skin conditions of both sides (left and right) of face were measured, and 5 days after that, they were repeatedly measured at the same sites to estimate the change in facial wrinkles. The skin conditions were measured in a thermohygrostatic room kept at 24 ° C and 40% of relative humidity. Wrinkles around the outer corner of the eyes were reproduced with a replica, and the facial wrinkles were measured with a facial wrinkle measuring instrument (Visiometer system; C+K Inc.).
  • the replica's image was three-dimensionally analyzed with a CCD (Charge Coupled Device) camera, and the depth and orientation of wrinkles were measured using a computer.
  • the facial wrinkles were analyzed by measuring the change in height of wrinkles between before the use of the cream and 5 days after the use of the cream
  • Test Example 3 Skin hydration effect
  • the cream prepared in Preparation Example 1 was applied to a patient's forehead, check and nose, and 5 days after that, the skin hydration effect of the experimental group was compared with that of the control group without the treatment of the cream.
  • the skin hydration effect was measured by applying a magnetic surface of a skin measuring instrument (IDIPS) to the forehead, check and nose of the patient, and the result was shown in Fig. 1.
  • IDIPS skin measuring instrument
  • y axis represents a relative value of the experimental group with respect to a perfect value of the skin hydration effect as 5 points.
  • the perfect value was 5 points and the lowest point was zero.
  • the skin hydration effect after the treatment with the cream of Preparation Example 1 was 4.2 points, which was 113.1% higher than that before the treatment.
  • Test Example 4 Test for a sense of use An essence prepared with the constitution of Example 1 was directly applied to the face of 100 adult female women. After 20 min, the essence was removed and a sensory test such as the feeling of use was carried out. The sensory test marked based on a 3-point classifying method.
  • the sensory test criterion of the feeling of use 19 extremely satisfaction in the feeling of use : ordinary satisfaction in the feeling of use x : dissatisfaction in the feeling of use
  • Test Example 5 Effect of cutaneous irritation An essence prepared with the constitution of Example 2 was patched to the brachial skin of 30 female volunteers (18 to 25 years old) having a healthy skin. 24 hrs after the patch test, the patch was removed and the level of cutaneous irritation was measured. As a result of analyzing skin reaction after 24 hrs that, it was found that there was no meaningful cutaneous irritation.
  • Test Example 6 Effect of improving skin An essence prepared with the constitution of Example 1 was spread onto the face and forearm of 50 adult males and females twice daily for a period of 2 weeks, and skin condition was observed with naked eyes. Further, a questionaire on the skin conditions was carried out in parallel with visual observations and the result was analyzed [Table 2]. At this time, a criterion for estimation was as follows [1; very large, 2; large, 3; normal, 4; small, 5; very small]. [Table 2]
  • Test Example 7 Effect of diminishing pores
  • the cream prepared in Preparation Example 1 was applied to a patient's forehead, check and nose, and 5 days after that, the effect of diminishing pores of the experimental group was compared with that of the control group without the treatment of the cream.
  • the effect of diminishing pores was measured by applying a magnetic surface of a skin measuring instrument (IDIPS) to the forehead, check and nose of the patient, and the result is shown in Fig. 4.
  • IDIPS skin measuring instrument
  • the pore size measured after the treatment with the cream was 294.3 ⁇ 41.4 ⁇ m which was higher than that before the treatment (686.6 ⁇ 137 ⁇ m). From this result, it was found that the cosmetic composition of the present invention had a significantly high effect of diminishing pores.
  • Test Example 8 Effect of protecting stratum corneum Epidermis is generated at ectodermal epithelium and comprises stratum corneum, stratum lucidium, stratum granulosum, stratum spinosum and stratum basale.
  • stratum spinosum and stratum basale called stratum germinativum are the parent matrix for the epidermal cell and divides to generate a new epidermis.
  • the old epidermis may be replaced by a young and soft stratum corneum for a period of 28 days, which is called keratinization. If active skin metabolism is inhibited at the cutaneous stratum corneum, a large quantity of grime is generated on the skin, skin pores are clogged, and accordingly, an acne breaks out.
  • the acne can be treated by making sebum excretion reduced, softening follicles and stratum corneum to reduce the number of bacteria in the follicles, peeling off the stratum corneum to prevent the follicles from destroying, and preventing the acne from being inflamed.
