WO2004103084A1 - The pour sac d'infusion destine au traitement de l'hypertension et ses procedes de preparation - Google Patents

The pour sac d'infusion destine au traitement de l'hypertension et ses procedes de preparation Download PDF

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Publication number
WO2004103084A1
WO2004103084A1 PCT/CN2003/000739 CN0300739W WO2004103084A1 WO 2004103084 A1 WO2004103084 A1 WO 2004103084A1 CN 0300739 W CN0300739 W CN 0300739W WO 2004103084 A1 WO2004103084 A1 WO 2004103084A1
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WO
WIPO (PCT)
Prior art keywords
teabag
treating hypertension
sunflower
concentrated
hypertension according
Prior art date
Application number
PCT/CN2003/000739
Other languages
English (en)
Chinese (zh)
Inventor
Peixue Ling
Ling Zhang
Lixia Shang
Original Assignee
Peixue Ling
Ling Zhang
Lixia Shang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peixue Ling, Ling Zhang, Lixia Shang filed Critical Peixue Ling
Priority to AU2003261596A priority Critical patent/AU2003261596A1/en
Publication of WO2004103084A1 publication Critical patent/WO2004103084A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
    • A23F3/00—Tea; Tea substitutes; Preparations thereof
    • A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Definitions

  • the invention belongs to the field of traditional Chinese medicine and relates to a new type of teabag for treating hypertension.
  • the present invention also relates to a method for preparing the same. Background technique
  • Hypertension is the most widespread disease in the world today, and it is also an important factor that causes stroke (ie, stroke), coronary heart disease, and renal failure. According to the results of the National Hypertension Sampling Survey, the prevalence of hypertension in people over the age of 15 in China has increased from 5.11% in 959 to 11.88 % in 1991. It is estimated that the number of hypertension patients has reached 100 million at present. With the improvement of people's living standards, it has been increasing year by year. In clinical treatment, due to the many toxic and side effects of western medicine antihypertensive drugs, the application of traditional Chinese medicine to treat hypertension is an important subject in the medical field. In recent years, traditional Chinese medicine has made great progress in the treatment of hypertension and has become one of the means for comprehensive treatment of hypertension.
  • Xiang Yue sunflower leaf is a dried leaf of Helianthus annuus L., a sunflower of the compositae family. It is warm in nature, sweet in taste, and non-toxic. According to reports, sunflower leaves and stem marrow contain a large amount of organic acids such as neochlorogenic acid, isochlorogenic acid, and fumaric acid, and their content is 9-12%. In addition, many acids exist in the form of salts and also contain biological Bases and glycosides such as oleanolic acid glycosides and acacia glycosides. It is precisely because of the above-mentioned various ingredients that Xiang Yuekui itself has a variety of pharmacological effects.
  • sunflower seeds can inhibit nitrosamine-induced precancerous lesions in rats; sunflower roots can cure gastric stagnation and pain, and the two can't pass; sunflower stems can cure chyluria, urination, and urethral stones; sunflower disk can treat Urine retention, extracted from sunflower disk, "Kwai Pan antihypertensive tablets," the clinical effect is ideal. Since sunflower is generally not used as a traditional Chinese medicine in clinical applications, it is limited to replacement pages (Article 26 of the detailed rules) In the above literature (for details, see “Heilongjiang Medicine” 1995 Vol. 1 No. 5). The "Kwai Pan Antihypertensive Tablets" reported in the literature has not been used clinically and sold. So far, no report has been made on the extraction and isolation of active ingredients and effective parts from sunflower leaves for the treatment of hypertension. Disclosure of the Invention
  • the object of the present invention is to provide a new teabag for treating hypertension.
  • Another object of the present invention is to provide a method for preparing a teabag for treating hypertension.
  • the teabag for treating hypertension is characterized in that: the teabag contains sunflower leaves.
  • Preparation method of teabag for treating hypertension scented teabag: Wash, dry, crush, and bag sunflower leaves; the drying temperature is 50 ⁇ 80 ° C.
  • the teabag for treating hypertension is characterized in that the teabag contains a sunflower leaf extract prepared by any extraction process.
  • sunflower leaf is dried, crushed, and extracted by water extraction and alcohol precipitation.
  • the water extract is concentrated to a concentrated solution, and then alcohol precipitated with 30 to 80% alcohol, and the alcohol precipitate is concentrated to a concentrated sunflower leaf extract.
  • the preparation method of the teabag (concentrated teabag) for treating hypertension according to the present invention is: spraying a concentrated solution of sunflower leaf extract on tea leaves, mixing, drying, and bagging; wherein the drying temperature is 50 ⁇ 80 ° C .
  • the teabag for treating hypertension contains pure natural plant sunflower leaf extract without any toxic and side effects, and can achieve the purpose of treating hypertension diseases while drinking tea daily.
  • Figure 1 shows a HPLC chart of the chlorogenic acid and other organic acid components of the sunflower leaf extract concentrate. Best way to implement the invention
  • the use method of the present invention brewed with boiling water, concentrated teabags 1-2 bags per day, and fragrance teabags 3-6 bags per day.
  • Concentrates of sunflower leaf extracts extracted from Examples 1, 2, and 3 were administered to the duodenum in anesthetized dogs. The effects of concentrated extracts of sunflower leaf extracts from different processes on normal blood pressure in anesthetized dogs were observed.
  • the concentrated extracts of sunflower leaf extracts prepared in Examples 1, 2 and 3 All three dosage forms are brown viscous liquids, and only the viscosity is different. Prepare the required replacement pages with normal saline when using (Article 26 of the detailed rules) concentration. Lot number: 20020718.
  • the animals were randomly divided into 3 groups, the first group: the sunflower leaf extract concentrated solution prepared in Example 1 was administered, 8. 33 g / kg; the second group: the sunflower leaf extract concentrated solution prepared in Example 2 was administered Liquid, 8. 33 g / kg; and the third group: the sunflower leaf extract concentrated solution prepared in Example 3 was administered, 8. 33 g / kg, 3 animals in each group.
  • Duodenal administration The administration volume was 5ml / kg in the first group; 10ml / kg in the second group; 8ml / kg in the third group.
  • the animals were surgically separated from the trachea and common carotid arteries under intravenous anesthesia with 2.5% sodium pentobarbital and 25 mg / kg.
  • the common carotid arteries were cannulated, and pressure transducers were connected to multiple physiological recorders to record blood pressure.
  • the duodenum is surgically isolated and cannulated for administration.
  • the second group of sunflower leaf extract concentrates significantly reduced the normal systolic blood pressure and diastolic blood pressure in anesthetized dogs.
  • Example 1 (first group)
  • Example 2 (second group)
  • Example 3 (third group) systolic blood pressure (ramHg) diastolic pressure