  • the cream prepared in Preparation Example 1 was applied to a patient's forehead, check and nose, and 5 days after that, the effect of protecting the stratum corneum of the experimental group was compared with that of the control group without the treatment of the cream.
  • the effect of protecting the stratum corneum was measured by applying a magnetic surface of a skin measuring instrument (IDIPS) to the forehead, check and nose of the patient, and the result was shown in Fig.
  • IDIPS skin measuring instrument
  • y axis represents a relative value of the experimental group with regard to a perfect value of the effect of protecting the stratum corneum as 5 points.
  • the perfect value was 5 points and the lowest point was zero.
  • the effect of protecting the stratum corneum after the treatment with the cream of Preparation Example 1 was 3.5 points which was 119.4% higher than that of before the treatment.
  • Test Example 9 Effect of preventing pigment deposition
  • the cream prepared in Preparation Example 1 was applied to a patient's forehead, check and nose, and 5 days after that, the effect of preventing pigment deposition of the experimental group was compared with that of the control group without the treatment of the cream.
  • the effect of preventing pigment deposition was measured by applying a magnetic surface of a skin measuring instrument (IDIPS) to the forehead, check and nose of the patient, and the result was shown in Fig. 6, where y axis represents an average pigment deposition rate which was calculated as a relative value of the experimental group with regard to a perfect value of the effect of preventing pigment deposition as 25 points. The perfect value was 25 points and the lowest point was zero.
  • IDIPS skin measuring instrument
  • the average pigment deposition rate after the treatment with the cream of Preparation Example 1 was 10.7 points which was 61.5% lower than that before the treatment (17.3 points).
  • Test Example 10 Anti-aging effect
  • the cream prepared in Preparation Example 1 was applied to a patient's forehead, check and nose, and 5 days after that, the anti-aging effect of the experimental group was compared with that of the control group without the treatment of the cream.
  • the anti-aging effect was measured by applying a magnetic surface of a skin measuring instrument (IDIPS) to the forehead, check and nose of the patient, and the result was shown in Fig. 7, where y axis represented a relative value of the experimental group with regard to a perfect value of the anti- aging effect as 5 points. The perfect value was 5 points and the lowest point was zero.
  • IDIPS skin measuring instrument
  • y axis represented a relative value of the experimental group with regard to a perfect value of the anti- aging effect as 5 points.
  • the perfect value was 5 points and the lowest point was zero.
  • the anti-aging effect after the treatment with the cream of Preparation Example 1 was 4.3 points which was 112.9% higher than that of before the treatment.
  • Test Example 11 Effect of reducing red degree at a target site
  • the cream prepared in Preparation Example 1 was applied to a patient's forehead, check and nose, and 5 days after that, the effect of reducing red degree of the experimental group was compared with that of the control group without the treatment of the cream.
  • the effect of reducing red degree was measured by applying a magnetic surface of a skin measuring instrument (IDIPS) to the forehead, check and nose of the patient, and the result was shown in Fig. 8, where y axis represents a relative value of the experimental group with regard to a perfect value of the effect of reducing red degree as 5 points. The perfect value was 5 points and the lowest point was zero.
  • IDIPS skin measuring instrument
  • the effect of reducing red degree after the treatment with the cream of Preparation Example 1 was 2.3 points which was 89.2% lower than that of before the treatment.
  • the cosmetic composition was prepared by mixing 13 kinds of herb medicines in a certain mixed ratio, it is possible to not only obtain the simultaneous effect of improving skin condition such as anti-aging, whitening, acne remedy and so on, but also maximize the effect at a short time compared with the conventional cosmetic composition used for improving skin conditions.
  • the rice bran instead of the rice bran, it is possible to employ Phellodendron amurense for obtaining the same whitening effect.
  • the cosmetic composition prepared by using the Phellodendron amurense it is yellowish, and accordingly, it is preferable to use the rice bran from a commercial value of view.

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Abstract

La présente invention concerne une composition cosmétique comprenant des extraits de Glycyrrhizae Radix, de Lonicera japonica, de Polygonum multiflorum, de Taraxacum platycarpum, d'Aloe ferox, de brou de châtaigne, d'Angelica dahurican, de Scutellaria baicalensis, de Poria cocos, de Saururus chinensis, de son de riz, de Coptis chinensis et d'Ostrea gigas selon un rapport mélangé constant. Par conséquent, cette composition est bénéfique pour la peau et la santé. Plus particulièrement, elle peut être utilisée efficacement pour augmenter l'élasticité de la peau, l'hydratation et la réduction des pores, comme agent anti-rides et pour traiter l'acné.
PCT/KR2004/001570 2003-06-27 2004-06-28 Composition cosmetique utilisant un medicament a base d'herbes WO2005000262A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2003-0042747 2003-06-27
KR20030042747 2003-06-27
KR1020040048735A KR100585444B1 (ko) 2003-06-27 2004-06-28 한방 약재를 이용한 피부노화 방지 및 여드름 개선용 화장료
KR10-2004-0048735 2004-06-28

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Cited By (9)

* Cited by examiner, † Cited by third party
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FR2902291A1 (fr) * 2005-04-28 2007-12-21 Derma Dev Sarl Nouvel agent conservateur anti bacterien et son procede d'obtention
US20120141613A1 (en) * 2009-08-14 2012-06-07 Amorepacific Corporation Composition containing a natural extract
WO2012135337A2 (fr) * 2011-03-28 2012-10-04 Mary Kay Inc. Formulations topiques de soins pour la peau comprenant des extraits végétaux
CN102716350A (zh) * 2012-05-10 2012-10-10 展继军 一种治疗痤疮的纯中药制剂
CN103655232A (zh) * 2013-12-24 2014-03-26 北海富安源生物科技有限公司 一种含有牡蛎多糖的防晒凝胶剂
WO2014092682A1 (fr) * 2012-12-11 2014-06-19 Avon Products, Inc. Extraits de serissa japonica et méthodes d'utilisation associées
US9034396B2 (en) 2012-12-11 2015-05-19 Avon Products, Inc. Serissa japonica extracts and methods of use
CN110384651A (zh) * 2019-09-05 2019-10-29 广州市华侬化妆品有限公司 修复过敏性皮肤及治疗湿疹的精华液
CN114344237A (zh) * 2022-01-15 2022-04-15 广州市蒂洲生物科技有限公司 一种植物复合麦芽四糖保湿修复剂及其制备方法

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CN103585342A (zh) * 2009-08-14 2014-02-19 株式会社爱茉莉太平洋 含有天然提取物的组合物
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CN103561754A (zh) * 2011-03-28 2014-02-05 玫琳凯有限公司 包含植物提取物的局部护肤制剂
WO2012135337A3 (fr) * 2011-03-28 2013-01-03 Mary Kay Inc. Formulations topiques de soins pour la peau comprenant des extraits végétaux
US11890369B2 (en) 2011-03-28 2024-02-06 Mary Kay Inc. Topical skin care formulations comprising plant extracts
US11833240B2 (en) 2011-03-28 2023-12-05 Mary Kay Inc. Topical skin care formulations comprising plant extracts
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US11752089B2 (en) 2011-03-28 2023-09-12 Mary Kay Inc. Topical skin care formulations comprising plant extracts
WO2012135337A2 (fr) * 2011-03-28 2012-10-04 Mary Kay Inc. Formulations topiques de soins pour la peau comprenant des extraits végétaux
US20120282194A1 (en) * 2011-03-28 2012-11-08 Tiffany Florence Topical skin care formulations comprising plant extracts
US11752090B2 (en) 2011-03-28 2023-09-12 Mary Kay Inc. Topical skin care formulations comprising plant extracts
US11583491B2 (en) 2011-03-28 2023-02-21 Mary Kay Inc. Topical skin care formulations comprising plant extracts
US10328019B2 (en) 2011-03-28 2019-06-25 Mary Kay Inc. Topical skin care formulations comprising plant extracts
US11684562B2 (en) 2011-03-28 2023-06-27 Mary Kay Inc. Topical skin care formulations comprising plant extracts
US11666525B2 (en) 2011-03-28 2023-06-06 Mary Kay Inc. Topical skin care formulations comprising plant extracts
US11607380B2 (en) 2011-03-28 2023-03-21 Mary Kay Inc. Topical skin care formulations comprising plant extracts
CN102716350A (zh) * 2012-05-10 2012-10-10 展继军 一种治疗痤疮的纯中药制剂
US9034396B2 (en) 2012-12-11 2015-05-19 Avon Products, Inc. Serissa japonica extracts and methods of use
US8999403B2 (en) 2012-12-11 2015-04-07 Avon Products, Inc. Serissa japonica extracts and methods of use
WO2014092682A1 (fr) * 2012-12-11 2014-06-19 Avon Products, Inc. Extraits de serissa japonica et méthodes d'utilisation associées
CN103655232B (zh) * 2013-12-24 2016-02-24 北海富安源生物科技有限公司 一种含有牡蛎多糖的防晒凝胶剂
CN103655232A (zh) * 2013-12-24 2014-03-26 北海富安源生物科技有限公司 一种含有牡蛎多糖的防晒凝胶剂
CN110384651B (zh) * 2019-09-05 2022-06-10 广州市华侬化妆品股份有限公司 修复过敏性皮肤及治疗湿疹的精华液
CN110384651A (zh) * 2019-09-05 2019-10-29 广州市华侬化妆品有限公司 修复过敏性皮肤及治疗湿疹的精华液
CN114344237B (zh) * 2022-01-15 2022-11-15 广州市蒂洲生物科技有限公司 一种植物复合麦芽四糖保湿修复剂及其制备方法
CN114344237A (zh) * 2022-01-15 2022-04-15 广州市蒂洲生物科技有限公司 一种植物复合麦芽四糖保湿修复剂及其制备方法

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