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

La présente invention concerne un thé pour sac d'infusion destiné au traitement de l'hypertension et contenant des feuilles de tournesol ou un extrait associé. Cette invention a aussi trait à des procédés de préparation du thé. Ledit thé contient l'extrait provenant de feuilles de tournesol naturel et il est exempt d'effet secondaire nocif. Boire ce thé quotidiennement permet d'atteindre le but dudit traitement contre l'hypertension.
PCT/CN2003/000739 2003-05-20 2003-09-03 The pour sac d'infusion destine au traitement de l'hypertension et ses procedes de preparation WO2004103084A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003261596A AU2003261596A1 (en) 2003-05-20 2003-09-03 A bag-soaking tea for treatment of hypertension and its preparation methods

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN03112252.3 2003-05-20
CNA031122523A CN1513493A (zh) 2003-05-20 2003-05-20 一种治疗高血压的袋泡茶及制备方法

Publications (1)

Publication Number Publication Date
WO2004103084A1 true WO2004103084A1 (fr) 2004-12-02

Family

ID=33459826

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2003/000739 WO2004103084A1 (fr) 2003-05-20 2003-09-03 The pour sac d'infusion destine au traitement de l'hypertension et ses procedes de preparation

Country Status (3)

Country Link
CN (1) CN1513493A (fr)
AU (1) AU2003261596A1 (fr)
WO (1) WO2004103084A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101816414B (zh) * 2009-02-27 2012-05-23 凌沛学 向日葵叶用于制备食品、辅助降压的保健食品的应用
CN105028805B (zh) * 2015-06-17 2018-10-09 陈云勇 奇蒿袋泡茶的制法
CN106260348A (zh) * 2016-08-17 2017-01-04 钱灿星 一种三叶降压袋泡茶及其制备方法
CN109497235B (zh) * 2018-12-27 2021-06-11 青海师范大学 一种浓香金露梅茶及其配制方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1102301A (zh) * 1994-09-05 1995-05-10 梁春发 降压茶
CN1336189A (zh) * 2000-07-31 2002-02-20 雷学军 一种含天然药物成份的抗突变功能水及其制作方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1102301A (zh) * 1994-09-05 1995-05-10 梁春发 降压茶
CN1336189A (zh) * 2000-07-31 2002-02-20 雷学军 一种含天然药物成份的抗突变功能水及其制作方法

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Publication number Publication date
AU2003261596A1 (en) 2004-12-13
CN1513493A (zh) 2004-07-21

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